{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T23:43:04Z","timestamp":1792712584561,"version":"4.5.0"},"reference-count":46,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.bbalip.2020.158699","type":"journal-article","created":{"date-parts":[[2020,3,20]],"date-time":"2020-03-20T03:09:11Z","timestamp":1584673751000},"page":"158699","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":83,"title":["Carotenoid research: History and new perspectives for chemistry in biological systems"],"prefix":"10.1016","volume":"1865","author":[{"given":"George","family":"Britton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbalip.2020.158699_bb0005","series-title":"Carotenoids: A Colourful History","author":"Britton","year":"2017"},{"key":"10.1016\/j.bbalip.2020.158699_bb0010","doi-asserted-by":"crossref","unstructured":"P. Karrer, E. Jucker, Carotenoids, (tr. E. A. Braude), Elsevier, Amsterdam, 1950.","DOI":"10.5962\/bhl.title.7317"},{"key":"10.1016\/j.bbalip.2020.158699_bb0015","series-title":"Carotenoids Vol. 5: Nutrition and Health","first-page":"45","article-title":"Carotenoids in food","author":"Britton","year":"2009"},{"key":"10.1016\/j.bbalip.2020.158699_bb0020","series-title":"Carotenoids and Related Lipids","author":"Palmer","year":"1922"},{"key":"10.1016\/j.bbalip.2020.158699_bb0025","series-title":"Carotenoids Vol. 5: Nutrition and Health","first-page":"115","article-title":"Absorption, transport, distribution in tissues and bioavailability","author":"Canene-Adams","year":"2009"},{"key":"10.1016\/j.bbalip.2020.158699_bb0030","unstructured":"J. von Lintig, J. Moon, J. Lee, S. Ramkumar, Carotenoid metabolism at the intestinal interface, this issue."},{"key":"10.1016\/j.bbalip.2020.158699_bb0035","unstructured":"X. Zheng, G. Giuliano, S. Al-Babili, Carotenoid biofortification in crop plants: citius, altius, fortius, this issue."},{"key":"10.1016\/j.bbalip.2020.158699_bb0040","series-title":"Carotenoids Vol. 5: Nutrition and Health","first-page":"301","article-title":"The eye","author":"Schalch","year":"2009"},{"key":"10.1016\/j.bbalip.2020.158699_bb0045","series-title":"The Control of Xerophthalmia; A Century of Contributions and Lessons","author":"McLaren","year":"2004"},{"key":"10.1016\/j.bbalip.2020.158699_bb0050","series-title":"Vitamin A Deficiency","author":"Sommer","year":"1996"},{"key":"10.1016\/j.bbalip.2020.158699_bb0055","unstructured":"L. Quadro, E. Giordano, B. K. Costabile, T. Nargis, J. Iqbal, Y. Kim, L. Wassef, M. M. Hussain, Interplay between \u03b2-carotene and lipoprotein metabolism at the maternal-fetal barrier, this issue."},{"key":"10.1016\/j.bbalip.2020.158699_bb0060","unstructured":"M. A. K. Widjaja-Adhi and M. Golczak, The molecular aspects of absirption and metabolism of carotenoids and retinoids in vertebrates, this issue."},{"key":"10.1016\/j.bbalip.2020.158699_bb0065","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S0021-9258(18)87612-8","article-title":"The essential factors in the diet during growth","volume":"23","author":"McCollum","year":"1915","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2020.158699_bb0070","series-title":"Carotenoids: Physical","first-page":"275","article-title":"The functional role of xanthophylls in the primate retina","author":"Schalch","year":"2010"},{"key":"10.1016\/j.bbalip.2020.158699_bb0075","unstructured":"R. Arunkumar, A. Gosusupudi, P. S. Bernstein, The macular carotenoids: a biochemical overview, this issue."},{"key":"10.1016\/j.bbalip.2020.158699_bb0080","series-title":"Carotenoids Vol. 5: Nutrition and Health","first-page":"191","article-title":"Epidemiology and intervention trials","author":"Mayne","year":"2009"},{"key":"10.1016\/j.bbalip.2020.158699_bb0085","series-title":"Carotenoids in Health and Disease","year":"2004"},{"key":"10.1016\/j.bbalip.2020.158699_bb0090","unstructured":"L. Packer, U. Oberm\u00fcller-Jevic, K. Kraemer, H. Sies (Eds), Carotenoids and Retinoids: Molecular Aspects and Health Issues, AOCS Press, Champaign, Illinois, 2005."},{"key":"10.1016\/j.bbalip.2020.158699_bb0095","doi-asserted-by":"crossref","unstructured":"M. M. Mathews-Roth, Carotenoids and cancer prevention \u2013 experimental and epidemiological studies, Pure Appl. Chem. 47 (1985) 717\u2013722.","DOI":"10.1351\/pac198557050717"},{"key":"10.1016\/j.bbalip.2020.158699_bb0100","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/290201a0","article-title":"Can dietary beta-carotene materially reduce human cancer rates?","volume":"290","author":"Peto","year":"1981","journal-title":"Nature"},{"key":"10.1016\/j.bbalip.2020.158699_bb0105","series-title":"Carotenoids Vol. 5: Nutrition and Health","first-page":"211","article-title":"Modulation of intracellular signalling pathways by carotenoids","author":"Palozza","year":"2009"},{"key":"10.1016\/j.bbalip.2020.158699_bb0110","series-title":"Carotenoids: Physical","first-page":"465","article-title":"Carotenoids as modulators of molecular pathways involved in cell proliferation and apoptosis","author":"Palozza","year":"2010"},{"key":"10.1016\/j.bbalip.2020.158699_bb0115","unstructured":"J. L. Rowles, J. W. Erdman, Carotenoids and their role in cancer prevention, this issue."},{"key":"10.1016\/j.bbalip.2020.158699_bb0120","unstructured":"J. Y. Lim and X.-D. Wang, Mechanistic understanding of \u03b2-cryptoxanthin and lycopene in cancer prevention in animal models, this issue."},{"key":"10.1016\/j.bbalip.2020.158699_bb0125","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1056\/NEJM199404143301501","article-title":"The effect of vitamin E and beta-carotene on the incidence of lung cancer and other cancers in male smokers","volume":"330","author":"The Alpha-Tocopherol Beta-Carotene Cancer Prevention Study Group","year":"1994","journal-title":"New England J. Med."},{"key":"10.1016\/j.bbalip.2020.158699_bb0130","series-title":"Carotenoid Chemistry and Biochemistry","first-page":"297","article-title":"Medical applications and uses of catotenoids","author":"Mathews-Roth","year":"1982"},{"key":"10.1016\/j.bbalip.2020.158699_bb0135","series-title":"Carotenoids Vol. 5: Nutrition and Health","first-page":"287","article-title":"Carotenoids and coronary heart disease","author":"Johnson","year":"2009"},{"key":"10.1016\/j.bbalip.2020.158699_bb0140","unstructured":"I. O. Sirbu, A. I. Chis, A. R. Moise, Role of carotenoids and retinoids during heart development, this issue."},{"key":"10.1016\/j.bbalip.2020.158699_bb0145","unstructured":"A. P. Miller, J. Coronel, J. Amengual, The role of \u03b2-carotene and vitamin A in atherogenesis: Evidence from preclinical and clinical studies, this issue."},{"key":"10.1016\/j.bbalip.2020.158699_bb0150","series-title":"Carotenoids: Physical","first-page":"437","article-title":"Lycopene oxidation, uptake and activity in human prostate cell cultures","author":"Bowen","year":"2010"},{"key":"10.1016\/j.bbalip.2020.158699_bb0155","series-title":"Carotenoids Vol. 5: Nutrition and Health","first-page":"363","article-title":"The immune system","author":"Chew","year":"2009"},{"key":"10.1016\/j.bbalip.2020.158699_bb0160","unstructured":"M. L. Bonet, J. Ribot, S. Galmes, F. Serra, A. Palou, Carotenoids and carotenoid conversion products in adipose tissue biology and obesity: preclinical and human studies, this issue."},{"key":"10.1016\/j.bbalip.2020.158699_bb0165","unstructured":"R. D, Clugston, Carotenoids and fatty liver disease; current knowledge and research gaps, this issue."},{"key":"10.1016\/j.bbalip.2020.158699_bb0170","series-title":"Carotenoids","year":"1971"},{"key":"10.1016\/j.bbalip.2020.158699_bb0175","series-title":"Carotenoids Vol. 4: Natural Functions","first-page":"53","article-title":"Aggregation and interface behaviour of carotenoids","author":"K\u00f6hn","year":"2008"},{"key":"10.1016\/j.bbalip.2020.158699_bb0180","series-title":"Carotenoids Vol. 4: Natural Functions","first-page":"15","article-title":"E\/Z Isomers and isomerization","author":"Liaaen-Jensen","year":"2008"},{"key":"10.1016\/j.bbalip.2020.158699_bb0185","series-title":"Carotenoids: Physical","first-page":"19","article-title":"Carotenoids in lipid membranes","author":"Gruszecki","year":"2010"},{"key":"10.1016\/j.bbalip.2020.158699_bb0190","series-title":"Carotenoids Vol. 4: Natural Functions","first-page":"99","article-title":"Carotenoid-protein interactions","author":"Britton","year":"2008"},{"key":"10.1016\/j.bbalip.2020.158699_bb0195","doi-asserted-by":"crossref","unstructured":"G. W. Burton, K. U. Ingold, \u03b2-Carotene, an unusual type of lipid antioxidant, Science 224 (1984) 569\u2013573.","DOI":"10.1126\/science.6710156"},{"key":"10.1016\/j.bbalip.2020.158699_bb0200","series-title":"Carotenoids Vol. 5: Nutrition and Health","first-page":"235","article-title":"Antioxidant\/pro-oxidant actions of carotenoids","author":"Yeum","year":"2009"},{"key":"10.1016\/j.bbalip.2020.158699_bb0205","series-title":"Food Colorants: Chemical and Functional Properties CRC Press","first-page":"177","article-title":"Antioxidant and prooxidant actions and stabilities of carotenoids in vitro and in vivo and carotenoid oxidation products","author":"Caris-Veyrat","year":"2008"},{"key":"10.1016\/j.bbalip.2020.158699_bb0210","series-title":"Carotenoids Vol. 4: Natural Functions","first-page":"119","article-title":"Carotenoid radicals and radical ions","author":"El-Agamey","year":"2008"},{"key":"10.1016\/j.bbalip.2020.158699_bb0215","series-title":"Carotenoids: Physical","first-page":"283","article-title":"Properties of carotenoid radicals and excited states and their potential role in biological systems","author":"Edge","year":"2010"},{"key":"10.1016\/j.bbalip.2020.158699_bb0220","series-title":"Carotenoids Vol. 5: Nutrition and Health","first-page":"409","article-title":"Editors' assessment","author":"Britton","year":"2009"},{"key":"10.1016\/j.bbalip.2020.158699_bb0225","series-title":"Carotenoids Vol. 4: Natural Functions","first-page":"309","article-title":"Functions of carotenoid metabolites and breakdown products","author":"Britton","year":"2008"},{"key":"10.1016\/j.bbalip.2020.158699_bb0230","series-title":"Carotenoids: Physical","first-page":"417","article-title":"Oxidative metabolites of lycopene and their biological functions","author":"Mein","year":"2010"}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1388198120300913?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1388198120300913?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T10:11:40Z","timestamp":1761387100000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1388198120300913"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":46,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["S1388198120300913"],"URL":"https:\/\/doi.org\/10.1016\/j.bbalip.2020.158699","relation":{},"ISSN":["1388-1981"],"issn-type":[{"value":"1388-1981","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Carotenoid research: History and new perspectives for chemistry in biological systems","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbalip.2020.158699","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"158699"}}