{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T01:19:44Z","timestamp":1790385584862,"version":"4.1.0"},"reference-count":93,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004362","name":"Schweizerische Herzstiftung","doi-asserted-by":"publisher","award":["2-72866-09"],"award-info":[{"award-number":["2-72866-09"]}],"id":[{"id":"10.13039\/501100004362","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Cell Research"],"published-print":{"date-parts":[[2016,7]]},"DOI":"10.1016\/j.bbamcr.2016.02.011","type":"journal-article","created":{"date-parts":[[2016,2,16]],"date-time":"2016-02-16T16:16:08Z","timestamp":1455639368000},"page":"1822-1828","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":56,"special_numbering":"PB","title":["Hypoxia-driven glycolytic and fructolytic metabolic programs: Pivotal to hypertrophic heart disease"],"prefix":"10.1016","volume":"1863","author":[{"given":"Peter","family":"Mirtschink","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilhelm","family":"Krek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbamcr.2016.02.011_bb0005","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1016\/S0140-6736(12)61728-0","article-title":"Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010","volume":"380","author":"Lozano","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.bbamcr.2016.02.011_bb0010","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1056\/NEJMra072139","article-title":"Cardiac plasticity","volume":"358","author":"Hill","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbamcr.2016.02.011_bb0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1161\/HYPERTENSIONAHA.109.141887","article-title":"A translational approach to hypertensive heart disease","volume":"55","author":"D\u00edez","year":"2010","journal-title":"Hypertension"},{"key":"10.1016\/j.bbamcr.2016.02.011_bb0020","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1016\/j.jacc.2009.04.072","article-title":"The case for myocardial ischemia in hypertrophic cardiomyopathy","volume":"54","author":"Maron","year":"2009","journal-title":"JACC."},{"key":"10.1016\/j.bbamcr.2016.02.011_bb0025","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1016\/S0140-6736(09)60211-7","article-title":"Aortic stenosis","volume":"373","author":"Carabello","year":"2009","journal-title":"Lancet"},{"key":"10.1016\/j.bbamcr.2016.02.011_bb0030","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.jjcc.2013.10.005","article-title":"Subendocardial ischemia in hypertrophic cardiomyopathy","volume":"63","author":"Kawasaki","year":"2014","journal-title":"J. Cardiol."},{"key":"10.1016\/j.bbamcr.2016.02.011_bb0035","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/2049-3002-2-19","article-title":"Endothelial cell metabolism: parallels and divergences with cancer cell metabolism","volume":"2","author":"Verdegem","year":"2014","journal-title":"Cancer Metab."},{"key":"10.1016\/j.bbamcr.2016.02.011_bb0040","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1093\/cvr\/cvr071","article-title":"Glucose metabolism and cardiac hypertrophy","volume":"90","author":"Kolwicz","year":"2011","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.bbamcr.2016.02.011_bb0045","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1002\/emmm.201303147","article-title":"VEGF-B-induced vascular growth leads to metabolic reprogramming and ischemia resistance in the heart","volume":"6","author":"Kivel\u00e4","year":"2014","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.bbamcr.2016.02.011_bb0050","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1038\/nature14508","article-title":"HIF-driven SF3B1 induces KHK-C to enforce fructolysis and heart disease","volume":"522","author":"Mirtschink","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.bbamcr.2016.02.011_bb0055","doi-asserted-by":"crossref","first-page":"a006783","DOI":"10.1101\/cshperspect.a006783","article-title":"Signaling in control of cell growth and metabolism","volume":"4","author":"Ward","year":"2012","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.bbamcr.2016.02.011_bb0060","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.gde.2009.01.002","article-title":"The molecular determinants of de novo nucleotide biosynthesis in cancer cells","volume":"19","author":"Tong","year":"2009","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.bbamcr.2016.02.011_bb0065","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1152\/physiolgenomics.00016.2011","article-title":"Cardiac O-GlcNAc signaling is increased in hypertrophy and heart failure","volume":"44","author":"Lunde","year":"2012","journal-title":"Physiol. Genomics"},{"key":"10.1016\/j.bbamcr.2016.02.011_bb0070","doi-asserted-by":"crossref","first-page":"2521","DOI":"10.1253\/circj.CJ-12-1063","article-title":"Multifaceted approach to analyzing the pathogenesis of cardiovascular disease","volume":"76","author":"Sano","year":"2012","journal-title":"Circ. J."},{"key":"10.1016\/j.bbamcr.2016.02.011_bb0075","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1161\/CIRCHEARTFAILURE.109.888479","article-title":"Analysis of metabolic remodeling in compensated left ventricular hypertrophy and heart failure","volume":"3","author":"Kato","year":"2010","journal-title":"Circ. Heart Fail."},{"key":"10.1016\/j.bbamcr.2016.02.011_bb0080","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1161\/CIRCRESAHA.113.300376","article-title":"Cardiac metabolism in heart failure implications beyond ATP Production","volume":"113","author":"Doenst","year":"2013","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbamcr.2016.02.011_bb0085","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.cmet.2009.05.005","article-title":"Activation of a HIF1alpha-PPARgamma axis underlies the integration of glycolytic and lipid anabolic pathways in pathologic cardiac hypertrophy","volume":"9","author":"Krishnan","year":"2009","journal-title":"Cell Metab."},{"key":"10.1016\/j.bbamcr.2016.02.011_bb0090","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1161\/01.RES.68.2.466","article-title":"Protective effect of increased glycolytic substrate against systolic and diastolic dysfunction and increased coronary resistance from prolonged global underperfusion and reperfusion in isolated rabbit hearts perfused with erythrocyte suspensions","volume":"68","author":"Eberli","year":"1991","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbamcr.2016.02.011_bb0095","doi-asserted-by":"crossref","first-page":"2090","DOI":"10.1161\/01.CIR.101.17.2090","article-title":"ATP synthesis during low-flow ischemia, influence of increased glycolytic substrate","volume":"101","author":"Cave","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.bbamcr.2016.02.011_bb0100","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1161\/01.CIR.45.2.491","article-title":"Metabolic response during impending myocardial infarction","volume":"45","author":"Oliver","year":"1972","journal-title":"Circulation"},{"key":"10.1016\/j.bbamcr.2016.02.011_bb0105","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1101\/gad.1529107","article-title":"The transcription factor HIF-1alpha plays a critical role in the growth factor-dependent regulation of both aerobic and anaerobic glycolysis","volume":"21","author":"Lum","year":"2007","journal-title":"Genes Dev."},{"key":"10.1016\/j.bbamcr.2016.02.011_bb0110","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/S0006-2952(02)01168-1","article-title":"Signal transduction to hypoxia-inducible factor 1","volume":"64","author":"Semenza","year":"2002","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bbamcr.2016.02.011_bb0115","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.cmet.2006.01.012","article-title":"HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption","volume":"3","author":"Papandreou","year":"2006","journal-title":"Cell Metab."},{"key":"10.1016\/j.bbamcr.2016.02.011_bb0120","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1161\/01.RES.0000137170.41939.d9","article-title":"Is the failing heart energy starved? On using chemical energy to support cardiac function","volume":"95","author":"Ingwall","year":"2004","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbamcr.2016.02.011_bb0125","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1161\/CIRCRESAHA.113.302095","article-title":"Cardiac metabolism and its interactions with contraction, growth, and survival of cardiomyocytes","volume":"113","author":"Kolwicz","year":"2013","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbamcr.2016.02.011_bb0130","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1056\/NEJMra1112570","article-title":"A tale of coronary artery disease and myocardial infarction","volume":"366","author":"Nabel","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbamcr.2016.02.011_bb0135","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1309\/W75NTE5QBC9DXE03","article-title":"Biological features (inflammation and neoangiogenesis) and atherosclerotic risk factors in carotid plaques and calcified aortic valve stenosis: two different sites of the same disease?","volume":"126","author":"Mazzone","year":"2006","journal-title":"Am. J. Clin. Pathol."},{"key":"10.1016\/j.bbamcr.2016.02.011_bb0140","first-page":"729","article-title":"Emerging medical treatments for aortic stenosis: statins, angiotensin converting enzyme inhibitors, or both?","author":"Newby","year":"2006","journal-title":"Heart"},{"key":"10.1016\/j.bbamcr.2016.02.011_bb0145","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1161\/01.CIR.0000155623.48408.C5","article-title":"Frequency by decades of unicuspid, bicuspid, and tricuspid aortic valves in adults having isolated aortic valve replacement for aortic stenosis, with or without associated aortic regurgitation","volume":"111","author":"Roberts","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.bbamcr.2016.02.011_bb0150","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1016\/j.amjcard.2012.01.391","article-title":"Comparison of left ventricular outflow geometry and aortic valve area in patients with aortic stenosis by 2-dimensional versus 3-dimensional echocardiography","volume":"109","author":"Saitoh","year":"2012","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.bbamcr.2016.02.011_bb0155","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/1476-7120-4-27","article-title":"Epidemiology and cardiovascular risk factors of aortic stenosis","volume":"4","author":"Faggiano","year":"2006","journal-title":"Cardiovasc. Ultrasound."},{"key":"10.1016\/j.bbamcr.2016.02.011_bb0160","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1006\/bbrc.1999.1221","article-title":"Structural analysis of the titin gene in hypertrophic cardiomyopathy: identification of a novel disease gene.","volume":"262","author":"Satoh","year":"1999","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbamcr.2016.02.011_bb0165","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1038\/ng1295-438","article-title":"Cardiac myosin binding protein-C gene splice acceptor site mutation is associated with familial hypertrophic cardiomyopathy","volume":"11","author":"Bonne","year":"1995","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbamcr.2016.02.011_bb0170","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.jacc.2012.02.068","article-title":"Genetics of hypertrophic cardiomyopathy after 20years","volume":"60","author":"Maron","year":"2012","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.bbamcr.2016.02.011_bb0175","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/S0140-6736(12)60397-3","article-title":"Hypertrophic cardiomyopathy","volume":"381","author":"Maron","year":"2013","journal-title":"Lancet"},{"key":"10.1016\/j.bbamcr.2016.02.011_bb0180","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1161\/CIRCINTERVENTIONS.110.952085","article-title":"Septal reduction therapy for obstructive hypertrophic cardiomyopathy and sudden death: what statistics cannot tell you","volume":"3","author":"Nishimura","year":"2010","journal-title":"Circ. Cardiovasc. Interv."},{"key":"10.1016\/j.bbamcr.2016.02.011_bb0185","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1093\/eurheartj\/ehi108","article-title":"Cardiovascular pre-participation screening of young competitive athletes for prevention of sudden death: proposal for a common European protocol","volume":"26","author":"Corrado","year":"2004","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.bbamcr.2016.02.011_bb0190","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1161\/01.HYP.0000070029.30058.59","article-title":"Symptomatic aortic stenosis: does systemic hypertension play an additional role?","volume":"41","author":"Antonini-Canterin","year":"2003","journal-title":"Hypertension"},{"key":"10.1016\/j.bbamcr.2016.02.011_bb0195","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/nature10316","article-title":"Dynamic molecular processes mediate cellular mechanotransduction","volume":"475","author":"Hoffman","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.bbamcr.2016.02.011_bb0200","doi-asserted-by":"crossref","first-page":"4134","DOI":"10.1128\/MCB.00154-10","article-title":"Myocardin-related transcription factor A is a common mediator of mechanical stress- and neurohumoral stimulation-induced cardiac hypertrophic signaling leading to activation of brain natriuretic peptide gene expression","volume":"30","author":"Kuwahara","year":"2010","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.bbamcr.2016.02.011_bb0205","doi-asserted-by":"crossref","first-page":"3221","DOI":"10.1074\/jbc.271.6.3221","article-title":"Endothelin-1 is involved in mechanical stress-induced cardiomyocyte hypertrophy","volume":"271","author":"Yamazaki","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamcr.2016.02.011_bb0210","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1038\/nrm1983","article-title":"Regulation of cardiac hypertrophy by intracellular signalling pathways","volume":"7","author":"Heineke","year":"2006","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bbamcr.2016.02.011_bb0215","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1161\/01.ATV.0000258979.92828.bc","article-title":"Reactive oxygen species activate the HIF-1 promoter via a functional NF B Site","volume":"27","author":"Bonello","year":"2007","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.bbamcr.2016.02.011_bb0220","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1016\/S0735-1097(00)00947-5","article-title":"Coronary flow reserve improves after aortic valve replacement for aortic stenosis: an adenosine transthoracic echocardiography study","volume":"36","author":"Hildick-Smith","year":"2000","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.bbamcr.2016.02.011_bb0225","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1016\/S0002-8703(98)70152-8","article-title":"Coronary vasodilator reserve is impaired in patients with hypertrophic cardiomyopathy and left ventricular dysfunction","volume":"136","author":"Lorenzoni","year":"1998","journal-title":"Am. Heart J."},{"key":"10.1016\/j.bbamcr.2016.02.011_bb0230","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1161\/01.CIR.47.3.527","article-title":"Left ventricular ejection time in valvular aortic stenosis","volume":"47","author":"Bache","year":"1973","journal-title":"Circulation"},{"key":"10.1016\/j.bbamcr.2016.02.011_bb0235","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1161\/01.CIR.100.4.361","article-title":"Alterations in the local myocardial motion pattern in patients suffering from pressure overload due to aortic stenosis","volume":"100","author":"Stuber","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.bbamcr.2016.02.011_bb0240","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1016\/0002-9149(75)90112-5","article-title":"Ischemia in aortic stenosis: hemodynamic prediction","volume":"35","author":"Buckberg","year":"1975","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.bbamcr.2016.02.011_bb0245","doi-asserted-by":"crossref","first-page":"2662","DOI":"10.1161\/CIRCULATIONAHA.107.742395","article-title":"Quantifying diastolic function in hypertrophic cardiomyopathy: the ongoing search for the Holy Grail","volume":"116","author":"Rakowski","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.bbamcr.2016.02.011_bb0250","doi-asserted-by":"crossref","first-page":"12607","DOI":"10.1073\/pnas.1309493110","article-title":"Molecular consequences of the R453C hypertrophic cardiomyopathy mutation on human \u03b2-cardiac myosin motor function","volume":"110","author":"Sommese","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbamcr.2016.02.011_bb0255","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1161\/CIRCULATIONAHA.108.838672","article-title":"Cardiac myosin-binding protein C mutations and hypertrophic cardiomyopathy: haploinsufficiency, deranged phosphorylation, and cardiomyocyte dysfunction","volume":"119","author":"van Dijk","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.bbamcr.2016.02.011_bb0260","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0168-9525(03)00081-7","article-title":"Hypertrophic cardiomyopathy: a paradigm for myocardial energy depletion","volume":"19","author":"Ashrafian","year":"2003","journal-title":"Trends Genet."},{"key":"10.1016\/j.bbamcr.2016.02.011_bb0265","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/0735-1097(93)90054-5","article-title":"Coexistence of sudden cardiac death and end-stage heart failure in familial hypertrophic cardiomyopathy","volume":"22","author":"Hecht","year":"1993","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.bbamcr.2016.02.011_bb0270","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1016\/S0735-1097(00)00830-5","article-title":"Systolic anterior motion begins at low left ventricular outflow tract velocity in obstructive hypertrophic cardiomyopathy","volume":"36","author":"Sherrid","year":"2000","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.bbamcr.2016.02.011_bb0275","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1136\/hrt.2007.122069","article-title":"Systolic anterior motion of the mitral valve\u2014beyond hypertrophic cardiomyopathy","volume":"94","author":"Luckie","year":"2008","journal-title":"Heart"},{"key":"10.1016\/j.bbamcr.2016.02.011_bb0280","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1016\/0735-1097(96)00038-1","article-title":"Hypertrophic obstructive cardiomyopathy: preoperative echocardiographic predictors of outcome after septal myectomy","volume":"27","author":"Mccully","year":"1996","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.bbamcr.2016.02.011_bb0285","doi-asserted-by":"crossref","first-page":"5510","DOI":"10.1073\/pnas.92.12.5510","article-title":"Hypoxia-inducible factor 1 is a basic-helix\u2013loop-helix-PAS heterodimer regulated by cellular O2 tension","volume":"92","author":"Wang","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbamcr.2016.02.011_bb0290","doi-asserted-by":"crossref","first-page":"32529","DOI":"10.1074\/jbc.271.51.32529","article-title":"Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase a gene promoters contain essential binding sites for hypoxia-inducible factor 1","volume":"271","author":"Semenza","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamcr.2016.02.011_bb0295","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/20459","article-title":"The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis","volume":"399","author":"Maxwell","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.bbamcr.2016.02.011_bb0300","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1126\/science.1066373","article-title":"A conserved family of prolyl-4-hydroxylases that modify HIF","volume":"294","author":"Bruick","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.bbamcr.2016.02.011_bb0305","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1126\/science.1059817","article-title":"HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing","volume":"292","author":"Ivan","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.bbamcr.2016.02.011_bb0310","doi-asserted-by":"crossref","first-page":"25e","DOI":"10.1161\/hh0202.104923","article-title":"Early expression of myocardial HIF-1alpha in response to mechanical stresses: regulation by stretch-activated channels and the phosphatidylinositol 3-kinase signaling pathway","volume":"90","author":"Kim","year":"2002","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbamcr.2016.02.011_bb0315","first-page":"887","article-title":"Heart HIF-1alpha and MAP kinases during hypoxia: are they associated in vivo?","volume":"232","author":"Caretti","year":"2007","journal-title":"Exp. Biol. Med. (Maywood)"},{"key":"10.1016\/j.bbamcr.2016.02.011_bb0320","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1146\/annurev-physiol-021113-170322","article-title":"Hypoxia-inducible factor 1 and cardiovascular disease","volume":"76","author":"Semenza","year":"2014","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.bbamcr.2016.02.011_bb0325","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1038\/cdd.2008.13","article-title":"Role of hypoxia-inducible factor in cell survival during myodardial ischemia\u2013reperfusion","volume":"15","author":"Loor","year":"2008","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.bbamcr.2016.02.011_bb0330","first-page":"500","article-title":"Oxygen, oxidative stress, hypoxia, and heart failure","volume":"115","author":"Giordano","year":"2005"},{"key":"10.1016\/j.bbamcr.2016.02.011_bb0335","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1038\/nature05602","article-title":"p53-induced inhibition of Hif-1 causes cardiac dysfunction during pressure overload","volume":"446","author":"Sano","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.bbamcr.2016.02.011_bb0340","doi-asserted-by":"crossref","first-page":"3790","DOI":"10.1128\/MCB.01580-07","article-title":"Hypoxia-inducible factor-dependent degeneration, failure, and malignant transformation of the heart in the absence of the von Hippel\u2013Lindau protein","volume":"28","author":"Lei","year":"2008","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.bbamcr.2016.02.011_bb0345","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1161\/CIRCULATIONAHA.109.922427","article-title":"Loss of hypoxia-inducible factor prolyl hydroxylase activity in cardiomyocytes phenocopies ischemic cardiomyopathy","volume":"122","author":"Moslehi","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.bbamcr.2016.02.011_bb0350","doi-asserted-by":"crossref","first-page":"11185","DOI":"10.1074\/jbc.M110.186809","article-title":"Cardiomyocyte-specific prolyl-4-hydroxylase domain 2 knock out protects from acute myocardial ischemic injury","volume":"286","author":"H\u00f6lscher","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamcr.2016.02.011_bb0355","doi-asserted-by":"crossref","first-page":"e11693","DOI":"10.1371\/journal.pone.0011693","article-title":"Conditional HIF-1\u03b1 expression produces a reversible cardiomyopathy","volume":"5","author":"Bekeredjian","year":"2010","journal-title":"PLoS ONE"},{"key":"10.1016\/j.bbamcr.2016.02.011_bb0360","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1093\/cvr\/cvs014","article-title":"Unfavourable consequences of chronic cardiac HIF-1\u03b1 stabilization","volume":"94","author":"H\u00f6lscher","year":"2012","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.bbamcr.2016.02.011_bb0365","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1007\/s00424-009-0748-x","article-title":"Impaired Ca2+-handling in HIF-1\u03b1+\/\u2212 mice as a consequence of pressure overload","volume":"459","author":"Silter","year":"2010","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.bbamcr.2016.02.011_bb0370","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1161\/01.RES.0000338613.89841.c1","article-title":"Essential role of developmentally activated hypoxia-inducible factor la for cardiac morphogenesis and function","volume":"103","author":"Krishnan","year":"2008","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbamcr.2016.02.011_bb0375","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1126\/science.1160809","article-title":"Understanding the Warburg effect: the metabolic requirements of cell proliferation","volume":"324","author":"Vander Heiden","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.bbamcr.2016.02.011_bb0380","doi-asserted-by":"crossref","first-page":"2962","DOI":"10.1038\/onc.2010.67","article-title":"Imatinib resistance associated with BCR-ABL upregulation is dependent on HIF-1\u03b1-induced metabolic reprograming","volume":"29","author":"Zhao","year":"2010","journal-title":"Oncogene"},{"key":"10.1016\/j.bbamcr.2016.02.011_bb0385","doi-asserted-by":"crossref","first-page":"6183","DOI":"10.1074\/jbc.M110978200","article-title":"Hypoxia-inducible factor-1-mediated expression of the 6-phosphofructo-2-kinase\/fructose-2,6-bisphosphatase-3 (PFKFB3) gene: its possible role in the Warburg-effect","volume":"277","author":"Minchenko","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamcr.2016.02.011_bb0390","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/S0014-5793(03)01179-7","article-title":"Hypoxic regulation of the 6-phosphofructo-2-kinase\/fructose-2,6-bisphosphatase gene family (PFKFB-1\u20134) expression in vivo","volume":"554","author":"Minchenko","year":"2003","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bbamcr.2016.02.011_bb0395","doi-asserted-by":"crossref","first-page":"H2223","DOI":"10.1152\/ajpheart.00563.2008","article-title":"The antioxidant tempol attenuates pressure overload-induced cardiac hypertrophy and contractile dysfunction in mice fed a high-fructose diet","volume":"295","author":"Chess","year":"2008","journal-title":"AJP Heart Circ. Physiol."},{"key":"10.1016\/j.bbamcr.2016.02.011_bb0400","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.atherosclerosis.2004.10.018","article-title":"Involvement of oxidative stress and NADPH oxidase activation in the development of cardiovascular complications in a model of insulin resistance, the fructose-fed rat","volume":"179","author":"Delbosc","year":"2005","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.bbamcr.2016.02.011_bb0405","doi-asserted-by":"crossref","first-page":"H125","DOI":"10.1152\/ajpheart.00199.2010","article-title":"TRANSLATIONAL PHYSIOLOGY. A high-fructose diet worsens eccentric left ventricular hypertrophy in experimental volume overload","volume":"300","author":"Lachance","year":"2011","journal-title":"AJP Heart Circ. Physiol."},{"key":"10.1016\/j.bbamcr.2016.02.011_bb0410","doi-asserted-by":"crossref","first-page":"e25204","DOI":"10.1371\/journal.pone.0025204","article-title":"Fructose modulates cardiomyocyte excitation-contraction coupling and Ca2+ handling In Vitro","volume":"6","author":"Mellor","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1016\/j.bbamcr.2016.02.011_bb0415","doi-asserted-by":"crossref","first-page":"H964","DOI":"10.1152\/ajpheart.00797.2011","article-title":"Fructose diet treatment in mice induces fundamental disturbance of cardiomyocyte Ca2+ handling and myofilament responsiveness","volume":"302","author":"Mellor","year":"2012","journal-title":"AJP Heart Circ. Physiol."},{"key":"10.1016\/j.bbamcr.2016.02.011_bb0420","article-title":"Myocardial autophagy activation and suppressed survival signaling is associated with insulin resistance in fructose-fed mice","volume":"1\u201332","author":"Mellor","year":"2011","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.bbamcr.2016.02.011_bb0425","doi-asserted-by":"crossref","first-page":"H1853","DOI":"10.1152\/ajpheart.00544.2007","article-title":"Deleterious effects of sugar and protective effects of starch on cardiac remodeling, contractile dysfunction, and mortality in response to pressure overload","volume":"293","author":"Chess","year":"2007","journal-title":"AJP Heart Circ. Physiol."},{"key":"10.1016\/j.bbamcr.2016.02.011_bb0430","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/nrm3525","article-title":"Alternative splicing: a pivotal step between eukaryotic transcription and translation","volume":"14","author":"Kornblihtt","year":"2013","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bbamcr.2016.02.011_bb0435","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1261\/rna.2224411","article-title":"Structural model of the p14\/SF3b155branch duplex complex","volume":"17","author":"Schellenberg","year":"2011","journal-title":"RNA"},{"key":"10.1016\/j.bbamcr.2016.02.011_bb0440","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1038\/nrd3823","article-title":"The spliceosome as a target of novel antitumour drugs","volume":"11","author":"Bonnal","year":"2012","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.bbamcr.2016.02.011_bb0445","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1107\/S0907444908041115","article-title":"Structures of alternatively spliced isoforms of human ketohexokinase","volume":"65","author":"Trinh","year":"2009","journal-title":"Acta Crystallogr. Sect. D."},{"key":"10.1016\/j.bbamcr.2016.02.011_bb0450","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1369\/jhc.2009.953190","article-title":"Ketohexokinase: expression and localization of the principal fructose-metabolizing enzyme","volume":"57","author":"Diggle","year":"2009","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.bbamcr.2016.02.011_bb0455","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/1532-429X-16-29","article-title":"Myocardial perfusion and oxygenation are impaired during stress in severe aortic stenosis and correlate with impaired energetics and subclinical left ventricular dysfunction","volume":"16","author":"Mahmod","year":"2014","journal-title":"J. Cardiovasc. Magn. Reson."},{"key":"10.1016\/j.bbamcr.2016.02.011_bb0460","doi-asserted-by":"crossref","first-page":"e46549","DOI":"10.1371\/journal.pone.0046549","article-title":"Cardiomyocyte aldose reductase causes heart failure and impairs recovery from ischemia","volume":"7","author":"Son","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.bbamcr.2016.02.011_bb0465","first-page":"1","article-title":"Endogenous fructose production and metabolism in the liver contributes to the development of metabolic syndrome","volume":"4","author":"Ishimoto","year":"2013","journal-title":"Nat. Commun."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167488916300271?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167488916300271?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T03:24:41Z","timestamp":1717212281000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167488916300271"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7]]},"references-count":93,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["S0167488916300271"],"URL":"https:\/\/doi.org\/10.1016\/j.bbamcr.2016.02.011","relation":{},"ISSN":["0167-4889"],"issn-type":[{"value":"0167-4889","type":"print"}],"subject":[],"published":{"date-parts":[[2016,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hypoxia-driven glycolytic and fructolytic metabolic programs: Pivotal to hypertrophic heart disease","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Cell Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbamcr.2016.02.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V.","name":"copyright","label":"Copyright"}]}}