{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T10:56:40Z","timestamp":1753441000957,"version":"3.38.0"},"reference-count":40,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.bbalip.2025.159604","type":"journal-article","created":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T19:31:17Z","timestamp":1740079877000},"page":"159604","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Preventive effect of siphonaxanthin, a carotenoid from green algae, against diabetic nephropathy and lipid metabolism insufficiency in skeletal muscle"],"prefix":"10.1016","volume":"1870","author":[{"given":"Jiawen","family":"Zheng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Manabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuya","family":"Sugawara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbalip.2025.159604_bb0005","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1007\/s00467-007-0583-2","article-title":"Diabetic nephropathy in children and adolescents","volume":"23","author":"Bogdanovi\u0107","year":"2008","journal-title":"Pediatr. Nephrol."},{"key":"10.1016\/j.bbalip.2025.159604_bb0010","doi-asserted-by":"crossref","first-page":"7881","DOI":"10.3390\/ijms22157881","article-title":"TGF-Beta as a master regulator of diabetic nephropathy","volume":"22","author":"Wang","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbalip.2025.159604_bb0015","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2020.00187","article-title":"Transforming growth factor-Beta1 in diabetic kidney disease","volume":"8","author":"Zhao","year":"2020","journal-title":"Frontiers in Cell and Developmental Biology"},{"key":"10.1016\/j.bbalip.2025.159604_bb0020","doi-asserted-by":"crossref","first-page":"8015","DOI":"10.1073\/pnas.120055097","article-title":"Long-term prevention of renal insufficiency, excess matrix gene expression, and glomerular mesangial matrix expansion by treatment with monoclonal antitransforming growth factor-\u03b2 antibody in <i>db\/db<\/i> diabetic mice","volume":"97","author":"Ziyadeh","year":"2000","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.bbalip.2025.159604_bb0025","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1016\/S0006-291X(03)00885-4","article-title":"Mice lacking Smad3 are protected against streptozotocin-induced diabetic glomerulopathy","volume":"305","author":"Fujimoto","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbalip.2025.159604_bb0030","doi-asserted-by":"crossref","first-page":"5815","DOI":"10.1073\/pnas.1504777112","article-title":"Low TGF\u03b21 expression prevents and high expression exacerbates diabetic nephropathy in mice","volume":"112","author":"Hathaway","year":"2015","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.bbalip.2025.159604_bb0035","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1038\/sj.ki.5002366","article-title":"Pitavastatin ameliorates albuminuria and renal mesangial expansion by downregulating NOX4 in db\/db mice","volume":"72","author":"Fujii","year":"2007","journal-title":"Kidney Int."},{"key":"10.1016\/j.bbalip.2025.159604_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102781","article-title":"Nox4 as a novel therapeutic target for diabetic vascular complications","volume":"64","author":"Wang","year":"2023","journal-title":"Redox Biol."},{"key":"10.1016\/j.bbalip.2025.159604_bb0045","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1186\/s13046-021-01960-4","article-title":"ROS and TGF\u03b2: from pancreatic tumour growth to metastasis","volume":"40","author":"Chang","year":"2021","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.bbalip.2025.159604_bb0050","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1159\/000479874","article-title":"Crosstalk of hyperglycemia and dyslipidemia in diabetic kidney disease","volume":"3","author":"Su","year":"2017","journal-title":"Kidney Diseases"},{"key":"10.1016\/j.bbalip.2025.159604_bb0055","article-title":"TGF-Beta as a master regulator of diabetic nephropathy, in","volume":"22","author":"Wang","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbalip.2025.159604_bb0060","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1080\/0886022X.2018.1450763","article-title":"Synergistic action of inflammation and lipid dysmetabolism on kidney damage in rats","volume":"40","author":"Wang","year":"2018","journal-title":"Ren. Fail."},{"key":"10.1016\/j.bbalip.2025.159604_bb0065","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1096\/fj.02-1117fje","article-title":"Advanced glycation end products activate Smad signaling via TGF-\u03b2-dependent and -independent mechanisms: implications for diabetic renal and vascular disease","volume":"18","author":"Li","year":"2004","journal-title":"FASEB J."},{"key":"10.1016\/j.bbalip.2025.159604_bb0070","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1038\/sj.ki.5001578","article-title":"Combined AGE inhibition and ACEi decreases the progression of established diabetic nephropathy in B6 db\/db mice","volume":"70","author":"Zheng","year":"2006","journal-title":"Kidney Int."},{"key":"10.1016\/j.bbalip.2025.159604_bb0075","doi-asserted-by":"crossref","first-page":"3660","DOI":"10.3390\/md12063660","article-title":"Siphonaxanthin, a green algal carotenoid, as a novel functional compound","volume":"12","author":"Sugawara","year":"2014","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.bbalip.2025.159604_bb0080","doi-asserted-by":"crossref","DOI":"10.1093\/database\/bax004","article-title":"Carotenoids database: structures, chemical fingerprints and distribution among organisms","volume":"2017","author":"Yabuzaki","year":"2017","journal-title":"Database"},{"key":"10.1016\/j.bbalip.2025.159604_bb0085","doi-asserted-by":"crossref","first-page":"62","DOI":"10.3177\/jnsv.69.62","article-title":"Intestinal absorption and anti-inflammatory effects of Siphonein, a Siphonaxanthin fatty acid Ester from green algae","volume":"69","author":"Manabe","year":"2023","journal-title":"J. Nutr. Sci. Vitaminol."},{"key":"10.1016\/j.bbalip.2025.159604_bb0090","first-page":"149","article-title":"Inhibitory effect of carotenoids on ligand-induced lipid raft translocation of Immunoreceptors, journal of oleo","volume":"68","author":"Manabe","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.bbalip.2025.159604_bb0095","doi-asserted-by":"crossref","first-page":"3699","DOI":"10.3390\/nu13113699","article-title":"Multivariate analysis reveals that unsubstituted \u03b2-ring and C8-keto structures are important factors for anti-inflammatory activity of carotenoids","volume":"13","author":"Manabe","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.bbalip.2025.159604_bb0100","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s11418-019-01354-z","article-title":"Siphonaxanthin, a carotenoid from green algae, suppresses advanced glycation end product-induced inflammatory responses, journal of","volume":"74","author":"Manabe","year":"2020","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbalip.2025.159604_bb0105","doi-asserted-by":"crossref","unstructured":"Z.-S. Li, K. Noda, E. Fujita, Y. Manabe, T. Hirata, T. Sugawara, The Green Algal Carotenoid Siphonaxanthin Inhibits Adipogenesis in 3T3-L1 Preadipocytes and the Accumulation of Lipids in White Adipose Tissue of KK-Ay Mice1, 2, 3, J. Nutr., 145 (2015) 490\u2013498.","DOI":"10.3945\/jn.114.200931"},{"key":"10.1016\/j.bbalip.2025.159604_bb0110","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.nutres.2020.02.001","article-title":"Siphonaxanthin, a carotenoid from green algae Codium cylindricum, protects Ob\/Ob mice fed on a high-fat diet against lipotoxicity by ameliorating somatic stresses and restoring anti-oxidative capacity","volume":"77","author":"Zheng","year":"2020","journal-title":"Nutr. Res."},{"key":"10.1016\/j.bbalip.2025.159604_bb0115","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.foodchem.2017.09.075","article-title":"Identification and biological activities of carotenoids from the freshwater alga Oedogonium intermedium","volume":"242","author":"Wang","year":"2018","journal-title":"Food Chem."},{"key":"10.1016\/j.bbalip.2025.159604_bb0120","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/ng1295-376","article-title":"Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase","volume":"11","author":"Li","year":"1995","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbalip.2025.159604_bb0125","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.2337\/diabetes.51.6.1913","article-title":"Gene expression profile in skeletal muscle of type 2 diabetes and the effect of insulin treatment","volume":"51","author":"Sreekumar","year":"2002","journal-title":"Diabetes"},{"key":"10.1016\/j.bbalip.2025.159604_bb0130","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0955-2863(99)00086-8","article-title":"Digestion of plant monogalactosyldiacylglycerol and digalactosyldiacylglycerol in rat alimentary canal11Address correspondence to","volume":"11","author":"Sugawara","year":"2000","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.bbalip.2025.159604_bb0135","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1017\/S0007114507895468","article-title":"Low bioavailability of dietary epoxyxanthophylls in humans","volume":"100","author":"Asai","year":"2008","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.bbalip.2025.159604_bb0140","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0288143","article-title":"Neoxanthin is undetectable in human blood after ingestion of fresh young spinach leaf","volume":"18","author":"Sekiya","year":"2023","journal-title":"PLoS One"},{"key":"10.1016\/j.bbalip.2025.159604_bb0145","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1093\/jn\/134.9.2237","article-title":"An Epoxide\u2013Furanoid Rearrangement of Spinach Neoxanthin Occurs in the Gastrointestinal Tract of Mice and In Vitro: Formation and Cytostatic Activity of Neochrome Stereoisomers","volume":"134","author":"Asai","year":"2004","journal-title":"J. Nutr."},{"key":"10.1016\/j.bbalip.2025.159604_bb0150","doi-asserted-by":"crossref","first-page":"3447","DOI":"10.3390\/ijms19113447","article-title":"PGC-1\u03b1 as a pivotal factor in lipid and metabolic regulation","volume":"19","author":"Cheng","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbalip.2025.159604_bb0155","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/ng1180","article-title":"PGC-1\u03b1-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes","volume":"34","author":"Mootha","year":"2003","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbalip.2025.159604_bb0160","doi-asserted-by":"crossref","first-page":"8466","DOI":"10.1073\/pnas.1032913100","article-title":"Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: potential role of <i>PGC1<\/i> and <i>NRF1<\/i>","volume":"100","author":"Patti","year":"2003","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.bbalip.2025.159604_bb0165","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.physbeh.2008.01.020","article-title":"Type 2 diabetes mellitus and skeletal muscle metabolic function","volume":"94","author":"Phielix","year":"2008","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.bbalip.2025.159604_bb0170","doi-asserted-by":"crossref","first-page":"332","DOI":"10.2337\/db07-1318","article-title":"Activation of Peroxisome Proliferator\u2013Activated Receptor (PPAR)\u03b4 Promotes Reversal of Multiple Metabolic Abnormalities, Reduces Oxidative Stress, and Increases Fatty Acid Oxidation in Moderately Obese Men","volume":"57","author":"Ris\u00e9rus","year":"2008","journal-title":"Diabetes"},{"key":"10.1016\/j.bbalip.2025.159604_bb0175","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s12902-021-00687-9","article-title":"Relationship between insulin sensitivity and gene expression in human skeletal muscle","volume":"21","author":"Parikh","year":"2021","journal-title":"BMC Endocr. Disord."},{"key":"10.1016\/j.bbalip.2025.159604_bb0180","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/j.bbrc.2007.01.092","article-title":"PPAR\u03b4, but not PPAR\u03b1, activates PGC-1\u03b1 gene transcription in muscle","volume":"354","author":"Hondares","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbalip.2025.159604_bb0185","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.febslet.2007.11.040","article-title":"PPAR\u03b4 as a therapeutic target in metabolic disease","volume":"582","author":"Reilly","year":"2008","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bbalip.2025.159604_bb0190","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.cardiores.2007.06.027","article-title":"Cardiac peroxisome proliferator-activated receptor \u03b4 is essential in protecting cardiomyocytes from oxidative damage","volume":"76","author":"Ding","year":"2007","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.bbalip.2025.159604_bb0195","doi-asserted-by":"crossref","first-page":"291","DOI":"10.3390\/md18060291","article-title":"Absorption and tissue distribution of Siphonaxanthin from green algae","volume":"18","author":"Li","year":"2020","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.bbalip.2025.159604_bb0200","article-title":"Dehydrometabolites of siphonaxanthin, a carotenoid from green algae, suppress TLR1\/2-induced inflammatory response more strongly than siphonaxanthin","volume":"108246","author":"Manabe","year":"2025","journal-title":"J. Biol. Chem."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1388198125000125?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1388198125000125?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T05:36:15Z","timestamp":1741930575000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1388198125000125"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":40,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["S1388198125000125"],"URL":"https:\/\/doi.org\/10.1016\/j.bbalip.2025.159604","relation":{},"ISSN":["1388-1981"],"issn-type":[{"type":"print","value":"1388-1981"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Preventive effect of siphonaxanthin, a carotenoid from green algae, against diabetic nephropathy and lipid metabolism insufficiency in skeletal muscle","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbalip.2025.159604","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"159604"}}