{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T21:19:49Z","timestamp":1788470389729,"version":"build-2803163510"},"reference-count":31,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003851","name":"Heilongjiang Province Department of Education","doi-asserted-by":"publisher","award":["LJGXCG2024-P09"],"award-info":[{"award-number":["LJGXCG2024-P09"]}],"id":[{"id":"10.13039\/501100003851","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010845","name":"Harbin Science and Technology Bureau","doi-asserted-by":"publisher","award":["2022CXRCCG014"],"award-info":[{"award-number":["2022CXRCCG014"]}],"id":[{"id":"10.13039\/501100010845","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.bbalip.2026.159746","type":"journal-article","created":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T15:06:48Z","timestamp":1777648008000},"page":"159746","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Study on the response of Punicalagin to AGEs \u2014 Induced inflammation based on lipidomics"],"prefix":"10.1016","volume":"1871","author":[{"given":"Lang","family":"Lang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinwen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenge","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbalip.2026.159746_bb0005","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1089\/dia.2011.0043","article-title":"Increased accumulation of skin advanced glycation end products is associated with microvascular complications in type 1 diabetes","volume":"13","author":"Araszkiewicz","year":"2011","journal-title":"Diabetes Technol. Ther."},{"key":"10.1016\/j.bbalip.2026.159746_bb0010","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.freeradbiomed.2017.06.014","article-title":"Punicalagin, a PTP1B inhibitor, induces M2c phenotype polarization via up-regulation of HO-1 in murine macrophages","volume":"110","author":"Xu","year":"2017","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbalip.2026.159746_bb0015","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.foodchem.2014.11.035","article-title":"Pomegranate peel and peel extracts: chemistry and food features","volume":"174","author":"Akhtar","year":"2015","journal-title":"Food Chem."},{"key":"10.1016\/j.bbalip.2026.159746_bb0020","doi-asserted-by":"crossref","DOI":"10.3390\/nu11030548","article-title":"Anti-inflammatory effects of pomegranate peel extracts on in vitro human intestinal Caco-2 cells and ex vivo porcine colonic tissue explants","volume":"11","author":"Mastrogiovanni","year":"2019","journal-title":"Nutrients"},{"key":"10.1016\/j.bbalip.2026.159746_bb0025","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1007\/s11427-020-1939-1","article-title":"Punicalagin ameliorates collagen-induced arthritis by downregulating M1 macrophage and pyroptosis via NF-\u03baB signaling pathway","volume":"65","author":"Ge","year":"2022","journal-title":"Sci. China Life Sci."},{"key":"10.1016\/j.bbalip.2026.159746_bb0030","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1002\/ptr.6882","article-title":"Natural compounds against doxorubicin-induced cardiotoxicity: a review on the involvement of Nrf2\/ARE signaling pathway","volume":"35","author":"Yarmohammadi","year":"2021","journal-title":"Phytother. Res."},{"key":"10.1016\/j.bbalip.2026.159746_bb0035","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1017\/S0007114512002206","article-title":"Polyphenol-rich extract of pomegranate peel alleviates tissue inflammation and hypercholesterolaemia in high-fat diet-induced obese mice: potential implication of the gut microbiota","volume":"109","author":"Neyrinck","year":"2013","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.bbalip.2026.159746_bb0040","doi-asserted-by":"crossref","first-page":"11297","DOI":"10.3168\/jds.2018-14506","article-title":"Supplementation effects of pomegranate by-products on oxidative status, metabolic profile, and performance in transition dairy cows","volume":"101","author":"Safari","year":"2018","journal-title":"J. Dairy Sci."},{"key":"10.1016\/j.bbalip.2026.159746_bb0045","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1142\/S0192415X16500439","article-title":"Punicalagin prevents hypoxic pulmonary hypertension via anti-oxidant effects in rats","volume":"44","author":"Shao","year":"2016","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.bbalip.2026.159746_bb0050","first-page":"681","article-title":"Effects of PUN on lipid metabolism and oxidative stress in diabetic mice","volume":"11","author":"Miao","year":"2018","journal-title":"Glob. Chin. Med."},{"key":"10.1016\/j.bbalip.2026.159746_bb0055","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1111\/imm.12910","article-title":"Implications of macrophage polarization in autoimmunity","volume":"154","author":"Funes","year":"2018","journal-title":"Immunology"},{"key":"10.1016\/j.bbalip.2026.159746_bb0060","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/nature12034","article-title":"Macrophage biology in development, homeostasis and disease","volume":"496","author":"Wynn","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.bbalip.2026.159746_bb0065","doi-asserted-by":"crossref","DOI":"10.1038\/srep35234","article-title":"Bone marrow-derived and peritoneal macrophages have different inflammatory response to oxLDL and M1\/M2 marker expression \u2014 implications for atherosclerosis research","volume":"6","author":"Bisgaard","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbalip.2026.159746_bb0070","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1128\/MMBR.00043-14","article-title":"JNK signaling: regulation and functions based on complex protein-protein partnerships","volume":"80","author":"Zeke","year":"2016","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"10.1016\/j.bbalip.2026.159746_bb0075","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1124\/pr.114.009639","article-title":"Cytokines as therapeutic targets in rheumatoid arthritis and other inflammatory diseases","volume":"67","author":"Siebert","year":"2015","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.bbalip.2026.159746_bb0080","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/ncpendmet0786","article-title":"Mechanisms of disease: advanced glycation end-products and their receptor in inflammation and diabetes complications","volume":"4","author":"Yan","year":"2008","journal-title":"Nat. Clin. Pract. Endocrinol. Metab."},{"key":"10.1016\/j.bbalip.2026.159746_bb0085","article-title":"Silymarin attenuates cigarette smoke extract-induced inflammation via simultaneous inhibition of autophagy and ERK\/p38 MAPK pathway in human bronchial epithelial cells","volume":"6","author":"Li","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbalip.2026.159746_bb0090","doi-asserted-by":"crossref","first-page":"2470","DOI":"10.1091\/mbc.E17-08-0504","article-title":"WDR62 mediates TNF\u03b1-dependent JNK activation via TRAF2-MLK3 axis","volume":"29","author":"Prinz","year":"2018","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.bbalip.2026.159746_bb0095","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1080\/21541248.2018.1536638","article-title":"Regulation of RhoA activation and cell motility by c-Jun N-terminal kinases and Net1","volume":"11","author":"Ulu","year":"2020","journal-title":"Small GTPases"},{"key":"10.1016\/j.bbalip.2026.159746_bb0100","doi-asserted-by":"crossref","first-page":"4217","DOI":"10.1002\/jcp.27185","article-title":"Insulin promotes macrophage phenotype transition through PI3K\/Akt and PPAR-\u03b3 signaling during diabetic wound healing","volume":"234","author":"Yu","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.bbalip.2026.159746_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2025.117239","article-title":"Formononetin ameliorates DSS-induced colitis by inhibiting the MAPK\/PPAR-\u03b3\/NF-\u03baB\/ROS signaling pathways","volume":"496","author":"Cao","year":"2025","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.bbalip.2026.159746_bb0110","doi-asserted-by":"crossref","first-page":"2619","DOI":"10.2147\/DDDT.S310163","article-title":"The agonists of peroxisome proliferator-activated receptor-\u03b3 for liver fibrosis","volume":"15","author":"Li","year":"2021","journal-title":"Drug Des. Devel. Ther."},{"key":"10.1016\/j.bbalip.2026.159746_bb0115","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.201601013","article-title":"Alliin, a garlic organosulfur compound, ameliorates gut inflammation through MAPK-NF-\u03baB\/AP-1\/STAT-1 inactivation and PPAR-\u03b3 activation","volume":"61","author":"Shi","year":"2017","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.bbalip.2026.159746_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2025.120954","article-title":"Anti-inflammatory effects and mechanisms of Podophyllum hexandrum rhizomes and fruits in a chronic pelvic inflammatory disease rat model","volume":"357","author":"Zhang","year":"2026","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.bbalip.2026.159746_bb0125","first-page":"32","article-title":"Research progress on the regulation of inflammatory signaling pathway by peroxisome proliferator-activated receptor \u03b3","volume":"58","author":"Li","year":"2022","journal-title":"Chin. J. Anim. Sci."},{"key":"10.1016\/j.bbalip.2026.159746_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.107979","article-title":"Lysophosphatidic acid-mediated GPR35 signaling in CX3CR1+ macrophages regulates intestinal homeostasis","volume":"32","author":"Kaya","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.bbalip.2026.159746_bb0135","article-title":"Arachidonic acid metabolism and kidney inflammation","volume":"20","author":"Wang","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbalip.2026.159746_bb0140","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18122730","article-title":"Lysophospholipid-related diseases and PPAR\u03b3 signaling pathway","volume":"18","author":"Tsukahara","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbalip.2026.159746_bb0145","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.cellsig.2011.08.004","article-title":"Lysophosphatidic acid increases soluble ST2 expression in mouse lung and human bronchial epithelial cells","volume":"24","author":"Zhao","year":"2012","journal-title":"Cell. Signal."},{"key":"10.1016\/j.bbalip.2026.159746_bb0150","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.imlet.2015.12.001","article-title":"Exogenous ceramide-1-phosphate (C1P) and phospho-ceramide analogue-1 (PCERA-1) regulate key macrophage activities via distinct receptors","volume":"169","author":"Katz","year":"2016","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.bbalip.2026.159746_bb0155","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.bbalip.2009.09.017","article-title":"Lipotoxicity in macrophages: evidence from diseases associated with the metabolic syndrome","volume":"1801","author":"Prieur","year":"2010","journal-title":"Biochim. Biophys. Acta"}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1388198126000326?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1388198126000326?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T17:24:40Z","timestamp":1783099480000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1388198126000326"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":31,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["S1388198126000326"],"URL":"https:\/\/doi.org\/10.1016\/j.bbalip.2026.159746","relation":{},"ISSN":["1388-1981"],"issn-type":[{"value":"1388-1981","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Study on the response of Punicalagin to AGEs \u2014 Induced inflammation based on lipidomics","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbalip.2026.159746","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"159746"}}