{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T22:08:59Z","timestamp":1762898939485},"reference-count":70,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T00:00:00Z","timestamp":1417392000000},"content-version":"vor","delay-in-days":365,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100003407","name":"MIUR","doi-asserted-by":"crossref","award":["PRIN 2007","PRIN 2008"],"award-info":[{"award-number":["PRIN 2007","PRIN 2008"]}],"id":[{"id":"10.13039\/501100003407","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100007496","name":"Fondazione CARIGE","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007496","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Regione Lombardia (\u201cNEDD\u201d, Network-Enabled Drug Design)"},{"name":"Fondazione Cariplo (N.O.B.E.L. project)"},{"name":"University of Genoa (Fondi di Ateneo)"},{"DOI":"10.13039\/501100002954","name":"University of Milano-Bicocca","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002954","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Cell Research"],"published-print":{"date-parts":[[2013,12]]},"DOI":"10.1016\/j.bbamcr.2013.08.019","type":"journal-article","created":{"date-parts":[[2013,9,11]],"date-time":"2013-09-11T18:30:28Z","timestamp":1378924228000},"page":"3155-3165","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["Different ataxin-3 amyloid aggregates induce intracellular Ca 2+ deregulation by different mechanisms in cerebellar granule cells"],"prefix":"10.1016","volume":"1833","author":[{"given":"Francesca","family":"Pellistri","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica","family":"Bucciantini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaetano","family":"Invernizzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Gatta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda","family":"Penco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna Maria","family":"Frana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniele","family":"Nosi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annalisa","family":"Relini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Elena","family":"Regonesi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra","family":"Gliozzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Tortora","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauro","family":"Robello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Stefani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbamcr.2013.08.019_bb0005","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1146\/annurev.neuro.23.1.217","article-title":"Glutamine repeats and neurodegeneration","volume":"23","author":"Zoghbi","year":"2000","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.bbamcr.2013.08.019_bb0010","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/35039051","article-title":"Molecular genetics: unmasking polyglutamine triggers in neurodegenerative disease","volume":"1","author":"Gusella","year":"2000","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.bbamcr.2013.08.019_bb0015","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1093\/hmg\/9.6.909","article-title":"Fourteen and counting: unraveling trinucleotide repeat diseases","volume":"9","author":"Cummings","year":"2000","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbamcr.2013.08.019_bb0020","doi-asserted-by":"crossref","first-page":"2905","DOI":"10.1093\/hmg\/11.23.2905","article-title":"Aggregated polyglutamine peptides delivered to nuclei are toxic to mammalian cells","volume":"11","author":"Yang","year":"2002","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbamcr.2013.08.019_bb0025","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/nature01301","article-title":"Pivotal role of oligomerization in expanded polyglutamine neurodegenerative disorders","volume":"421","author":"Sanchez","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.bbamcr.2013.08.019_bb0030","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/j.jmb.2004.09.065","article-title":"Characterization of the structure and the amyloidogenic properties of the Josephin domain of the polyglutamine-containing protein ataxin-3","volume":"344","author":"Masino","year":"2004","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.bbamcr.2013.08.019_bb0035","doi-asserted-by":"crossref","first-page":"16888","DOI":"10.1074\/jbc.M601470200","article-title":"The two-stage pathway of ataxin-3 fibrillogenesis involves a polyglutamine-independent step","volume":"281","author":"Ellisdon","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamcr.2013.08.019_bb0040","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1016\/j.bpj.2011.02.056","article-title":"The Josephin domain determines the morphological and mechanical properties of ataxin-3 fibrils","volume":"100","author":"Masino","year":"2011","journal-title":"Biophys. J."},{"key":"10.1016\/j.bbamcr.2013.08.019_bb0045","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1038\/nn0901-887","article-title":"The \u2018Arctic\u2019 APP mutation (E693G) causes Alzheimer's disease by enhanced Abeta protofibril formation","volume":"9","author":"Nilsberth","year":"2001","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.bbamcr.2013.08.019_bb0050","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1038\/416507a","article-title":"Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases","volume":"416","author":"Bucciantini","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.bbamcr.2013.08.019_bb0055","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/416535a","article-title":"Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo","volume":"416","author":"Walsh","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.bbamcr.2013.08.019_bb0060","doi-asserted-by":"crossref","first-page":"10417","DOI":"10.1073\/pnas.1834302100","article-title":"Alzheimer's disease-affected brain: presence of oligomeric Abeta ligands (ADDL) suggests a molecular basis for reversible memory loss","volume":"100","author":"Gong","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbamcr.2013.08.019_bb0065","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/nn1372","article-title":"Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function","volume":"8","author":"Cleary","year":"2005","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.bbamcr.2013.08.019_bb0070","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/nature04533","article-title":"A specific amyloid-beta protein assembly in the brain impairs memory","volume":"440","author":"Lesn\u00e8","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.bbamcr.2013.08.019_bb0075","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1038\/nature02998","article-title":"Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death","volume":"431","author":"Arrasate","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.bbamcr.2013.08.019_bb0080","doi-asserted-by":"crossref","first-page":"10887","DOI":"10.1073\/pnas.0409283102","article-title":"Formation of morphologically similar globular aggregates from diverse aggregation-prone proteins in mammalian cells","volume":"102","author":"Mukai","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbamcr.2013.08.019_bb0085","doi-asserted-by":"crossref","first-page":"12713","DOI":"10.1523\/JNEUROSCI.3909-08.2008","article-title":"Deranged calcium signaling and neurodegeneration in spinocerebellar ataxia type 3","volume":"28","author":"Chen","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbamcr.2013.08.019_bb0090","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1177\/1073858407303428","article-title":"Generic cell dysfunction in neurodegenerative disorders: role of surfaces in early protein misfolding, aggregation and aggregate cytotoxicity","volume":"13","author":"Stefani","year":"2007","journal-title":"Neuroscientist"},{"key":"10.1016\/j.bbamcr.2013.08.019_bb0095","doi-asserted-by":"crossref","first-page":"29950","DOI":"10.1074\/jbc.M803992200","article-title":"Nonspecific interaction of prefibrillar amyloid aggregates with glutamatergic receptors results in Ca2+ increase in primary neuronal cells","volume":"44","author":"Pellistri","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamcr.2013.08.019_bb0100","doi-asserted-by":"crossref","first-page":"11590","DOI":"10.1074\/jbc.M607483200","article-title":"Abeta oligomers induce neuronal oxidative stress through an N-methyl-d-aspartate receptor-dependent mechanism that is blocked by the Alzheimer drug memantine","volume":"282","author":"De Felice","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamcr.2013.08.019_bb0105","doi-asserted-by":"crossref","first-page":"8160","DOI":"10.1523\/JNEUROSCI.4809-05.2006","article-title":"Prefibrillar amyloid aggregates could be generic toxins in higher organisms","volume":"26","author":"Baglioni","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbamcr.2013.08.019_bb0110","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.1016\/j.neurobiolaging.2013.03.020","article-title":"Amyloid-\u03b2 oligomer synaptotoxicity is mimicked by oligomers of the model protein HypF-N","volume":"34","author":"Tatini","year":"2013","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.bbamcr.2013.08.019_bb0115","doi-asserted-by":"crossref","first-page":"17294","DOI":"10.1074\/jbc.M500997200","article-title":"Calcium dysregulation and membrane disruption as a ubiquitous neurotoxic mechanism of soluble amyloid oligomers","volume":"280","author":"Demuro","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamcr.2013.08.019_bb0120","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1038\/nchembio.283","article-title":"A causative link between the structure of aberrant protein oligomers and their toxicity","volume":"6","author":"Campioni","year":"2010","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.bbamcr.2013.08.019_bb0125","doi-asserted-by":"crossref","first-page":"9220","DOI":"10.1523\/JNEUROSCI.2617-07.2007","article-title":"Different species of alpha-synuclein oligomers induce calcium influx and seeding","volume":"27","author":"Danzer","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbamcr.2013.08.019_bb0130","doi-asserted-by":"crossref","first-page":"6011","DOI":"10.1523\/JNEUROSCI.1189-06.2006","article-title":"Different conformations of amyloid beta induce neurotoxicity by distinct mechanisms in human cortical neurons","volume":"26","author":"Deshpande","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbamcr.2013.08.019_bb0135","doi-asserted-by":"crossref","first-page":"9679","DOI":"10.1073\/pnas.0812083106","article-title":"Distinct conformations of in vitro and in vivo amyloids of huntingtin-exon 1 show different cytotoxicity","volume":"106","author":"Nekooki-Machida","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbamcr.2013.08.019_bb0140","doi-asserted-by":"crossref","first-page":"24765","DOI":"10.1074\/jbc.M111.329763","article-title":"Conformational differences between two amyloid \u03b2 oligomers of similar size and dissimilar toxicity","volume":"287","author":"Ladiwala","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamcr.2013.08.019_bb0145","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1073\/pnas.1209527109","article-title":"Conserved features of intermediates in amyloid assembly determine their benign or toxic states","volume":"109","author":"Krishnan","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbamcr.2013.08.019_bb0150","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1016\/j.cell.2012.03.037","article-title":"Direct observation of the interconversion of normal and toxic forms of \u03b1-synuclein","volume":"149","author":"Cremades","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.bbamcr.2013.08.019_bb0155","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.pneurobio.2012.03.002","article-title":"Structural features and cytotoxicity of amyloid oligomers: implications in Alzheimer's disease and other diseases with amyloid deposits","volume":"99","author":"Stefani","year":"2012","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.bbamcr.2013.08.019_bb0160","doi-asserted-by":"crossref","first-page":"e18789","DOI":"10.1371\/journal.pone.0018789","article-title":"A major role for side-chain polyglutamine hydrogen bonding in irreversible ataxin-3 aggregation","volume":"6","author":"Natalello","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.bbamcr.2013.08.019_bb0165","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1111\/j.1742-4658.2011.08438.x","article-title":"The role of the central flexible region on the aggregation and conformational properties of human ataxin-3","volume":"279","author":"Santambrogio","year":"2012","journal-title":"FEBS J."},{"key":"10.1016\/j.bbamcr.2013.08.019_bb0170","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0306-4522(93)90291-M","article-title":"Regulation of GABAA receptor in cerebellar granule cells in culture: differential involvement of kinase activities","volume":"53","author":"Robello","year":"1993","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbamcr.2013.08.019_bb0175","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1152\/jn.1995.73.3.1169","article-title":"Functional characterization of the effect of nimodipine on the calcium current in rat cerebellar granule cells","volume":"73","author":"Marchetti","year":"1995","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.bbamcr.2013.08.019_bb0180","doi-asserted-by":"crossref","first-page":"31374","DOI":"10.1074\/jbc.M400348200","article-title":"Prefibrillar amyloid protein aggregates share common features of cytotoxicity","volume":"279","author":"Bucciantini","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamcr.2013.08.019_bb0185","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1021\/cb1001203","article-title":"ANS binding reveals common features of cytotoxic amyloid species","volume":"5","author":"Bolognesi","year":"2010","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.bbamcr.2013.08.019_bb0190","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.bpc.2006.07.012","article-title":"Amyloid fibrils formation and amorphous aggregation in concanavalin A","volume":"125","author":"Vetri","year":"2007","journal-title":"Biophys. Chem."},{"key":"10.1016\/j.bbamcr.2013.08.019_bb0195","doi-asserted-by":"crossref","first-page":"47643","DOI":"10.1074\/jbc.M405799200","article-title":"Polyglutamine expansion in ataxin-3 does not affect protein stability: implications for misfolding and disease","volume":"279","author":"Chow","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamcr.2013.08.019_bb0200","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1038\/nn1503","article-title":"Regulation of NMDA receptor trafficking by amyloid-beta","volume":"8","author":"Snyder","year":"2005","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.bbamcr.2013.08.019_bb0205","doi-asserted-by":"crossref","first-page":"10639","DOI":"10.1074\/jbc.M806508200","article-title":"Regulation of N-methyl d-aspartic acid (NMDA) receptors by metabotropic glutamate receptor 7","volume":"284","author":"Gu","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamcr.2013.08.019_bb0210","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1016\/j.bbadis.2011.09.011","article-title":"Submicromolar A\u03b242 reduces hippocampal glutamate receptors and presynaptic markers in an aggregation-dependent manner","volume":"1812","author":"Wisniewski","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbamcr.2013.08.019_bb0215","doi-asserted-by":"crossref","first-page":"3590","DOI":"10.1523\/JNEUROSCI.5824-08.2009","article-title":"Regulation of group I metabotropic glutamate receptor trafficking and signaling by the caveolar\/lipid raft pathway","volume":"29","author":"Francesconi","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbamcr.2013.08.019_bb0220","doi-asserted-by":"crossref","first-page":"2416","DOI":"10.1242\/jcs.098434","article-title":"Membrane lipid composition and its physicochemical properties define cell vulnerability to aberrant protein oligomers","volume":"125","author":"Evangelisti","year":"2012","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.bbamcr.2013.08.019_bb0225","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1096\/fj.11-189381","article-title":"Toxic effects of amyloid fibrils on cell membranes: the importance of ganglioside GM1","volume":"26","author":"Bucciantini","year":"2012","journal-title":"FASEB J."},{"key":"10.1016\/j.bbamcr.2013.08.019_bb0230","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.bbadis.2010.01.007","article-title":"Lipid raft disruption protects mature neurons against amyloid oligomer toxicity","volume":"1802","author":"Malchiodi-Albedi","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbamcr.2013.08.019_bb0235","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1126\/science.1079469","article-title":"Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis","volume":"300","author":"Kayed","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.bbamcr.2013.08.019_bb0240","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1046\/j.1440-1681.2002.03737.x","article-title":"Ion channel formation and membrane-linked pathologies of misfolded hydrophobic proteins: the role of dangerous unchaperoned molecules","volume":"29","author":"Kourie","year":"2002","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.bbamcr.2013.08.019_bb0245","doi-asserted-by":"crossref","first-page":"10427","DOI":"10.1073\/pnas.0502066102","article-title":"Amyloid ion channels: a common structural link for protein-misfolding disease","volume":"102","author":"Quist","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbamcr.2013.08.019_bb0250","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.chemphyslip.2008.11.003","article-title":"The two-fold aspect of the interplay of amyloidogenic proteins with lipid membranes","volume":"158","author":"Relini","year":"2009","journal-title":"Chem. Phys. Lipids"},{"key":"10.1016\/j.bbamcr.2013.08.019_bb0255","doi-asserted-by":"crossref","first-page":"5628","DOI":"10.1002\/anie.200906670","article-title":"Amyloidogenic protein\u2013membrane interactions: mechanistic insight from model systems","volume":"49","author":"Butterfield","year":"2010","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.bbamcr.2013.08.019_bb0260","doi-asserted-by":"crossref","first-page":"4602","DOI":"10.1111\/j.1742-4658.2010.07889.x","article-title":"Biochemical and biophysical features of both oligomer\/fibril and cell membrane in amyloid cytotoxicity","volume":"277","author":"Stefani","year":"2010","journal-title":"FEBS J."},{"key":"10.1016\/j.bbamcr.2013.08.019_bb0265","doi-asserted-by":"crossref","first-page":"28079","DOI":"10.1074\/jbc.M605081200","article-title":"Beta-amyloid-induced dynamin 1 degradation is mediated by N-methyl-d-aspartate receptors in hippocampal neurons","volume":"281","author":"Kelly","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamcr.2013.08.019_bb0270","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/j.neuron.2006.10.035","article-title":"AMPAR removal underlies Abeta-induced synaptic depression and dendritic spine loss","volume":"52","author":"Hsieh","year":"2006","journal-title":"Neuron"},{"key":"10.1016\/j.bbamcr.2013.08.019_bb0275","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1111\/j.1471-4159.2006.04210.x","article-title":"Transthyretin oligomers induce calcium influx via voltage-gated calcium channels","volume":"100","author":"Hou","year":"2007","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbamcr.2013.08.019_bb0280","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1111\/j.1471-4159.2010.07058.x","article-title":"N-Methyl-d-aspartate receptors are required for synaptic targeting of Alzheimer's toxic amyloid-\u03b2 peptide oligomers","volume":"115","author":"Decker","year":"2010","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbamcr.2013.08.019_bb0285","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.brainres.2007.01.071","article-title":"Susceptibility of hippocampal neurons to Abeta peptide toxicity is associated with perturbation of Ca2+ homeostasis","volume":"1143","author":"Resende","year":"2007","journal-title":"Brain Res."},{"key":"10.1016\/j.bbamcr.2013.08.019_bb0290","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jalz.2005.11.003","article-title":"Synaptic targeting by Abeta oligomers (ADDLS) as a basis for memory loss in early Alzheimer's disease","volume":"2","author":"Klein","year":"2006","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.bbamcr.2013.08.019_bb0295","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1080\/15216540701283882","article-title":"Soluble protein oligomers as emerging toxins in Alzheimer's and other amyloid diseases","volume":"59","author":"Ferreira","year":"2007","journal-title":"IUBMB Life"},{"key":"10.1016\/j.bbamcr.2013.08.019_bb0300","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.tins.2007.01.006","article-title":"Ca2+-permeable AMPA receptors in synaptic plasticity and neuronal death","volume":"30","author":"Liu","year":"2007","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.bbamcr.2013.08.019_bb0305","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.tins.2008.07.004","article-title":"Polyglutamine neurodegeneration: protein misfolding revisited","volume":"31","author":"Williams","year":"2008","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.bbamcr.2013.08.019_bb0310","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1016\/j.bbadis.2012.01.016","article-title":"Toxic effects of expanded ataxin-1 involve mechanical instability of the nuclear membrane","volume":"1822","author":"Mapelli","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbamcr.2013.08.019_bb0315","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1111\/j.1471-4159.2006.03895.x","article-title":"Expanded polyglutamines impair synaptic transmission and ubiquitin\u2013proteasome system in Caenorhabditis elegans","volume":"98","author":"Khan","year":"2006","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbamcr.2013.08.019_bb0320","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.expneurol.2006.03.029","article-title":"Potassium channel dysfunction and depolarized resting membrane potential in a cell model of SCA3","volume":"201","author":"Jeub","year":"2006","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.bbamcr.2013.08.019_bb0325","doi-asserted-by":"crossref","first-page":"13002","DOI":"10.1523\/JNEUROSCI.2789-11.2011","article-title":"Early changes in cerebellar physiology accompany motor dysfunction in the polyglutamine disease spinocerebellar ataxia type","volume":"31","author":"Shakkottai","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbamcr.2013.08.019_bb0330","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1093\/brain\/awr118","article-title":"N-terminal ataxin-3 causes neurological symptoms with inclusions, endoplasmic reticulum stress and ribosomal dislocation","volume":"134","author":"H\u00fcbener","year":"2011","journal-title":"Brain"},{"key":"10.1016\/j.bbamcr.2013.08.019_bb0335","doi-asserted-by":"crossref","first-page":"2866","DOI":"10.1523\/JNEUROSCI.4970-06.2007","article-title":"Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway","volume":"271","author":"Shankar","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbamcr.2013.08.019_bb0340","first-page":"1","article-title":"Amyloid oligomer neurotoxicity, calcium dysregulation and lipid rafts","volume":"906964","author":"Malchiodi-Albedi","year":"2011","journal-title":"Int. J. Alzheimers Dis."},{"issue":"603052","key":"10.1016\/j.bbamcr.2013.08.019_bb0345","first-page":"1","article-title":"Lipid rafts: linking Alzheimer's amyloid-\u03b2 production, aggregation, and toxicity at neuronal membranes","volume":"2011","author":"Rushworth","year":"2010","journal-title":"Int. J. Alzheimers Dis."},{"key":"10.1016\/j.bbamcr.2013.08.019_bb0350","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1111\/j.1471-4159.2004.02849.x","article-title":"Structural membrane alterations in Alzheimer brains found to be associated with regional disease development; increased density of gangliosides GM1 and GM2 and loss of cholesterol in detergent-resistant membrane domains","volume":"92","author":"Molander-Melin","year":"2005","journal-title":"J. Neurochem."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167488913003182?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167488913003182?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,7,23]],"date-time":"2019-07-23T20:12:03Z","timestamp":1563912723000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167488913003182"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12]]},"references-count":70,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["S0167488913003182"],"URL":"https:\/\/doi.org\/10.1016\/j.bbamcr.2013.08.019","relation":{},"ISSN":["0167-4889"],"issn-type":[{"value":"0167-4889","type":"print"}],"subject":[],"published":{"date-parts":[[2013,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Different ataxin-3 amyloid aggregates induce intracellular Ca2+ deregulation by different mechanisms in cerebellar granule cells","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Cell Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbamcr.2013.08.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}