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Biol."},{"key":"10.1016\/j.bbalip.2022.159262_bb0405","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.diabres.2008.05.003","article-title":"Effect of fasting on PPARgamma and AMPK activity in adipocytes","volume":"81","author":"Kajita","year":"2008","journal-title":"Diabetes Res. Clin. Pract."},{"key":"10.1016\/j.bbalip.2022.159262_bb0410","doi-asserted-by":"crossref","first-page":"6105","DOI":"10.1016\/j.febslet.2005.09.078","article-title":"Involvement of AMP-activated protein kinase in fat depot-specific metabolic changes during starvation","volume":"579","author":"Sponarova","year":"2005","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bbalip.2022.159262_bb0415","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1128\/MCB.00244-16","article-title":"AMPK phosphorylates Desnutrin\/ATGL and hormone-sensitive lipase to regulate lipolysis and fatty acid oxidation within adipose tissue","volume":"36","author":"Kim","year":"2016","journal-title":"Mol. Cell. 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Rep."},{"key":"10.1016\/j.bbalip.2022.159262_bb0430","doi-asserted-by":"crossref","first-page":"E1293","DOI":"10.1210\/jc.2011-0149","article-title":"Fasting, but not exercise, increases adipose triglyceride lipase (ATGL) protein and reduces G(0)\/G(1) switch gene 2 (G0S2) protein and mRNA content in human adipose tissue","volume":"96","author":"Nielsen","year":"2011","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bbalip.2022.159262_bb0435","doi-asserted-by":"crossref","first-page":"33336","DOI":"10.1074\/jbc.M105193200","article-title":"Adiponutrin, a transmembrane protein corresponding to a novel dietary- and obesity-linked mRNA specifically expressed in the adipose lineage","volume":"276","author":"Baulande","year":"2001","journal-title":"J. Biol. 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Nutr."},{"issue":"407\u2013418","key":"10.1016\/j.bbalip.2022.159262_bb0500","article-title":"Triglyceride synthesis by DGAT1 protects adipocytes from lipid-induced ER stress during lipolysis","volume":"26","author":"Chitraju","year":"2017","journal-title":"Cell Metab."},{"key":"10.1016\/j.bbalip.2022.159262_bb0505","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/S0006-291X(02)02466-X","article-title":"Concerted elevation of acyl-coenzyme a:diacylglycerol acyltransferase (DGAT) activity through independent stimulation of mRNA expression of DGAT1 and DGAT2 by carbohydrate and insulin","volume":"298","author":"Meegalla","year":"2002","journal-title":"Biochem. Biophys. Res. 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Invest."},{"key":"10.1016\/j.bbalip.2022.159262_bb0520","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/333183a0","article-title":"Insulin-regulatable tissues express a unique insulin-sensitive glucose transport protein","volume":"333","author":"James","year":"1988","journal-title":"Nature"},{"key":"10.1016\/j.bbalip.2022.159262_bb0525","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/340070a0","article-title":"Decreased expression of the insulin-responsive glucose transporter in diabetes and fasting","volume":"340","author":"Berger","year":"1989","journal-title":"Nature"},{"key":"10.1016\/j.bbalip.2022.159262_bb0530","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1038\/340072a0","article-title":"Regulation of glucose transporter messenger RNA in insulin-deficient states","volume":"340","author":"Sivitz","year":"1989","journal-title":"Nature"},{"key":"10.1016\/j.bbalip.2022.159262_bb0535","doi-asserted-by":"crossref","first-page":"12434","DOI":"10.1016\/S0021-9258(19)38365-6","article-title":"Hexose transport stimulation and membrane redistribution of glucose transporter isoforms in response to cholera toxin, dibutyryl cyclic AMP, and insulin in 3T3-L1 adipocytes","volume":"265","author":"Clancy","year":"1990","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2022.159262_bb0540","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1111\/j.1432-1033.1969.tb00537.x","article-title":"Glyceroneogenesis in adipose tissue of fasted, diabetic and triamcinolone treated rats","volume":"8","author":"Gorin","year":"1969","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.bbalip.2022.159262_bb0545","doi-asserted-by":"crossref","first-page":"27565","DOI":"10.1074\/jbc.M804393200","article-title":"Glyceroneogenesis is the dominant pathway for triglyceride glycerol synthesis in vivo in the rat","volume":"283","author":"Nye","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2022.159262_bb0550","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1042\/bst0311125","article-title":"Fatty acid recycling in adipocytes: a role for glyceroneogenesis and phosphoenolpyruvate carboxykinase","volume":"31","author":"Forest","year":"2003","journal-title":"Biochem. Soc. 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Med."},{"key":"10.1016\/j.bbalip.2022.159262_bb0575","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/0014-5793(95)00943-4","article-title":"Diet- and diabetes-induced changes of Ob gene expression in rat adipose tissue","volume":"371","author":"Becker","year":"1995","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bbalip.2022.159262_bb0580","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1006\/bbrc.1996.0951","article-title":"Circulating leptin levels are modulated by fasting, cold exposure and insulin administration in lean but not zucker (fa\/fa) rats as measured by ELISA","volume":"223","author":"Hardie","year":"1996","journal-title":"Biochem. Biophys. Res. 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Disord."},{"key":"10.1016\/j.bbalip.2022.159262_bb0610","doi-asserted-by":"crossref","DOI":"10.3390\/metabo10050179","article-title":"The role of autophagy in white adipose tissue function: implications for metabolic health","volume":"10","author":"Clemente-Postigo","year":"2020","journal-title":"Metabolites"},{"key":"10.1016\/j.bbalip.2022.159262_bb0615","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1038\/nature07976","article-title":"Autophagy regulates lipid metabolism","volume":"458","author":"Singh","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.bbalip.2022.159262_bb0620","doi-asserted-by":"crossref","first-page":"3320","DOI":"10.1083\/jcb.201803153","article-title":"Lipid droplet size directs lipolysis and lipophagy catabolism in hepatocytes","volume":"218","author":"Schott","year":"2019","journal-title":"J. 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