{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T21:00:03Z","timestamp":1782939603777,"version":"3.54.5"},"reference-count":45,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T00:00:00Z","timestamp":1417392000000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","award":["SGR2009-00196"],"award-info":[{"award-number":["SGR2009-00196"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002809","name":"Generalitat de Catalunya","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Cell Research"],"published-print":{"date-parts":[[2013,12]]},"DOI":"10.1016\/j.bbamcr.2013.09.019","type":"journal-article","created":{"date-parts":[[2013,10,5]],"date-time":"2013-10-05T08:30:32Z","timestamp":1380961832000},"page":"3326-3337","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"title":["Metabolic remodeling in frataxin-deficient yeast is mediated by Cth2 and Adr1"],"prefix":"10.1016","volume":"1833","author":[{"given":"Armando","family":"Moreno-Cerme\u00f1o","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Alsina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Cabiscol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordi","family":"Tamarit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaquim","family":"Ros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"Suppl. 1","key":"10.1016\/j.bbamcr.2013.09.019_bb0005","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s00415-009-1002-3","article-title":"Friedreich ataxia: the clinical picture","volume":"256","author":"Pandolfo","year":"2009","journal-title":"J. Neurol."},{"key":"10.1016\/j.bbamcr.2013.09.019_bb0010","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1126\/science.276.5319.1709","article-title":"Regulation of mitochondrial iron accumulation by Yfh1p, a putative homolog of frataxin","volume":"276","author":"Babcock","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.bbamcr.2013.09.019_bb0015","doi-asserted-by":"crossref","first-page":"e16199","DOI":"10.1371\/journal.pone.0016199","article-title":"Mammalian frataxin: an essential function for cellular viability through an interaction with a preformed ISCU\/NFS1\/ISD11 iron\u2013sulfur assembly complex","volume":"6","author":"Schmucker","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.bbamcr.2013.09.019_bb0020","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1073\/pnas.0709691105","article-title":"Hydrogen peroxide scavenging rescues frataxin deficiency in a Drosophila model of Friedreich's ataxia","volume":"105","author":"Anderson","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbamcr.2013.09.019_bb0025","doi-asserted-by":"crossref","first-page":"41653","DOI":"10.1074\/jbc.M110.149443","article-title":"Frataxin depletion in yeast triggers up-regulation of iron transport systems before affecting iron\u2013sulfur enzyme activities","volume":"285","author":"Moreno-Cermeno","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamcr.2013.09.019_bb0030","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1042\/BJ20111637","article-title":"Mutation in the Fe\u2013S scaffold protein Isu bypasses frataxin deletion","volume":"441","author":"Yoon","year":"2012","journal-title":"Biochem. J."},{"key":"10.1016\/j.bbamcr.2013.09.019_bb0035","doi-asserted-by":"crossref","first-page":"92506","DOI":"10.1021\/bi201628j","article-title":"Effector role reversal during evolution: the case of frataxin in Fe\u2013S cluster biosynthesis","volume":"51","author":"Bridwell-Rabb","year":"2012","journal-title":"Biochemistry"},{"key":"10.1016\/j.bbamcr.2013.09.019_bb0040","doi-asserted-by":"crossref","first-page":"4948","DOI":"10.1021\/bi800052m","article-title":"Structural basis of the iron storage function of frataxin from single-particle reconstruction of the iron-loaded oligomer","volume":"47","author":"Schagerlof","year":"2008","journal-title":"Biochemistry"},{"key":"10.1016\/j.bbamcr.2013.09.019_bb0045","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1093\/hmg\/ddi214","article-title":"Frataxin interacts functionally with mitochondrial electron transport chain proteins","volume":"14","author":"Gonzalez-Cabo","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbamcr.2013.09.019_bb0050","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1093\/hmg\/ddp592","article-title":"Molecular control of the cytosolic aconitase\/IRP1 switch by extramitochondrial frataxin","volume":"19","author":"Condo","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbamcr.2013.09.019_bb0055","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1128\/jb.56.1.115-124.1948","article-title":"Growth and assimilation in cultures of Saccharomyces cerevisiae","volume":"56","author":"Swanson","year":"1948","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.bbamcr.2013.09.019_bb0060","doi-asserted-by":"crossref","first-page":"26948","DOI":"10.1074\/jbc.M800408200","article-title":"Mitochondrial oxidative phosphorylation is regulated by fructose 1,6-bisphosphate. A possible role in Crabtree effect induction?","volume":"283","author":"Diaz-Ruiz","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamcr.2013.09.019_bb0065","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1038\/ncomms1305","article-title":"Parallel evolution of the make-accumulate-consume strategy in Saccharomyces and Dekkera yeasts","volume":"2","author":"Rozpedowska","year":"2011","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbamcr.2013.09.019_bb0070","doi-asserted-by":"crossref","first-page":"3978","DOI":"10.1111\/j.1742-4658.2011.08315.x","article-title":"The AMPK\/SNF1\/SnRK1 fuel gauge and energy regulator: structure, function and regulation","volume":"278","author":"Ghillebert","year":"2011","journal-title":"FEBS J."},{"key":"10.1016\/j.bbamcr.2013.09.019_bb0075","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1016\/j.bbamcr.2012.01.012","article-title":"Metabolic remodeling in iron-deficient fungi","volume":"1823","author":"Philpott","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbamcr.2013.09.019_bb0080","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.cmet.2008.04.010","article-title":"Cooperation of two mRNA-binding proteins drives metabolic adaptation to iron deficiency","volume":"7","author":"Puig","year":"2008","journal-title":"Cell Metab."},{"key":"10.1016\/j.bbamcr.2013.09.019_bb0085","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1002\/yea.1142","article-title":"A versatile toolbox for PCR-based tagging of yeast genes: new fluorescent proteins, more markers and promoter substitution cassettes","volume":"21","author":"Janke","year":"2004","journal-title":"Yeast"},{"key":"10.1016\/j.bbamcr.2013.09.019_bb0090","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1091\/mbc.01-10-0517","article-title":"Grx5 is a mitochondrial glutaredoxin required for the activity of iron\/sulfur enzymes","volume":"13","author":"Rodr\u00edguez-Manzaneque","year":"2002","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.bbamcr.2013.09.019_bb0095","doi-asserted-by":"crossref","first-page":"43614","DOI":"10.1074\/jbc.M403606200","article-title":"Characterization of the calcium-mediated response to alkaline stress in Saccharomyces cerevisiae","volume":"279","author":"Viladevall","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamcr.2013.09.019_bb0100","series-title":"Real-time PCR","first-page":"63","article-title":"Relative quantification","author":"Pfaffl","year":"2006"},{"key":"10.1016\/j.bbamcr.2013.09.019_bb0105","series-title":"Handbook of Detection of Enzymes on Electrophoretic Gels","author":"Manchenko","year":"1994"},{"key":"10.1016\/j.bbamcr.2013.09.019_bb0110","series-title":"Mitochondria: A Practical Approach","first-page":"153","author":"Robinson","year":"1987"},{"key":"10.1016\/j.bbamcr.2013.09.019_bb0115","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1006\/abio.1993.1127","article-title":"Detection of c-type cytochromes using enhanced chemiluminescence","volume":"209","author":"Vargas","year":"1993","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.bbamcr.2013.09.019_bb0120","doi-asserted-by":"crossref","first-page":"10948","DOI":"10.1073\/pnas.96.20.10948","article-title":"Friedreich's ataxia is a mitochondrial disorder","volume":"96","author":"Kaplan","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbamcr.2013.09.019_bb0125","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1111\/j.1567-1364.2008.00387.x","article-title":"The alcohol dehydrogenases of Saccharomyces cerevisiae: a comprehensive review","volume":"8","author":"de Smidt","year":"2008","journal-title":"FEMS Yeast Res."},{"key":"10.1016\/j.bbamcr.2013.09.019_bb0130","doi-asserted-by":"crossref","first-page":"3667","DOI":"10.1099\/mic.0.2007\/009340-0","article-title":"Chronological and replicative life-span extension in Saccharomyces cerevisiae by increased dosage of alcohol dehydrogenase 1","volume":"153","author":"Reverter-Branchat","year":"2007","journal-title":"Microbiology"},{"key":"10.1016\/j.bbamcr.2013.09.019_bb0135","doi-asserted-by":"crossref","first-page":"12227","DOI":"10.1074\/jbc.M511649200","article-title":"Manganese is the link between frataxin and iron\u2013sulfur deficiency in the yeast model of Friedreich ataxia","volume":"281","author":"Irazusta","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamcr.2013.09.019_bb0140","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.freeradbiomed.2009.11.010","article-title":"Yeast frataxin mutants display decreased superoxide dismutase activity crucial to promote protein oxidative damage","volume":"48","author":"Irazusta","year":"2010","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbamcr.2013.09.019_bb0145","doi-asserted-by":"crossref","first-page":"26146","DOI":"10.1074\/jbc.M301981200","article-title":"Multiple pathways are co-regulated by the protein kinase Snf1 and the transcription factors Adr1 and Cat8","volume":"278","author":"Young","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamcr.2013.09.019_bb0150","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1567-1364.2009.00555.x","article-title":"Transcriptional regulation of nonfermentable carbon utilization in budding yeast","volume":"10","author":"Turcotte","year":"2010","journal-title":"FEMS Yeast Res."},{"key":"10.1016\/j.bbamcr.2013.09.019_bb0155","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1534\/genetics.109.103432","article-title":"Snf1 controls the activity of adr1 through dephosphorylation of Ser230","volume":"182","author":"Ratnakumar","year":"2009","journal-title":"Genetics"},{"key":"10.1016\/j.bbamcr.2013.09.019_bb0160","doi-asserted-by":"crossref","first-page":"5273","DOI":"10.1128\/MCB.00715-10","article-title":"14-3-3 (Bmh) proteins inhibit transcription activation by Adr1 through direct binding to its regulatory domain","volume":"30","author":"Parua","year":"2010","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.bbamcr.2013.09.019_bb0165","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1038\/nature02026","article-title":"Global analysis of protein localization in budding yeast","volume":"425","author":"Huh","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.bbamcr.2013.09.019_bb0170","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1038\/nsmb.1579","article-title":"Bacterial frataxin CyaY is the gatekeeper of iron\u2013sulfur cluster formation catalyzed by IscS","volume":"16","author":"Adinolfi","year":"2009","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.bbamcr.2013.09.019_bb0180","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1074\/mcp.M700468-MCP200","article-title":"A multidimensional chromatography technology for in-depth phosphoproteome","volume":"7","author":"Albuquerque","year":"2008","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.bbamcr.2013.09.019_bb0185","doi-asserted-by":"crossref","first-page":"9149","DOI":"10.1074\/jbc.M411062200","article-title":"Pkc1 and the upstream elements of the cell integrity pathway in Saccharomyces","volume":"280","author":"Vilella","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamcr.2013.09.019_bb0190","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1007\/s00438-006-0175-z","article-title":"Oxidative stress in Schizosaccharomyces pombe: different H2O2 levels, different response pathways","volume":"276","author":"Vivancos","year":"2006","journal-title":"Mol. Genet. Genomics"},{"key":"10.1016\/j.bbamcr.2013.09.019_bb0195","doi-asserted-by":"crossref","first-page":"5157","DOI":"10.1093\/emboj\/19.19.5157","article-title":"H2O2 sensing through oxidation of the Yap1 transcription factor","volume":"19","author":"Delaunay","year":"2000","journal-title":"EMBO J."},{"key":"10.1016\/j.bbamcr.2013.09.019_bb0200","doi-asserted-by":"crossref","first-page":"27393","DOI":"10.1016\/S0021-9258(19)61523-1","article-title":"Oxidative stress promotes specific protein damage in Saccharomyces cerevisiae","volume":"275","author":"Cabiscol","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamcr.2013.09.019_bb0205","doi-asserted-by":"crossref","first-page":"2178","DOI":"10.1128\/MCB.01458-12","article-title":"Negative feedback regulation of the yeast CTH1 and CTH2 mRNA binding proteins is required for adaptation to iron deficiency and iron supplementation","volume":"33","author":"Mart\u00ednez-Pastor","year":"2013","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.bbamcr.2013.09.019_bb0210","doi-asserted-by":"crossref","first-page":"43042","DOI":"10.1074\/jbc.M112.421735","article-title":"Cells Lacking Pfh1, a fission yeast homolog of mammalian frataxin, display constitutive activation of the iron starvation response","volume":"287","author":"Gabrielli","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamcr.2013.09.019_bb0215","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1182\/blood-2011-04-343541","article-title":"Iron regulatory protein-1 and -2: transcriptome-wide definition of binding mRNAs and shaping of the cellular proteome by iron regulatory proteins","volume":"118","author":"Sanchez","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.bbamcr.2013.09.019_bb0220","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.cmet.2012.10.001","article-title":"mTOR regulates cellular iron homeostasis through tristetraprolin","volume":"16","author":"Bayeva","year":"2012","journal-title":"Cell Metab."},{"key":"10.1016\/j.bbamcr.2013.09.019_bb0225","doi-asserted-by":"crossref","first-page":"7645","DOI":"10.1074\/jbc.M411478200","article-title":"Yeast flavohemoglobin, a nitric oxide oxidoreductase, is located in both the cytosol and the mitochondrial matrix: effects of respiration, anoxia, and the mitochondrial genome on its intracellular level and distribution","volume":"280","author":"Cassanova","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamcr.2013.09.019_bb0230","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1152\/physiolgenomics.00055.2005","article-title":"Gene expression profiling and phenotype analyses of S. cerevisiae in response to changing copper reveals six genes with new roles in copper and iron metabolism","volume":"22","author":"van Bakel","year":"2005","journal-title":"Physiol. Genomics"}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167488913003418?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167488913003418?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T19:45:55Z","timestamp":1759088755000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167488913003418"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12]]},"references-count":45,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["S0167488913003418"],"URL":"https:\/\/doi.org\/10.1016\/j.bbamcr.2013.09.019","relation":{},"ISSN":["0167-4889"],"issn-type":[{"value":"0167-4889","type":"print"}],"subject":[],"published":{"date-parts":[[2013,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Metabolic remodeling in frataxin-deficient yeast is mediated by Cth2 and Adr1","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Cell Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbamcr.2013.09.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}