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Cell Biol."},{"key":"10.1016\/j.bbalip.2020.158820_bb0380","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1113\/expphysiol.2010.053157","article-title":"Neuron-glia metabolic coupling and plasticity","volume":"96","author":"Magistretti","year":"2011","journal-title":"Exp. 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Biol."},{"key":"10.1016\/j.bbalip.2020.158820_bb0410","doi-asserted-by":"crossref","first-page":"7088","DOI":"10.1073\/pnas.0800896105","article-title":"Human ApoD, an apolipoprotein up-regulated in neurodegenerative diseases, extends lifespan and increases stress resistance in Drosophila","volume":"105","author":"Muffat","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbalip.2020.158820_bb0415","doi-asserted-by":"crossref","first-page":"2828","DOI":"10.1093\/hmg\/ddq183","article-title":"Altered lipid metabolism in a Drosophila model of Friedreich\u2019s ataxia","volume":"19","author":"Navarro","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbalip.2020.158820_bb0420","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/s41593-019-0566-1","article-title":"Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain","volume":"23","author":"Marschallinger","year":"2020","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.bbalip.2020.158820_bb0425","doi-asserted-by":"crossref","first-page":"995","DOI":"10.3233\/JAD-180088","article-title":"Diaphanous 1 (DIAPH1) is highly expressed in the aged human medial temporal cortex and upregulated in myeloid cells during Alzheimer\u2019s disease","volume":"64","author":"Derk","year":"2018","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.bbalip.2020.158820_bb0430","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1038\/ncb1001-905","article-title":"Acyl-coenzyme a: cholesterol acyltransferase modulates the generation of the amyloid beta-peptide","volume":"3","author":"Puglielli","year":"2001","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.bbalip.2020.158820_bb0435","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.stem.2018.12.013","article-title":"Cholesterol metabolism is a druggable axis that independently regulates tau and amyloid-beta in iPSC-derived Alzheimer\u2019s disease neurons","volume":"24","author":"van der Kant","year":"2019","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.bbalip.2020.158820_bb0440","doi-asserted-by":"crossref","first-page":"2481","DOI":"10.1016\/j.bbamcr.2016.03.013","article-title":"Monocarboxylate transporters in the brain and in cancer","volume":"1863","author":"Perez-Escuredo","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbalip.2020.158820_bb0445","doi-asserted-by":"crossref","first-page":"585","DOI":"10.3389\/fneur.2019.00585","article-title":"Ketone bodies in neurological diseases: focus on Neuroprotection and underlying mechanisms","volume":"10","author":"Yang","year":"2019","journal-title":"Front. Neurol."},{"key":"10.1016\/j.bbalip.2020.158820_bb0450","doi-asserted-by":"crossref","first-page":"92","DOI":"10.3389\/fcell.2016.00092","article-title":"Diacylglycerol kinases in the coordination of synaptic plasticity","volume":"4","author":"Lee","year":"2016","journal-title":"Front Cell Dev Biol."},{"key":"10.1016\/j.bbalip.2020.158820_bb0455","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1007\/s12035-019-01775-7","article-title":"A perspective: active role of lipids in neurotransmitter dynamics","volume":"57","author":"Postila","year":"2020","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.bbalip.2020.158820_bb0460","doi-asserted-by":"crossref","unstructured":"M. Uhlen, L. Fagerberg, B.M. Hallstrom, C. Lindskog, P. Oksvold, A. Mardinoglu, A. Sivertsson, C. Kampf, E. Sjostedt, A. Asplund, I. Olsson, K. Edlund, E. Lundberg, S. Navani, C.A. Szigyarto, J. Odeberg, D. Djureinovic, J.O. Takanen, S. Hober, T. Alm, P.H. Edqvist, H. Berling, H. Tegel, J. Mulder, J. Rockberg, P. Nilsson, J.M. Schwenk, M. Hamsten, K. von Feilitzen, M. Forsberg, L. Persson, F. Johansson, M. Zwahlen, G. von Heijne, J. Nielsen, F. Ponten, Proteomics. Tissue-based map of the human proteome, Science. 347 (2015) 1260419. doi:https:\/\/doi.org\/10.1126\/science.1260419.","DOI":"10.1126\/science.1260419"},{"key":"10.1016\/j.bbalip.2020.158820_bb0465","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.nbd.2008.05.004","article-title":"Characterization of seipin\/BSCL2, a protein associated with spastic paraplegia 17","volume":"31","author":"Ito","year":"2008","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.bbalip.2020.158820_bb0470","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1111\/jnc.12638","article-title":"Motor neuropathy-associated mutation impairs Seipin functions in neurotransmission","volume":"129","author":"Wei","year":"2014","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbalip.2020.158820_bb0475","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.amjmed.2018.07.012","article-title":"Motor neuron disease: pathophysiology, diagnosis, and management","volume":"132","author":"Foster","year":"2019","journal-title":"Am. J. Med."},{"key":"10.1016\/j.bbalip.2020.158820_bb0480","doi-asserted-by":"crossref","unstructured":"M. Auer-Grumbach, B. Schlotter-Weigel, H. Lochmuller, G. Strobl-Wildemann, P. Auer-Grumbach, R. Fischer, H. Offenbacher, E.B. Zwick, T. Robl, G. Hartl, H.P. Hartung, K. Wagner, C. Windpassinger, G. Austrian Peripheral Neuropathy Study, Phenotypes of the N88S Berardinelli-Seip congenital lipodystrophy 2 mutation, Ann Neurol. 57 (2005) 415\u2013424. doi:https:\/\/doi.org\/10.1002\/ana.20410.","DOI":"10.1002\/ana.20410"},{"key":"10.1016\/j.bbalip.2020.158820_bb0485","doi-asserted-by":"crossref","unstructured":"D. Ito, T. Yagi, N. 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Mol. Genet."},{"key":"10.1016\/j.bbalip.2020.158820_bb0625","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1005107","article-title":"Network analyses reveal novel aspects of ALS pathogenesis","volume":"11","author":"Sanhueza","year":"2015","journal-title":"PLoS Genet."},{"key":"10.1016\/j.bbalip.2020.158820_bb0630","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1003738","article-title":"VAPB\/ALS8 MSP ligands regulate striated muscle energy metabolism critical for adult survival in caenorhabditis elegans","volume":"9","author":"Han","year":"2013","journal-title":"PLoS Genet."},{"key":"10.1016\/j.bbalip.2020.158820_bb0635","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1016\/j.cub.2006.07.062","article-title":"The lipid-droplet proteome reveals that droplets are a protein-storage depot","volume":"16","author":"Cermelli","year":"2006","journal-title":"Curr. 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Hardwick, KCTD7 deficiency defines a distinct neurodegenerative disorder with a conserved autophagy-lysosome defect, Ann Neurol. 84 (2018) 766\u2013780. doi:https:\/\/doi.org\/10.1002\/ana.25351.","DOI":"10.1002\/ana.25351"},{"key":"10.1016\/j.bbalip.2020.158820_bb0645","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1111\/j.1469-1809.2012.00710.x","article-title":"Novel mutation in potassium channel related gene KCTD7 and progressive myoclonic epilepsy","volume":"76","author":"Krabichler","year":"2012","journal-title":"Ann. Hum. Genet."},{"key":"10.1016\/j.bbalip.2020.158820_bb0650","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1002\/ana.21121","article-title":"Mutation of a potassium channel-related gene in progressive myoclonic epilepsy","volume":"61","author":"Van Bogaert","year":"2007","journal-title":"Ann. 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Disord."},{"key":"10.1016\/j.bbalip.2020.158820_bb0680","doi-asserted-by":"crossref","first-page":"53","DOI":"10.3233\/JAD-2007-11109","article-title":"Ultrastructural localization of intraneuronal Abeta-peptide in Alzheimer disease brains","volume":"11","author":"Gomez-Ramos","year":"2007","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.bbalip.2020.158820_bb0685","doi-asserted-by":"crossref","first-page":"397","DOI":"10.3389\/fnins.2018.00397","article-title":"Plin4-dependent lipid droplets hamper neuronal Mitophagy in the MPTP\/p-induced mouse model of Parkinson\u2019s disease","volume":"12","author":"Han","year":"2018","journal-title":"Front. 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Al-Gazali, B.B. de Vries, A.P. de Brouwer, Mutations in DDHD2, encoding an intracellular phospholipase A(1), cause a recessive form of complex hereditary spastic paraplegia, Am J Hum Genet. 91 (2012) 1073\u20131081. doi:https:\/\/doi.org\/10.1016\/j.ajhg.2012.10.017.","DOI":"10.1016\/j.ajhg.2012.10.017"},{"key":"10.1016\/j.bbalip.2020.158820_bb0735","doi-asserted-by":"crossref","unstructured":"C.J. McDermott, C.E. Burness, J. Kirby, L.E. Cox, D.G. Rao, C. Hewamadduma, B. Sharrack, M. Hadjivassiliou, P.F. Chinnery, A. Dalton, P.J. Shaw, Uk, H.S.P.C. Irish, Clinical features of hereditary spastic paraplegia due to spastin mutation, Neurology. 67 (2006) 45\u201351. doi:https:\/\/doi.org\/10.1212\/01.wnl.0000223315.62404.00.","DOI":"10.1212\/01.wnl.0000223315.62404.00"},{"key":"10.1016\/j.bbalip.2020.158820_bb0740","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.brainresbull.2007.06.018","article-title":"Motor and somatosensory evoked potentials in autosomal dominant hereditary spastic paraparesis (ADHSP) linked to chromosome 2p, SPG4","volume":"74","author":"Sartucci","year":"2007","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.bbalip.2020.158820_bb0745","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/ng937","article-title":"SPG20 is mutated in Troyer syndrome, an hereditary spastic paraplegia","volume":"31","author":"Patel","year":"2002","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbalip.2020.158820_bb0750","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S0888-7543(03)00011-9","article-title":"The identification of a conserved domain in both spartin and spastin, mutated in hereditary spastic paraplegia","volume":"81","author":"Ciccarelli","year":"2003","journal-title":"Genomics."},{"key":"10.1016\/j.bbalip.2020.158820_bb0755","doi-asserted-by":"crossref","first-page":"a001537","DOI":"10.1101\/mcs.a001537","article-title":"SPG20 mutation in three siblings with familial hereditary spastic paraplegia","volume":"3","author":"Dardour","year":"2017","journal-title":"Cold Spring Harb Mol Case Stud."},{"key":"10.1016\/j.bbalip.2020.158820_bb0760","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s40035-017-0079-3","article-title":"Clinical features and genotype-phenotype correlation analysis in patients with ATL1 mutations: a literature reanalysis","volume":"6","author":"Zhao","year":"2017","journal-title":"Transl Neurodegener."},{"key":"10.1016\/j.bbalip.2020.158820_bb0765","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1002\/ana.24488","article-title":"Hereditary spastic paraplegia-linked REEP1 modulates endoplasmic reticulum\/mitochondria contacts","volume":"78","author":"Lim","year":"2015","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.bbalip.2020.158820_bb0770","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1086\/425287","article-title":"A mutation in the vesicle-trafficking protein VAPB causes late-onset spinal muscular atrophy and amyotrophic lateral sclerosis","volume":"75","author":"Nishimura","year":"2004","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.bbalip.2020.158820_bb0775","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.cell.2016.06.037","article-title":"Endosome-ER contacts control actin nucleation and retromer function through VAP-dependent regulation of PI4P","volume":"166","author":"Dong","year":"2016","journal-title":"Cell."},{"key":"10.1016\/j.bbalip.2020.158820_bb0780","doi-asserted-by":"crossref","unstructured":"A.C. Thomas, H. Williams, N. Seto-Salvia, C. Bacchelli, D. Jenkins, M. O'Sullivan, K. Mengrelis, M. Ishida, L. Ocaka, E. Chanudet, C. James, F. Lescai, G. Anderson, D. Morrogh, M. Ryten, A.J. Duncan, Y.J. Pai, J.M. Saraiva, F. Ramos, B. Farren, D. Saunders, B. Vernay, P. Gissen, A. Straatmaan-Iwanowska, F. Baas, N.W. Wood, J. Hersheson, H. Houlden, J. Hurst, R. Scott, M. Bitner-Glindzicz, G.E. Moore, S.B. Sousa, P. Stanier, Mutations in SNX14 cause a distinctive autosomal-recessive cerebellar ataxia and intellectual disability syndrome, Am J Hum Genet. 95 (2014) 611\u2013621. doi: doi:https:\/\/doi.org\/10.1016\/j.ajhg.2014.10.007.","DOI":"10.1016\/j.ajhg.2014.10.007"},{"key":"10.1016\/j.bbalip.2020.158820_bb0785","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/362059a0","article-title":"Mutations in Cu\/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis","volume":"362","author":"Rosen","year":"1993","journal-title":"Nature."},{"key":"10.1016\/j.bbalip.2020.158820_bb0790","doi-asserted-by":"crossref","unstructured":"M. De Jesus-Hernandez, I.R. Mackenzie, B.F. Boeve, A.L. Boxer, M. Baker, N.J. Rutherford, A.M. Nicholson, N.A. Finch, H. Flynn, J. Adamson, N. Kouri, A. Wojtas, P. Sengdy, G.Y. Hsiung, A. Karydas, W.W. Seeley, K.A. Josephs, G. Coppola, D.H. Geschwind, Z.K. Wszolek, H. Feldman, D.S. Knopman, R.C. Petersen, B.L. Miller, D.W. Dickson, K.B. Boylan, N.R. Graff-Radford, R. Rademakers, Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS, Neuron. 72 (2011) 245\u2013256. doi:https:\/\/doi.org\/10.1016\/j.neuron.2011.09.011.","DOI":"10.1016\/j.neuron.2011.09.011"},{"key":"10.1016\/j.bbalip.2020.158820_bb0795","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1212\/WNL.0b013e31827f08ea","article-title":"C9ORF72 hexanucleotide expansions of 20-22 repeats are associated with frontotemporal deterioration","volume":"80","author":"Gomez-Tortosa","year":"2013","journal-title":"Neurology."},{"key":"10.1016\/j.bbalip.2020.158820_bb0800","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.ajhg.2012.05.023","article-title":"A homozygous mutation in KCTD7 links neuronal ceroid lipofuscinosis to the ubiquitin-proteasome system","volume":"91","author":"Staropoli","year":"2012","journal-title":"Am. J. Hum. 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