{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:41:29Z","timestamp":1790174489695,"version":"4.1.0"},"reference-count":55,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,11,3]],"date-time":"2019-11-03T00:00:00Z","timestamp":1572739200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003958","name":"Stichting voor de Technische Wetenschappen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003958","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1016\/j.bbalip.2019.158546","type":"journal-article","created":{"date-parts":[[2019,11,3]],"date-time":"2019-11-03T02:54:40Z","timestamp":1572749680000},"page":"158546","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["The effects of LXR agonist T0901317 and LXR antagonist GSK2033 on morphogenesis and lipid properties in full thickness skin models"],"prefix":"10.1016","volume":"1865","author":[{"given":"Richard W.J.","family":"Helder","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter A.","family":"Boiten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4068-1854","authenticated-orcid":false,"given":"Rianne","family":"van Dijk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerrit S.","family":"Gooris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdoelwaheb","family":"El Ghalbzouri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joke A.","family":"Bouwstra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.bbalip.2019.158546_bb0005","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1111\/exd.13531","article-title":"3D skin models for 3R research: the potential of 3D reconstructed skin models to study skin barrier function","volume":"27","author":"Niehues","year":"2018","journal-title":"Exp Dermatol."},{"issue":"5","key":"10.1016\/j.bbalip.2019.158546_bb0010","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1016\/j.tiv.2008.03.012","article-title":"Leiden reconstructed human epidermal model as a tool for the evaluation of the skin corrosion and irritation potential according to the ECVAM guidelines","volume":"22","author":"El Ghalbzouri","year":"2008","journal-title":"Toxicol. in Vitro"},{"issue":"1","key":"10.1016\/j.bbalip.2019.158546_bb0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/ten.tec.2011.0175","article-title":"Unraveling barrier properties of three different in-house human skin equivalents","volume":"18","author":"Thakoersing","year":"2012","journal-title":"Tissue Eng Part C Methods"},{"issue":"8","key":"10.1016\/j.bbalip.2019.158546_bb0020","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1194\/jlr.D800055-JLR200","article-title":"Comprehensive quantification of ceramide species in human stratum corneum","volume":"50","author":"Masukawa","year":"2009","journal-title":"J. Lipid Res."},{"issue":"3","key":"10.1016\/j.bbalip.2019.158546_bb0025","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.bbalip.2013.08.011","article-title":"Ceramide synthesis in the epidermis","volume":"1841","author":"Rabionet","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"issue":"6","key":"10.1016\/j.bbalip.2019.158546_bb0030","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1194\/jlr.M014456","article-title":"LC\/MS analysis of stratum corneum lipids: ceramide profiling and discovery","volume":"52","author":"van Smeden","year":"2011","journal-title":"J. Lipid Res."},{"issue":"1","key":"10.1016\/j.bbalip.2019.158546_bb0035","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1021\/ac202646v","article-title":"Profiling and characterizing skin ceramides using reversed-phase liquid chromatography-quadrupole time-of-flight mass spectrometry","volume":"84","author":"t' Kindt","year":"2012","journal-title":"Anal. Chem."},{"key":"10.1016\/j.bbalip.2019.158546_bb0040","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1111\/1523-1747.ep12492217","article-title":"Structural investigations of human stratum corneum by small-angle X-ray scattering","volume":"Dec(6)","author":"Bouwstra","year":"1991","journal-title":"J Invest Dermatol."},{"issue":"3","key":"10.1016\/j.bbalip.2019.158546_bb0045","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1111\/1523-1747.ep12336024","article-title":"The formation of competent barrier lipids in reconstructed human epidermis requires the presence of vitamin C","volume":"109","author":"Ponec","year":"1997","journal-title":"J Invest Dermatol."},{"issue":"2","key":"10.1016\/j.bbalip.2019.158546_bb0050","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1111\/1523-1747.ep12363678","article-title":"Lipid supplemented medium induces lamellar bodies and precursors of barrier lipids in cultured analogues of human skin","volume":"101","author":"Boyce","year":"1993","journal-title":"J Invest Dermatol."},{"issue":"1","key":"10.1016\/j.bbalip.2019.158546_bb0055","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/jid.2012.262","article-title":"Increased presence of monounsaturated fatty acids in the stratum corneum of human skin equivalents","volume":"133","author":"Thakoersing","year":"2013","journal-title":"J. Investig. Dermatol."},{"issue":"22","key":"10.1016\/j.bbalip.2019.158546_bb0060","doi-asserted-by":"crossref","first-page":"6534","DOI":"10.1021\/la500972w","article-title":"Monounsaturated fatty acids reduce the barrier of stratum corneum lipid membranes by enhancing the formation of a hexagonal lateral packing","volume":"30","author":"Mojumdar","year":"2014","journal-title":"Langmuir."},{"issue":"1","key":"10.1016\/j.bbalip.2019.158546_bb0065","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/exd.12293","article-title":"The importance of free fatty acid chain length for the skin barrier function in atopic eczema patients","volume":"23","author":"van Smeden","year":"2014","journal-title":"Exp. Dermatol."},{"issue":"10","key":"10.1016\/j.bbalip.2019.158546_bb0070","doi-asserted-by":"crossref","first-page":"2511","DOI":"10.1038\/jid.2010.161","article-title":"Changes in the ceramide profile of atopic dermatitis patients","volume":"130","author":"Ishikawa","year":"2010","journal-title":"J Invest Dermatol."},{"issue":"1","key":"10.1016\/j.bbalip.2019.158546_bb0075","doi-asserted-by":"crossref","first-page":"E28","DOI":"10.1152\/ajpendo.90897.2008","article-title":"Biochemical and physiological function of stearoyl-CoA desaturase","volume":"297","author":"Paton","year":"2009","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.bbalip.2019.158546_bb0080","doi-asserted-by":"crossref","first-page":"2831","DOI":"10.1101\/gad.850400","article-title":"Role of LXRs in control of lipogenesis","volume":"14","author":"Schultz","year":"2000","journal-title":"Genes Dev."},{"issue":"9","key":"10.1016\/j.bbalip.2019.158546_bb0085","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1111\/exd.12740","article-title":"Modulation of stratum corneum lipid composition and organization of human skin equivalents by specific medium supplements","volume":"24","author":"Thakoersing","year":"2015","journal-title":"Exp. Dermatol."},{"issue":"21\u221222","key":"10.1016\/j.bbalip.2019.158546_bb0090","doi-asserted-by":"crossref","first-page":"3041","DOI":"10.1089\/ten.tea.2014.0011","article-title":"Barrier properties of an N\/TERT-based human skin equivalent","volume":"20","author":"van Drongelen","year":"2014","journal-title":"Tissue Eng Part A."},{"issue":"12","key":"10.1016\/j.bbalip.2019.158546_bb0095","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1371\/journal.pone.0082800","article-title":"Inflammatory and antimicrobial responses to methicillin-resistant Staphylococcus aureus in an in vitro wound infection model","volume":"8","author":"Haisma","year":"2013","journal-title":"PLoS One"},{"issue":"11","key":"10.1016\/j.bbalip.2019.158546_bb0100","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1016\/j.bbalip.2016.07.004","article-title":"Quantitative analysis of ceramides using a novel lipidomics approach with three dimensional response modelling","volume":"1861","author":"Boiten","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"issue":"2","key":"10.1016\/j.bbalip.2019.158546_bb0105","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/0925-4439(93)90135-N","article-title":"Ceramide composition of the psoriatic scale","volume":"1182","author":"Motta","year":"1993","journal-title":"Biochim. Biophys. Acta"},{"issue":"12","key":"10.1016\/j.bbalip.2019.158546_bb0110","doi-asserted-by":"crossref","first-page":"2755","DOI":"10.1194\/jlr.P030338","article-title":"Increase in short-chain ceramides correlates with an altered lipid organization and decreased barrier function in atopic eczema patients","volume":"53","author":"Janssens","year":"2012","journal-title":"J. Lipid Res."},{"issue":"9","key":"10.1016\/j.bbalip.2019.158546_bb0115","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1016\/j.bbalip.2019.05.003","article-title":"Selectivity in cornified envelop binding of ceramides in human skin and the role of LXR inactivation on ceramide binding","volume":"1864","author":"Boiten","year":"2019","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"issue":"5","key":"10.1016\/j.bbalip.2019.158546_bb0120","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1038\/jid.2013.517","article-title":"Intercellular skin barrier lipid composition and organization in Netherton syndrome patients","volume":"134","author":"van Smeden","year":"2014","journal-title":"J Invest Dermatol."},{"issue":"43","key":"10.1016\/j.bbalip.2019.158546_bb0125","doi-asserted-by":"crossref","first-page":"18439","DOI":"10.1073\/pnas.1005572107","article-title":"ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid synthesis","volume":"107","author":"Ohno","year":"2010","journal-title":"PNAS"},{"issue":"2","key":"10.1016\/j.bbalip.2019.158546_bb0130","doi-asserted-by":"crossref","first-page":"83","DOI":"10.4062\/biomolther.2014.017","article-title":"Metabolism of very long-chain fatty acids: genes and pathophysiology","volume":"22","author":"Sassa","year":"2014","journal-title":"Biomol Ther (Seoul)"},{"issue":"14","key":"10.1016\/j.bbalip.2019.158546_bb0135","doi-asserted-by":"crossref","first-page":"2787","DOI":"10.1128\/MCB.00192-13","article-title":"Impaired epidermal permeability barrier in mice lacking elovl1, the gene responsible for very-long-chain fatty acid production","volume":"33","author":"Sassa","year":"2013","journal-title":"Mol. Cell. Biol."},{"issue":"3","key":"10.1016\/j.bbalip.2019.158546_bb0140","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1194\/jlr.M044586","article-title":"Lorenzo's oil inhibits ELOVL1 and lowers the level of sphingomyelin with a saturated very long-chain fatty acid","volume":"55","author":"Sassa","year":"2014","journal-title":"J. Lipid Res."},{"issue":"8","key":"10.1016\/j.bbalip.2019.158546_bb0145","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1529\/biophysj.106.094292","article-title":"Infrared spectroscopic study of stratum corneum model membranes prepared from human ceramides, cholesterol, and fatty acids","volume":"92","author":"Gooris","year":"2007","journal-title":"Biophys. J."},{"issue":"11","key":"10.1016\/j.bbalip.2019.158546_bb0150","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1016\/S0022-2275(20)31502-9","article-title":"Phase behavior of lipid mixtures based on human ceramides: coexistence of crystalline and liquid phases","volume":"42","author":"Bouwstra","year":"2001","journal-title":"J. Lipid Res."},{"issue":"27","key":"10.1016\/j.bbalip.2019.158546_bb0155","doi-asserted-by":"crossref","first-page":"24046","DOI":"10.1074\/jbc.M111.251496","article-title":"Lipoxygenases mediate the effect of essential fatty acid in skin barrier formation: a proposed role in releasing omega-hydroxyceramide for construction of the corneocyte lipid envelope","volume":"286","author":"Zheng","year":"2011","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.bbalip.2019.158546_bb0160","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1038\/jid.2012.250","article-title":"Aloxe3 knockout mice reveal a function of epidermal lipoxygenase-3 as hepoxilin synthase and its pivotal role in barrier formation","volume":"133","author":"Krieg","year":"2013","journal-title":"J Invest Dermatol."},{"issue":"3","key":"10.1016\/j.bbalip.2019.158546_bb0165","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1073\/pnas.95.3.1044","article-title":"Defective stratum corneum and early neonatal death in mice lacking the gene for transglutaminase 1 (keratinocyte transglutaminase)","volume":"95","author":"Matsuki","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"3","key":"10.1016\/j.bbalip.2019.158546_bb0170","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.jdermsci.2011.12.011","article-title":"Knocking-in the R142C mutation in transglutaminase 1 disrupts the stratum corneum barrier and postnatal survival of mice","volume":"65","author":"Nakagawa","year":"2012","journal-title":"J. Dermatol. Sci."},{"key":"10.1016\/j.bbalip.2019.158546_bb0175","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.bbalip.2013.08.005","article-title":"The role of lipoxygenases in epidermis","volume":"1841","author":"Krieg","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"issue":"25","key":"10.1016\/j.bbalip.2019.158546_bb0180","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1073\/pnas.1503491112","article-title":"Essential role of the cytochrome P450 CYP4F22 in the production of acylceramide, the key lipid for skin permeability barrier formation","volume":"112","author":"Ohno","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"2","key":"10.1016\/j.bbalip.2019.158546_bb0185","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.jid.2016.08.036","article-title":"PNPLA1 deficiency in mice and humans leads to a defect in the synthesis of omega-O-acylceramides","volume":"137","author":"Grond","year":"2017","journal-title":"J Invest Dermatol."},{"issue":"2","key":"10.1016\/j.bbalip.2019.158546_bb0190","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1038\/sj.jid.5700046","article-title":"Basis for improved permeability barrier homeostasis induced by PPAR and LXR activators: liposensors stimulate lipid synthesis, lamellar body secretion, and post-secretory lipid processing","volume":"126","author":"Man","year":"2006","journal-title":"J Invest Dermatol."},{"key":"10.1016\/j.bbalip.2019.158546_bb0195","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1194\/jlr.R800001-JLR200","article-title":"Peroxisome proliferator-activated receptors and liver X receptors in epidermal biology","volume":"49","author":"Schmuth","year":"2008","journal-title":"J. Lipid Res."},{"issue":"1841","key":"10.1016\/j.bbalip.2019.158546_bb0200","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.bbalip.2013.11.012","article-title":"Role of PPAR, LXR, and PXR in epidermal homeostasis and inflammation","volume":"1","author":"Schmuth","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbalip.2019.158546_bb0205","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1046\/j.1523-1747.2003.12033.x","article-title":"Liver X receptor activators display anti-inflammatory activity in irritant and allergic contact dermatitis models: liver-X-receptor-specific inhibition of inflammation and primary cytokine production","volume":"120","author":"Fowler","year":"2003","journal-title":"J. Invest. Dermatol."},{"issue":"11","key":"10.1016\/j.bbalip.2019.158546_bb0210","doi-asserted-by":"crossref","first-page":"2407","DOI":"10.1210\/me.2008-0232","article-title":"Liver X receptor is a therapeutic target for photoaging and chronological skin aging","volume":"22","author":"Chang","year":"2008","journal-title":"Mol. Endocrinol."},{"issue":"9","key":"10.1016\/j.bbalip.2019.158546_bb0215","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1016\/j.febslet.2007.03.047","article-title":"T0901317 is a potent PXR ligand: implications for the biology ascribed to LXR","volume":"581","author":"Mitro","year":"2007","journal-title":"FEBS Lett."},{"issue":"13","key":"10.1016\/j.bbalip.2019.158546_bb0220","doi-asserted-by":"crossref","first-page":"11019","DOI":"10.1074\/jbc.M111041200","article-title":"Direct and indirect mechanisms for regulation of fatty acid synthase gene expression by liver X receptors","volume":"277","author":"Joseph","year":"2002","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.bbalip.2019.158546_bb0225","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1172\/JCI119583","article-title":"Activators of the nuclear hormone receptors PPARalpha and FXR accelerate the development of the fetal epidermal permeability barrier","volume":"100","author":"Hanley","year":"1997","journal-title":"J. Clin. Invest."},{"issue":"10","key":"10.1016\/j.bbalip.2019.158546_bb0230","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1111\/j.1600-0625.2007.00612.x","article-title":"Characterization of liver X receptor expression and function in human skin and the pilosebaceous unit","volume":"16","author":"Russell","year":"2007","journal-title":"Exp. Dermatol."},{"issue":"4","key":"10.1016\/j.bbalip.2019.158546_bb0235","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S1537-1891(02)00175-1","article-title":"LXRs; oxysterol-activated nuclear receptors that regulate genes controlling lipid homeostasis","volume":"38","author":"Edwards","year":"2002","journal-title":"Vasc. Pharmacol."},{"issue":"4","key":"10.1016\/j.bbalip.2019.158546_bb0240","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.bcp.2005.11.004","article-title":"Different roles of liver X receptor a and b in lipid metabolism: effects of an a-selective and a dual agonist in mice deficient in each subtype","volume":"71","author":"Lund","year":"2006","journal-title":"Biochem. Pharmacol."},{"issue":"4","key":"10.1016\/j.bbalip.2019.158546_bb0245","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1124\/mol.106.022608","article-title":"Liver X receptor (LXR) - regulation in LXR - deficient mice: implications for therapeutic targeting","volume":"70","author":"Quinet","year":"2006","journal-title":"Mol. Pharmacol."},{"issue":"6","key":"10.1016\/j.bbalip.2019.158546_bb0250","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.anai.2018.03.013","article-title":"Effect of short-term liver X receptor activation on epidermal barrier features in mild to moderate atopic dermatitis: a randomized controlled trial","volume":"120","author":"Czarnowicki","year":"2018","journal-title":"Ann. Allergy Asthma Immunol."},{"issue":"1\u20132","key":"10.1016\/j.bbalip.2019.158546_bb0255","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.ymgme.2004.07.007","article-title":"T0901317 is a dual LXR\/FXR agonist","volume":"83","author":"Houck","year":"2004","journal-title":"Mol. Genet. Metab."},{"issue":"2","key":"10.1016\/j.bbalip.2019.158546_bb0260","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.abb.2004.08.030","article-title":"Regulatory network of lipid-sensing nuclear receptors: roles for CAR, PXR, LXR, and FXR","volume":"433","author":"Handschin","year":"2005","journal-title":"Biochemistry and Biophysics"},{"issue":"3","key":"10.1016\/j.bbalip.2019.158546_bb0265","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.bbrc.2016.09.036","article-title":"Promiscuous activity of the LXR antagonist GSK2033 in a mouse model of fatty liver disease","volume":"479","author":"Griffett","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"1","key":"10.1016\/j.bbalip.2019.158546_bb0270","doi-asserted-by":"crossref","first-page":"14","DOI":"10.2133\/dmpk.23.14","article-title":"Interplay of pregnane X receptor with other nuclear receptors on gene regulation","volume":"23","author":"Lim","year":"2008","journal-title":"Drug Metabolism and Pharmacokinetics."},{"key":"10.1016\/j.bbalip.2019.158546_bb0275","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.jsbmb.2019.01.022","article-title":"Shedding light on the effects of 1,25-dihydroxyvitamin D3 on epidermal lipid barrier formation in three-dimensional human skin equivalents","volume":"189","author":"Mieremet","year":"2019","journal-title":"J. Steroid Biochem. Mol. Biol."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1388198119301970?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1388198119301970?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T10:06:59Z","timestamp":1761386819000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1388198119301970"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":55,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["S1388198119301970"],"URL":"https:\/\/doi.org\/10.1016\/j.bbalip.2019.158546","relation":{},"ISSN":["1388-1981"],"issn-type":[{"value":"1388-1981","type":"print"}],"subject":[],"published":{"date-parts":[[2020,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The effects of LXR agonist T0901317 and LXR antagonist GSK2033 on morphogenesis and lipid properties in full thickness skin models","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbalip.2019.158546","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"158546"}}