{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T21:09:42Z","timestamp":1793740182188,"version":"4.6.1"},"reference-count":40,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,6]],"date-time":"2022-05-06T00:00:00Z","timestamp":1651795200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 DK068437"],"award-info":[{"award-number":["R01 DK068437"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 DK122071"],"award-info":[{"award-number":["R01 DK122071"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 EY023948"],"award-info":[{"award-number":["R01 EY023948"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21 AA028110"],"award-info":[{"award-number":["R21 AA028110"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1016\/j.bbalip.2022.159179","type":"journal-article","created":{"date-parts":[[2022,5,6]],"date-time":"2022-05-06T12:17:36Z","timestamp":1651839456000},"page":"159179","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Retinol-binding protein 2 (RBP2): More than just dietary retinoid uptake"],"prefix":"10.1016","volume":"1867","author":[{"given":"Jacqueline","family":"Plau","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcin","family":"Golczak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jisun","family":"Paik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rossana M.","family":"Calderon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William S.","family":"Blaner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbalip.2022.159179_bb0005","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1016\/S0021-9258(17)43432-6","article-title":"A novel retinol-binding protein from rat. Purification and partial characterization","volume":"259","author":"Ong","year":"1984","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2022.159179_bb0010","doi-asserted-by":"crossref","first-page":"S24","DOI":"10.1111\/j.1753-4887.1994.tb01383.x","article-title":"Cellular transport and metabolism of vitamin a: roles of the cellular retinoid-binding proteins","volume":"52","author":"Ong","year":"1994","journal-title":"Nutr. Rev."},{"key":"10.1016\/j.bbalip.2022.159179_bb0015","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/978-94-024-0945-1_2","article-title":"Functions of intracellular retinoid binding-proteins","volume":"81","author":"Napoli","year":"2016","journal-title":"Subcell Biochem."},{"key":"10.1016\/j.bbalip.2022.159179_bb0020","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1080\/10409238.2020.1768207","article-title":"Retinol-binding protein 2 (RBP2): biology and pathobiology","volume":"55","author":"Blaner","year":"2020","journal-title":"Crit. Rev. Biochem. Mol. Biol."},{"key":"10.1016\/j.bbalip.2022.159179_bb0025","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.pharmthera.2017.01.004","article-title":"Cellular retinoid binding-proteins, CRBP, CRABP, FABP5: effects on retinoid metabolism, function and related diseases","volume":"173","author":"Napoli","year":"2017","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.bbalip.2022.159179_bb0030","doi-asserted-by":"crossref","first-page":"36617","DOI":"10.1074\/jbc.M205519200","article-title":"Increased neonatal mortality in mice lacking cellular retinol-binding protein II","volume":"277","author":"Zhang","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2022.159179_bb0035","doi-asserted-by":"crossref","first-page":"13510","DOI":"10.1074\/jbc.M800777200","article-title":"The molecular basis of retinoid absorption: a genetic dissection","volume":"283","author":"Wongsiriroj","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2022.159179_bb0040","first-page":"G347","article-title":"Analysis of cloned cDNAs differentially expressed in adapting remnant small intestine after partial resection","volume":"271","author":"Dodson","year":"1996","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.bbalip.2022.159179_bb0045","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1016\/j.ajpath.2011.11.009","article-title":"Epithelial expression of the cytosolic retinoid chaperone cellular retinol binding protein II is essential for in vivo imprinting of local gut dendritic cells by lumenal retinoids","volume":"180","author":"McDonald","year":"2012","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bbalip.2022.159179_bb0050","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/0304-4165(93)90140-4","article-title":"Adaptive changes of intestinal cellular retinol-binding protein, type II following jejunum-bypass operation in the rat","volume":"1156","author":"Takase","year":"1993","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbalip.2022.159179_bb0055","doi-asserted-by":"crossref","first-page":"724","DOI":"10.3892\/ijmm.2015.2066","article-title":"Massive bowel resection upregulates the intestinal mRNA expression levels of cellular retinol-binding protein II and apolipoprotein A-IV and alters the intestinal vitamin a status in rats","volume":"35","author":"Hebiguchi","year":"2015","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.bbalip.2022.159179_bb0060","doi-asserted-by":"crossref","first-page":"eaay8937","DOI":"10.1126\/sciadv.aay8937","article-title":"Retinol-binding protein 2 (RBP2) binds monoacylglycerols and modulates gut endocrine signaling and body weight","volume":"6","author":"Lee","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.bbalip.2022.159179_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.jlr.2021.100054","article-title":"Molecular basis for the interaction of cellular retinol binding protein 2 (CRBP2) with nonretinoid ligands","volume":"62","author":"Silvaroli","year":"2021","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.bbalip.2022.159179_bb0070","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1146\/annurev.nutr.27.061406.093710","article-title":"The emerging functions and mechanisms of mammalian fatty acid-binding proteins","volume":"28","author":"Storch","year":"2008","journal-title":"Annu. Rev. Nutr."},{"key":"10.1016\/j.bbalip.2022.159179_bb0075","doi-asserted-by":"crossref","first-page":"32679","DOI":"10.1074\/jbc.R110.135210","article-title":"Tissue-specific functions in the fatty acid-binding protein family","volume":"285","author":"Storch","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2022.159179_bb0080","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1038\/nrendo.2015.122","article-title":"Metabolic functions of FABPs\u2013mechanisms and therapeutic implications","volume":"11","author":"Hotamisligil","year":"2015","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.bbalip.2022.159179_bb0085","doi-asserted-by":"crossref","first-page":"3415","DOI":"10.1074\/jbc.M111.304907","article-title":"Fatty acid-binding proteins transport N-acylethanolamines to nuclear receptors and are targets of endocannabinoid transport inhibitors","volume":"287","author":"Kaczocha","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2022.159179_bb0090","doi-asserted-by":"crossref","first-page":"6375","DOI":"10.1073\/pnas.0901515106","article-title":"Identification of intracellular carriers for the endocannabinoid anandamide","volume":"106","author":"Kaczocha","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbalip.2022.159179_bb0095","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1016\/j.ajpath.2011.11.009","article-title":"Epithelial expression of the cytosolic retinoid chaperone cellular retinol binding protein II is essential for in vivo imprinting of local gut dendritic cells by lumenal retinoids","volume":"180","author":"McDonald","year":"2012","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bbalip.2022.159179_bb0100","doi-asserted-by":"crossref","first-page":"19805","DOI":"10.1074\/jbc.M113.473579","article-title":"Liver fatty acid-binding protein binds monoacylglycerol in vitro and in mouse liver cytosol","volume":"288","author":"Lagakos","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2022.159179_bb0105","doi-asserted-by":"crossref","first-page":"8711","DOI":"10.1074\/jbc.M114.618447","article-title":"Fatty acid-binding proteins (FABPs) are intracellular carriers for Delta9-tetrahydrocannabinol (THC) and cannabidiol (CBD)","volume":"290","author":"Elmes","year":"2015","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2022.159179_bb0110","doi-asserted-by":"crossref","first-page":"8218","DOI":"10.1016\/S0021-9258(19)83898-X","article-title":"Rat heart fatty acid-binding protein is highly homologous to the murine adipocyte 422 protein and the P2 protein of peripheral nerve myelin","volume":"261","author":"Sacchettini","year":"1986","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2022.159179_bb0115","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1002\/j.1460-2075.1988.tb02985.x","article-title":"The three-dimensional structure of P2 myelin protein","volume":"7","author":"Jones","year":"1988","journal-title":"EMBO J."},{"key":"10.1016\/j.bbalip.2022.159179_bb0120","doi-asserted-by":"crossref","first-page":"5815","DOI":"10.1016\/S0021-9258(18)60638-6","article-title":"The structure of crystalline Escherichia coli-derived rat intestinal fatty acid-binding protein at 2.5-a resolution","volume":"263","author":"Sacchettini","year":"1988","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2022.159179_bb0125","doi-asserted-by":"crossref","first-page":"5428","DOI":"10.1016\/S0021-9258(18)61206-2","article-title":"Crystallization of rat intestinal fatty acid binding protein. Preliminary X-ray data obtained from protein expressed in Escherichia coli","volume":"262","author":"Sacchettini","year":"1987","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2022.159179_bb0130","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1006\/jmbi.1993.1239","article-title":"Crystal structures of holo and apo-cellular retinol-binding protein II","volume":"230","author":"Winter","year":"1993","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.bbalip.2022.159179_bb0135","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1006\/jmbi.1999.2544","article-title":"The structure and dynamics of rat apo-cellular retinol-binding protein II in solution: comparison with the X-ray structure","volume":"286","author":"Lu","year":"1999","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.bbalip.2022.159179_bb0140","doi-asserted-by":"crossref","first-page":"3226","DOI":"10.1107\/S1399004714023839","article-title":"Structures of holo wild-type human cellular retinol-binding protein II (hCRBPII) bound to retinol and retinal","volume":"70","author":"Nossoni","year":"2014","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.bbalip.2022.159179_bb0145","doi-asserted-by":"crossref","first-page":"7333","DOI":"10.1021\/acs.jpclett.9b02861","article-title":"Modulating ligand dissociation through methyl isomerism in accessory sites: binding of retinol to cellular carriers","volume":"10","author":"Estarellas","year":"2019","journal-title":"J. Phys. Chem. Lett."},{"key":"10.1016\/j.bbalip.2022.159179_bb0150","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1006\/jmbi.2000.3883","article-title":"Binding of retinol induces changes in rat cellular retinol-binding protein II conformation and backbone dynamics","volume":"300","author":"Lu","year":"2000","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.bbalip.2022.159179_bb0155","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1021\/acschembio.8b01070","article-title":"Abnormal cannabidiol modulates vitamin a metabolism by acting as a competitive inhibitor of CRBP1","volume":"14","author":"Silvaroli","year":"2019","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.bbalip.2022.159179_bb0160","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1021\/bi00054a019","article-title":"Ligand-protein electrostatic interactions govern the specificity of retinol- and fatty acid-binding proteins","volume":"32","author":"Jakoby","year":"1993","journal-title":"Biochemistry"},{"key":"10.1016\/j.bbalip.2022.159179_bb0165","doi-asserted-by":"crossref","first-page":"8528","DOI":"10.1074\/jbc.M116.714535","article-title":"Ligand binding induces conformational changes in human cellular retinol-binding protein 1 (CRBP1) revealed by atomic resolution crystal structures","volume":"291","author":"Silvaroli","year":"2016","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2022.159179_bb0170","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1146\/annurev-med-042320-014032","article-title":"The gut-brain Axis","volume":"73","author":"Mayer","year":"2021","journal-title":"Annu. Rev. Med."},{"key":"10.1016\/j.bbalip.2022.159179_bb0175","doi-asserted-by":"crossref","first-page":"R75","DOI":"10.1530\/EJE-21-0277","article-title":"Mechanisms in endocrinology: the gut-brain axis: regulating energy balance independent of food intake","volume":"185","author":"Nogueiras","year":"2021","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.bbalip.2022.159179_bb0180","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1002\/biof.1168","article-title":"Endocannabinoids and energy homeostasis: an update","volume":"40","author":"Cristino","year":"2014","journal-title":"Biofactors"},{"key":"10.1016\/j.bbalip.2022.159179_bb0185","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.cmet.2013.03.001","article-title":"The endocannabinoid system in energy homeostasis and the etiopathology of metabolic disorders","volume":"17","author":"Silvestri","year":"2013","journal-title":"Cell Metab."},{"key":"10.1016\/j.bbalip.2022.159179_bb0190","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1194\/jlr.R100015-JLR200","article-title":"Gene expression regulation by retinoic acid","volume":"43","author":"Balmer","year":"2002","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.bbalip.2022.159179_bb0195","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1146\/annurev-pathol-011110-130303","article-title":"Retinoids, retinoic acid receptors, and cancer","volume":"6","author":"Tang","year":"2011","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.bbalip.2022.159179_bb0200","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1194\/jlr.R030833","article-title":"Vitamin a and retinoid signaling: genomic and nongenomic effects","volume":"54","author":"Al Tanoury","year":"2013","journal-title":"J. Lipid Res."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1388198122000695?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1388198122000695?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T10:12:53Z","timestamp":1761387173000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1388198122000695"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8]]},"references-count":40,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["S1388198122000695"],"URL":"https:\/\/doi.org\/10.1016\/j.bbalip.2022.159179","relation":{},"ISSN":["1388-1981"],"issn-type":[{"value":"1388-1981","type":"print"}],"subject":[],"published":{"date-parts":[[2022,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Retinol-binding protein 2 (RBP2): More than just dietary retinoid uptake","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbalip.2022.159179","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"159179"}}