{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:52:21Z","timestamp":1791996741412,"version":"4.4.0"},"reference-count":65,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T00:00:00Z","timestamp":1786233600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006111","name":"Minist\u00e9rio da Ci\u00eancia, Tecnologia e Ensino Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006111","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000266","name":"Engineering and Physical Sciences Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.bbalip.2026.159765","type":"journal-article","created":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T06:52:05Z","timestamp":1786171925000},"page":"159765","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Remodeling of lipid metabolism orchestrates human adipose-derived mesenchymal stem cells osteodifferentiation"],"prefix":"10.1016","volume":"1871","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5813-5421","authenticated-orcid":false,"given":"Daniela S.C.","family":"Bispo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5041-8785","authenticated-orcid":false,"given":"Jennifer H.","family":"Haggarty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-4804-5215","authenticated-orcid":false,"given":"In\u00eas","family":"Gra\u00e7a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3191-7121","authenticated-orcid":false,"given":"Brian J.","family":"Goodfellow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8621-5410","authenticated-orcid":false,"given":"Jo\u00e3o","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2342-3765","authenticated-orcid":false,"given":"Jo\u00e3o F.","family":"Mano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7638-6657","authenticated-orcid":false,"given":"Mariana B.","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5124-7458","authenticated-orcid":false,"given":"Penelope M.","family":"Tsimbouri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0528-3359","authenticated-orcid":false,"given":"Matthew J.","family":"Dalby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3766-4364","authenticated-orcid":false,"given":"Ana M.","family":"Gil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbalip.2026.159765_bb0005","author":"World Health Organization"},{"key":"10.1016\/j.bbalip.2026.159765_bb0010","author":"International Osteoporosis Foundation"},{"key":"10.1016\/j.bbalip.2026.159765_bb0015","doi-asserted-by":"crossref","first-page":"61","DOI":"10.3389\/fbioe.2020.00061","article-title":"Reconstruction of large skeletal defects: current clinical therapeutic strategies and future directions using 3D printing","volume":"8","author":"Vidal","year":"2020","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.bbalip.2026.159765_bb0020","doi-asserted-by":"crossref","first-page":"268","DOI":"10.3389\/fcell.2019.00268","article-title":"Adult stem cells for bone regeneration and repair","volume":"7","author":"Iaquinta","year":"2019","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.bbalip.2026.159765_bb0025","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.tem.2017.11.008","article-title":"The metabolic microenvironment steers bone tissue regeneration","volume":"29","author":"Loeffler","year":"2018","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.bbalip.2026.159765_bb0030","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1007\/s12015-021-10193-z","article-title":"Metabolomic applications in stem cell research: a review","volume":"17","author":"Bispo","year":"2021","journal-title":"Stem Cell Rev. Rep."},{"key":"10.1016\/j.bbalip.2026.159765_bb0035","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1007\/s00198-012-2138-z","article-title":"The omega-6 arachidonic fatty acid, but not the omega-3 fatty acids, inhibits osteoblastogenesis and induces adipogenesis of human mesenchymal stem cells: potential implication in osteoporosis","volume":"24","author":"Casado-D\u00edaz","year":"2013","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.bbalip.2026.159765_bb0040","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.steroids.2013.01.007","article-title":"Cholesterol loading affects osteoblastic differentiation in mouse mesenchymal stem cells","volume":"78","author":"Li","year":"2013","journal-title":"Steroids"},{"key":"10.1016\/j.bbalip.2026.159765_bb0045","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1128\/MCB.01343-14","article-title":"Wnt-Lrp5 signaling regulates fatty acid metabolism in the osteoblast","volume":"35","author":"Frey","year":"2015","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.bbalip.2026.159765_bb0050","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.bone.2019.02.017","article-title":"Treatment with an inhibitor of fatty acid synthase attenuates bone loss in ovariectomized mice","volume":"122","author":"Bermeo","year":"2019","journal-title":"Bone"},{"key":"10.1016\/j.bbalip.2026.159765_bb0055","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s10020-019-0123-0","article-title":"Deficiency of sphingomyelin synthase 1 but not sphingomyelin synthase 2 reduces bone formation due to impaired osteoblast differentiation","volume":"25","author":"Matsumoto","year":"2019","journal-title":"Mol. Med."},{"key":"10.1016\/j.bbalip.2026.159765_bb0060","doi-asserted-by":"crossref","first-page":"3773","DOI":"10.1002\/jcb.24252","article-title":"Caveolin-1 regulates proliferation and osteogenic differentiation of human mesenchymal stem cells","volume":"113","author":"Baker","year":"2012","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.bbalip.2026.159765_bb0065","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.3390\/cells11081257","article-title":"Endo- and exometabolome crosstalk in mesenchymal stem cells undergoing osteogenic differentiation","volume":"11","author":"Bispo","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.bbalip.2026.159765_bb0070","article-title":"Lipid metabolic adaptations of multi-donor mesenchymal stem cells during osteodifferentiation","volume":"1870","author":"Bispo","year":"2025","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"key":"10.1016\/j.bbalip.2026.159765_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemphyslip.2024.105420","article-title":"Sphingolipidomic profiling of human dental pulp stem cells undergoing osteogenic differentiation","volume":"263","author":"Moggio","year":"2024","journal-title":"Chem. Phys. Lipids"},{"key":"10.1016\/j.bbalip.2026.159765_bb0080","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aao1193","article-title":"W-3 polyunsaturated fatty acids direct differentiation of the membrane phenotype in mesenchymal stem cells to potentiate osteogenesis","volume":"3","author":"Levental","year":"2017","journal-title":"Sci. Adv."},{"key":"10.1016\/j.bbalip.2026.159765_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemphyslip.2020.104964","article-title":"Lipidomics of mesenchymal stem cell differentiation","volume":"232","author":"Silva","year":"2020","journal-title":"Chem. Phys. Lipids"},{"key":"10.1016\/j.bbalip.2026.159765_bb0090","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/3674931","article-title":"Energy metabolism and Lipidome are highly regulated during osteogenic differentiation of dental follicle cells","volume":"2022","author":"Pieles","year":"2022","journal-title":"Stem Cells Int."},{"key":"10.1016\/j.bbalip.2026.159765_bb0095","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/j.ijbiomac.2022.11.005","article-title":"Thermal treatment of magnesium particles in polylactic acid polymer films elicits the expression of osteogenic differentiation markers and lipidome profile remodeling in human adipose stem cells","volume":"223","author":"Argentati","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.bbalip.2026.159765_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2024.117363","article-title":"Clinical challenges in bone tissue engineering - a narrative review","volume":"192","author":"Hoveidaei","year":"2025","journal-title":"Bone"},{"key":"10.1016\/j.bbalip.2026.159765_bb0105","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.chempr.2016.07.001","article-title":"Tunable supramolecular hydrogels for selection of lineage-guiding metabolites in stem cell cultures","volume":"1","author":"Alakpa","year":"2016","journal-title":"Chem"},{"key":"10.1016\/j.bbalip.2026.159765_bb0110","doi-asserted-by":"crossref","first-page":"10027","DOI":"10.1021\/acsnano.0c03130","article-title":"Nanovibrational stimulation of mesenchymal stem cells induces therapeutic reactive oxygen species and inflammation for three-dimensional bone tissue engineering","volume":"14","author":"Orapiriyakul","year":"2020","journal-title":"ACS Nano"},{"key":"10.1016\/j.bbalip.2026.159765_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioadv.2025.214567","article-title":"Global metabolomics identifies new extracellular biomarkers of nanovibration-driven mesenchymal stem cells osteodifferentiation","volume":"180","author":"Bispo","year":"2026","journal-title":"Biomater. Adv."},{"key":"10.1016\/j.bbalip.2026.159765_bb0120","doi-asserted-by":"crossref","first-page":"535","DOI":"10.3390\/bioengineering10050535","article-title":"3D-printed bioactive scaffold loaded with GW9508 promotes critical-size bone defect repair by regulating intracellular metabolism","volume":"10","author":"Huang","year":"2023","journal-title":"Bioengineering"},{"key":"10.1016\/j.bbalip.2026.159765_bb0125","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1186\/s13287-025-04419-x","article-title":"Metabolic markers detect early ostedifferentiation of mesenchymal stem cells from multiple donors","volume":"16","author":"Bispo","year":"2025","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.bbalip.2026.159765_bb0130","doi-asserted-by":"crossref","first-page":"3745","DOI":"10.3390\/cells11233745","article-title":"An intracellular metabolic signature as a potential donor-independent marker of the osteogenic differentiation of adipose tissue mesenchymal stem cells","volume":"11","author":"Bispo","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.bbalip.2026.159765_bb0135","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1038\/nbt.2377","article-title":"A cross-platform toolkit for mass spectrometry and proteomics","volume":"30","author":"Chambers","year":"2012","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.bbalip.2026.159765_bb0140","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1002\/jcb.25292","article-title":"Mesenchymal stem cells respond to hypoxia by increasing diacylglycerols","volume":"117","author":"Lakatos","year":"2016","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.bbalip.2026.159765_bb0145","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1021\/acs.jproteome.8b00936","article-title":"Integrated Lipidomics and transcriptomics characterization upon aging-related changes of lipid species and pathways in human bone marrow mesenchymal stem cells","volume":"18","author":"Lu","year":"2019","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.bbalip.2026.159765_bb0150","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-70972-5","article-title":"Monitoring membrane viscosity in differentiating stem cells using BODIPY-based molecular rotors and FLIM","volume":"10","author":"Kashirina","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbalip.2026.159765_bb0155","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.3390\/cells11121906","article-title":"In search of the holy grail: toward a unified hypothesis on mitochondrial dysfunction in age-related diseases","volume":"11","author":"Zhang","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.bbalip.2026.159765_bb0160","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.biochi.2023.09.004","article-title":"Ether-lipids and cellular signaling: a differential role of alkyl- and alkenyl-ether-lipids?","volume":"215","author":"Papin","year":"2023","journal-title":"Biochimie"},{"key":"10.1016\/j.bbalip.2026.159765_bb0165","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.bbalip.2018.12.013","article-title":"1-Deoxysphingolipids","volume":"1864","author":"Santos","year":"2019","journal-title":"BBA - Mol Cell Biol Lipids"},{"key":"10.1016\/j.bbalip.2026.159765_bb0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111063","article-title":"Structural basis for acyl chain control over glycosphingolipid sorting and vesicular trafficking","volume":"40","author":"Schmieder","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.bbalip.2026.159765_bb0175","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/s41574-023-00845-0","article-title":"Lipid droplet biogenesis and functions in health and disease","volume":"19","author":"Zadoorian","year":"2023","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.bbalip.2026.159765_bb0180","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1016\/j.msec.2013.01.005","article-title":"Phosphatidylserine enhances osteogenic differentiation in human mesenchymal stem cells via ERK signal pathways","volume":"33","author":"Xu","year":"2013","journal-title":"Mater. Sci. Eng. C"},{"key":"10.1016\/j.bbalip.2026.159765_bb0185","doi-asserted-by":"crossref","first-page":"5036","DOI":"10.3390\/ijms14035036","article-title":"Phospholipases of mineralization competent cells and matrix vesicles\u00a0: roles in physiological and pathological Mineralizations","volume":"14","author":"Mebarek","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbalip.2026.159765_bb0190","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1177\/00220345221103145","article-title":"Matrix vesicle \u2013 mediated mineralization and potential applications","volume":"101","author":"Iwayama","year":"2022","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.bbalip.2026.159765_bb0195","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1093\/jbmr\/zjaf076","article-title":"Taking a closer look at matrix vesicle biogenesis","volume":"40","author":"Clews","year":"2025","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bbalip.2026.159765_bb0200","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.673917","article-title":"Potential role of Plasmalogens in the modulation of biomembrane morphology","volume":"9","author":"Almsherqi","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.bbalip.2026.159765_bb0205","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1634\/stemcells.2007-0509","article-title":"Coordinated changes of mitochondrial biogenesis and antioxidant enzymes during osteogenic differentiation of human mesenchymal stem cells","volume":"26","author":"Chen","year":"2008","journal-title":"Stem Cells"},{"key":"10.1016\/j.bbalip.2026.159765_bb0210","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1089\/scd.2015.0193","article-title":"Energy metabolism in mesenchymal stem cells during osteogenic differentiation","volume":"25","author":"Shum","year":"2016","journal-title":"Stem Cells Dev."},{"key":"10.1016\/j.bbalip.2026.159765_bb0215","doi-asserted-by":"crossref","first-page":"4120","DOI":"10.3390\/ijms22084120","article-title":"Glucose metabolism in osteoblasts in healthy and pathophysiological conditions","volume":"22","author":"Donat","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbalip.2026.159765_bb0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2024.109358","article-title":"SGMS1 facilitates osteogenic differentiation of MSCs and strengthens osteogenesis-angiogenesis coupling by modulating Cer\/PP2A\/Akt pathway","volume":"27","author":"Yang","year":"2024","journal-title":"iScience"},{"key":"10.1016\/j.bbalip.2026.159765_bb0225","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1021\/acsphyschemau.5c00010","article-title":"The effect of ceramide ratio on the membrane curvature of mimetic models of matrix vesicles","volume":"5","author":"Lima","year":"2025","journal-title":"ACS Phys Chem Au"},{"key":"10.1016\/j.bbalip.2026.159765_bb0230","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1042\/BJ20040511","article-title":"Human PHOSPHO1 exhibits high specific phosphoethanolamine and phosphocholine phosphatase activities","volume":"382","author":"Roberts","year":"2004","journal-title":"Biochem. J."},{"key":"10.1016\/j.bbalip.2026.159765_bb0235","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1021\/bi0156557","article-title":"Lipid rafts are enriched in arachidonic acid and Plasmenylethanolamine and their composition is independent of Caveolin-1 expression: a quantitative electrospray ionization\/mass spectrometric analysis","volume":"41","author":"Pike","year":"2002","journal-title":"Biochemistry"},{"key":"10.1016\/j.bbalip.2026.159765_bb0240","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1080\/21623945.2017.1356505","article-title":"Intracellular lipid droplets support osteoblast function intracellular lipid droplets support osteoblast function","volume":"6","author":"Rendina-ruedy","year":"2017","journal-title":"Adipocyte"},{"key":"10.1016\/j.bbalip.2026.159765_bb0245","doi-asserted-by":"crossref","first-page":"2812","DOI":"10.2741\/3887","article-title":"Matrix vesicles: structure, composition, formation and function in calcification","volume":"16","author":"Wuthier","year":"2011","journal-title":"Front. Biosci."},{"key":"10.1016\/j.bbalip.2026.159765_bb0250","article-title":"Osteogenesis is improved by low tumour necrosis factor-\u03b1 concentration through the modulation of Gs-coupled receptor signals 3","volume":"37","author":"Danielea","year":"2017","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.bbalip.2026.159765_bb0255","doi-asserted-by":"crossref","first-page":"9004","DOI":"10.3390\/ijms21239004","article-title":"JAK\/STAT activation: a general mechanism for bone development, homeostasis, and regeneration","volume":"21","author":"Damerau","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbalip.2026.159765_bb0260","doi-asserted-by":"crossref","first-page":"2639","DOI":"10.2147\/JIR.S457927","article-title":"The impact of NLRP3 Inflammasome on osteoblasts and osteogenic differentiation\u00a0: a literature review","volume":"14","author":"Yang","year":"2024","journal-title":"J. Inflamm. Res."},{"key":"10.1016\/j.bbalip.2026.159765_bb0265","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.it.2012.10.001","article-title":"Indoleamine 2,3 dioxygenase and metabolic control of immune responses","volume":"34","author":"Munn","year":"2013","journal-title":"Trends Immunol."},{"key":"10.1016\/j.bbalip.2026.159765_bb0270","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.molimm.2023.11.006","article-title":"Immunomodulation by mesenchymal stem cells during osteogenic differentiation: clinical implications during bone regeneration","volume":"164","author":"Mahajan","year":"2023","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.bbalip.2026.159765_bb0275","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/s41413-023-00297-2","article-title":"Lipolysis supports bone formation by providing osteoblasts with endogenous fatty acid substrates to maintain bioenergetic status","volume":"11","author":"Nandy","year":"2023","journal-title":"Bone Res"},{"key":"10.1016\/j.bbalip.2026.159765_bb0280","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1007\/s00204-011-0645-x","article-title":"Ceramide induces apoptosis via caspase-dependent and caspase-independent pathways in mesenchymal stem cells derived from human adipose tissue","volume":"85","author":"Yeon","year":"2011","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.bbalip.2026.159765_bb0285","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2022.1035516","article-title":"Glucose transporters GLUT1, GLUT3, and GLUT4 have different effects on osteoblast proliferation and metabolism","volume":"13","author":"Arponen","year":"2022","journal-title":"Front. Physiol."},{"key":"10.1016\/j.bbalip.2026.159765_bb0290","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.209452","article-title":"Glycans modify mesenchymal stem cell differentiation to impact on the function of resulting osteoblasts","volume":"131","author":"Wilson","year":"2018","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.bbalip.2026.159765_bb0295","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1093\/jbmr\/zjae088","article-title":"The multifaceted roles of mitochondria in osteoblasts\u00a0: from energy production to mitochondrial-derived vesicle","volume":"39","author":"Suh","year":"2024","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bbalip.2026.159765_bb0300","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1210\/er.2015-1036","article-title":"The regulation of steroid action by Sulfation and Desulfation","volume":"36","author":"Mueller","year":"2015","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.bbalip.2026.159765_bb0305","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/1743-7075-9-14","article-title":"Multiple functions of microsomal triglyceride transfer protein","volume":"9","author":"Hussain","year":"2012","journal-title":"Nutr. Metab. (Lond.)"},{"key":"10.1016\/j.bbalip.2026.159765_bb0310","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s40729-021-00341-y","article-title":"Facile distribution of an alkaline microenvironment improves human bone marrow mesenchymal stem cell osteogenesis on a titanium surface through the ITG \/ FAK \/ ALP pathway","volume":"7","author":"Wang","year":"2021","journal-title":"Int J Implant Dent"},{"key":"10.1016\/j.bbalip.2026.159765_bb0315","doi-asserted-by":"crossref","first-page":"2310","DOI":"10.4161\/15548627.2014.984272","article-title":"Loss of functional MYO1C\/myosin 1c, a motor protein involved in lipid raft traf fi cking, disrupts autophagosome-lysosome fusion","volume":"10","author":"Brandstaetter","year":"2014","journal-title":"Autophagy"},{"key":"10.1016\/j.bbalip.2026.159765_bb0320","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.78069","article-title":"Biphasic regulation of osteoblast development via the ERK MAPK \u2013 mTOR pathway","volume":"11","author":"Kim","year":"2022","journal-title":"Elife"},{"key":"10.1016\/j.bbalip.2026.159765_bb0325","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/s13287-019-1187-z","article-title":"Impact of c-MYC expression on proliferation, differentiation, and risk of neoplastic transformation of human mesenchymal stromal cells","volume":"10","author":"Melnik","year":"2019","journal-title":"Stem Cell Res. Ther."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S138819812600051X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S138819812600051X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:28:58Z","timestamp":1791995338000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S138819812600051X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":65,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["S138819812600051X"],"URL":"https:\/\/doi.org\/10.1016\/j.bbalip.2026.159765","relation":{},"ISSN":["1388-1981"],"issn-type":[{"value":"1388-1981","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Remodeling of lipid metabolism orchestrates human adipose-derived mesenchymal stem cells osteodifferentiation","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbalip.2026.159765","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Crown Copyright \u00a9 2026 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"159765"}}