{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T22:32:06Z","timestamp":1792708326514,"version":"4.5.0"},"reference-count":27,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T00:00:00Z","timestamp":1704240000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1016\/j.bbalip.2023.159447","type":"journal-article","created":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T15:41:25Z","timestamp":1704296485000},"page":"159447","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Discovery of novel diagnostic biomarkers for Sj\u00f6gren-Larsson syndrome by untargeted lipidomics"],"prefix":"10.1016","volume":"1869","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9048-1041","authenticated-orcid":false,"given":"Fr\u00e9d\u00e9ric M.","family":"Vaz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0238-1412","authenticated-orcid":false,"given":"Pippa","family":"Staps","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9855-3548","authenticated-orcid":false,"given":"Jan Bert","family":"van Klinken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2603-159X","authenticated-orcid":false,"given":"Henk","family":"van Lenthe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2116-7697","authenticated-orcid":false,"given":"Martin","family":"Vervaart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7818-1452","authenticated-orcid":false,"given":"Ronald J.A.","family":"Wanders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5624-8094","authenticated-orcid":false,"given":"Mia L.","family":"Pras-Raves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4916-2866","authenticated-orcid":false,"given":"Michel","family":"van Weeghel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2509-3648","authenticated-orcid":false,"given":"Gajja S.","family":"Salomons","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7738-5709","authenticated-orcid":false,"given":"Sacha","family":"Ferdinandusse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2278-9746","authenticated-orcid":false,"given":"Ron A.","family":"Wevers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7860-7791","authenticated-orcid":false,"given":"Mich\u00e8l A.A.P.","family":"Willemsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.bbalip.2023.159447_bb0005","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1038\/ng0196-52","article-title":"Sj\u00f6gren-Larsson syndrome is caused by mutations in the fatty aldehyde dehydrogenase gene","volume":"12","author":"De Laurenzi","year":"1996","journal-title":"Nat. Genet."},{"issue":"3","key":"10.1016\/j.bbalip.2023.159447_bb0010","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1172\/JCI113379","article-title":"Sj\u00f6gren-Larsson syndrome. Impaired fatty alcohol oxidation in cultured fibroblasts due to deficient fatty alcohol:nicotinamide adenine dinucleotide oxidoreductase activity","volume":"81","author":"Rizzo","year":"1988","journal-title":"J. Clin. Invest."},{"issue":"6","key":"10.1016\/j.bbalip.2023.159447_bb0015","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1007\/s10545-012-9518-6","article-title":"Sj\u00f6gren-Larsson syndrome in clinical practice","volume":"35","author":"Fuijkschot","year":"2012","journal-title":"J. Inherit. Metab. Dis."},{"issue":"6","key":"10.1016\/j.bbalip.2023.159447_bb0020","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.oret.2019.01.023","article-title":"Retinal morphology in Sj\u00f6gren-Larsson syndrome on OCT: from metabolic crystalline maculopathy to early-onset macular degeneration","volume":"3","author":"Staps","year":"2019","journal-title":"Ophthalmology. Retina"},{"issue":"3","key":"10.1016\/j.bbalip.2023.159447_bb0025","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.bbalip.2013.09.001","article-title":"Fatty aldehyde and fatty alcohol metabolism: review and importance for epidermal structure and function","volume":"1841","author":"Rizzo","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"issue":"11","key":"10.1016\/j.bbalip.2023.159447_bb0030","doi-asserted-by":"crossref","first-page":"9802","DOI":"10.1074\/jbc.M413362200","article-title":"Breakdown of 2-hydroxylated straight chain fatty acids via peroxisomal 2-hydroxyphytanoyl-CoA lyase: a revised pathway for the \u03b1-oxidation of straight chain fatty acids","volume":"280","author":"Foulon","year":"2005","journal-title":"J. Biol. Chem."},{"issue":"6","key":"10.1016\/j.bbalip.2023.159447_bb0035","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1002\/jimd.12275","article-title":"Disturbed brain ether lipid metabolism and histology in Sj\u00f6gren-Larsson syndrome","volume":"43","author":"Staps","year":"2020","journal-title":"J. Inherit. Metab. Dis."},{"issue":"6","key":"10.1016\/j.bbalip.2023.159447_bb0040","doi-asserted-by":"crossref","first-page":"682","DOI":"10.3390\/metabo13060682","article-title":"Untargeted metabolomic analysis of Sj\u00f6gren-Larsson syndrome reveals a distinctive pattern of multiple disrupted biochemical pathways","volume":"13","author":"Dai","year":"2023","journal-title":"Metabolites"},{"key":"10.1016\/j.bbalip.2023.159447_bb0045","article-title":"The platelet Lipidome is altered in patients with COVID-19 and correlates with platelet reactivity","author":"Schuurman","year":"2022","journal-title":"Thromb. Haemost."},{"issue":"8","key":"10.1016\/j.bbalip.2023.159447_bb0050","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1194\/jlr.M067470","article-title":"Lipidomic analysis of fibroblasts from Zellweger spectrum disorder patients identifies disease-specific phospholipid ratios","volume":"57","author":"Herzog","year":"2016","journal-title":"J. Lipid Res."},{"issue":"11","key":"10.1016\/j.bbalip.2023.159447_bb0055","doi-asserted-by":"crossref","first-page":"2576","DOI":"10.1093\/jac\/dks275","article-title":"Miltefosine: a review of its pharmacology and therapeutic efficacy in the treatment of leishmaniasis","volume":"67","author":"Dorlo","year":"2012","journal-title":"J. Antimicrob. Chemother."},{"issue":"1","key":"10.1016\/j.bbalip.2023.159447_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijantimicag.2021.106459","article-title":"An update on the clinical pharmacology of miltefosine in the treatment of leishmaniasis","volume":"59","author":"Pali\u0107","year":"2022","journal-title":"Int. J. Antimicrob. Agents"},{"issue":"1\u20132","key":"10.1016\/j.bbalip.2023.159447_bb0065","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.jchromb.2008.02.005","article-title":"Development and validation of a quantitative assay for the measurement of miltefosine in human plasma by liquid chromatography-tandem mass spectrometry","volume":"865","author":"Dorlo","year":"2008","journal-title":"J. Chromatogr. B Analyt. Technol. Biomed. Life Sci."},{"issue":"2","key":"10.1016\/j.bbalip.2023.159447_bb0070","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.chroma.2007.10.055","article-title":"Determination of the ubiquinol-10 and ubiquinone-10 (coenzyme Q10) in human serum by liquid chromatography tandem mass spectrometry to evaluate the oxidative stress","volume":"1175","author":"Ruiz-Jim\u00e9nez","year":"2007","journal-title":"J. Chromatogr. A"},{"issue":"4","key":"10.1016\/j.bbalip.2023.159447_bb0075","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.bbalip.2009.12.004","article-title":"Fatty acid 2-hydroxylation in mammalian sphingolipid biology","volume":"1801","author":"Hama","year":"2010","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"key":"10.1016\/j.bbalip.2023.159447_bb0080","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1007\/978-1-4419-6741-1_5","article-title":"Tales and mysteries of the enigmatic sphingomyelin synthase family","volume":"688","author":"Holthuis","year":"2010","journal-title":"Adv. Exp. Med. Biol."},{"issue":"7","key":"10.1016\/j.bbalip.2023.159447_bb0085","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1016\/j.bbamem.2019.05.001","article-title":"Ceramide phosphoethanolamine, an enigmatic cellular membrane sphingolipid","volume":"1861","author":"Panevska","year":"2019","journal-title":"Biochimica et Biophysica Acta (BBA)"},{"issue":"5","key":"10.1016\/j.bbalip.2023.159447_bb0090","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/BF02536296","article-title":"The effect of two synthetic phospholipids on cell proliferation and phosphatidylcholine biosynthesis in Madin-Darby canine kidney cells","volume":"30","author":"Wieder","year":"1995","journal-title":"Lipids"},{"issue":"8","key":"10.1016\/j.bbalip.2023.159447_bb0095","doi-asserted-by":"crossref","first-page":"3556","DOI":"10.1167\/iovs.02-1172","article-title":"Alkylphosphocholines inhibit proliferation of human retinal pigment epithelial cells","volume":"44","author":"Eibl","year":"2003","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"issue":"8","key":"10.1016\/j.bbalip.2023.159447_bb0100","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22084101","article-title":"Peroxisomal disorders and their mouse models point to essential roles of peroxisomes for retinal integrity","volume":"22","author":"Das","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbalip.2023.159447_bb0105","first-page":"160","article-title":"Topical application of hexadecylphosphocholine in patients with cutaneous lymphomas","volume":"34","author":"Dummer","year":"1992","journal-title":"Progr\u00e8s de La Recherche Exp\u00e9rimentale Des Tumeurs"},{"issue":"2\u20134","key":"10.1016\/j.bbalip.2023.159447_bb0110","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1002\/biof.5520090205","article-title":"Metabolism of coenzyme Q10: biliary and urinary excretion study in guinea pigs","volume":"9","author":"Nakamura","year":"1999","journal-title":"BioFactors (Oxford, England)"},{"issue":"2","key":"10.1016\/j.bbalip.2023.159447_bb0115","doi-asserted-by":"crossref","first-page":"469","DOI":"10.18388\/abp.2000_4027","article-title":"Ubiquinone. Biosynthesis of quinone ring and its isoprenoid side chain. Intracellular localization","volume":"47","author":"Szkopi\u0144ska","year":"2000","journal-title":"Acta Biochim. Pol."},{"issue":"5","key":"10.1016\/j.bbalip.2023.159447_bb0120","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1111\/j.1365-313X.2007.03091.x","article-title":"Arabidopsis thaliana plants possess a specific farnesylcysteine lyase that is involved in detoxification and recycling of farnesylcysteine","volume":"50","author":"Crowell","year":"2007","journal-title":"The Plant Journal: For Cell and Molecular Biology"},{"issue":"1\u20133","key":"10.1016\/j.bbalip.2023.159447_bb0125","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.bbalip.2004.01.003","article-title":"Omega-hydroxylation of farnesol by mammalian cytochromes p450","volume":"1682","author":"DeBarber","year":"2004","journal-title":"Biochim. Biophys. Acta"},{"issue":"7","key":"10.1016\/j.bbalip.2023.159447_bb0130","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1194\/jlr.M400064-JLR200","article-title":"\u03c9-Hydroxylation of phytanic acid in rat liver microsomes: implications for Refsum disease","volume":"45","author":"Komen","year":"2004","journal-title":"J. Lipid Res."},{"issue":"3","key":"10.1016\/j.bbalip.2023.159447_bb0135","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1042\/bj1440585","article-title":"Biosynthesis of trans, trans- and cis, trans-farnesols by soluble enzymes from tissue cultures of Andrographis paniculata","volume":"144","author":"Overton","year":"1974","journal-title":"Biochem. J."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1388198123001713?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1388198123001713?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T10:16:06Z","timestamp":1761387366000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1388198123001713"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":27,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["S1388198123001713"],"URL":"https:\/\/doi.org\/10.1016\/j.bbalip.2023.159447","relation":{},"ISSN":["1388-1981"],"issn-type":[{"value":"1388-1981","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Discovery of novel diagnostic biomarkers for Sj\u00f6gren-Larsson syndrome by untargeted lipidomics","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbalip.2023.159447","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"159447"}}