{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T13:50:43Z","timestamp":1787579443903,"version":"build-2736575974"},"reference-count":55,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition","award":["14DZ2272400"],"award-info":[{"award-number":["14DZ2272400"]}]},{"DOI":"10.13039\/100007219","name":"Shanghai Natural Science Foundation","doi-asserted-by":"publisher","award":["19ZR1442000"],"award-info":[{"award-number":["19ZR1442000"]}],"id":[{"id":"10.13039\/100007219","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007219","name":"Shanghai Natural Science Foundation","doi-asserted-by":"publisher","award":["19ZR1406300"],"award-info":[{"award-number":["19ZR1406300"]}],"id":[{"id":"10.13039\/100007219","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids"],"published-print":{"date-parts":[[2020,6]]},"DOI":"10.1016\/j.bbalip.2020.158663","type":"journal-article","created":{"date-parts":[[2020,2,12]],"date-time":"2020-02-12T08:42:28Z","timestamp":1581496948000},"page":"158663","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Carboxyl ester lipase is highly conserved in utilizing maternal supplied lipids during early development of zebrafish and human"],"prefix":"10.1016","volume":"1865","author":[{"given":"Yaqi","family":"Qiu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuna","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianxian","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiefei","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linxi","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbalip.2020.158663_bb0005","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1146\/annurev-food-041715-033120","article-title":"Infant formula fat analogs and human milk fat: new focus on infant developmental needs","volume":"7","author":"Zou","year":"2016","journal-title":"Annu. Rev. Food Sci. Technol."},{"key":"10.1016\/j.bbalip.2020.158663_bb0010","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1111\/j.1651-2227.2011.02343.x","article-title":"Physiological aspects of human milk lipids and implications for infant feeding: a workshop report","volume":"100","author":"Koletzko","year":"2011","journal-title":"Acta Paediatr."},{"key":"10.1016\/j.bbalip.2020.158663_bb0015","first-page":"314","article-title":"Lipid digestion and absorption in early life: an update","volume":"13","author":"Lindquist","year":"2010","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"10.1016\/j.bbalip.2020.158663_bb0020","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1111\/j.1471-4159.2009.05917.x","article-title":"Marked differences in cholesterol synthesis between neurons and glial cells from postnatal rats","volume":"109","author":"Nieweg","year":"2009","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbalip.2020.158663_bb0025","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.clp.2016.11.004","article-title":"Neurodevelopmental outcomes of preterm infants fed human milk: a systematic review","volume":"44","author":"Lechner","year":"2017","journal-title":"Clin. Perinatol."},{"key":"10.1016\/j.bbalip.2020.158663_bb0030","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1194\/jlr.R200013-JLR200","article-title":"Carboxyl ester lipase: structure-function relationship and physiological role in lipoprotein metabolism and atherosclerosis","volume":"43","author":"Hui","year":"2002","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.bbalip.2020.158663_bb0035","first-page":"220","article-title":"Nutrition in the preterm infant: what's new?","volume":"19","author":"Cleminson","year":"2016","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"10.1016\/j.bbalip.2020.158663_bb0040","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1194\/jlr.M015685","article-title":"BSSL and PLRP2: key enzymes for lipid digestion in the newborn examined using the Caco-2 cell line","volume":"52","author":"Andersson","year":"2011","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.bbalip.2020.158663_bb0045","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1203\/PDR.0b013e3181559e75","article-title":"Bile salt-stimulated lipase and pancreatic lipase-related protein 2 are the dominating lipases in neonatal fat digestion in mice and rats","volume":"62","author":"Li","year":"2007","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.bbalip.2020.158663_bb0050","first-page":"G914","article-title":"Rat pancreatic lipase and two related proteins: enzymatic properties and mRNA expression during development","volume":"266","author":"Payne","year":"1994","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.bbalip.2020.158663_bb0055","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1203\/00006450-200002000-00006","article-title":"Discoordinate expression of pancreatic lipase and two related proteins in the human fetal pancreas","volume":"47","author":"Yang","year":"2000","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.bbalip.2020.158663_bb0060","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1093\/jn\/138.5.927","article-title":"Carboxyl ester lipase from either mother's milk or the pancreas is required for efficient dietary triglyceride digestion in suckling mice","volume":"138","author":"Miller","year":"2008","journal-title":"J. Nutr."},{"key":"10.1016\/j.bbalip.2020.158663_bb0065","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1017\/S0007114518001836","article-title":"Fat composition in infant formula contributes to the severity of necrotising enterocolitis","volume":"120","author":"Sodhi","year":"2018","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.bbalip.2020.158663_bb0070","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/s12033-014-9822-5","article-title":"Transgenic mouse milk expressing human bile salt-stimulated lipase improves the survival and growth status of premature mice","volume":"57","author":"Wang","year":"2015","journal-title":"Mol. Biotechnol."},{"key":"10.1016\/j.bbalip.2020.158663_bb0075","doi-asserted-by":"crossref","first-page":"781643","DOI":"10.1155\/2011\/781643","article-title":"Comparative structures and evolution of vertebrate carboxyl ester lipase (CEL) genes and proteins with a major role in reverse cholesterol transport","volume":"2011","author":"Holmes","year":"2011","journal-title":"Cholesterol"},{"key":"10.1016\/j.bbalip.2020.158663_bb0080","doi-asserted-by":"crossref","first-page":"159","DOI":"10.3389\/fendo.2016.00159","article-title":"Zebrafish models for dyslipidemia and atherosclerosis research","volume":"7","author":"Schlegel","year":"2016","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.bbalip.2020.158663_bb0085","first-page":"915","article-title":"Zebrafish yolk lipid processing: a tractable tool for the study of vertebrate lipid transport and metabolism","volume":"7","author":"Miyares","year":"2014","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.bbalip.2020.158663_bb0090","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1016\/j.celrep.2016.01.016","article-title":"Zebrafish embryonic lipidomic analysis reveals that the yolk cell is metabolically active in processing lipid","volume":"14","author":"Fraher","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.bbalip.2020.158663_bb0095","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/S1095-6433(02)00188-5","article-title":"Energy and nutrient utilisation by embryonic reptiles","volume":"133","author":"Thompson","year":"2002","journal-title":"Comp. Biochem. Physiol. A Mol. Integr. Physiol."},{"key":"10.1016\/j.bbalip.2020.158663_bb0100","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/S0271-5317(05)80312-4","article-title":"Energy contribution of proteins and lipids during prolonged fasting in the rat","volume":"11","author":"Belkhou","year":"1991","journal-title":"Nutr. Res."},{"key":"10.1016\/j.bbalip.2020.158663_bb0105","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/42408","article-title":"Functional rafts in cell membranes","volume":"387","author":"Simons","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.bbalip.2020.158663_bb0110","doi-asserted-by":"crossref","first-page":"170063","DOI":"10.1098\/rsob.170063","article-title":"Zebrafish lipid droplets regulate embryonic ATP homeostasis to power early development","volume":"7","author":"Dutta","year":"2017","journal-title":"Open Biol."},{"key":"10.1016\/j.bbalip.2020.158663_bb0115","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.4161\/cc.5.11.2804","article-title":"Lipid modification of secreted signaling proteins","volume":"5","author":"Miura","year":"2006","journal-title":"Cell Cycle"},{"key":"10.1016\/j.bbalip.2020.158663_bb0120","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1194\/jlr.M012377","article-title":"Requirement of Npc1 and availability of cholesterol for early embryonic cell movements in zebrafish","volume":"52","author":"Schwend","year":"2011","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.bbalip.2020.158663_bb0125","first-page":"295","article-title":"Zebrafish as a model for apolipoprotein biology: comprehensive expression analysis and a role for ApoA-IV in regulating food intake","volume":"8","author":"Otis","year":"2015","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.bbalip.2020.158663_bb0130","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1002\/dvdy.20251","article-title":"Developmental expression and nutritional regulation of a zebrafish gene homologous to mammalian microsomal triglyceride transfer protein large subunit","volume":"232","author":"Marza","year":"2005","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.bbalip.2020.158663_bb0135","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1038\/nm.2759","article-title":"ApoB-containing lipoproteins regulate angiogenesis by modulating expression of VEGF receptor 1","volume":"18","author":"Avraham-Davidi","year":"2012","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbalip.2020.158663_bb0140","doi-asserted-by":"crossref","first-page":"15179","DOI":"10.1021\/bi0619268","article-title":"Microsomal triglyceride transfer protein is required for yolk lipid utilization and absorption of dietary lipids in zebrafish larvae","volume":"45","author":"Schlegel","year":"2006","journal-title":"Biochemistry"},{"key":"10.1016\/j.bbalip.2020.158663_bb0145","series-title":"The Zebrafish Book. A Guide for the Laboratory Use of Zebrafish (Danio rerio). 4 th ed.","author":"Westerfield","year":"2000"},{"key":"10.1016\/j.bbalip.2020.158663_bb0150","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/aja.1002030302","article-title":"Stages of embryonic development of the zebrafish","volume":"203","author":"Kimmel","year":"1995","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.bbalip.2020.158663_bb0155","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/labinvest.3700516","article-title":"Fetal alcohol exposure impairs Hedgehog cholesterol modification and signaling","volume":"87","author":"Li","year":"2007","journal-title":"Lab. Investig."},{"key":"10.1016\/j.bbalip.2020.158663_bb0160","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1111\/j.1600-0854.2008.00801.x","article-title":"BODIPY-cholesterol: a new tool to visualize sterol trafficking in living cells and organisms","volume":"9","author":"Holtta-Vuori","year":"2008","journal-title":"Traffic"},{"key":"10.1016\/j.bbalip.2020.158663_bb0165","doi-asserted-by":"crossref","first-page":"4357","DOI":"10.1242\/dev.01301","article-title":"Synergistic and antagonistic roles of the Sonic hedgehog N- and C-terminal lipids","volume":"131","author":"Feng","year":"2004","journal-title":"Development"},{"key":"10.1016\/j.bbalip.2020.158663_bb0170","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1002\/dvdy.20032","article-title":"Expression analyses of zebrafish transferrin, ifabp, and elastaseB mRNAs as differentiation markers for the three major endodermal organs: liver, intestine, and exocrine pancreas","volume":"230","author":"Mudumana","year":"2004","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.bbalip.2020.158663_bb0175","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1111\/jfb.12423","article-title":"Comparative studies of zebrafish Danio rerio lipoprotein lipase (lpl) and hepatic lipase (lipc) genes belonging to the lipase gene family: evolution and expression pattern","volume":"85","author":"Feng","year":"2014","journal-title":"J. Fish Biol."},{"key":"10.1016\/j.bbalip.2020.158663_bb0180","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1038\/nature04436","article-title":"Pregnenolone stabilizes microtubules and promotes zebrafish embryonic cell movement","volume":"439","author":"Hsu","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.bbalip.2020.158663_bb0185","doi-asserted-by":"crossref","first-page":"e104","DOI":"10.1371\/journal.pone.0000104","article-title":"Genome-wide reverse genetics framework to identify novel functions of the vertebrate secretome","volume":"1","author":"Pickart","year":"2006","journal-title":"PLoS One"},{"key":"10.1016\/j.bbalip.2020.158663_bb0190","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0167644","article-title":"Sterol O-acyltransferase 2 contributes to the yolk cholesterol trafficking during zebrafish embryogenesis","volume":"11","author":"Chang","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.bbalip.2020.158663_bb0195","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/0012-1606(85)90011-9","article-title":"Cell lineage of zebrafish blastomeres. II. Formation of the yolk syncytial layer","volume":"108","author":"Kimmel","year":"1985","journal-title":"Dev. Biol."},{"key":"10.1016\/j.bbalip.2020.158663_bb0200","doi-asserted-by":"crossref","first-page":"7196","DOI":"10.1074\/jbc.271.12.7196","article-title":"Dietary free and esterified cholesterol absorption in cholesterol esterase (bile salt-stimulated lipase) gene-targeted mice","volume":"271","author":"Howles","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2020.158663_bb0205","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1038\/pr.2013.90","article-title":"Pancreatic lipase-related protein 2 digests fats in human milk and formula in concert with gastric lipase and carboxyl ester lipase","volume":"74","author":"Johnson","year":"2013","journal-title":"Pediatr. Res."},{"issue":"Suppl. 2","key":"10.1016\/j.bbalip.2020.158663_bb0210","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1159\/000452819","article-title":"Human Milk Lipids","volume":"69","author":"Koletzko","year":"2016","journal-title":"Ann. Nutr. Metab."},{"key":"10.1016\/j.bbalip.2020.158663_bb0215","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1097\/MPG.0000000000000818","article-title":"Lipid quality in infant nutrition: current knowledge and future opportunities","volume":"61","author":"Delplanque","year":"2015","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"10.1016\/j.bbalip.2020.158663_bb0220","first-page":"95","article-title":"Fluorescent sterols and cholesteryl esters as probes for intracellular cholesterol transport","volume":"8","author":"Solanko","year":"2015","journal-title":"Lipid Insights"},{"key":"10.1016\/j.bbalip.2020.158663_bb0225","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s00232-011-9412-4","article-title":"Functions of cholesterol and the cholesterol bilayer domain specific to the fiber-cell plasma membrane of the eye lens","volume":"245","author":"Subczynski","year":"2012","journal-title":"J. Membr. Biol."},{"key":"10.1016\/j.bbalip.2020.158663_bb0230","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1161\/01.ATV.0000120374.59826.1b","article-title":"Brain cholesterol: long secret life behind a barrier","volume":"24","author":"Bjorkhem","year":"2004","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.bbalip.2020.158663_bb0235","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1002\/(SICI)1096-9926(199709)56:3<188::AID-TERA2>3.0.CO;2-Y","article-title":"Cholesterol biosynthesis inhibited by BM15.766 induces holoprosencephaly in the rat","volume":"56","author":"Kolf-Clauw","year":"1997","journal-title":"Teratology"},{"key":"10.1016\/j.bbalip.2020.158663_bb0240","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.bbrc.2012.09.076","article-title":"Acetoacetyl-CoA synthetase is essential for normal neuronal development","volume":"427","author":"Hasegawa","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbalip.2020.158663_bb0245","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1126\/science.274.5285.255","article-title":"Cholesterol modification of hedgehog signaling proteins in animal development","volume":"274","author":"Porter","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.bbalip.2020.158663_bb0250","doi-asserted-by":"crossref","first-page":"2537","DOI":"10.1242\/dev.121.8.2537","article-title":"Distribution of Sonic hedgehog peptides in the developing chick and mouse embryo","volume":"121","author":"Marti","year":"1995","journal-title":"Development"},{"key":"10.1016\/j.bbalip.2020.158663_bb0255","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1126\/science.1139740","article-title":"Patched1 regulates hedgehog signaling at the primary cilium","volume":"317","author":"Rohatgi","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.bbalip.2020.158663_bb0260","first-page":"1651","article-title":"The loss of Hh responsiveness by a non-ciliary Gli2 variant","volume":"142","author":"Liu","year":"2015","journal-title":"Development"},{"key":"10.1016\/j.bbalip.2020.158663_bb0265","doi-asserted-by":"crossref","first-page":"873","DOI":"10.2174\/156652409789105570","article-title":"Hedgehog target genes: mechanisms of carcinogenesis induced by aberrant hedgehog signaling activation","volume":"9","author":"Katoh","year":"2009","journal-title":"Curr. Mol. Med."},{"key":"10.1016\/j.bbalip.2020.158663_bb0270","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/S0092-8674(00)80853-3","article-title":"A homeodomain protein code specifies progenitor cell identity and neuronal fate in the ventral neural tube","volume":"101","author":"Briscoe","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.bbalip.2020.158663_bb0275","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1111\/j.1460-9568.2010.07560.x","article-title":"Sonic hedgehog (Shh)-Gli signaling controls neural progenitor cell division in the developing tectum in zebrafish","volume":"33","author":"Feijoo","year":"2011","journal-title":"Eur. J. Neurosci."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S138819812030055X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S138819812030055X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T10:06:52Z","timestamp":1761386812000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S138819812030055X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6]]},"references-count":55,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["S138819812030055X"],"URL":"https:\/\/doi.org\/10.1016\/j.bbalip.2020.158663","relation":{},"ISSN":["1388-1981"],"issn-type":[{"value":"1388-1981","type":"print"}],"subject":[],"published":{"date-parts":[[2020,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Carboxyl ester lipase is highly conserved in utilizing maternal supplied lipids during early development of zebrafish and human","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbalip.2020.158663","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"158663"}}