{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T20:09:56Z","timestamp":1778616596008,"version":"3.51.4"},"reference-count":39,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB 1039"],"award-info":[{"award-number":["SFB 1039"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["BO3755\/3-1"],"award-info":[{"award-number":["BO3755\/3-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB\/TRR219"],"award-info":[{"award-number":["SFB\/TRR219"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["DJ100\/1-1"],"award-info":[{"award-number":["DJ100\/1-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB\/TRR57"],"award-info":[{"award-number":["SFB\/TRR57"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["BO3755\/6-1"],"award-info":[{"award-number":["BO3755\/6-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f&amp;#x00FC;r Bildung und Forschung","doi-asserted-by":"publisher","award":["STOP-FSGS-01GM1901A"],"award-info":[{"award-number":["STOP-FSGS-01GM1901A"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.bbalip.2020.158821","type":"journal-article","created":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T02:35:51Z","timestamp":1601519751000},"page":"158821","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Consistent alteration of chain length-specific ceramides in human and mouse fibrotic kidneys"],"prefix":"10.1016","volume":"1866","author":[{"given":"Timon","family":"Eckes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Trautmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonja","family":"Djudjaj","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Beyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sammy","family":"Patyna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Schwalm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Gauer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominique","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liliana","family":"Schaefer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Boor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Koch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josef","family":"Pfeilschifter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbalip.2020.158821_bb0005","doi-asserted-by":"crossref","first-page":"A7","DOI":"10.1053\/j.ajkd.2019.01.001","article-title":"2018 annual data report: epidemiology of kidney disease in the United States","volume":"73","author":"Saran","year":"2019","journal-title":"Am. J. Kidney Dis."},{"key":"10.1016\/j.bbalip.2020.158821_bb0010","doi-asserted-by":"crossref","unstructured":"T.J. Hoerger, J.S. Wittenborn, J.E. Segel, N.R. Burrows, K. Imai, P. Eggers, M.E. Pavkov, R. Jordan, S.M. Hailpern, A.C. Schoolwerth, D.E. Williams, A health policy model of CKD: 1. Model construction, assumptions, and validation of health consequences, American Journal of Kidney Diseases. 55 (2010) 452\u2013462. doi:https:\/\/doi.org\/10.1053\/j.ajkd.2009.11.016.","DOI":"10.1053\/j.ajkd.2009.11.016"},{"key":"10.1016\/j.bbalip.2020.158821_bb0015","unstructured":"K. Ku\u0107, P. Kici\u0144ski, S. Przybylska-Ku\u0107, J. Mosiewicz, W. My\u015bli\u0144ski, [Serum creatinine level and eGFR as the indices of renal function in present-day clinical practice], Prz. Lek. 67 (2010) 491\u2013495."},{"key":"10.1016\/j.bbalip.2020.158821_bb0020","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/nrm.2017.107","article-title":"Sphingolipids and their metabolism in physiology and disease","volume":"19","author":"Hannun","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bbalip.2020.158821_bb0025","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.plipres.2011.11.001","article-title":"Chain length-specific properties of ceramides","volume":"51","author":"Gr\u00f6sch","year":"2012","journal-title":"Prog. Lipid Res."},{"key":"10.1016\/j.bbalip.2020.158821_bb0030","doi-asserted-by":"crossref","unstructured":"R. Brunkhorst, W. Pfeilschifter, S. Patyna, S. B\u00fcttner, T. Eckes, S. Trautmann, D. Thomas, J. Pfeilschifter, A. Koch, Preanalytical biases in the measurement of human blood sphingolipids, Int J Mol Sci. 19 (2018). doi:https:\/\/doi.org\/10.3390\/ijms19051390.","DOI":"10.3390\/ijms19051390"},{"key":"10.1016\/j.bbalip.2020.158821_bb0035","series-title":"Bioactive Ceramides in Health and Disease: Intertwined Roles of Enigmatic Lipids","first-page":"109","article-title":"Sphingolipids as biomarkers of disease","author":"Matanes","year":"2019"},{"key":"10.1016\/j.bbalip.2020.158821_bb0040","doi-asserted-by":"crossref","unstructured":"G. Grammatikos, J. Dietz, N. Ferreiros, A. Koch, G. Dultz, D. Bon, I. Karakasiliotis, T. Lutz, G. Knecht, P. Gute, E. Herrmann, S. Zeuzem, P. Mavromara, C. Sarrazin, J. Pfeilschifter, Persistence of HCV in acutely-infected patients depletes C24-ceramide and upregulates sphingosine and sphinganine serum levels, Int J Mol Sci. 17 (2016). doi:https:\/\/doi.org\/10.3390\/ijms17060922.","DOI":"10.3390\/ijms17060922"},{"key":"10.1016\/j.bbalip.2020.158821_bb0045","doi-asserted-by":"crossref","first-page":"337","DOI":"10.2337\/db08-1228","article-title":"Plasma ceramides are elevated in obese subjects with type 2 diabetes and correlate with the severity of insulin resistance","volume":"58","author":"Haus","year":"2009","journal-title":"Diabetes."},{"key":"10.1016\/j.bbalip.2020.158821_bb0050","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1161\/ATVBAHA.118.311199","article-title":"Plasma ceramides","volume":"38","author":"Meeusen","year":"2018","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.bbalip.2020.158821_bb0055","doi-asserted-by":"crossref","first-page":"2424","DOI":"10.1161\/ATVBAHA.116.307497","article-title":"Circulating ceramides predict cardiovascular outcomes in the population-based FINRISK 2002 cohort","volume":"36","author":"Havulinna","year":"2016","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.bbalip.2020.158821_bb0060","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1093\/ndt\/gfw427","article-title":"Sphingosine-1-phosphate and its receptors in anti-neutrophil cytoplasmic antibody-associated vasculitis","volume":"32","author":"Sun","year":"2017","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.bbalip.2020.158821_bb0065","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1007\/s10875-012-9710-3","article-title":"Increased serum concentration of sphingosine-1-phosphate in juvenile-onset systemic lupus erythematosus","volume":"32","author":"Watson","year":"2012","journal-title":"J. Clin. Immunol."},{"key":"10.1016\/j.bbalip.2020.158821_bb0070","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1016\/j.clinbiochem.2015.08.001","article-title":"The effect of nephropathy on plasma sphingosine 1-phosphate concentrations in patients with type 2 diabetes","volume":"48","author":"Bekpinar","year":"2015","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.bbalip.2020.158821_bb0075","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1177\/0961203316686707","article-title":"Dysregulations in circulating sphingolipids associate with disease activity indices in female patients with systemic lupus erythematosus: a cross-sectional study","volume":"26","author":"Checa","year":"2017","journal-title":"Lupus."},{"key":"10.1016\/j.bbalip.2020.158821_bb0080","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/1476-511X-12-98","article-title":"Role of ceramide in diabetes mellitus: evidence and mechanisms","volume":"12","author":"Galadari","year":"2013","journal-title":"Lipids Health Dis."},{"key":"10.1016\/j.bbalip.2020.158821_bb0085","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s00467-013-2642-1","article-title":"CKiD study group, Ceramides and cardiac function in children with chronic kidney disease","volume":"29","author":"Mitsnefes","year":"2014","journal-title":"Pediatr. Nephrol."},{"key":"10.1016\/j.bbalip.2020.158821_bb0090","doi-asserted-by":"crossref","first-page":"106348","DOI":"10.1016\/j.prostaglandins.2019.106348","article-title":"Blood ceramides as novel markers for renal impairment in systemic lupus erythematosus","volume":"144","author":"Patyna","year":"2019","journal-title":"Prostaglandins Other Lipid Mediat."},{"key":"10.1016\/j.bbalip.2020.158821_bb0095","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1164\/rccm.200905-0799OC","article-title":"Ceramide is increased in the lower airway epithelium of people with advanced cystic fibrosis lung disease","volume":"182","author":"Brodlie","year":"2010","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.bbalip.2020.158821_bb0100","doi-asserted-by":"crossref","first-page":"2070","DOI":"10.1073\/pnas.0305799101","article-title":"Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer\u2019s disease","volume":"101","author":"Cutler","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbalip.2020.158821_bb0105","doi-asserted-by":"crossref","first-page":"6068","DOI":"10.3748\/wjg.15.6068","article-title":"Elevated pro-inflammatory and lipotoxic mucosal lipids characterise irritable bowel syndrome","volume":"15","author":"Kajander","year":"2009","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.bbalip.2020.158821_bb0110","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1681\/ASN.2014050508","article-title":"Renal glycosphingolipid metabolism is dysfunctional in lupus nephritis","volume":"26","author":"Nowling","year":"2015","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.bbalip.2020.158821_bb0115","series-title":"Sphingosine kinase-2 deficiency ameliorates kidney fibrosis by up-regulating Smad7 in a mouse model of unilateral ureteral obstruction, The American Journal of Pathology","author":"Schwalm","year":"2017"},{"key":"10.1016\/j.bbalip.2020.158821_bb0120","doi-asserted-by":"crossref","first-page":"3590","DOI":"10.1681\/ASN.2017020190","article-title":"Macrophage migration inhibitory factor limits renal inflammation and fibrosis by counteracting tubular cell cycle arrest","volume":"28","author":"Djudjaj","year":"2017","journal-title":"JASN."},{"key":"10.1016\/j.bbalip.2020.158821_bb0125","unstructured":"H. Geidis, Praktische Mikroskopie, in: Praktische Mikroskopie, 1935: p. 28f."},{"key":"10.1016\/j.bbalip.2020.158821_bb0130","doi-asserted-by":"crossref","first-page":"120593","DOI":"10.1016\/j.talanta.2019.120593","article-title":"Implementation of lipidomics in clinical routine: can fluoride\/citrate blood sampling tubes improve preanalytical stability?","volume":"209","author":"Hahnefeld","year":"2020","journal-title":"Talanta."},{"key":"10.1016\/j.bbalip.2020.158821_bb0135","article-title":"Aging-related lipidomic changes in mouse serum, kidney, and heart by nanoflow ultrahigh-performance liquid chromatography-tandem mass spectrometry","volume":"460849","author":"Eum","year":"2020","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.bbalip.2020.158821_bb0140","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1002\/iub.319","article-title":"Mammalian ceramide synthases","volume":"62","author":"Levy","year":"2010","journal-title":"IUBMB Life"},{"key":"10.1016\/j.bbalip.2020.158821_bb0145","doi-asserted-by":"crossref","first-page":"5677","DOI":"10.1074\/jbc.M707386200","article-title":"Characterization of ceramide synthase 2 tissue distribution, substrate specificity, and inhibition by sphingosine 1-phosphate","volume":"283","author":"Laviad","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2020.158821_bb0150","doi-asserted-by":"crossref","first-page":"10902","DOI":"10.1074\/jbc.M109.077594","article-title":"A critical role for ceramide synthase 2 in liver homeostasis","volume":"285","author":"Pewzner-Jung","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2020.158821_bb0155","doi-asserted-by":"crossref","unstructured":"M. Uhl\u00e9n, L. Fagerberg, B.M. Hallstr\u00f6m, C. Lindskog, P. Oksvold, A. Mardinoglu, \u00c5. Sivertsson, C. Kampf, E. Sj\u00f6stedt, A. Asplund, I. Olsson, K. Edlund, E. Lundberg, S. Navani, C.A.-K. Szigyarto, J. Odeberg, D. Djureinovic, J.O. Takanen, S. Hober, T. Alm, P.-H. Edqvist, H. Berling, H. Tegel, J. Mulder, J. Rockberg, P. Nilsson, J.M. Schwenk, M. Hamsten, K. von Feilitzen, M. Forsberg, L. Persson, F. Johansson, M. Zwahlen, G. von Heijne, J. Nielsen, F. Pont\u00e9n, Tissue-based map of the human proteome, Science. 347 (2015). doi:https:\/\/doi.org\/10.1126\/science.1260419.","DOI":"10.1126\/science.1260419"},{"key":"10.1016\/j.bbalip.2020.158821_bb0160","doi-asserted-by":"crossref","first-page":"11818","DOI":"10.1074\/jbc.M109.078121","article-title":"The BCL-2 protein BAK is required for long-chain ceramide generation during apoptosis","volume":"285","author":"Siskind","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2020.158821_bb0165","doi-asserted-by":"crossref","first-page":"7477","DOI":"10.1074\/jbc.M115.695858","article-title":"Enzyme activities of the ceramide synthases CERS2\u20136 are regulated by phosphorylation in the C-terminal region","volume":"291","author":"Sassa","year":"2016","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2020.158821_bb0170","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1042\/BJ20050291","article-title":"Mammalian Lass6 and its related family members regulate synthesis of specific ceramides","volume":"390","author":"Mizutani","year":"2005","journal-title":"Biochem. J."},{"key":"10.1016\/j.bbalip.2020.158821_bb0175","doi-asserted-by":"crossref","first-page":"18439","DOI":"10.1073\/pnas.1005572107","article-title":"ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid synthesis","volume":"107","author":"Ohno","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbalip.2020.158821_bb0180","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.plipres.2016.03.006","article-title":"The enigma of ceramide synthase regulation in mammalian cells","volume":"63","author":"Wegner","year":"2016","journal-title":"Prog. Lipid Res."},{"key":"10.1016\/j.bbalip.2020.158821_bb0185","first-page":"1001","article-title":"Correlation between renal growth retardation and apoptosis of cortical tubules in experimentally induced acute ascending pyelonephritis in infant rat","volume":"34","author":"Sung","year":"2000","journal-title":"Korean J Pathol."},{"key":"10.1016\/j.bbalip.2020.158821_bb0190","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1038\/sj.ki.5000357","article-title":"Osteopontin regulates renal apoptosis and interstitial fibrosis in neonatal chronic unilateral ureteral obstruction","volume":"70","author":"Yoo","year":"2006","journal-title":"Kidney Int."},{"key":"10.1016\/j.bbalip.2020.158821_bb0195","doi-asserted-by":"crossref","unstructured":"T.V. Dupre, M.A. Doll, P.P. Shah, C.N. Sharp, D. Siow, J. Megyesi, J. Shayman, A. Bielwska, J. Bielawski, L.J. Beverly, others, Inhibiting glucosylceramide synthase exacerbates cisplatin-induced acute kidney injury, Journal of Lipid Research. (2017) jlr\u2013M076745.","DOI":"10.1194\/jlr.M076745"}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1388198120302134?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1388198120302134?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T19:17:10Z","timestamp":1778613430000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1388198120302134"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["S1388198120302134"],"URL":"https:\/\/doi.org\/10.1016\/j.bbalip.2020.158821","relation":{},"ISSN":["1388-1981"],"issn-type":[{"value":"1388-1981","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Consistent alteration of chain length-specific ceramides in human and mouse fibrotic kidneys","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbalip.2020.158821","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"158821"}}