{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T04:11:18Z","timestamp":1790223078465,"version":"4.1.0"},"reference-count":75,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["DFG CH288\/6-2"],"award-info":[{"award-number":["DFG CH288\/6-2"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Wuhan-Heidelberg scholarship","award":["HGMF WW 2011-2012"],"award-info":[{"award-number":["HGMF WW 2011-2012"]}]},{"DOI":"10.13039\/501100004543","name":"China scholarship council","doi-asserted-by":"publisher","award":["201508320262"],"award-info":[{"award-number":["201508320262"]}],"id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1016\/j.bbalip.2017.09.001","type":"journal-article","created":{"date-parts":[[2017,9,6]],"date-time":"2017-09-06T17:41:51Z","timestamp":1504719711000},"page":"1520-1533","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"title":["Ageing sensitized by iPLA 2 \u03b2 deficiency induces liver fibrosis and intestinal atrophy involving suppression of homeostatic genes and alteration of intestinal lipids and bile acids"],"prefix":"10.1016","volume":"1862","author":[{"given":"Li","family":"Jiao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongying","family":"Gan-Schreier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingya","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Tuma-Kellner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard","family":"Liebisch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Stremmel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walee","family":"Chamulitrat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbalip.2017.09.001_bb0005","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1016\/j.bbamem.2006.09.024","article-title":"G protein-coupled receptor systems and their lipid environment in health disorders during aging","volume":"1768","author":"Alemany","year":"2007","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbalip.2017.09.001_bb0010","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1093\/ajcn\/77.4.803","article-title":"Cognitive decline and fatty acid composition of erythrocyte membranes\u2013the EVA study","volume":"77","author":"Heude","year":"2003","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.bbalip.2017.09.001_bb0015","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1159\/000213253","article-title":"Alzheimer's disease and cellular aging: membrane-related events as clues to primary mechanisms","volume":"37","author":"Bosman","year":"1991","journal-title":"Gerontology"},{"key":"10.1016\/j.bbalip.2017.09.001_bb0020","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1146\/annurev.nutr.012809.104635","article-title":"Docosahexaenoic acid signalolipidomics in nutrition: significance in aging, neuroinflammation, macular degeneration, Alzheimer's, and other neurodegenerative diseases","volume":"31","author":"Bazan","year":"2011","journal-title":"Annu. Rev. Nutr."},{"key":"10.1016\/j.bbalip.2017.09.001_bb0025","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1093\/ageing\/afn242","article-title":"Chronic liver disease in an ageing population","volume":"38","author":"Frith","year":"2009","journal-title":"Age Ageing"},{"key":"10.1016\/j.bbalip.2017.09.001_bb0030","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.bpg.2009.10.008","article-title":"Demography of aging and the epidemiology of gastrointestinal disorders in the elderly","volume":"23","author":"Goldacre","year":"2009","journal-title":"Best Pract. Res. Clin. Gastroenterol."},{"key":"10.1016\/j.bbalip.2017.09.001_bb0035","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1023\/A:1015211530695","article-title":"The anorexia of ageing","volume":"3","author":"Chapman","year":"2002","journal-title":"Biogerontology"},{"key":"10.1016\/j.bbalip.2017.09.001_bb0040","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1097\/MCO.0b013e32830b5d37","article-title":"The clinical significance of gastrointestinal changes with aging","volume":"11","author":"Bhutto","year":"2008","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"10.1016\/j.bbalip.2017.09.001_bb0045","doi-asserted-by":"crossref","first-page":"465","DOI":"10.2165\/00002512-199506060-00006","article-title":"Epidemiology of constipation in elderly patients. Drug utilisation and cost-containment strategies","volume":"6","author":"Lederle","year":"1995","journal-title":"Drugs Aging"},{"key":"10.1016\/j.bbalip.2017.09.001_bb0050","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1080\/10446670310001642168","article-title":"Basis for the age-related decline in intestinal mucosal immunity","volume":"10","author":"Schmucker","year":"2003","journal-title":"Clin. Dev. Immunol."},{"key":"10.1016\/j.bbalip.2017.09.001_bb0055","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1111\/j.1474-9726.2012.00865.x","article-title":"Human serum metabolic profiles are age dependent","volume":"11","author":"Yu","year":"2012","journal-title":"Aging Cell"},{"key":"10.1016\/j.bbalip.2017.09.001_bb0060","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1111\/j.1365-2362.1981.tb02009.x","article-title":"Age dependent differences in human bile acid metabolism and 7 alpha-dehydroxylation","volume":"11","author":"van der Werf","year":"1981","journal-title":"Eur. J. Clin. Investig."},{"key":"10.1016\/j.bbalip.2017.09.001_bb0065","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.maturitas.2013.02.004","article-title":"Probiotics and prebiotics and health in ageing populations","volume":"75","author":"Duncan","year":"2013","journal-title":"Maturitas"},{"key":"10.1016\/j.bbalip.2017.09.001_bb0070","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1038\/ng.2797","article-title":"Discovery and refinement of loci associated with lipid levels","volume":"45","author":"Willer","year":"2013","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbalip.2017.09.001_bb0075","doi-asserted-by":"crossref","first-page":"9400","DOI":"10.1074\/jbc.274.14.9400","article-title":"Cellular responses to excess phospholipid","volume":"274","author":"Baburina","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2017.09.001_bb0080","doi-asserted-by":"crossref","first-page":"8527","DOI":"10.1073\/pnas.92.18.8527","article-title":"Inhibition of calcium-independent phospholipase A2 prevents arachidonic acid incorporation and phospholipid remodeling in P388D1 macrophages","volume":"92","author":"Balsinde","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbalip.2017.09.001_bb0085","doi-asserted-by":"crossref","first-page":"4134","DOI":"10.1242\/jcs.015834","article-title":"The increase of cell-membranous phosphatidylcholines containing polyunsaturated fatty acid residues induces phosphorylation of p53 through activation of ATR","volume":"120","author":"Zhang","year":"2007","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.bbalip.2017.09.001_bb0090","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1016\/j.cellsig.2005.03.002","article-title":"Cellular regulation and proposed biological functions of group VIA calcium-independent phospholipase A2 in activated cells","volume":"17","author":"Balsinde","year":"2005","journal-title":"Cell. Signal."},{"key":"10.1016\/j.bbalip.2017.09.001_bb0095","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/S0092-8674(03)00422-7","article-title":"Apoptotic cells induce migration of phagocytes via caspase-3-mediated release of a lipid attraction signal","volume":"113","author":"Lauber","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.bbalip.2017.09.001_bb0100","doi-asserted-by":"crossref","first-page":"20958","DOI":"10.1074\/jbc.M600075200","article-title":"Insulin secretory responses and phospholipid composition of pancreatic islets from mice that do not express Group VIA phospholipase A2 and effects of metabolic stress on glucose homeostasis","volume":"281","author":"Bao","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2017.09.001_bb0105","doi-asserted-by":"crossref","first-page":"868","DOI":"10.2353\/ajpath.2008.070756","article-title":"Age-related changes in bone morphology are accelerated in group VIA phospholipase A2 (iPLA2beta)-null mice","volume":"172","author":"Ramanadham","year":"2008","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bbalip.2017.09.001_bb0110","doi-asserted-by":"crossref","first-page":"406","DOI":"10.2353\/ajpath.2008.070823","article-title":"Disrupted membrane homeostasis and accumulation of ubiquitinated proteins in a mouse model of infantile neuroaxonal dystrophy caused by PLA2G6 mutations","volume":"172","author":"Malik","year":"2008","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bbalip.2017.09.001_bb0115","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1007\/s11064-014-1342-y","article-title":"iPLA2beta knockout mouse, a genetic model for progressive human motor disorders, develops age-related neuropathology","volume":"39","author":"Blanchard","year":"2014","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.bbalip.2017.09.001_bb0120","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1016\/j.bbalip.2012.02.003","article-title":"Disturbed brain phospholipid and docosahexaenoic acid metabolism in calcium-independent phospholipase A(2)-VIA (iPLA(2)beta)-knockout mice","volume":"1821","author":"Cheon","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbalip.2017.09.001_bb0125","series-title":"Oxidants, Oxidative Stress and the Biology of Ageing, 408","first-page":"239","author":"Finkel","year":"2000"},{"key":"10.1016\/j.bbalip.2017.09.001_bb0130","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1093\/brain\/awv132","article-title":"Loss of PLA2G6 leads to elevated mitochondrial lipid peroxidation and mitochondrial dysfunction","volume":"138","author":"Kinghorn","year":"2015","journal-title":"Brain"},{"key":"10.1016\/j.bbalip.2017.09.001_bb0135","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1016\/j.bbadis.2015.04.025","article-title":"Sensitization to autoimmune hepatitis in group VIA calcium-independent phospholipase A2-null mice led to duodenal villous atrophy with apoptosis, goblet cell hyperplasia and leaked bile acids","volume":"1852","author":"Jiao","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbalip.2017.09.001_bb0140","series-title":"The International Liver CongressTM (EASL), Barcelona, Spain","article-title":"Deficiences of calcium-independent phospholipase A2 B in vivo causes reduced systemic lipids and lipoproteins concomitant With increased hepatic apoptosis and inflammation","author":"Xu","year":"2012"},{"key":"10.1016\/j.bbalip.2017.09.001_bb0145","doi-asserted-by":"crossref","first-page":"3590","DOI":"10.1007\/s10620-015-3807-5","article-title":"Deficiency of group via phospholipase A2 (iPLA2beta) renders susceptibility for chemical-induced colitis","volume":"60","author":"Jiao","year":"2015","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.bbalip.2017.09.001_bb0150","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.cell.2014.10.039","article-title":"Geroscience: linking aging to chronic disease","volume":"159","author":"Kennedy","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.bbalip.2017.09.001_bb0155","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1093\/gerona\/glu057","article-title":"Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases","volume":"69","author":"Franceschi","year":"2014","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"10.1016\/j.bbalip.2017.09.001_bb0160","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/B978-0-12-385928-0.00016-X","article-title":"Quantitative measurement of events in the mammalian unfolded protein response","volume":"491","author":"Shang","year":"2011","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.bbalip.2017.09.001_bb0165","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1194\/jlr.M033506","article-title":"Shorthand notation for lipid structures derived from mass spectrometry","volume":"54","author":"Liebisch","year":"2013","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.bbalip.2017.09.001_bb0170","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.jchromb.2008.08.018","article-title":"Quantitative-profiling of bile acids and their conjugates in mouse liver, bile, plasma, and urine using LC-MS\/MS","volume":"873","author":"Alnouti","year":"2008","journal-title":"J. Chromatogr. B Anal. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.bbalip.2017.09.001_bb0175","doi-asserted-by":"crossref","first-page":"S186","DOI":"10.2337\/diabetes.53.2007.S186","article-title":"Beta-cell calcium-independent group VIA phospholipase A(2) (iPLA(2)beta): tracking iPLA(2)beta movements in response to stimulation with insulin secretagogues in INS-1 cells","volume":"53","author":"Bao","year":"2004","journal-title":"Diabetes"},{"key":"10.1016\/j.bbalip.2017.09.001_bb0180","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1194\/jlr.R067595","article-title":"The role of ER stress in lipid metabolism and lipotoxicity","volume":"57","author":"Han","year":"2016","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.bbalip.2017.09.001_bb0185","doi-asserted-by":"crossref","first-page":"32300","DOI":"10.1074\/jbc.M111.247866","article-title":"Hepatic nuclear factor 1alpha (HNF1alpha) dysfunction down-regulates X-box-binding protein 1 (XBP1) and sensitizes beta-cells to endoplasmic reticulum stress","volume":"286","author":"Kirkpatrick","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2017.09.001_bb0190","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.bbalip.2016.02.004","article-title":"iPLA2beta deficiency attenuates obesity and hepatic steatosis in ob\/ob mice through hepatic fatty-acyl phospholipid remodeling","volume":"1861","author":"Deng","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbalip.2017.09.001_bb0195","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1126\/science.284.5418.1365","article-title":"Bile acids: natural ligands for an orphan nuclear receptor","volume":"284","author":"Parks","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.bbalip.2017.09.001_bb0200","doi-asserted-by":"crossref","first-page":"2384","DOI":"10.1038\/ncomms3384","article-title":"Microbiome remodelling leads to inhibition of intestinal farnesoid X receptor signalling and decreased obesity","volume":"4","author":"Li","year":"2013","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbalip.2017.09.001_bb0205","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1247\/csf.06016","article-title":"XBP1 is critical to protect cells from endoplasmic reticulum stress: evidence from Site-2 protease-deficient Chinese hamster ovary cells","volume":"31","author":"Yoshida","year":"2006","journal-title":"Cell Struct. Funct."},{"key":"10.1016\/j.bbalip.2017.09.001_bb0210","doi-asserted-by":"crossref","first-page":"99-10","DOI":"10.1111\/j.1463-1326.2010.01281.x","article-title":"The unfolded protein response is required to maintain the integrity of the endoplasmic reticulum, prevent oxidative stress and preserve differentiation in \u03b2-cells","volume":"12","author":"Kaufman","year":"2010","journal-title":"Diabetes Obes. Metab."},{"key":"10.1016\/j.bbalip.2017.09.001_bb0215","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1016\/j.celrep.2014.09.048","article-title":"Changes in nucleosome occupancy associated with metabolic alterations in aged mammalian liver","volume":"9","author":"Bochkis","year":"2014","journal-title":"Cell Rep."},{"key":"10.1016\/j.bbalip.2017.09.001_bb0220","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.molcel.2017.05.031","article-title":"The UPRER: sensor and coordinator of organismal homeostasis","volume":"66","author":"Frakes","year":"2017","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bbalip.2017.09.001_bb0225","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.cell.2008.07.021","article-title":"XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease","volume":"134","author":"Kaser","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.bbalip.2017.09.001_bb0230","doi-asserted-by":"crossref","DOI":"10.1002\/ibd.21856","article-title":"Quantification of low expressed SCD1 gene in colonic mucosa from patients with active ulcerative colitis","volume":"17","author":"Bueno-Hern\u00e1ndez","year":"2011","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.bbalip.2017.09.001_bb0235","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.lfs.2008.11.009","article-title":"Regulation of fatty acid synthesis and Delta9-desaturation in senescence of human fibroblasts","volume":"84","author":"Maeda","year":"2009","journal-title":"Life Sci."},{"key":"10.1016\/j.bbalip.2017.09.001_bb0240","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.bbagrm.2016.02.005","article-title":"Hepatocyte nuclear factor 1 coordinates multiple processes in a model of intestinal epithelial cell function","volume":"1859","author":"Yang","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbalip.2017.09.001_bb0245","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1074\/jbc.M114.620211","article-title":"Transcription factors GATA4 and HNF4A control distinct aspects of intestinal homeostasis in conjunction with transcription factor CDX2","volume":"290","author":"San Roman","year":"2015","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2017.09.001_bb0250","first-page":"B4820","article-title":"The role of CDX2 in inflammatory bowel disease","volume":"61","author":"Coskun","year":"2014","journal-title":"Dan. Med. J."},{"key":"10.1016\/j.bbalip.2017.09.001_bb0255","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.bcp.2006.03.016","article-title":"Alterations in transporter expression in liver, kidney, and duodenum after targeted disruption of the transcription factor HNF1alpha","volume":"72","author":"Maher","year":"2006","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bbalip.2017.09.001_bb0260","doi-asserted-by":"crossref","first-page":"27117","DOI":"10.1016\/S0021-9258(19)61487-0","article-title":"Regulation of the liver fatty acid-binding protein gene by hepatocyte nuclear factor 1alpha (HNF1alpha). Alterations in fatty acid homeostasis in HNF1alpha-deficient mice","volume":"275","author":"Akiyama","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2017.09.001_bb0265","doi-asserted-by":"crossref","first-page":"G227","DOI":"10.1152\/ajpgi.00267.2012","article-title":"A novel mechanism for gut barrier dysfunction by dietary fat: epithelial disruption by hydrophobic bile acids","volume":"304","author":"Stenman","year":"2013","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.bbalip.2017.09.001_bb0270","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0054472","article-title":"The bile acid sensor FXR is required for immune-regulatory activities of TLR-9 in intestinal inflammation","volume":"8","author":"Renga","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.bbalip.2017.09.001_bb0275","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1210\/me.2015-1087","article-title":"Suppression of the HPA axis during cholestasis can be attributed to hypothalamic bile acid signaling","volume":"29","author":"McMillin","year":"2015","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.bbalip.2017.09.001_bb0280","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1016\/j.cell.2016.11.018","article-title":"Gut microbiota regulate motor deficits and neuroinflammation in a model of Parkinson's disease","volume":"167","author":"Sampson","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.bbalip.2017.09.001_bb0285","doi-asserted-by":"crossref","first-page":"380","DOI":"10.3109\/10409238.2015.1067186","article-title":"Nuclear hormone receptors: roles of xenobiotic detoxification and sterol homeostasis in healthy aging","volume":"50","author":"Hoffmann","year":"2015","journal-title":"Crit. Rev. Biochem. Mol. Biol."},{"key":"10.1016\/j.bbalip.2017.09.001_bb0290","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.arr.2005.03.006","article-title":"C. elegans DAF-12, nuclear hormone receptors and human longevity and disease at old age","volume":"4","author":"Mooijaart","year":"2005","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.bbalip.2017.09.001_bb0295","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/j.jhep.2013.12.003","article-title":"Hepatic steatosis exacerbated by endoplasmic reticulum stress-mediated downregulation of FXR in aging mice","volume":"60","author":"Xiong","year":"2014","journal-title":"J. Hepatol."},{"key":"10.1016\/j.bbalip.2017.09.001_bb0300","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1093\/gerona\/62.4.343","article-title":"Liver X receptor alpha associates with human life span","volume":"62","author":"Mooijaart","year":"2007","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"10.1016\/j.bbalip.2017.09.001_bb0305","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1053\/j.gastro.2013.12.029","article-title":"Intestine-specific deletion of SIRT1 in mice impairs DCoH2-HNF-1\u03b1-FXR signaling and alters systemic bile acid homeostasis","volume":"146","author":"Kazgan","year":"2014","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bbalip.2017.09.001_bb0310","doi-asserted-by":"crossref","first-page":"E2271","DOI":"10.1073\/pnas.1318262111","article-title":"Activation of the endoplasmic reticulum unfolded protein response by lipid disequilibrium without disturbed proteostasis in vivo","volume":"111","author":"Hou","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbalip.2017.09.001_bb0315","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1111\/acel.12154","article-title":"The conserved Mediator subunit MDT-15 is required for oxidative stress responses in Caenorhabditis elegans","volume":"13","author":"Goh","year":"2014","journal-title":"Aging Cell"},{"key":"10.1016\/j.bbalip.2017.09.001_bb0320","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1016\/j.bbamcr.2013.05.018","article-title":"The role of phospholipids in the biological activity and structure of the endoplasmic reticulum","volume":"1833","author":"Lagace","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbalip.2017.09.001_bb0325","doi-asserted-by":"crossref","first-page":"10170","DOI":"10.1021\/bi700017z","article-title":"The group VIA calcium-independent phospholipase A2 participates in ER stress-induced INS-1 insulinoma cell apoptosis by promoting ceramide generation via hydrolysis of sphingomyelins by neutral sphingomyelinase","volume":"46","author":"Lei","year":"2007","journal-title":"Biochemistry"},{"key":"10.1016\/j.bbalip.2017.09.001_bb0330","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1016\/j.febslet.2010.02.026","article-title":"Ceramide-rich platforms in transmembrane signaling","volume":"584","author":"Stancevic","year":"2010","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bbalip.2017.09.001_bb0335","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0092142","article-title":"Ceramide transfer protein deficiency compromises organelle function and leads to senescence in primary cells","volume":"9","author":"Rao","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.bbalip.2017.09.001_bb0340","doi-asserted-by":"crossref","first-page":"11364","DOI":"10.1073\/pnas.0705049104","article-title":"Ceramide transfer protein function is essential for normal oxidative stress response and lifespan","volume":"104","author":"Rao","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbalip.2017.09.001_bb0345","doi-asserted-by":"crossref","first-page":"35578","DOI":"10.1074\/jbc.M111.226530","article-title":"Adipocyte-specific inactivation of acyl-CoA synthetase fatty acid transport protein 4 (Fatp4) in mice causes adipose hypertrophy and alterations in metabolism of complex lipids under high fat diet","volume":"286","author":"Lenz","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2017.09.001_bb0350","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1084\/jem.20071243","article-title":"iPLA2beta: front and center in human monocyte chemotaxis to MCP-1","volume":"205","author":"Mishra","year":"2008","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.bbalip.2017.09.001_bb0355","doi-asserted-by":"crossref","first-page":"28162","DOI":"10.1074\/jbc.M500013200","article-title":"Genetic and pharmacologic evidence that calcium-independent phospholipase A2beta regulates virus-induced inducible nitric-oxide synthase expression by macrophages","volume":"280","author":"Moran","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2017.09.001_bb0360","doi-asserted-by":"crossref","first-page":"2427","DOI":"10.3390\/cancers7040901","article-title":"Deficiency of iPLA\u2082\u03b2 primes immune cells for proinflammation: potential involvement in age-related mesenteric lymph node lymphoma","volume":"7","author":"Inhoffen","year":"2015","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.bbalip.2017.09.001_bb0365","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/ni.1857","article-title":"TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages","volume":"11","author":"Martinon","year":"2010","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.bbalip.2017.09.001_bb0370","doi-asserted-by":"crossref","first-page":"3108","DOI":"10.1128\/IAI.68.6.3108-3115.2000","article-title":"Enterohemorrhagic Escherichia coli induces apoptosis which augments bacterial binding and phosphatidylethanolamine exposure on the plasma membrane outer leaflet","volume":"68","author":"Barnett Foster","year":"2000","journal-title":"Infect. Immun."},{"key":"10.1016\/j.bbalip.2017.09.001_bb0375","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1074\/jbc.M003649200","article-title":"Loss of phospholipid asymmetry and surface exposure of phosphatidylserine is required for phagocytosis of apoptotic cells by macrophages and fibroblasts","volume":"276","author":"Fadok","year":"2001","journal-title":"J. Biol. Chem."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1388198117301865?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1388198117301865?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,8,2]],"date-time":"2022-08-02T08:48:28Z","timestamp":1659430108000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1388198117301865"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12]]},"references-count":75,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["S1388198117301865"],"URL":"https:\/\/doi.org\/10.1016\/j.bbalip.2017.09.001","relation":{},"ISSN":["1388-1981"],"issn-type":[{"value":"1388-1981","type":"print"}],"subject":[],"published":{"date-parts":[[2017,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ageing sensitized by iPLA2\u03b2 deficiency induces liver fibrosis and intestinal atrophy involving suppression of homeostatic genes and alteration of intestinal lipids and bile acids","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbalip.2017.09.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}