{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T05:27:13Z","timestamp":1791350833017,"version":"4.3.1"},"reference-count":38,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T00:00:00Z","timestamp":1422748800000},"content-version":"vor","delay-in-days":365,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Cell Research"],"published-print":{"date-parts":[[2014,2]]},"DOI":"10.1016\/j.bbamcr.2013.10.022","type":"journal-article","created":{"date-parts":[[2013,11,4]],"date-time":"2013-11-04T16:00:51Z","timestamp":1383580851000},"page":"234-244","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"title":["Valvular dystrophy associated filamin A mutations reveal a new role of its first repeats in small-GTPase regulation"],"prefix":"10.1016","volume":"1843","author":[{"given":"D.","family":"Duval","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Lardeux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Le Tourneau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.A.","family":"Norris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.R.","family":"Markwald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Sauzeau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Probst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Le Marec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Levine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.J.","family":"Schott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Merot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbamcr.2013.10.022_bb0005","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1038\/ncb1104-1034","article-title":"The many faces of filamin: a versatile molecular scaffold for cell motility and signalling","volume":"6","author":"Feng","year":"2004","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.bbamcr.2013.10.022_bb0010","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1083\/jcb.200707073","article-title":"Structural basis of filamin A functions","volume":"179","author":"Nakamura","year":"2007","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.bbamcr.2013.10.022_bb0015","doi-asserted-by":"crossref","first-page":"160","DOI":"10.4161\/cam.5.2.14401","article-title":"The filamins: organizers of cell structure and function","volume":"5","author":"Nakamura","year":"2011","journal-title":"Cell Adh. Migr."},{"key":"10.1016\/j.bbamcr.2013.10.022_bb0020","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1083\/jcb.87.3.841","article-title":"Actin-binding protein promotes the bipolar and perpendicular branching of actin filaments","volume":"87","author":"Hartwig","year":"1980","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.bbamcr.2013.10.022_bb0025","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1038\/35052082","article-title":"Filamins as integrators of cell mechanics and signalling","volume":"2","author":"Stossel","year":"2001","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bbamcr.2013.10.022_bb0030","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.tcb.2009.12.001","article-title":"Filamins in cell signaling, transcription and organ development","volume":"20","author":"Zhou","year":"2010","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.bbamcr.2013.10.022_bb0035","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.tcm.2007.08.001","article-title":"Filamins in cardiovascular development","volume":"17","author":"Zhou","year":"2007","journal-title":"Trends Cardiovasc. Med."},{"key":"10.1016\/j.bbamcr.2013.10.022_bb0040","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1083\/jcb.129.6.1589","article-title":"Actin polymerization and intracellular solvent flow in cell surface blebbing","volume":"129","author":"Cunningham","year":"1995","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.bbamcr.2013.10.022_bb0045","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1007\/s12265-011-9308-9","article-title":"Filamin-a-related myxomatous mitral valve dystrophy: genetic, echocardiographic and functional aspects","volume":"4","author":"Lardeux","year":"2011","journal-title":"J. Cardiovasc. Transl. Res."},{"key":"10.1016\/j.bbamcr.2013.10.022_bb0050","doi-asserted-by":"crossref","first-page":"35113","DOI":"10.1074\/jbc.M109.060954","article-title":"Identification and characterization of multiple similar ligand-binding repeats in filamin: implication on filamin-mediated receptor clustering and cross-talk","volume":"284","author":"Ithychanda","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamcr.2013.10.022_bb0055","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1016\/j.yexcr.2010.02.007","article-title":"Regulation of cell adhesion to collagen via beta1 integrins is dependent on interactions of filamin A with vimentin and protein kinase C epsilon","volume":"316","author":"Kim","year":"2010","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.bbamcr.2013.10.022_bb0060","doi-asserted-by":"crossref","first-page":"e11269","DOI":"10.1371\/journal.pone.0011269","article-title":"R-Ras regulates migration through an interaction with filamin A in melanoma cells","volume":"5","author":"Gawecka","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.bbamcr.2013.10.022_bb0065","doi-asserted-by":"crossref","first-page":"2287","DOI":"10.1002\/jcp.22565","article-title":"R-Ras interacts with filamin a to maintain endothelial barrier function","volume":"226","author":"Griffiths","year":"2011","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.bbamcr.2013.10.022_bb0070","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1084\/jem.20100222","article-title":"A novel interaction between FlnA and Syk regulates platelet ITAM-mediated receptor signaling and function","volume":"207","author":"Falet","year":"2010","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.bbamcr.2013.10.022_bb0075","doi-asserted-by":"crossref","first-page":"C221","DOI":"10.1152\/ajpcell.00323.2009","article-title":"Filamin A is required for vimentin-mediated cell adhesion and spreading","volume":"298","author":"Kim","year":"2010","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.bbamcr.2013.10.022_bb0080","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1002\/ajmg.a.31322","article-title":"Frontometaphyseal dysplasia: mutations in FLNA and phenotypic diversity","volume":"140","author":"Robertson","year":"2006","journal-title":"Am. J. Med. Genet. A"},{"key":"10.1016\/j.bbamcr.2013.10.022_bb0085","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1093\/hmg\/10.17.1775","article-title":"Mutations in the X-linked filamin 1 gene cause periventricular nodular heterotopia in males as well as in females","volume":"10","author":"Sheen","year":"2001","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbamcr.2013.10.022_bb0090","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1212\/01.WNL.0000149512.79621.DF","article-title":"Filamin A mutations cause periventricular heterotopia with Ehlers\u2013Danlos syndrome","volume":"64","author":"Sheen","year":"2005","journal-title":"Neurology"},{"key":"10.1016\/j.bbamcr.2013.10.022_bb0095","doi-asserted-by":"crossref","first-page":"2236","DOI":"10.1002\/ajmg.a.34132","article-title":"Familial cardiac valvulopathy due to filamin A mutation","volume":"155A","author":"Bernstein","year":"2011","journal-title":"Am. J. Med. Genet. A"},{"key":"10.1016\/j.bbamcr.2013.10.022_bb0100","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1161\/CIRCULATIONAHA.106.622621","article-title":"Mutations in the gene encoding filamin A as a cause for familial cardiac valvular dystrophy","volume":"115","author":"Kyndt","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.bbamcr.2013.10.022_bb0105","doi-asserted-by":"crossref","first-page":"e7830","DOI":"10.1371\/journal.pone.0007830","article-title":"Filamins regulate cell spreading and initiation of cell migration","volume":"4","author":"Baldassarre","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.bbamcr.2013.10.022_bb0110","doi-asserted-by":"crossref","first-page":"4739","DOI":"10.1091\/mbc.E12-04-0310","article-title":"FilGAP, a Rho\/Rho-associated protein kinase-regulated GTPase-activating protein for Rac, controls tumor cell migration","volume":"23","author":"Saito","year":"2012","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.bbamcr.2013.10.022_bb0115","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.placenta.2010.02.008","article-title":"New technology for investigating trophoblast function","volume":"31","author":"Keogh","year":"2010","journal-title":"Placenta"},{"key":"10.1016\/j.bbamcr.2013.10.022_bb0120","doi-asserted-by":"crossref","first-page":"2050","DOI":"10.1038\/nprot.2011.411","article-title":"Analysis of RhoA and Rho GEF activity in whole cells and the cell nucleus","volume":"6","author":"Guilluy","year":"2011","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.bbamcr.2013.10.022_bb0125","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1126\/science.1549777","article-title":"Actin-binding protein requirement for cortical stability and efficient locomotion","volume":"255","author":"Cunningham","year":"1992","journal-title":"Science"},{"key":"10.1016\/j.bbamcr.2013.10.022_bb0130","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1038\/ncb1437","article-title":"FilGAP, a Rho- and ROCK-regulated GAP for Rac binds filamin A to control actin remodelling","volume":"8","author":"Ohta","year":"2006","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.bbamcr.2013.10.022_bb0135","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1042\/BJ20130290","article-title":"FilGAP and its close relatives: a mediator of Rho-Rac antagonism that regulates cell morphology and migration","volume":"453","author":"Nakamura","year":"2013","journal-title":"Biochem. J."},{"key":"10.1016\/j.bbamcr.2013.10.022_bb0140","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.jmb.2012.09.016","article-title":"Crystal structure of the filamin N-terminal region reveals a hinge between the actin binding and first repeat domains","volume":"424","author":"Sawyer","year":"2012","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.bbamcr.2013.10.022_bb0145","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.cell.2008.09.043","article-title":"Rac activation and inactivation control plasticity of tumor cell movement","volume":"135","author":"Sanz-Moreno","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.bbamcr.2013.10.022_bb0150","doi-asserted-by":"crossref","first-page":"2122","DOI":"10.1073\/pnas.96.5.2122","article-title":"The small GTPase RalA targets filamin to induce filopodia","volume":"96","author":"Ohta","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbamcr.2013.10.022_bb0155","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1038\/nature10430","article-title":"Mechanical strain in actin networks regulates FilGAP and integrin binding to filamin A","volume":"478","author":"Ehrlicher","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.bbamcr.2013.10.022_bb0160","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/ncb833","article-title":"Tiam1 mediates Ras activation of Rac by a PI(3)K-independent mechanism","volume":"4","author":"Lambert","year":"2002","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.bbamcr.2013.10.022_bb0165","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1126\/science.279.5350.560","article-title":"Coupling of Ras and Rac guanosine triphosphatases through the Ras exchanger Sos","volume":"279","author":"Nimnual","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.bbamcr.2013.10.022_bb0170","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/nrc2109","article-title":"Hyperactive Ras in developmental disorders and cancer","volume":"7","author":"Schubbert","year":"2007","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.bbamcr.2013.10.022_bb0175","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1146\/annurev-physiol-012110-142145","article-title":"Heart valve structure and function in development and disease","volume":"73","author":"Hinton","year":"2011","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.bbamcr.2013.10.022_bb0180","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1093\/cvr\/cvs238","article-title":"Developmental basis for filamin-A-associated myxomatous mitral valve disease","volume":"96","author":"Sauls","year":"2012","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.bbamcr.2013.10.022_bb0185","doi-asserted-by":"crossref","first-page":"2918","DOI":"10.1074\/jbc.M604195200","article-title":"Transglutaminase-dependent RhoA activation and depletion by serotonin in vascular smooth muscle cells","volume":"282","author":"Guilluy","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamcr.2013.10.022_bb0190","doi-asserted-by":"crossref","first-page":"2118","DOI":"10.1002\/dvdy.22346","article-title":"Expression of the familial cardiac valvular dystrophy gene, filamin-A, during heart morphogenesis","volume":"239","author":"Norris","year":"2010","journal-title":"Dev. Dyn."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167488913003674?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167488913003674?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:09:01Z","timestamp":1564618141000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167488913003674"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2]]},"references-count":38,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["S0167488913003674"],"URL":"https:\/\/doi.org\/10.1016\/j.bbamcr.2013.10.022","relation":{},"ISSN":["0167-4889"],"issn-type":[{"value":"0167-4889","type":"print"}],"subject":[],"published":{"date-parts":[[2014,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Valvular dystrophy associated filamin A mutations reveal a new role of its first repeats in small-GTPase regulation","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Cell Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbamcr.2013.10.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}