{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T20:34:42Z","timestamp":1767990882130,"version":"3.49.0"},"reference-count":45,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Boshell Diabetes and Metabolic Diseases Research Program"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.bbalip.2020.158731","type":"journal-article","created":{"date-parts":[[2020,5,11]],"date-time":"2020-05-11T10:06:11Z","timestamp":1589191571000},"page":"158731","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Niacin increases diet-induced hepatic steatosis in B6129 mice"],"prefix":"10.1016","volume":"1865","author":[{"given":"Han","family":"Fang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhuoyue","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily C.","family":"Graff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kayleen J.","family":"McCafferty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert L.","family":"Judd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbalip.2020.158731_bb0005","doi-asserted-by":"crossref","first-page":"S99","DOI":"10.1002\/hep.20973","article-title":"Nonalcoholic fatty liver disease: from steatosis to cirrhosis","volume":"43","author":"Farrell","year":"2006","journal-title":"Hepatology"},{"key":"10.1016\/j.bbalip.2020.158731_bb0010","doi-asserted-by":"crossref","first-page":"8263","DOI":"10.3748\/wjg.v23.i47.8263","article-title":"Clinical epidemiology and disease burden of nonalcoholic fatty liver disease","volume":"23","author":"Perumpail","year":"2017","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.bbalip.2020.158731_bb0015","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1159\/000282080","article-title":"Epidemiology of non-alcoholic fatty liver disease","volume":"28","author":"Bellentani","year":"2010","journal-title":"Dig. Dis."},{"key":"10.1016\/j.bbalip.2020.158731_bb0020","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/0003-9861(55)90070-9","article-title":"Influence of nicotinic acid on serum cholesterol in man","volume":"54","author":"Altschul","year":"1955","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.bbalip.2020.158731_bb0025","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1016\/S0002-9149(03)00394-1","article-title":"Effects of extended-release niacin on lipoprotein subclass distribution","volume":"91","author":"Morgan","year":"2003","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.bbalip.2020.158731_bb0030","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1097\/00041433-200412000-00006","article-title":"Niacin therapy in atherosclerosis","volume":"15","author":"Meyers","year":"2004","journal-title":"Curr. Opin. Lipidol."},{"key":"10.1016\/j.bbalip.2020.158731_bb0035","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1111\/j.1365-2796.2005.01528.x","article-title":"Nicotinic acid: the broad-spectrum lipid drug. A 50th anniversary review","volume":"258","author":"Carlson","year":"2005","journal-title":"J. Intern. Med."},{"key":"10.1016\/j.bbalip.2020.158731_bb0040","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1194\/jlr.P023614","article-title":"Liver fat reduction with niacin is influenced by DGAT-2 polymorphisms in hypertriglyceridemic patients","volume":"53","author":"Hu","year":"2012","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.bbalip.2020.158731_bb0045","doi-asserted-by":"crossref","first-page":"G320","DOI":"10.1152\/ajpgi.00181.2013","article-title":"Therapeutic role of niacin in the prevention and regression of hepatic steatosis in rat model of nonalcoholic fatty liver disease","volume":"306","author":"Ganji","year":"2014","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.bbalip.2020.158731_bb0050","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1016\/j.metabol.2015.05.002","article-title":"Niacin inhibits fat accumulation, oxidative stress, and inflammatory cytokine IL-8 in cultured hepatocytes: impact on non-alcoholic fatty liver disease","volume":"64","author":"Ganji","year":"2015","journal-title":"Metabolism"},{"key":"10.1016\/j.bbalip.2020.158731_bb0055","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1093\/jn\/82.1.83","article-title":"Fatty livers produced in albino rats by excess niacin in high fat diets. I. Alterations in enzyme and coenzyme systems induced by supplementing 40 percent fat diets with O.1 percent of niacin","volume":"82","author":"Rikans","year":"1964","journal-title":"J. Nutr."},{"key":"10.1016\/j.bbalip.2020.158731_bb0060","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1093\/jn\/85.1.107","article-title":"Fatty livers produced in albino rats by excess niacin in high fat diets. II. Effect of choline supplements","volume":"85","author":"Rikans","year":"1965","journal-title":"J. Nutr."},{"key":"10.1016\/j.bbalip.2020.158731_bb0065","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/0002-9343(92)90018-7","article-title":"Hepatic toxicity of unmodified and time-release preparations of niacin","volume":"92","author":"Rader","year":"1992","journal-title":"Am. J. Med."},{"key":"10.1016\/j.bbalip.2020.158731_bb0070","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/0002-9343(92)90689-9","article-title":"Hepatotoxicity associated with sustained-release niacin","volume":"93","author":"Dalton","year":"1992","journal-title":"Am. J. Med."},{"key":"10.1016\/j.bbalip.2020.158731_bb0075","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1097\/00007611-199401000-00007","article-title":"Niacin-induced hepatotoxicity: unusual presentations","volume":"87","author":"Coppola","year":"1994","journal-title":"South. Med. J."},{"key":"10.1016\/j.bbalip.2020.158731_bb0080","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1038\/ajg.2017.171","article-title":"Niacin-associated acute hepatotoxicity leading to emergency liver transplantation","volume":"112","author":"Schaffellner","year":"2017","journal-title":"Am. J. Gastroenterol."},{"issue":"2003","key":"10.1016\/j.bbalip.2020.158731_bb0085","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.japh.2018.04.033","article-title":"Hepatotoxicity upon using niacin to pass a drug test: a case report","volume":"58","author":"Durham","year":"2018","journal-title":"J. Am. Pharm. Assoc."},{"key":"10.1016\/j.bbalip.2020.158731_bb0090","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1002\/hep4.1253","article-title":"Niacin-induced anicteric microvesicular steatotic acute liver failure","volume":"2","author":"Leung","year":"2018","journal-title":"Hepatol. Commun."},{"key":"10.1016\/j.bbalip.2020.158731_bb0095","first-page":"15","article-title":"5-Lipoxygenase (5LOX)-deficient mice express reduced anxiety-like behavior","volume":"20","author":"Uz","year":"2002","journal-title":"Restor. Neurol. Neurosci."},{"key":"10.1016\/j.bbalip.2020.158731_bb0100","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.surg.2012.06.005","article-title":"Lack of interleukin-1 signaling results in perturbed early vein graft wall adaptations","volume":"153","author":"Yu","year":"2013","journal-title":"Surgery"},{"key":"10.1016\/j.bbalip.2020.158731_bb0105","doi-asserted-by":"crossref","first-page":"2110","DOI":"10.1097\/01.ccm.0000281447.22966.8b","article-title":"Proinflammatory cytokines cause down-regulation of renal chloride entry pathways during sepsis","volume":"35","author":"Schmidt","year":"2007","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.bbalip.2020.158731_bb0110","first-page":"S38","article-title":"Mechanisms of sex differences in TNFR2-mediated cardioprotection","volume":"118","author":"Wang","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.bbalip.2020.158731_bb0115","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1016\/j.bbi.2008.02.001","article-title":"Sleep-wake behavior and responses to sleep deprivation of mice lacking both interleukin-1 beta receptor 1 and tumor necrosis factor-alpha receptor 1","volume":"22","author":"Baracchi","year":"2008","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbalip.2020.158731_bb0120","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1111\/j.1476-5381.2012.02014.x","article-title":"Epithelium-dependent modulation of responsiveness of airways from caveolin-1 knockout mice is mediated through cyclooxygenase-2 and 5-lipoxygenase","volume":"167","author":"Sharma","year":"2012","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bbalip.2020.158731_bb0125","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1177\/0963689718788067","article-title":"In vivo tracking of intravenously injected mesenchymal stem cells in an Alzheimer\u2019s animal model","volume":"27","author":"Park","year":"2018","journal-title":"Cell Transplant."},{"key":"10.1016\/j.bbalip.2020.158731_bb0130","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.bbr.2014.10.033","article-title":"Reference and working memory deficits in the 3xTg-AD mouse between 2 and 15-months of age: a cross-sectional study","volume":"278","author":"Stevens","year":"2015","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbalip.2020.158731_bb0135","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2017.279","article-title":"LISPRO mitigates beta-amyloid and associated pathologies in Alzheimer\u2019s mice","volume":"8","author":"Habib","year":"2017","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bbalip.2020.158731_bb0140","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.jhep.2016.05.005","article-title":"A diet-induced animal model of non-alcoholic fatty liver disease and hepatocellular cancer","volume":"65","author":"Asgharpour","year":"2016","journal-title":"J. Hepatol."},{"key":"10.1016\/j.bbalip.2020.158731_bb0145","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0115922","article-title":"Establishment of a general NAFLD scoring system for rodent models and comparison to human liver pathology","volume":"9","author":"Liang","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.bbalip.2020.158731_bb0150","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1038\/nprot.2012.024","article-title":"A positive\/negative ion-switching, targeted mass spectrometry-based metabolomics platform for bodily fluids, cells, and fresh and fixed tissue","volume":"7","author":"Yuan","year":"2012","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.bbalip.2020.158731_bb0155","doi-asserted-by":"crossref","DOI":"10.1007\/s11306-016-1157-8","article-title":"A relative quantitative positive\/negative ion switching method for untargeted lipidomics via high resolution LC-MS\/MS from any biological source","volume":"13","author":"Breitkopf","year":"2017","journal-title":"Metabolomics"},{"key":"10.1016\/j.bbalip.2020.158731_bb0160","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0090917","article-title":"p-Hydroxyphenylpyruvate, an intermediate of the Phe\/Tyr catabolism, improves mitochondrial oxidative metabolism under stressing conditions and prolongs survival in rats subjected to profound hemorrhagic shock","volume":"9","author":"Cotoia","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.bbalip.2020.158731_bb0165","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.cld.2007.06.010","article-title":"Lipid-lowering agents that cause drug-induced hepatotoxicity","volume":"11","author":"Bhardwaj","year":"2007","journal-title":"Clin. Liver Dis."},{"key":"10.1016\/j.bbalip.2020.158731_bb0170","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1177\/0091270007300264","article-title":"Effect of the rate of niacin administration on the plasma and urine pharmacokinetics of niacin and its metabolites","volume":"47","author":"Menon","year":"2007","journal-title":"J. Clin. Pharmacol."},{"key":"10.1016\/j.bbalip.2020.158731_bb0175","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1093\/jn\/113.2.215","article-title":"Metabolic effects of nicotinamide administration in rats","volume":"113","author":"Kang-Lee","year":"1983","journal-title":"J. Nutr."},{"key":"10.1016\/j.bbalip.2020.158731_bb0180","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1007\/s11596-018-1862-9","article-title":"B vitamins can reduce body weight gain by increasing metabolism-related enzyme activities in rats fed on a high-fat diet","volume":"38","author":"Zheng","year":"2018","journal-title":"Curr. Med. Sci."},{"key":"10.1016\/j.bbalip.2020.158731_bb0185","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1038\/hr.2011.133","article-title":"Dietary methyl-consuming compounds and metabolic syndrome","volume":"34","author":"Zhou","year":"2011","journal-title":"Hypertens. Res."},{"key":"10.1016\/j.bbalip.2020.158731_bb0190","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s00726-009-0246-7","article-title":"High fat feeding and dietary L-arginine supplementation differentially regulate gene expression in rat white adipose tissue","volume":"37","author":"Jobgen","year":"2009","journal-title":"Amino Acids"},{"key":"10.1016\/j.bbalip.2020.158731_bb0195","doi-asserted-by":"crossref","first-page":"230","DOI":"10.3945\/jn.108.096362","article-title":"Dietary L-arginine supplementation reduces white fat gain and enhances skeletal muscle and brown fat masses in diet-induced obese rats","volume":"139","author":"Jobgen","year":"2009","journal-title":"J. Nutr."},{"key":"10.1016\/j.bbalip.2020.158731_bb0200","doi-asserted-by":"crossref","first-page":"411","DOI":"10.3109\/1040841X.2013.856854","article-title":"Key roles of microsymbiont amino acid metabolism in rhizobia-legume interactions","volume":"41","author":"Dunn","year":"2015","journal-title":"Crit. Rev. Microbiol."},{"key":"10.1016\/j.bbalip.2020.158731_bb0205","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.tcb.2015.12.007","article-title":"Understanding ubiquinone","volume":"26","author":"Wang","year":"2016","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.bbalip.2020.158731_bb0210","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1002\/hep.21763","article-title":"A lipidomic analysis of nonalcoholic fatty liver disease","volume":"46","author":"Puri","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.bbalip.2020.158731_bb0215","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1016\/j.celrep.2017.05.035","article-title":"Hepatic diacylglycerol-associated protein kinase cepsilon translocation links hepatic steatosis to hepatic insulin resistance in humans","volume":"19","author":"Ter Horst","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.bbalip.2020.158731_bb0220","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1139\/cjpp-2014-0478","article-title":"Niacin as antidyslipidemic drug","volume":"93","author":"Julius","year":"2015","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.bbalip.2020.158731_bb0225","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0155163","article-title":"Susceptibility of different mouse wild type strains to develop diet-induced NAFLD\/AFLD-associated liver disease","volume":"11","author":"Fengler","year":"2016","journal-title":"PLoS One"}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1388198120301232?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1388198120301232?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T10:07:00Z","timestamp":1761386820000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1388198120301232"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":45,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["S1388198120301232"],"URL":"https:\/\/doi.org\/10.1016\/j.bbalip.2020.158731","relation":{},"ISSN":["1388-1981"],"issn-type":[{"value":"1388-1981","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Niacin increases diet-induced hepatic steatosis in B6129 mice","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbalip.2020.158731","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"158731"}}