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A."},{"key":"10.1016\/j.bbamcr.2015.11.006_bb0430","doi-asserted-by":"crossref","first-page":"140041","DOI":"10.1098\/rsob.140041","article-title":"Titin kinase is an inactive pseudokinase scaffold that supports MuRF1 recruitment to the sarcomeric M-line","volume":"4","author":"Bogomolovas","year":"2014","journal-title":"Open Biol."},{"key":"10.1016\/j.bbamcr.2015.11.006_bb0435","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1126\/science.1110463","article-title":"The kinase domain of titin controls muscle gene expression and protein turnover","volume":"308","author":"Lange","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.bbamcr.2015.11.006_bb0440","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1161\/01.CIR.99.3.384","article-title":"Increased protein kinase C activity and expression of Ca2+-sensitive isoforms in the failing human heart","volume":"99","author":"Bowling","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.bbamcr.2015.11.006_bb0445","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1172\/JCI62839","article-title":"Signaling effectors underlying pathologic growth and remodeling of the heart","volume":"123","author":"van Berlo","year":"2013","journal-title":"J. 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