{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T21:10:14Z","timestamp":1791407414676,"version":"4.3.3"},"reference-count":128,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T00:00:00Z","timestamp":1430438400000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia (FCT, Portugal)"},{"DOI":"10.13039\/501100000780","name":"European Union","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"crossref"}]},{"name":"QREN"},{"DOI":"10.13039\/501100008530","name":"FEDER","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100011929","name":"COMPETE","doi-asserted-by":"crossref","award":["PEst-C\/QUI\/UI0062\/2013"],"award-info":[{"award-number":["PEst-C\/QUI\/UI0062\/2013"]}],"id":[{"id":"10.13039\/501100011929","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100011929","name":"COMPETE","doi-asserted-by":"crossref","award":["FCOMP-01-0124-FEDER-037296"],"award-info":[{"award-number":["FCOMP-01-0124-FEDER-037296"]}],"id":[{"id":"10.13039\/501100011929","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100011929","name":"COMPETE","doi-asserted-by":"crossref","award":["PEst-C\/SAU\/UI0051\/2011"],"award-info":[{"award-number":["PEst-C\/SAU\/UI0051\/2011"]}],"id":[{"id":"10.13039\/501100011929","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100011929","name":"COMPETE","doi-asserted-by":"crossref","award":["SFRH\/BD\/91067\/2012"],"award-info":[{"award-number":["SFRH\/BD\/91067\/2012"]}],"id":[{"id":"10.13039\/501100011929","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Cell Research"],"published-print":{"date-parts":[[2014,5]]},"DOI":"10.1016\/j.bbamcr.2014.01.030","type":"journal-article","created":{"date-parts":[[2014,2,2]],"date-time":"2014-02-02T06:33:57Z","timestamp":1391322837000},"page":"885-893","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"title":["Cellular interplay in pulmonary arterial hypertension: Implications for new therapies"],"prefix":"10.1016","volume":"1843","author":[{"given":"Rita","family":"Nogueira-Ferreira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiago","family":"Henriques-Coelho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbamcr.2014.01.030_bb0005","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1161\/CIRCULATIONAHA.108.847707","article-title":"Basic science of pulmonary arterial hypertension for clinicians: new concepts and experimental therapies","volume":"121","author":"Archer","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0010","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1183\/09059180.00008411","article-title":"Pulmonary hypertension: the science behind the disease spectrum","volume":"21","author":"Wilkins","year":"2012","journal-title":"Eur. Respir. Rev."},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0015","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.cca.2009.01.018","article-title":"Molecular mechanisms of pulmonary hypertension","volume":"403","author":"Yildiz","year":"2009","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0020","doi-asserted-by":"crossref","first-page":"S43","DOI":"10.1016\/j.jacc.2009.04.012","article-title":"Updated clinical classification of pulmonary hypertension","volume":"54","author":"Simonneau","year":"2009","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0025","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/nrcardio.2011.87","article-title":"Mechanisms of disease: pulmonary arterial hypertension","volume":"8","author":"Schermuly","year":"2011","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0030","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.1016\/j.ehj.2004.09.014","article-title":"Guidelines on diagnosis and treatment of pulmonary arterial hypertension","volume":"25","author":"Gali\u00e8","year":"2004","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbabio.2007.10.010","article-title":"Oxygen sensors in context","volume":"1777","author":"Ward","year":"2008","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0040","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.devcel.2009.01.003","article-title":"Regulation of angiogenesis by oxygen and metabolism","volume":"16","author":"Fraisl","year":"2009","journal-title":"Dev. Cell"},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0045","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/j.jbiomech.2006.04.011","article-title":"Molecular basis of the effects of mechanical stretch on vascular smooth muscle cells","volume":"40","author":"Haga","year":"2007","journal-title":"J. Biomech."},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0050","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1513\/pats.200803-027HR","article-title":"Lung vascular cell heterogeneity: endothelium, smooth muscle, and fibroblasts","volume":"5","author":"Stevens","year":"2008","journal-title":"Proc. Am. Thorac. Soc."},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0055","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/j.1469-0691.2010.03285.x","article-title":"Inflammation, immunological reaction and role of infection in pulmonary hypertension","volume":"17","author":"Pullamsetti","year":"2011","journal-title":"Clin. Microbiol. Infect."},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0060","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1186\/1465-9921-10-95","article-title":"Endothelial cells and pulmonary arterial hypertension: apoptosis, proliferation, interaction and transdifferentiation","volume":"10","author":"Sakao","year":"2009","journal-title":"Respir. Res."},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0065","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1161\/01.RES.0000137877.89448.78","article-title":"Endothelial progenitor cells","volume":"95","author":"Urbich","year":"2004","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0070","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.tcm.2010.03.003","article-title":"Endothelial progenitor cells in pulmonary arterial hypertension","volume":"20","author":"Diller","year":"2010","journal-title":"Trends Cardiovasc. Med."},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0075","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1016\/j.jacc.2006.12.037","article-title":"Transplantation of autologous endothelial progenitor cells may be beneficial in patients with idiopathic pulmonary arterial hypertension: a pilot randomized controlled trial","volume":"49","author":"Wang","year":"2007","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0080","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1111\/j.1399-3046.2007.00863.x","article-title":"Safety and efficacy of autologous endothelial progenitor cells transplantation in children with idiopathic pulmonary arterial hypertension: open-label pilot study","volume":"12","author":"Zhu","year":"2008","journal-title":"Pediatr. Transplant."},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0085","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1164\/rccm.200810-1662OC","article-title":"Evidence of dysfunction of endothelial progenitors in pulmonary arterial hypertension","volume":"180","author":"Toshner","year":"2009","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0090","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.ijcard.2011.05.002","article-title":"Enhanced protection against pulmonary hypertension with sildenafil and endothelial progenitor cell in rats","volume":"162","author":"Sun","year":"2011","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0095","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1165\/rcmb.2009-0152OC","article-title":"Innate immunity in the therapeutic actions of endothelial progenitor cells in pulmonary hypertension","volume":"43","author":"Ormiston","year":"2010","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0100","doi-asserted-by":"crossref","first-page":"S20","DOI":"10.1016\/j.jacc.2009.04.018","article-title":"Cellular and molecular basis of pulmonary arterial hypertension","volume":"54","author":"Morrell","year":"2009","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0105","doi-asserted-by":"crossref","first-page":"L843","DOI":"10.1152\/ajplung.00120.2007","article-title":"Regulation of vascular endothelial cell barrier function and cytoskeleton structure by protein phosphatases of the PPP family","volume":"293","author":"Csortos","year":"2007","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0110","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1182\/blood-2010-05-285973","article-title":"Bone morphogenetic protein receptor II regulates pulmonary artery endothelial cell barrier function","volume":"117","author":"Burton","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0115","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.cytogfr.2010.06.001","article-title":"BMP signaling in vascular development and disease","volume":"21","author":"Lowery","year":"2010","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0120","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1016\/j.febslet.2012.04.030","article-title":"BMP signaling in vascular diseases","volume":"586","author":"Cai","year":"2012","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0125","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1378\/chest.08-1341","article-title":"Molecular mechanisms of pulmonary arterial hypertension: role of mutations in the bone morphogenetic protein type II receptor","volume":"134","author":"Davies","year":"2008","journal-title":"Chest"},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0130","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1002\/humu.20285","article-title":"Mutations of the TGF-\u03b2 type II receptor BMPR2 in pulmonary arterial hypertension","volume":"27","author":"Machado","year":"2006","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0135","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1161\/01.CIR.0000012754.72951.3D","article-title":"Primary pulmonary hypertension is associated with reduced pulmonary vascular expression of type II bone morphogenetic protein receptor","volume":"105","author":"Atkinson","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0140","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1161\/01.RES.0000200180.01710.e6","article-title":"Bone morphogenetic protein receptor-2 signaling promotes pulmonary arterial endothelial cell survival","volume":"98","author":"Teichert-Kuliszewska","year":"2006","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0145","doi-asserted-by":"crossref","first-page":"2263","DOI":"10.1161\/01.CIR.0000033830.36431.46","article-title":"Stimulation of Id1 expression by bone morphogenetic protein is sufficient and necessary for bone morphogenetic protein-induced activation of endothelial cells","volume":"106","author":"Valdimarsdottir","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0150","doi-asserted-by":"crossref","first-page":"33134","DOI":"10.1074\/jbc.M111.274100","article-title":"Bone morphogenetic protein receptor II is a novel mediator of endothelial nitric-oxide synthase activation","volume":"286","author":"Gangopahyay","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0155","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1073\/pnas.0605080104","article-title":"Alterations of cellular bioenergetics in pulmonary artery endothelial cells","volume":"104","author":"Xu","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0160","doi-asserted-by":"crossref","first-page":"17","DOI":"10.4103\/2045-8932.78097","article-title":"Protein trafficking dysfunctions: role in the pathogenesis of pulmonary arterial hypertension","volume":"1","author":"Sehgal","year":"2011","journal-title":"Pulm. Circ."},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0165","doi-asserted-by":"crossref","first-page":"H77","DOI":"10.1152\/ajpheart.01386.2006","article-title":"Pulmonary arterial hypertension: a disease of tethers, SNAREs and SNAPs?","volume":"293","author":"Sehgal","year":"2007","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0170","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0092-8674(03)01079-1","article-title":"The mechanisms of vesicle budding and fusion","volume":"116","author":"Bonifacino","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0175","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1161\/01.CIR.0000141576.39579.23","article-title":"Disruption of endothelial-cell caveolin-1\u03b1\/raft scaffolding during development of monocrotaline-induced pulmonary hypertension","volume":"110","author":"Mathew","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0180","doi-asserted-by":"crossref","first-page":"H1373","DOI":"10.1152\/ajpheart.00990.2006","article-title":"Aberrant cytoplasmic sequestration of eNOS in endothelial cells after monocrotaline, hypoxia, and senescence: live-cell caveolar and cytoplasmic NO imaging","volume":"292","author":"Mukhopadhyay","year":"2007","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0185","doi-asserted-by":"crossref","first-page":"L1526","DOI":"10.1152\/ajplung.00463.2006","article-title":"Dysfunction of Golgi tethers, SNAREs, and SNAPs in monocrotaline-induced pulmonary hypertension","volume":"292","author":"Sehgal","year":"2007","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0190","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.pharmthera.2013.10.002","article-title":"Targeted therapies in pulmonary arterial hypertension","volume":"141","author":"Montani","year":"2014","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0195","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.2146\/ajhp110687","article-title":"A new epoprostenol formulation for the treatment of pulmonary arterial hypertension","volume":"69","author":"Fuentes","year":"2012","journal-title":"Am. J. Health Syst. Pharm."},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0200","doi-asserted-by":"crossref","first-page":"235","DOI":"10.2147\/DDDT.S31628","article-title":"Stability and preservation of a new formulation of epoprostenol sodium for treatment of pulmonary arterial hypertension","volume":"6","author":"Lambert","year":"2012","journal-title":"Drug Des. Devel. Ther."},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0205","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1183\/09059180.00001713","article-title":"Therapies for pulmonary arterial hypertension: where are we today, where do we go tomorrow?","volume":"22","author":"Seferian","year":"2013","journal-title":"Eur. Respir. Rev."},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0210","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1007\/s11906-013-0394-8","article-title":"An update on medical therapy for pulmonary arterial hypertension","volume":"15","author":"Wu","year":"2013","journal-title":"Curr. Hypertens. Rep."},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0215","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1056\/NEJMoa1213917","article-title":"Macitentan and morbidity and mortality in pulmonary arterial hypertension","volume":"369","author":"Pulido","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0220","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1056\/NEJMoa1209655","article-title":"Riociguat for the treatment of pulmonary arterial hypertension","volume":"369","author":"Ghofrani","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0225","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1007\/s00380-009-1176-8","article-title":"Acute vasodilator effects of inhaled fasudil, a specific Rho-kinase inhibitor, in patients with pulmonary arterial hypertension","volume":"25","author":"Fujita","year":"2010","journal-title":"Heart Vessels"},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0230","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.jconrel.2013.01.011","article-title":"Liposomal fasudil, a rho-kinase inhibitor, for prolonged pulmonary preferential vasodilation in pulmonary arterial hypertension","volume":"167","author":"Gupta","year":"2013","journal-title":"J. Control. Release"},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0235","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1183\/09059180.00006411","article-title":"Looking to the future: a new decade of pulmonary arterial hypertension therapy","volume":"20","author":"McLaughlin","year":"2011","journal-title":"Eur. Respir. Rev."},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0240","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1007\/BF03085963","article-title":"Regulation and characteristics of vascular smooth muscle cell phenotypic diversity","volume":"15","author":"Rensen","year":"2007","journal-title":"Neth. Heart J."},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0245","doi-asserted-by":"crossref","first-page":"C59","DOI":"10.1152\/ajpcell.00394.2006","article-title":"Multiple repressor pathways contribute to phenotypic switching of vascular smooth muscle cells","volume":"292","author":"Kawai-Kowase","year":"2007","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0250","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1161\/01.ATV.0000090130.85752.ED","article-title":"Arterial smooth muscle cell heterogeneity","volume":"23","author":"Hao","year":"2003","journal-title":"Arterioscler. Thromb. Vasc."},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0255","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1152\/jappl.2001.90.1.358","article-title":"Invited review: molecular mechanisms of phenotypic plasticity in smooth muscle cells","volume":"90","author":"Halayko","year":"2001","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0260","doi-asserted-by":"crossref","first-page":"A25","DOI":"10.1016\/j.jvs.2007.03.001","article-title":"Regulation of vascular smooth muscle cell differentiation","volume":"45","author":"Rzucidlo","year":"2007","journal-title":"J. Vasc. Surg."},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0265","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1007\/s00424-008-0491-8","article-title":"The non-excitable smooth muscle: calcium signaling and phenotypic switching during vascular disease","volume":"456","author":"House","year":"2008","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0270","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1161\/01.ATV.0000022407.91111.E4","article-title":"Heterogeneity of smooth muscle cell populations cultured from pig coronary artery","volume":"22","author":"Hao","year":"2002","journal-title":"Arterioscler. Thromb. Vasc."},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0275","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0008-6363(02)00607-7","article-title":"Chimeric DNA\u2013RNA hammerhead ribozyme targeting PDGF A-chain mRNA specifically inhibits neointima formation in rat carotid artery after balloon injury","volume":"57","author":"Kotani","year":"2003","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0280","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1038\/sj.gt.3300918","article-title":"Targeting endogenous platelet-derived growth factor B-chain by adenovirus-mediated gene transfer potently inhibits in vivo smooth muscle proliferation after arterial injury","volume":"6","author":"Deguchi","year":"1999","journal-title":"Gene Ther."},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0285","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.1073\/pnas.1019219108","article-title":"PDGF-BB and TGF-{beta}1 on cross-talk between endothelial and smooth muscle cells in vascular remodeling induced by low shear stress","volume":"108","author":"Qi","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0290","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1517\/14728222.2013.765863","article-title":"MicroRNAs: promising therapeutic targets for the treatment of pulmonary arterial hypertension","volume":"17","author":"Yuan","year":"2013","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0295","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.arcmed.2013.08.003","article-title":"Pulmonary arterial hypertension and microRNAs\u2014an ever-growing partnership","volume":"44","author":"Wang","year":"2013","journal-title":"Arch. Med. Res."},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0300","doi-asserted-by":"crossref","first-page":"4479","DOI":"10.1007\/s00018-013-1382-5","article-title":"MicroRNAs in pulmonary arterial remodeling","volume":"70","author":"Grant","year":"2013","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0305","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1084\/jem.20101812","article-title":"Role for miR-204 in human pulmonary arterial hypertension","volume":"208","author":"Courboulin","year":"2011","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0310","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1161\/ATVBAHA.109.202028","article-title":"Dynamic changes in lung microRNA profiles during the development of pulmonary hypertension due to chronic hypoxia and monocrotaline","volume":"30","author":"Caruso","year":"2010","journal-title":"Arterioscler. Thromb. Vasc."},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0315","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1161\/CIRCRESAHA.112.267591","article-title":"A role for miR-145 in pulmonary arterial hypertension: evidence from mouse models and patient samples","volume":"111","author":"Caruso","year":"2012","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0320","doi-asserted-by":"crossref","first-page":"28097","DOI":"10.1074\/jbc.M111.236950","article-title":"Down-regulation of Kruppel-like factor-4 (KLF4) by microRNA-143\/145 is critical for modulation of vascular smooth muscle cell phenotype by transforming growth factor-beta and bone morphogenetic protein 4","volume":"286","author":"Davis-Dusenbery","year":"2011","journal-title":"J. Biol. Chem."},{"issue":"Suppl. 1","key":"10.1016\/j.bbamcr.2014.01.030_bb0325","first-page":"S99","article-title":"Potassium channels in the regulation of pulmonary artery smooth muscle cell proliferation and apoptosis: pharmacotherapeutic implications","volume":"153","author":"Burg","year":"2008","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0330","doi-asserted-by":"crossref","first-page":"951497","DOI":"10.1155\/2012\/951497","article-title":"Pathogenic role of store-operated and receptor-operated Ca(2+) channels in pulmonary arterial hypertension","volume":"2012","author":"Fernandez","year":"2012","journal-title":"J. Signal Transduct."},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0335","doi-asserted-by":"crossref","first-page":"H1546","DOI":"10.1152\/ajpheart.00944.2011","article-title":"New mechanisms of pulmonary arterial hypertension: role of Ca(2)(+) signaling","volume":"302","author":"Kuhr","year":"2012","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0340","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S1537-1891(02)00123-4","article-title":"Role of K+ channels in pulmonary hypertension","volume":"38","author":"Mandegar","year":"2002","journal-title":"Vasc. Pharmacol."},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0345","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1165\/rcmb.2008-0412OC","article-title":"Endothelin-1 inhibits background two-pore domain channel TASK-1 in primary human pulmonary artery smooth muscle cells","volume":"41","author":"Tang","year":"2009","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0350","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1111\/j.1476-5381.2010.01164.x","article-title":"New perspectives for the treatment of pulmonary hypertension","volume":"163","author":"Baliga","year":"2011","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0355","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1183\/09059180.00006911","article-title":"The value of tools to assess pulmonary arterial hypertension","volume":"20","author":"Gupta","year":"2011","journal-title":"Eur. Respir. Rev."},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0360","doi-asserted-by":"crossref","first-page":"3105","DOI":"10.1161\/CIRCULATIONAHA.104.488486","article-title":"Long-term response to calcium channel blockers in idiopathic pulmonary arterial hypertension","volume":"111","author":"Sitbon","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0365","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.1093\/eurheartj\/ehp297","volume":"30","author":"Galie","year":"2009","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0370","first-page":"2604","article-title":"Mechanisms responsible for pulmonary hypertension","volume":"121","author":"Prabha","year":"2008","journal-title":"Chin. Med. J. (Engl.)"},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0375","first-page":"134","article-title":"Role of the adventitia in pulmonary vascular remodeling","volume":"21","author":"Stenmark","year":"2006","journal-title":"Physiology (Bethesda)"},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0380","first-page":"1411","article-title":"Persistence, re-expression, and induction of pulmonary arterial fibronectin, tropoelastin, and type I procollagen mRNA expression in neonatal hypoxic pulmonary hypertension","volume":"145","author":"Durmowicz","year":"1994","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0385","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1183\/09031936.00159507","article-title":"Increased hyaluronic acid content in idiopathic pulmonary arterial hypertension","volume":"32","author":"Papakonstantinou","year":"2008","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0390","doi-asserted-by":"crossref","first-page":"L789","DOI":"10.1152\/ajplung.90306.2008","article-title":"High levels of hyaluronan in idiopathic pulmonary arterial hypertension","volume":"295","author":"Aytekin","year":"2008","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0395","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.4049\/jimmunol.177.2.1272","article-title":"Hyaluronan fragments act as an endogenous danger signal by engaging TLR2","volume":"177","author":"Scheibner","year":"2006","journal-title":"J. Immunol."},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0400","doi-asserted-by":"crossref","first-page":"L148","DOI":"10.1152\/ajplung.00097.2009","article-title":"The enzymatic degradation of hyaluronan is associated with disease progression in experimental pulmonary hypertension","volume":"298","author":"Ormiston","year":"2010","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0405","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1183\/13993003\/erj.18.5.838","article-title":"Gelatinase expression in pulmonary arteries during experimental pulmonary hypertension","volume":"18","author":"Frisdal","year":"2001","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0410","first-page":"375","article-title":"Effect of elastase inhibitor on pulmonary hypertension induced by monocrotaline","volume":"42","author":"Fu","year":"2004","journal-title":"Zhonghua Er Ke Za Zhi"},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0415","doi-asserted-by":"crossref","first-page":"213S","DOI":"10.1378\/chest.114.3_Supplement.213S","article-title":"Elastase and the pathobiology of unexplained pulmonary hypertension","volume":"114","author":"Rabinovitch","year":"1998","journal-title":"Chest"},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0420","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1002\/(SICI)1097-4652(199603)166:3<495::AID-JCP4>3.0.CO;2-K","article-title":"Exogenous leukocyte and endogenous elastases can mediate mitogenic activity in pulmonary artery smooth muscle cells by release of extracellular-matrix bound basic fibroblast growth factor","volume":"166","author":"Thompson","year":"1996","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0425","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1161\/hc0402.102866","article-title":"Overexpression of the serine elastase inhibitor elafin protects transgenic mice from hypoxic pulmonary hypertension","volume":"105","author":"Zaidi","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0430","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1016\/j.jacc.2009.04.006","article-title":"Inflammation, growth factors, and pulmonary vascular remodeling","volume":"54","author":"Hassoun","year":"2009","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0435","doi-asserted-by":"crossref","first-page":"226","DOI":"10.4103\/2045-8932.109940","article-title":"Anticipated classes of new medications and molecular targets for pulmonary arterial hypertension","volume":"3","author":"Morrell","year":"2013","journal-title":"Pulm. Circ."},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0440","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1084\/jem.20071008","article-title":"Pulmonary arterial remodeling induced by a Th2 immune response","volume":"205","author":"Daley","year":"2008","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0445","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/j.1600-065X.2008.00742.x","article-title":"The tyrosine kinase network regulating mast cell activation","volume":"228","author":"Gilfillan","year":"2009","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0450","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1159\/000121410","article-title":"Prevention of mast cell degranulation by disodium cromoglycate attenuates the development of hypoxic pulmonary hypertension in rats exposed to chronic hypoxia","volume":"76","author":"Banasova","year":"2008","journal-title":"Respiration"},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0455","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/1465-9921-12-60","article-title":"Involvement of mast cells in monocrotaline-induced pulmonary hypertension in rats","volume":"12","author":"Dahal","year":"2011","journal-title":"Respir. Res."},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0460","doi-asserted-by":"crossref","first-page":"220","DOI":"10.4103\/2045-8932.97609","article-title":"Mast cell number, phenotype, and function in human pulmonary arterial hypertension","volume":"2","author":"Farha","year":"2012","journal-title":"Pulm. Circ."},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0465","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1378\/chest.11-0793","article-title":"Inflammation in pulmonary arterial hypertension","volume":"141","author":"Price","year":"2012","journal-title":"Chest"},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0470","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1183\/09031936.00174908","article-title":"Growth factors and interleukin-6 across the lung circulation in pulmonary hypertension","volume":"34","author":"Selimovic","year":"2009","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0475","doi-asserted-by":"crossref","first-page":"L1473","DOI":"10.1152\/ajplung.00197.2006","article-title":"Interaction of interleukin-6 and the BMP pathway in pulmonary smooth muscle","volume":"292","author":"Hagen","year":"2007","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0480","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1164\/ajrccm.163.2.2006093","article-title":"40-O-(2-hydroxyethyl)-rapamycin attenuates pulmonary arterial hypertension and neointimal formation in rats","volume":"163","author":"Nishimura","year":"2001","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0485","doi-asserted-by":"crossref","first-page":"2252","DOI":"10.1164\/ajrccm.162.6.2002018","article-title":"Triptolide attenuates pulmonary arterial hypertension and neointimal formation in rats","volume":"162","author":"Faul","year":"2000","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0490","doi-asserted-by":"crossref","first-page":"4367","DOI":"10.1210\/en.2008-0018","article-title":"Thymulin inhibits monocrotaline-induced pulmonary hypertension modulating interleukin-6 expression and suppressing p38 pathway","volume":"149","author":"Henriques-Coelho","year":"2008","journal-title":"Endocrinology"},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0495","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1161\/CIRCULATIONAHA.104.503540","article-title":"Pulmonary arterial hypertension","volume":"114","author":"McLaughlin","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0500","first-page":"145","article-title":"Platelets in pulmonary hypertension: a causative role or a simple association?","volume":"22","author":"Zanjani","year":"2012","journal-title":"Iran. J. Pediatr."},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0505","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.thromres.2009.04.018","article-title":"Platelet protease-activated receptor 1 and membrane expression of P-selectin in pulmonary arterial hypertension","volume":"125","author":"Maeda","year":"2010","journal-title":"Thromb. Res."},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0510","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.thromres.2010.10.019","article-title":"Platelets as initiators and mediators of inflammation at the vessel wall","volume":"127","author":"Shi","year":"2011","journal-title":"Thromb. Res."},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0515","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/S0022-2143(99)90094-X","article-title":"Prothrombotic mechanisms in primary pulmonary hypertension","volume":"134","author":"Farber","year":"1999","journal-title":"J. Lab. Clin. Med."},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0520","doi-asserted-by":"crossref","first-page":"193","DOI":"10.4103\/2045-8932.97605","article-title":"Furegrelate, a thromboxane synthase inhibitor, blunts the development of pulmonary arterial hypertension in neonatal piglets","volume":"2","author":"Hirenallur","year":"2012","journal-title":"Pulm. Circ."},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0525","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.amjmed.2004.11.007","article-title":"Thromboxane-dependent portopulmonary hypertension","volume":"118","author":"Maruyama","year":"2005","journal-title":"Am. J. Med."},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0530","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.vph.2008.06.003","article-title":"Endothelial cell dysfunction and cross talk between endothelium and smooth muscle cells in pulmonary arterial hypertension","volume":"49","author":"Humbert","year":"2008","journal-title":"Vasc. Pharmacol."},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0535","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1056\/NEJM199507273330403","article-title":"Reduced expression of endothelial nitric oxide synthase in the lungs of patients with pulmonary hypertension","volume":"333","author":"Giaid","year":"1995","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0540","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1038\/sj.bjp.0704984","article-title":"Increased expression of the cGMP-inhibited cAMP-specific (PDE3) and cGMP binding cGMP-specific (PDE5) phosphodiesterases in models of pulmonary hypertension","volume":"137","author":"Murray","year":"2002","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0545","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1096\/fj.04-3223fje","article-title":"Increased levels and reduced catabolism of asymmetric and symmetric dimethylarginines in pulmonary hypertension","volume":"19","author":"Pullamsetti","year":"2005","journal-title":"FASEB J."},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0550","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1183\/09031936.00114407","article-title":"Expression and function of soluble guanylate cyclase in pulmonary arterial hypertension","volume":"32","author":"Schermuly","year":"2008","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0555","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.cell.2011.08.035","article-title":"Inducible NOS inhibition reverses tobacco-smoke-induced emphysema and pulmonary hypertension in mice","volume":"147","author":"Seimetz","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0560","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1056\/NEJM199207093270202","article-title":"An imbalance between the excretion of thromboxane and prostacyclin metabolites in pulmonary hypertension","volume":"327","author":"Christman","year":"1992","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0565","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1164\/ajrccm.159.6.9804054","article-title":"Prostacyclin synthase expression is decreased in lungs from patients with severe pulmonary hypertension","volume":"159","author":"Tuder","year":"1999","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0570","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1164\/ajrccm.164.2.2010150","article-title":"Prostacyclin receptor-dependent modulation of pulmonary vascular remodeling","volume":"164","author":"Hoshikawa","year":"2001","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0575","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1378\/chest.120.5.1639","article-title":"Increased levels of prostaglandin D2 suggest macrophage activation in patients with primary pulmonary hypertension","volume":"120","author":"Robbins","year":"2001","journal-title":"Chest"},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0580","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s00018-010-0518-0","article-title":"Endothelin","volume":"68","author":"Kawanabe","year":"2011","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0585","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.pharmthera.2008.10.002","article-title":"Therapeutic targets in pulmonary arterial hypertension","volume":"121","author":"Rhodes","year":"2009","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0590","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1056\/NEJM199306173282402","article-title":"Expression of endothelin-1 in the lungs of patients with pulmonary hypertension","volume":"328","author":"Giaid","year":"1993","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0595","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1164\/rccm.200707-1037OC","article-title":"Platelet-derived growth factor expression and function in idiopathic pulmonary arterial hypertension","volume":"178","author":"Perros","year":"2008","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0600","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1164\/ajrccm.162.4.9912131","article-title":"Distribution of obstructive intimal lesions and their cellular phenotypes in chronic pulmonary hypertension. A morphometric and immunohistochemical study","volume":"162","author":"Yi","year":"2000","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0605","first-page":"376","article-title":"Coagulation and anticoagulation in pulmonary arterial hypertension","volume":"11","author":"Berger","year":"2009","journal-title":"Isr. Med. Assoc. J."},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0610","doi-asserted-by":"crossref","first-page":"13S","DOI":"10.1016\/j.jacc.2004.02.029","article-title":"Cellular and molecular pathobiology of pulmonary arterial hypertension","volume":"43","author":"Humbert","year":"2004","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0615","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1161\/01.RES.0000129568.71027.fc","article-title":"The serotonin transporter: a vehicle to elucidate pulmonary hypertension?","volume":"94","author":"Weir","year":"2004","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0620","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1164\/rccm.200302-264OC","article-title":"Proliferation and signaling in fibroblasts: role of 5-hydroxytryptamine2A receptor and transporter","volume":"170","author":"Welsh","year":"2004","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0625","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0002-9343(99)80156-9","article-title":"Increased plasma serotonin in primary pulmonary hypertension","volume":"99","author":"Herv\u00e9","year":"1995","journal-title":"Am. J. Med."},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0630","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1164\/ajrccm.165.4.2012112","article-title":"Chemokine RANTES in severe pulmonary arterial hypertension","volume":"165","author":"Dorfmuller","year":"2002","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0635","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1164\/rccm.2106007","article-title":"CX3C chemokine fractalkine in pulmonary arterial hypertension","volume":"165","author":"Balabanian","year":"2002","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.bbamcr.2014.01.030_bb0640","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1183\/09031936.00104706","article-title":"Fractalkine-induced smooth muscle cell proliferation in pulmonary hypertension","volume":"29","author":"Perros","year":"2007","journal-title":"Eur. Respir. J."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167488914000421?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167488914000421?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T19:45:46Z","timestamp":1759088746000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167488914000421"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5]]},"references-count":128,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["S0167488914000421"],"URL":"https:\/\/doi.org\/10.1016\/j.bbamcr.2014.01.030","relation":{},"ISSN":["0167-4889"],"issn-type":[{"value":"0167-4889","type":"print"}],"subject":[],"published":{"date-parts":[[2014,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cellular interplay in pulmonary arterial hypertension: Implications for new therapies","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Cell Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbamcr.2014.01.030","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier B.V.","name":"copyright","label":"Copyright"}]}}