{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T02:47:41Z","timestamp":1793155661668,"version":"4.5.0"},"reference-count":48,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T00:00:00Z","timestamp":1763078400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002996","name":"Netherlands Heart Foundation","doi-asserted-by":"publisher","award":["CVON2014\\u201302 ENERGISE"],"award-info":[{"award-number":["CVON2014\\u201302 ENERGISE"]}],"id":[{"id":"10.13039\/501100002996","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.bbalip.2025.159703","type":"journal-article","created":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T23:15:49Z","timestamp":1762902949000},"page":"159703","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["ATGL-mediated lipolysis is essential for myocellular mitochondrial function, mitochondria-lipid droplet interaction and mitochondrial network connectivity"],"prefix":"10.1016","volume":"1871","author":[{"given":"Anne","family":"Gemmink","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tineke","family":"van de Weijer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gert","family":"Schaart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gernot F.","family":"Grabner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Kornips","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K\u00e8vin","family":"Knoops","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudolf","family":"Zechner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Schweiger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthijs K.C.","family":"Hesselink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbalip.2025.159703_bb0005","doi-asserted-by":"crossref","first-page":"e51","DOI":"10.1161\/CIRCRESAHA.113.300944","article-title":"Effects of bezafibrate treatment in a patient and a carrier with mutations in the PNPLA2 gene, causing neutral lipid storage disease with myopathy","volume":"112","author":"van de Weijer","year":"2013","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbalip.2025.159703_bb0010","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1038\/ng1951","article-title":"The gene encoding adipose triglyceride lipase (PNPLA2) is mutated in neutral lipid storage disease with myopathy","volume":"39","author":"Fischer","year":"2007","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbalip.2025.159703_bb0015","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1001\/archneurol.2011.631","article-title":"Blocked muscle fat oxidation during exercise in neutral lipid storage disease","volume":"69","author":"Laforet","year":"2012","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.bbalip.2025.159703_bb0020","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/s13023-017-0646-9","article-title":"Neutral Lipid Storage Diseases: clinical\/genetic features and natural history in a large cohort of Italian patients","volume":"12","author":"Pennisi","year":"2017","journal-title":"Orphanet J. Rare Dis."},{"key":"10.1016\/j.bbalip.2025.159703_bb0025","first-page":"880","article-title":"Of mice and men: The physiological role of adipose triglyceride lipase (ATGL)","volume":"2019","author":"Schreiber","year":"1864","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"key":"10.1016\/j.bbalip.2025.159703_bb0030","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.nmd.2017.01.011","article-title":"Late onset of neutral lipid storage disease due to novel PNPLA2 mutations causing total loss of lipase activity in a patient with myopathy and slight cardiac involvement","volume":"27","author":"Missaglia","year":"2017","journal-title":"Neuromuscul. Disord."},{"key":"10.1016\/j.bbalip.2025.159703_bb0035","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.gendis.2019.07.006","article-title":"A novel PNPLA2 mutation causing total loss of RNA and protein expression in two NLSDM siblings with early onset but slowly progressive severe myopathy","volume":"8","author":"Tavian","year":"2021","journal-title":"Genes Dis."},{"key":"10.1016\/j.bbalip.2025.159703_bb0040","doi-asserted-by":"crossref","first-page":"5755","DOI":"10.1210\/jcem.86.12.8075","article-title":"Skeletal muscle lipid content and insulin resistance: evidence for a paradox in endurance-trained athletes","volume":"86","author":"Goodpaster","year":"2001","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bbalip.2025.159703_bb0045","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s001250051123","article-title":"Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: a 1H NMR spectroscopy study","volume":"42","author":"Krssak","year":"1999","journal-title":"Diabetologia"},{"key":"10.1016\/j.bbalip.2025.159703_bb0050","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1007\/s001250051250","article-title":"Relation of triglyceride stores in skeletal muscle cells to central obesity and insulin sensitivity in European and South Asian men","volume":"42","author":"Forouhi","year":"1999","journal-title":"Diabetologia"},{"key":"10.1016\/j.bbalip.2025.159703_bb0055","doi-asserted-by":"crossref","first-page":"E152","DOI":"10.1152\/ajpendo.00142.2017","article-title":"Intramuscular triglyceride synthesis: importance in muscle lipid partitioning in humans","volume":"314","author":"Bergman","year":"2018","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.bbalip.2025.159703_bb0060","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1016\/j.bbalip.2017.07.007","article-title":"Regulation of lipid droplet-associated proteins by peroxisome proliferator-activated receptors","volume":"1862","author":"de la Rosa Rodriguez","year":"2017","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"key":"10.1016\/j.bbalip.2025.159703_bb0065","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1038\/nm.2439","article-title":"ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-alpha and PGC-1","volume":"17","author":"Haemmerle","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbalip.2025.159703_bb0070","doi-asserted-by":"crossref","first-page":"15924","DOI":"10.1073\/pnas.0306981100","article-title":"Activation of peroxisome proliferator-activated receptor delta induces fatty acid beta-oxidation in skeletal muscle and attenuates metabolic syndrome","volume":"100","author":"Tanaka","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbalip.2025.159703_bb0075","first-page":"12","article-title":"PPARdelta activation in human myotubes increases mitochondrial fatty acid oxidative capacity and reduces glucose utilization by a switch in substrate preference, Arch Physiol","volume":"120","author":"Feng","year":"2014","journal-title":"Biochem"},{"key":"10.1016\/j.bbalip.2025.159703_bb0080","doi-asserted-by":"crossref","first-page":"H1078","DOI":"10.1152\/ajpheart.00679.2014","article-title":"Activation of PPARdelta signaling improves skeletal muscle oxidative metabolism and endurance function in an animal model of ischemic left ventricular dysfunction","volume":"308","author":"Zizola","year":"2015","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.bbalip.2025.159703_bb0085","doi-asserted-by":"crossref","first-page":"E960","DOI":"10.1152\/ajpendo.00598.2014","article-title":"ATGL-mediated triglyceride turnover and the regulation of mitochondrial capacity in skeletal muscle","volume":"308","author":"Meex","year":"2015","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.bbalip.2025.159703_bb0090","doi-asserted-by":"crossref","first-page":"5111","DOI":"10.1038\/s41467-018-07676-y","article-title":"Subcellular connectomic analyses of energy networks in striated muscle","volume":"9","author":"Bleck","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbalip.2025.159703_bb0095","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/j.devcel.2015.01.029","article-title":"Fatty acid trafficking in starved cells: regulation by lipid droplet lipolysis, autophagy, and mitochondrial fusion dynamics","volume":"32","author":"Rambold","year":"2015","journal-title":"Dev. Cell"},{"key":"10.1016\/j.bbalip.2025.159703_bb0100","doi-asserted-by":"crossref","first-page":"3691","DOI":"10.1113\/JP279802","article-title":"Drp1 knockdown induces severe muscle atrophy and remodelling, mitochondrial dysfunction, autophagy impairment and denervation","volume":"598","author":"Dulac","year":"2020","journal-title":"J. Physiol."},{"key":"10.1016\/j.bbalip.2025.159703_bb0105","doi-asserted-by":"crossref","first-page":"6237","DOI":"10.1021\/jacs.1c10836","article-title":"Small-Molecule Inhibitors Targeting Lipolysis in Human Adipocytes","volume":"144","author":"Grabner","year":"2022","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bbalip.2025.159703_bb0110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.exger.2017.05.020","article-title":"Exercise training protects against aging-induced mitochondrial fragmentation in mouse skeletal muscle in a PGC-1\u03b1 dependent manner","volume":"96","author":"Halling","year":"2017","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.bbalip.2025.159703_bb0115","doi-asserted-by":"crossref","DOI":"10.15252\/embr.201948686","article-title":"PINK1 phosphorylates Drp1(S616) to regulate mitophagy-independent mitochondrial dynamics","volume":"21","author":"Han","year":"2020","journal-title":"EMBO Rep."},{"key":"10.1016\/j.bbalip.2025.159703_bb0120","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1042\/CS20150780","article-title":"Mitochondrial dynamics, quality control and miRNA regulation in skeletal muscle: implications for obesity and related metabolic disease","volume":"130","author":"Dahlmans","year":"2016","journal-title":"Clin. Sci. (Lond.)"},{"key":"10.1016\/j.bbalip.2025.159703_bb0125","doi-asserted-by":"crossref","first-page":"3822","DOI":"10.1096\/fj.201600571RR","article-title":"PPARalpha-ATGL pathway improves muscle mitochondrial metabolism: implication in aging","volume":"30","author":"Biswas","year":"2016","journal-title":"FASEB J."},{"key":"10.1016\/j.bbalip.2025.159703_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.110267","article-title":"Lipid droplet dynamics regulate adult muscle stem cell fate","volume":"38","author":"Yue","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.bbalip.2025.159703_bb0135","doi-asserted-by":"crossref","first-page":"E879","DOI":"10.1152\/ajpendo.00530.2014","article-title":"Adipose triglyceride lipase deletion from adipocytes, but not skeletal myocytes, impairs acute exercise performance in mice","volume":"308","author":"Dube","year":"2015","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.bbalip.2025.159703_bb0140","doi-asserted-by":"crossref","first-page":"3350","DOI":"10.2337\/db13-0500","article-title":"Skeletal muscle triacylglycerol hydrolysis does not influence metabolic complications of obesity","volume":"62","author":"Sitnick","year":"2013","journal-title":"Diabetes"},{"key":"10.1016\/j.bbalip.2025.159703_bb0145","doi-asserted-by":"crossref","first-page":"E71","DOI":"10.1152\/ajpendo.00597.2011","article-title":"Increased intramyocellular lipids but unaltered in vivo mitochondrial oxidative phosphorylation in skeletal muscle of adipose triglyceride lipase-deficient mice","volume":"303","author":"Nunes","year":"2012","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.bbalip.2025.159703_bb0150","doi-asserted-by":"crossref","first-page":"E505","DOI":"10.1152\/ajpendo.00190.2009","article-title":"Adipose triacylglycerol lipase deletion alters whole body energy metabolism and impairs exercise performance in mice","volume":"297","author":"Huijsman","year":"2009","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.bbalip.2025.159703_bb0155","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1194\/jlr.M001073","article-title":"Adipose triglyceride lipase plays a key role in the supply of the working muscle with fatty acids","volume":"51","author":"Schoiswohl","year":"2010","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.bbalip.2025.159703_bb0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.jlr.2022.100194","article-title":"Hormone-sensitive lipase protects adipose triglyceride lipase-deficient mice from lethal lipotoxic cardiomyopathy","volume":"63","author":"Yamada","year":"2022","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.bbalip.2025.159703_bb0165","doi-asserted-by":"crossref","first-page":"579","DOI":"10.2337\/db07-1438","article-title":"Muscle-derived angiopoietin-like protein 4 is induced by fatty acids via peroxisome proliferator-activated receptor (PPAR)-delta and is of metabolic relevance in humans","volume":"58","author":"Staiger","year":"2009","journal-title":"Diabetes"},{"key":"10.1016\/j.bbalip.2025.159703_bb0170","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1021\/jm990554g","article-title":"The PPARs: from orphan receptors to drug discovery","volume":"43","author":"Willson","year":"2000","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bbalip.2025.159703_bb0175","doi-asserted-by":"crossref","first-page":"18624","DOI":"10.1074\/jbc.M109.008797","article-title":"PPAR{delta} agonism activates fatty acid oxidation via PGC-1{alpha} but does not increase mitochondrial gene expression and function","volume":"284","author":"Kleiner","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2025.159703_bb0180","doi-asserted-by":"crossref","first-page":"98","DOI":"10.2144\/000113610","article-title":"Mitochondrial membrane potential probes and the proton gradient: a practical usage guide","volume":"50","author":"Perry","year":"2011","journal-title":"Biotechniques"},{"key":"10.1016\/j.bbalip.2025.159703_bb0185","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/bs.mcb.2019.10.003","article-title":"Visualization of mitochondrial membrane potential in mammalian cells","volume":"155","author":"Esteras","year":"2020","journal-title":"Methods Cell Biol."},{"key":"10.1016\/j.bbalip.2025.159703_bb0190","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/j.cmet.2015.08.023","article-title":"Endogenous and Synthetic ABHD5 Ligands Regulate ABHD5-Perilipin Interactions and Lipolysis in Fat and Muscle","volume":"22","author":"Sanders","year":"2015","journal-title":"Cell Metab."},{"key":"10.1016\/j.bbalip.2025.159703_bb0195","first-page":"339","article-title":"Low cardiac lipolysis reduces mitochondrial fission and prevents lipotoxic heart dysfunction in Perilipin 5 mutant mice","volume":"116","author":"Kolleritsch","year":"2020","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.bbalip.2025.159703_bb0200","doi-asserted-by":"crossref","first-page":"2576","DOI":"10.1038\/s41467-019-10226-9","article-title":"DRP1-mediated mitochondrial shape controls calcium homeostasis and muscle mass","volume":"10","author":"Favaro","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbalip.2025.159703_bb0205","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1016\/j.cmet.2017.04.021","article-title":"Age-Associated Loss of OPA1 in Muscle Impacts Muscle Mass, Metabolic Homeostasis, Systemic Inflammation, and Epithelial Senescence","volume":"25","author":"Tezze","year":"2017","journal-title":"Cell Metab."},{"key":"10.1016\/j.bbalip.2025.159703_bb0210","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1007\/s00018-020-03662-0","article-title":"The connection between the dynamic remodeling of the mitochondrial network and the regulation of muscle mass","volume":"78","author":"Romanello","year":"2021","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.bbalip.2025.159703_bb0215","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1083\/jcb.201312066","article-title":"Mitochondrial fusion is frequent in skeletal muscle and supports excitation-contraction coupling","volume":"205","author":"Eisner","year":"2014","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.bbalip.2025.159703_bb0220","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1038\/ijo.2015.130","article-title":"Low brown adipose tissue activity in endurance-trained compared with lean sedentary men","volume":"39","author":"Vosselman","year":"2015","journal-title":"Int. J. Obes."},{"key":"10.1016\/j.bbalip.2025.159703_bb0225","doi-asserted-by":"crossref","first-page":"4773","DOI":"10.1038\/s41467-021-24956-2","article-title":"Impact of aging and exercise on skeletal muscle mitochondrial capacity, energy metabolism, and physical function","volume":"12","author":"Grevendonk","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbalip.2025.159703_bb0230","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0021068","article-title":"Remodeling lipid metabolism and improving insulin responsiveness in human primary myotubes","volume":"6","author":"Sparks","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.bbalip.2025.159703_bb0235","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.bbalip.2025.159703_bb0240","doi-asserted-by":"crossref","first-page":"3532","DOI":"10.1093\/bioinformatics\/btw413","article-title":"MorphoLibJ: integrated library and plugins for mathematical morphology with ImageJ","volume":"32","author":"Legland","year":"2016","journal-title":"Bioinformatics"}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1388198125001118?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1388198125001118?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T14:30:27Z","timestamp":1771511427000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1388198125001118"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":48,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["S1388198125001118"],"URL":"https:\/\/doi.org\/10.1016\/j.bbalip.2025.159703","relation":{},"ISSN":["1388-1981"],"issn-type":[{"value":"1388-1981","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"ATGL-mediated lipolysis is essential for myocellular mitochondrial function, mitochondria-lipid droplet interaction and mitochondrial network connectivity","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbalip.2025.159703","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"159703"}}