{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:03:14Z","timestamp":1791291794484,"version":"4.1.0"},"reference-count":382,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"vor","delay-in-days":365,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Cell Research"],"published-print":{"date-parts":[[2016,6]]},"DOI":"10.1016\/j.bbamcr.2016.02.016","type":"journal-article","created":{"date-parts":[[2016,2,26]],"date-time":"2016-02-26T03:55:14Z","timestamp":1456458914000},"page":"1238-1260","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":110,"special_numbering":"PA","title":["The molecular and cellular origin of human prostate cancer"],"prefix":"10.1016","volume":"1863","author":[{"given":"John R.","family":"Packer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1607-9035","authenticated-orcid":false,"given":"Norman J.","family":"Maitland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbamcr.2016.02.016_bb0005","author":"Cancer Research UK"},{"issue":"14","key":"10.1016\/j.bbamcr.2016.02.016_bb0010","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1093\/jnci\/91.14.1194","article-title":"Tobacco smoke carcinogens and lung cancer","volume":"91","author":"Hecht","year":"1999","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.bbamcr.2016.02.016_bb0015","series-title":"Prostate Cancer \u2014 Biochemistry, Molecular Biology and Genetics","first-page":"3","article-title":"Stem Cells in the Normal and Malignant Prostate","author":"Maitland","year":"2013"},{"key":"10.1016\/j.bbamcr.2016.02.016_bb0020","series-title":"Advances in Experimental Medicine and Biology","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/978-1-4614-0254-1_9","article-title":"Cancer Stem Cells, Models of Study and Implications of Therapy Resistance Mechanisms","author":"Frame","year":"2011"},{"key":"10.1016\/j.bbamcr.2016.02.016_bb0025","doi-asserted-by":"crossref","DOI":"10.1002\/(SICI)1097-0045(19981101)37:3<149::AID-PROS4>3.0.CO;2-E","article-title":"Basal cells are progenitors of luminal cells in primary cultures of differentiating human prostatic epithelium","author":"Robinson","year":"1998","journal-title":"Prostate"},{"issue":"19","key":"10.1016\/j.bbamcr.2016.02.016_bb0030","doi-asserted-by":"crossref","first-page":"3161","DOI":"10.1016\/j.yexcr.2010.08.004","article-title":"Development and limitations of lentivirus vectors as tools for tracking differentiation in prostate epithelial cells","volume":"316","author":"Frame","year":"2010","journal-title":"Exp. Cell Res."},{"issue":"2","key":"10.1016\/j.bbamcr.2016.02.016_bb0035","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1002\/path.2965","article-title":"In situ lineage tracking of human prostatic epithelial stem cell fate reveals a common clonal origin for basal and luminal cells","volume":"225","author":"Blackwood","year":"2011","journal-title":"J. Pathol."},{"key":"10.1016\/j.bbamcr.2016.02.016_bb0040","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1002\/jcb.21555","article-title":"p63 in prostate biology and pathology","author":"Grisanzio","year":"2008","journal-title":"J. Cell. Biochem."},{"issue":"2","key":"10.1016\/j.bbamcr.2016.02.016_bb0045","first-page":"140","article-title":"Loss of basement membrane components by invasive tumors but not by their benign counterparts","volume":"49","author":"Barsky","year":"1983","journal-title":"Lab. Investig."},{"issue":"18","key":"10.1016\/j.bbamcr.2016.02.016_bb0050","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1101\/gad.1965810","article-title":"Molecular genetics of prostate cancer: new prospects for old challenges","volume":"24","author":"Shen","year":"2010","journal-title":"Genes Dev."},{"issue":"19","key":"10.1016\/j.bbamcr.2016.02.016_bb0055","first-page":"5002","article-title":"Carcinoma-associated fibroblasts direct tumor progression of initiated human prostatic epithelium","volume":"59","author":"Olumi","year":"1999","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbamcr.2016.02.016_bb0060","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1054\/bjoc.1999.1029","article-title":"In vitro modelling of epithelial and stromal interactions in non-malignant and malignant prostates","volume":"82","author":"Lang","year":"2000","journal-title":"Br. J. Cancer"},{"issue":"8","key":"10.1016\/j.bbamcr.2016.02.016_bb0065","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1038\/sj.bjc.6601717","article-title":"Stromal\u2013epithelial interactions influence prostate cancer cell invasion by altering the balance of metallopeptidase expression","volume":"90","author":"Dawson","year":"2004","journal-title":"Br. J. Cancer"},{"issue":"1","key":"10.1016\/j.bbamcr.2016.02.016_bb0070","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/ijc.11335","article-title":"Role of the stromal microenvironment in carcinogenesis of the prostate","volume":"107","author":"Cunha","year":"2003","journal-title":"Int. J. Cancer"},{"issue":"1\u20132","key":"10.1016\/j.bbamcr.2016.02.016_bb0075","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.mce.2008.02.024","article-title":"Androgen receptor signalling in prostate: effects of stromal factors on normal and cancer stem cells","volume":"288","author":"Berry","year":"2008","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.bbamcr.2016.02.016_bb0080","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1530\/ERC-15-0195","article-title":"The many ways to make a luminal cell and a prostate cancer cell","volume":"22","author":"Strand","year":"2015","journal-title":"Endocr. Relat. Cancer"},{"key":"10.1016\/j.bbamcr.2016.02.016_bb0085","first-page":"1996","article-title":"Tumors as caricatures of the process of tissue renewal: prospects for therapy by directing differentiation","author":"Pierce","year":"1988","journal-title":"Cancer Res."},{"issue":"5861","key":"10.1016\/j.bbamcr.2016.02.016_bb0090","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1126\/science.1150648","article-title":"Initiating and cancer-propagating cells in TEL-AML1-associated childhood leukemia","volume":"319","author":"Hong","year":"2008","journal-title":"Science"},{"issue":"4260","key":"10.1016\/j.bbamcr.2016.02.016_bb0095","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1126\/science.959840","article-title":"The clonal evolution of tumor cell populations","volume":"194","author":"Nowell","year":"1976","journal-title":"Science"},{"issue":"5","key":"10.1016\/j.bbamcr.2016.02.016_bb0100","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/0092-8674(90)90186-I","article-title":"A genetic model for colorectal tumorigenesis","volume":"61","author":"Fearon","year":"1990","journal-title":"Cell"},{"issue":"11","key":"10.1016\/j.bbamcr.2016.02.016_bb0105","doi-asserted-by":"crossref","first-page":"4918","DOI":"10.1172\/JCI70354","article-title":"Tracking the clonal origin of lethal prostate cancer","volume":"123","author":"Haffner","year":"2013","journal-title":"J. Clin. Invest."},{"issue":"6127","key":"10.1016\/j.bbamcr.2016.02.016_bb0110","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1126\/science.1235122","article-title":"Cancer genome landscapes","volume":"339","author":"Vogelstein","year":"2013","journal-title":"Science"},{"issue":"5","key":"10.1016\/j.bbamcr.2016.02.016_bb0115","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1002\/1097-0142(195309)6:5<963::AID-CNCR2820060515>3.0.CO;2-Q","article-title":"Field cancerization in oral stratified squamous epithelium; clinical implications of multicentric origin","volume":"6","author":"Slaughter","year":"1953","journal-title":"Cancer."},{"issue":"1","key":"10.1016\/j.bbamcr.2016.02.016_bb0120","doi-asserted-by":"crossref","first-page":"244","DOI":"10.4081\/oncol.2014.244","article-title":"Oral field cancerization: an update on current concepts","volume":"8","author":"Mohan","year":"2014","journal-title":"Oncol. Rev."},{"issue":"13","key":"10.1016\/j.bbamcr.2016.02.016_bb0125","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1002\/pros.20983","article-title":"Evidence for field cancerization of the prostate","volume":"15;69","author":"Nonn","year":"2009","journal-title":"Prostate"},{"issue":"2","key":"10.1016\/j.bbamcr.2016.02.016_bb0130","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1002\/pros.20675","article-title":"Quantitative, spatial resolution of the epigenetic field effect in prostate cancer","volume":"68","author":"Mehrotra","year":"2008","journal-title":"Prostate"},{"issue":"4","key":"10.1016\/j.bbamcr.2016.02.016_bb0135","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/ng.3221","article-title":"Analysis of the genetic phylogeny of multifocal prostate cancer","volume":"47","author":"Cooper","year":"2015","journal-title":"Nat. Genet."},{"issue":"5991","key":"10.1016\/j.bbamcr.2016.02.016_bb0140","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1126\/science.1189992","article-title":"Identification of a cell of origin for human prostate cancer","volume":"329","author":"Goldstein","year":"2010","journal-title":"Science"},{"issue":"7229","key":"10.1016\/j.bbamcr.2016.02.016_bb0145","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1038\/nature07602","article-title":"Crypt stem cells as the cells-of-origin of intestinal cancer","volume":"457","author":"Barker","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.bbamcr.2016.02.016_bb0150","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/j.stem.2012.05.007","article-title":"Cancer stem cells: current status and evolving complexities","author":"Visvader","year":"2012","journal-title":"Cell Stem Cell"},{"issue":"3","key":"10.1016\/j.bbamcr.2016.02.016_bb0155","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/nm.2304","article-title":"The cancer stem cell: premises, promises and challenges","volume":"17","author":"Clevers","year":"2011","journal-title":"Nat. Med."},{"issue":"23","key":"10.1016\/j.bbamcr.2016.02.016_bb0160","doi-asserted-by":"crossref","first-page":"10946","DOI":"10.1158\/0008-5472.CAN-05-2018","article-title":"Prospective identification of tumorigenic prostate cancer stem cells","volume":"65","author":"Collins","year":"2005","journal-title":"Cancer Res."},{"issue":"7330","key":"10.1016\/j.bbamcr.2016.02.016_bb0165","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1038\/nature09650","article-title":"Genetic variegation of clonal architecture and propagating cells in leukaemia","volume":"469","author":"Anderson","year":"2011","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.bbamcr.2016.02.016_bb0170","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1016\/S0002-9440(10)63220-8","article-title":"Pretumor progression: clonal evolution of human stem cell populations","volume":"164","author":"Calabrese","year":"2004","journal-title":"Am. J. Pathol."},{"issue":"6217","key":"10.1016\/j.bbamcr.2016.02.016_bb0175","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1126\/science.1260825","article-title":"Variation in cancer risk among tissues can be explained by the number of stem cell divisions","volume":"347","author":"Tomasetti","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.bbamcr.2016.02.016_bb0180","doi-asserted-by":"crossref","DOI":"10.1093\/jnci\/djv213","article-title":"Strategies to prevent \u201cbad luck\u201d in cancer","author":"Albini","year":"2015","journal-title":"J. Natl. Cancer Inst."},{"issue":"1","key":"10.1016\/j.bbamcr.2016.02.016_bb0185","first-page":"87","article-title":"Most types of cancer not due to \u201cbad luck\u201d. IARC responds to scientific article claiming that environmental and lifestyle factors account for less than one third of cancers","volume":"23","author":"IACR","year":"2015","journal-title":"Cent. Eur. J. Public Health"},{"issue":"6223","key":"10.1016\/j.bbamcr.2016.02.016_bb0190","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1126\/science.aaa6507","article-title":"Cancer risk: tumours excluded","volume":"347","author":"Potter","year":"2015","journal-title":"Science"},{"issue":"6223","key":"10.1016\/j.bbamcr.2016.02.016_bb0195","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1126\/science.aaa6094","article-title":"Cancer risk: many factors contribute","volume":"347","author":"Song","year":"2015","journal-title":"Science"},{"issue":"6223","key":"10.1016\/j.bbamcr.2016.02.016_bb0200","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1126\/science.aaa6799","article-title":"Cancer risk: role of chance overstated","volume":"347","author":"Wild","year":"2015","journal-title":"Science"},{"issue":"6223","key":"10.1016\/j.bbamcr.2016.02.016_bb0205","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1126\/science.aaa6462","article-title":"Cancer risk: prevention is crucial","volume":"347","author":"Gotay","year":"2015","journal-title":"Science"},{"issue":"6223","key":"10.1016\/j.bbamcr.2016.02.016_bb0210","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1126\/science.aaa6212","article-title":"Cancer risk: accuracy of literature","volume":"347","author":"O'Callaghan","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.bbamcr.2016.02.016_bb0215","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1002\/jcb.21843","article-title":"Inflammation as the primary aetiological agent of human prostate cancer: a stem cell connection?","author":"Maitland","year":"2008","journal-title":"J. Cell. Biochem."},{"issue":"10","key":"10.1016\/j.bbamcr.2016.02.016_bb0220","doi-asserted-by":"crossref","first-page":"4008","DOI":"10.1073\/pnas.0611179104","article-title":"Mathematical modeling of cell population dynamics in the colonic crypt and in colorectal cancer","volume":"104","author":"Johnston","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbamcr.2016.02.016_bb0225","doi-asserted-by":"crossref","DOI":"10.1016\/S0002-9440(10)64896-1","article-title":"How many mutations in a cancer?","author":"Tomlinson","year":"2002","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bbamcr.2016.02.016_bb0230","doi-asserted-by":"crossref","DOI":"10.1038\/4687","article-title":"Selection, the mutation rate and cancer: ensuring that the tail does not wag the dog","author":"Tomlinson","year":"1999","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbamcr.2016.02.016_bb0235","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/nature10762","article-title":"Clonal evolution in cancer","author":"Greaves","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.bbamcr.2016.02.016_bb0240","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1519556112","article-title":"Extremely high genetic diversity in a single tumor points to prevalence of non-Darwinian cell evolution","author":"Ling","year":"2015","journal-title":"PNAS"},{"key":"10.1016\/j.bbamcr.2016.02.016_bb0245","doi-asserted-by":"crossref","DOI":"10.1038\/ng.3489","article-title":"Identification of neutral tumor evolution across cancer types","author":"Williams","year":"2016","journal-title":"Nat. Genet."},{"issue":"5","key":"10.1016\/j.bbamcr.2016.02.016_bb0250","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1038\/cdd.2010.150","article-title":"Acidic stress promotes a glioma stem cell phenotype","volume":"18","author":"Hjelmeland","year":"2011","journal-title":"Cell Death Differ."},{"issue":"7325","key":"10.1016\/j.bbamcr.2016.02.016_bb0255","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1038\/nature09557","article-title":"Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells","volume":"468","author":"Ricci-Vitiani","year":"2010","journal-title":"Nature"},{"issue":"7325","key":"10.1016\/j.bbamcr.2016.02.016_bb0260","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1038\/nature09624","article-title":"Glioblastoma stem-like cells give rise to tumour endothelium","volume":"468","author":"Wang","year":"2010","journal-title":"Nature"},{"issue":"Pt 21","key":"10.1016\/j.bbamcr.2016.02.016_bb0265","doi-asserted-by":"crossref","first-page":"3865","DOI":"10.1242\/jcs.114.21.3865","article-title":"Identification and isolation of human prostate epithelial stem cells based on alpha(2)beta(1)-integrin expression","volume":"114","author":"Collins","year":"2001","journal-title":"J. Cell Sci."},{"issue":"40","key":"10.1016\/j.bbamcr.2016.02.016_bb0270","doi-asserted-by":"crossref","first-page":"14842","DOI":"10.1073\/pnas.0606857103","article-title":"Bone morphogenetic protein antagonist gremlin 1 is widely expressed by cancer-associated stromal cells and can promote tumor cell proliferation","volume":"103","author":"Sneddon","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"5457","key":"10.1016\/j.bbamcr.2016.02.016_bb0275","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1126\/science.287.5457.1427","article-title":"Out of Eden: stem cells and their niches","volume":"287","author":"Watt","year":"2000","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.bbamcr.2016.02.016_bb0280","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/nrm2319","article-title":"No place like home: anatomy and function of the stem cell niche","volume":"9","author":"Jones","year":"2008","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"4","key":"10.1016\/j.bbamcr.2016.02.016_bb0285","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1089\/scd.2009.0291","article-title":"Modeling the prostate stem cell niche: an evaluation of stem cell survival and expansion in vitro","volume":"19","author":"Lang","year":"2010","journal-title":"Stem Cells Dev."},{"issue":"4","key":"10.1016\/j.bbamcr.2016.02.016_bb0290","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1172\/JCI43414","article-title":"Human prostate cancer metastases target the hematopoietic stem cell niche to establish footholds in mouse bone marrow","volume":"121","author":"Shiozawa","year":"2011","journal-title":"J. Clin. Invest."},{"issue":"19","key":"10.1016\/j.bbamcr.2016.02.016_bb0295","doi-asserted-by":"crossref","first-page":"10839","DOI":"10.1073\/pnas.191225998","article-title":"Investigating stem cells in human colon by using methylation patterns","volume":"98","author":"Yatabe","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbamcr.2016.02.016_bb0300","doi-asserted-by":"crossref","unstructured":"Takebe N, Harris PJ, Warren RQ, Ivy SP. Targeting cancer stem cells by inhibiting Wnt, Notch, and Hedgehog pathways. Nat. Rev. Clin. Oncol. 2011;8(2):97\u2013106.","DOI":"10.1038\/nrclinonc.2010.196"},{"key":"10.1016\/j.bbamcr.2016.02.016_bb0305","first-page":"91","article-title":"Penetrance of adrenocortical tumours associated with the germline TP53 R337H mutation","author":"Figueiredo","year":"2006","journal-title":"J. Med. Genet."},{"issue":"4","key":"10.1016\/j.bbamcr.2016.02.016_bb0310","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/j.celrep.2014.07.019","article-title":"Quantification of crypt and stem cell evolution in the normal and neoplastic human colon","volume":"8","author":"Baker","year":"2014","journal-title":"Cell Rep."},{"issue":"1","key":"10.1016\/j.bbamcr.2016.02.016_bb0315","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/bjc.2015.214","article-title":"Stem vs Non-stem Cell Origin of Colorectal Cancer","volume":"113","author":"Huels","year":"2015","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.bbamcr.2016.02.016_bb0320","doi-asserted-by":"crossref","DOI":"10.1038\/nm0797-730","article-title":"Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell","author":"Bonnet","year":"1997","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbamcr.2016.02.016_bb0325","doi-asserted-by":"crossref","DOI":"10.1002\/stem.92","article-title":"Differentiation of a highly tumorigenic basal cell compartment in urothelial carcinoma","author":"He","year":"2009","journal-title":"Stem Cells"},{"key":"10.1016\/j.bbamcr.2016.02.016_bb0330","article-title":"Identification of a cancer stem cell in human brain tumors","author":"Singh","year":"2003","journal-title":"Pathobiology"},{"issue":"11","key":"10.1016\/j.bbamcr.2016.02.016_bb0335","doi-asserted-by":"crossref","first-page":"3983","DOI":"10.1073\/pnas.0530291100","article-title":"Prospective identification of tumorigenic breast cancer cells","volume":"100","author":"Al-Hajj","year":"2003","journal-title":"PNAS"},{"key":"10.1016\/j.bbamcr.2016.02.016_bb0340","doi-asserted-by":"crossref","DOI":"10.1038\/nature05384","article-title":"Identification and expansion of human colon-cancer-initiating cells","author":"Ricci-Vitiani","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.bbamcr.2016.02.016_bb0345","article-title":"Identification and characterization of cancer stem-like cells from primary carcinoma of the cervix uteri","author":"Feng","year":"2009","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.bbamcr.2016.02.016_bb0350","doi-asserted-by":"crossref","DOI":"10.1158\/1078-0432.CCR-08-1883","article-title":"Human cancer biology cells with characteristics of cancer stem\/progenitor cells express the CD133 antigen in human endometrial tumors","author":"Rutella","year":"2009","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.bbamcr.2016.02.016_bb0355","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.0610117104","article-title":"Identification of a subpopulation of cells with cancer stem cell properties in head and neck squamous cell carcinoma","author":"Prince","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbamcr.2016.02.016_bb0360","doi-asserted-by":"crossref","DOI":"10.1053\/j.gastro.2007.04.025","article-title":"Identification and characterization of tumorigenic liver cancer stem\/progenitor cells","author":"Ma","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bbamcr.2016.02.016_bb0365","doi-asserted-by":"crossref","DOI":"10.1038\/sj.cdd.4402283","article-title":"Identification and expansion of the tumorigenic lung cancer stem cell population","author":"Eramo","year":"2008","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.bbamcr.2016.02.016_bb0370","doi-asserted-by":"crossref","DOI":"10.1158\/0008-5472.CAN-05-1343","article-title":"A tumorigenic subpopulation with stem cell properties in melanomas","author":"Fang","year":"2005","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbamcr.2016.02.016_bb0375","doi-asserted-by":"crossref","DOI":"10.1182\/blood-2003-09-3064","article-title":"Characterization of clonogenic multiple myeloma cells","author":"Matsui","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.bbamcr.2016.02.016_bb0380","article-title":"Identification of pancreatic cancer stem cells","author":"Li","year":"2007","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbamcr.2016.02.016_bb0385","doi-asserted-by":"crossref","DOI":"10.1158\/0008-5472.CAN-08-0364","article-title":"Identification and characterization of ovarian cancer-initiating cells from primary human tumors","author":"Zhang","year":"2008","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbamcr.2016.02.016_bb0390","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1002\/pros.2990150506","article-title":"Etiology and disease process of benign prostatic hyperplasia","volume":"2","author":"Isaacs","year":"1989","journal-title":"Prostate Suppl."},{"issue":"1","key":"10.1016\/j.bbamcr.2016.02.016_bb0395","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s12672-010-0058-y","article-title":"Prostate cancer stem cells: do they have a basal or luminal phenotype?","volume":"2","author":"Maitland","year":"2011","journal-title":"Horm. Cancer"},{"issue":"Pt 16","key":"10.1016\/j.bbamcr.2016.02.016_bb0400","doi-asserted-by":"crossref","first-page":"3539","DOI":"10.1242\/jcs.01222","article-title":"CD133, a novel marker for human prostatic epithelial stem cells","volume":"117","author":"Richardson","year":"2004","journal-title":"J. Cell Sci."},{"issue":"5","key":"10.1016\/j.bbamcr.2016.02.016_bb0405","doi-asserted-by":"crossref","first-page":"R83","DOI":"10.1186\/gb-2008-9-5-r83","article-title":"Gene expression profiling of human prostate cancer stem cells reveals a pro-inflammatory phenotype and the importance of extracellular matrix interactions","volume":"9","author":"Birnie","year":"2008","journal-title":"Genome Biol."},{"key":"10.1016\/j.bbamcr.2016.02.016_bb0410","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1038\/ncomms2627","article-title":"Monoallelic expression of TMPRSS2\/ERG in prostate cancer stem cells","volume":"4","author":"Polson","year":"2013","journal-title":"Nat. Commun."},{"issue":"12","key":"10.1016\/j.bbamcr.2016.02.016_bb0415","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1038\/sj.onc.1209327","article-title":"Highly purified CD44+ prostate cancer cells from xenograft human tumors are enriched in tumorigenic and metastatic progenitor cells","volume":"25","author":"Patrawala","year":"2006","journal-title":"Oncogene"},{"issue":"6","key":"10.1016\/j.bbamcr.2016.02.016_bb0420","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/j.stem.2010.11.013","article-title":"Bmi-1 is a crucial regulator of prostate stem cell self-renewal and malignant transformation","volume":"7","author":"Lukacs","year":"2010","journal-title":"Cell Stem Cell"},{"issue":"2","key":"10.1016\/j.bbamcr.2016.02.016_bb0425","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1007\/s11596-012-0043-5","article-title":"Implication of expression of Nanog in prostate cancer cells and their stem cells","volume":"32","author":"Gong","year":"2012","journal-title":"J. Huazhong Univ. Sci. Technolog. Med. Sci."},{"key":"10.1016\/j.bbamcr.2016.02.016_bb0430","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.cell.2014.08.017","article-title":"Identification of multipotent luminal progenitor cells in human prostate organoid cultures","volume":"159","author":"Karthaus","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.bbamcr.2016.02.016_bb0435","unstructured":"Sabbath KD, Ball ED, Larcom P, Davis RB, Griffin JD. Heterogeneity of Clonogenic Cells in Acute Myeloblastic Leukemia."},{"key":"10.1016\/j.bbamcr.2016.02.016_bb0440","article-title":"Coexistence of quiescent and active adult stem cells in mammals","author":"Li","year":"2010","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.bbamcr.2016.02.016_bb0445","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.ccr.2010.12.012","article-title":"Coexistence of LMPP-like and GMP-like leukemia stem cells in acute myeloid leukemia","volume":"19","author":"Goardon","year":"2011","journal-title":"Cancer Cell"},{"issue":"2","key":"10.1016\/j.bbamcr.2016.02.016_bb0450","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.stem.2012.01.004","article-title":"Decoupling of tumor-initiating activity from stable immunophenotype in HoxA9-Meis1-driven AML","volume":"10","author":"Gibbs","year":"2012","journal-title":"Cell Stem Cell"},{"issue":"11","key":"10.1016\/j.bbamcr.2016.02.016_bb0455","doi-asserted-by":"crossref","first-page":"4624","DOI":"10.1158\/0008-5472.CAN-09-3619","article-title":"CD44posCD49fhiCD133\/2hi defines xenograft-initiating cells in estrogen receptor-negative breast cancer","volume":"70","author":"Meyer","year":"2010","journal-title":"Cancer Res."},{"issue":"26","key":"10.1016\/j.bbamcr.2016.02.016_bb0460","doi-asserted-by":"crossref","first-page":"10544","DOI":"10.1073\/pnas.1107807108","article-title":"Tumor-initiating stem cells of squamous cell carcinomas and their control by TGF-\u03b2 and integrin\/focal adhesion kinase (FAK) signaling","volume":"108","author":"Schober","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"16","key":"10.1016\/j.bbamcr.2016.02.016_bb0465","doi-asserted-by":"crossref","first-page":"6468","DOI":"10.1073\/pnas.1005529108","article-title":"Phenotypic heterogeneity and instability of human ovarian tumor-initiating cells","volume":"108","author":"Stewart","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"42","key":"10.1016\/j.bbamcr.2016.02.016_bb0470","doi-asserted-by":"crossref","first-page":"18115","DOI":"10.1073\/pnas.1006732107","article-title":"Cancer stem cells from human breast tumors are involved in spontaneous metastases in orthotopic mouse models","volume":"107","author":"Liu","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"3","key":"10.1016\/j.bbamcr.2016.02.016_bb0475","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.stem.2007.06.002","article-title":"Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer","volume":"1","author":"Hermann","year":"2007","journal-title":"Cell Stem Cell"},{"issue":"4","key":"10.1016\/j.bbamcr.2016.02.016_bb0480","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/nrc3910","article-title":"Metastasis prevention by targeting the dormant niche","volume":"15","author":"Ghajar","year":"2015","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.bbamcr.2016.02.016_bb0485","series-title":"HDAC Inhibitor Confers Radiosensitivity to Prostate Stem-like Cells","volume":"Vol. 109","author":"Frame","year":"2013"},{"issue":"3","key":"10.1016\/j.bbamcr.2016.02.016_bb0490","first-page":"125","article-title":"Classification of prostatic carcinomas","volume":"50","author":"Gleason","year":"1966","journal-title":"Cancer Chemother. Rep."},{"issue":"5","key":"10.1016\/j.bbamcr.2016.02.016_bb0495","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1016\/j.juro.2012.07.055","article-title":"Do gleason patterns 3 and 4 prostate cancer represent separate disease states?","volume":"188","author":"Lavery","year":"2012","journal-title":"J. Urol."},{"issue":"2","key":"10.1016\/j.bbamcr.2016.02.016_bb0500","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.eururo.2008.03.049","article-title":"Comparing the gleason prostate biopsy and gleason prostatectomy grading system: The Lahey Clinic Medical Center experience and an international meta-analysis","volume":"54","author":"Cohen","year":"2008","journal-title":"Eur. Urol."},{"issue":"16","key":"10.1016\/j.bbamcr.2016.02.016_bb0505","doi-asserted-by":"crossref","first-page":"5163","DOI":"10.1158\/0008-5472.CAN-13-0427","article-title":"Gleason grade progression is uncommon","volume":"73","author":"Penney","year":"2013","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbamcr.2016.02.016_bb0510","doi-asserted-by":"crossref","first-page":"3275","DOI":"10.1158\/0008-5472.CAN-12-2803","article-title":"Lineage relationship of gleason patterns in gleason score 7 prostate cancer","volume":"73","author":"Kovtun","year":"2013","journal-title":"Cancer Res."},{"issue":"3","key":"10.1016\/j.bbamcr.2016.02.016_bb0515","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/j.juro.2010.10.057","article-title":"Predicting 15-year prostate cancer specific mortality after radical prostatectomy","volume":"185","author":"Eggener","year":"2011","journal-title":"J. Urol."},{"issue":"1","key":"10.1016\/j.bbamcr.2016.02.016_bb0520","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.urology.2007.10.055","article-title":"Natural history of pathologically organ-confined (pT2), Gleason score 6 or less, prostate cancer after radical prostatectomy","volume":"72","author":"Hernandez","year":"2008","journal-title":"Urology"},{"issue":"4","key":"10.1016\/j.bbamcr.2016.02.016_bb0525","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1016\/j.juro.2009.06.048","article-title":"Tertiary Gleason patterns and biochemical recurrence after prostatectomy: proposal for a modified Gleason scoring system","volume":"182","author":"Trock","year":"2009","journal-title":"J. Urol."},{"issue":"29","key":"10.1016\/j.bbamcr.2016.02.016_bb0530","doi-asserted-by":"crossref","first-page":"10991","DOI":"10.1073\/pnas.0603678103","article-title":"A molecular correlate to the Gleason grading system for prostate adenocarcinoma","volume":"103","author":"True","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.bbamcr.2016.02.016_bb0535","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/ng1935","article-title":"Integrative molecular concept modeling of prostate cancer progression","volume":"39","author":"Tomlins","year":"2007","journal-title":"Nat. Genet."},{"issue":"3","key":"10.1016\/j.bbamcr.2016.02.016_bb0540","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1097\/MOU.0000000000000165","article-title":"Should Gleason 6 be labeled as cancer?","volume":"25","author":"Kulac","year":"2015","journal-title":"Curr. Opin. Urol."},{"key":"10.1016\/j.bbamcr.2016.02.016_bb0545","doi-asserted-by":"crossref","DOI":"10.1097\/PAS.0000000000000530","article-title":"The 2014 International Society of Urological Pathology (ISUP) consensus conference on Gleason grading of prostatic carcinoma: definition of grading patterns and proposal for a new grading system","author":"Epstein","year":"2015","journal-title":"Am. J. Surg. Pathol."},{"key":"10.1016\/j.bbamcr.2016.02.016_bb0550","doi-asserted-by":"crossref","DOI":"10.1016\/j.molonc.2010.06.001","article-title":"Targeting leukemic stem cells by breaking their dormancy","author":"Essers","year":"2010","journal-title":"Mol. Oncol."},{"issue":"1","key":"10.1016\/j.bbamcr.2016.02.016_bb0555","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1038\/nbt.1517","article-title":"Analysis of histone 2B-GFP retention reveals slowly cycling hematopoietic stem cells","volume":"27","author":"Foudi","year":"2009","journal-title":"Nat. Biotechnol."},{"issue":"5","key":"10.1016\/j.bbamcr.2016.02.016_bb0560","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1089\/scd.2007.0017","article-title":"The effect of bleeding on hematopoietic stem cell cycling and self-renewal","volume":"16","author":"Cheshier","year":"2007","journal-title":"Stem Cells Dev."},{"key":"10.1016\/j.bbamcr.2016.02.016_bb0565","doi-asserted-by":"crossref","DOI":"10.1038\/nri2726","article-title":"Awakening dormant haematopoietic stem cells","author":"Trumpp","year":"2010","journal-title":"Nat. Rev. Immunol."},{"issue":"6","key":"10.1016\/j.bbamcr.2016.02.016_bb0570","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1016\/j.cell.2008.10.048","article-title":"Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair","volume":"135","author":"Wilson","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.bbamcr.2016.02.016_bb0575","doi-asserted-by":"crossref","DOI":"10.1038\/nature11438","article-title":"The aged niche disrupts muscle stem cell quiescence","author":"Chakkalakal","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.bbamcr.2016.02.016_bb0580","unstructured":"Aguirre-Ghiso JA. Models, mechanisms and clinical evidence for cancer dormancy."},{"issue":"5505","key":"10.1016\/j.bbamcr.2016.02.016_bb0585","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/255197a0","article-title":"Mutation selection and the natural history of cancer","volume":"255","author":"Cairns","year":"1975","journal-title":"Nature"},{"key":"10.1016\/j.bbamcr.2016.02.016_bb0590","unstructured":"Cairns J. Perspectives Anecdotal, Historical and Critical Commentaries on Genetics Cancer and the Immortal Strand Hypothesis."},{"issue":"7","key":"10.1016\/j.bbamcr.2016.02.016_bb0595","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1016\/j.cell.2007.06.019","article-title":"The immortal strand hypothesis: segregation and reconstruction","volume":"129","author":"Rando","year":"2007","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.bbamcr.2016.02.016_bb0600","first-page":"656","article-title":"3-Methyladenine DNA glycosylase-deficient Aag null mice display unexpected bone marrow alkylation resistance","volume":"62","author":"Roth","year":"2002","journal-title":"Cancer Res."},{"issue":"753","key":"10.1016\/j.bbamcr.2016.02.016_bb0605","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1126\/science.154.3753.1202","article-title":"Segregation of sister chromatids in mammalian cells","volume":"154","author":"Lark","year":"1966","journal-title":"Science"},{"issue":"Pt 11","key":"10.1016\/j.bbamcr.2016.02.016_bb0610","doi-asserted-by":"crossref","first-page":"2381","DOI":"10.1242\/jcs.115.11.2381","article-title":"Intestinal stem cells protect their genome by selective segregation of template DNA strands","volume":"115","author":"Potten","year":"2002","journal-title":"J. Cell Sci."},{"issue":"7","key":"10.1016\/j.bbamcr.2016.02.016_bb0615","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.0050182","article-title":"High incidence of non-random template strand segregation and asymmetric fate determination in dividing stem cells and their progeny","volume":"5","author":"Conboy","year":"2007","journal-title":"PLoS Biol."},{"issue":"7159","key":"10.1016\/j.bbamcr.2016.02.016_bb0620","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/nature06115","article-title":"Haematopoietic stem cells do not asymmetrically segregate chromosomes or retain BrdU","volume":"449","author":"Kiel","year":"2007","journal-title":"Nature"},{"issue":"7382","key":"10.1016\/j.bbamcr.2016.02.016_bb0625","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1038\/nature10734","article-title":"Multi-isotope imaging mass spectrometry quantifies stem cell division and metabolism","volume":"481","author":"Steinhauser","year":"2012","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.bbamcr.2016.02.016_bb0630","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.scr.2015.01.005","article-title":"The (not so) immortal strand hypothesis","volume":"14","author":"Tomasetti","year":"2015","journal-title":"Stem Cell Res."},{"issue":"23","key":"10.1016\/j.bbamcr.2016.02.016_bb0635","first-page":"6791","article-title":"Cosegregation of chromosomes containing immortal DNA strands in cells that cycle with asymmetric stem cell kinetics","volume":"62","author":"Merok","year":"2002","journal-title":"Cancer Res."},{"issue":"6","key":"10.1016\/j.bbamcr.2016.02.016_bb0640","doi-asserted-by":"crossref","first-page":"T199","DOI":"10.1530\/ERC-15-0367","article-title":"Stem cells in genetically-engineered mouse models of prostate cancer","volume":"22","author":"Shibata","year":"2015","journal-title":"Endocr. Relat. Cancer."},{"issue":"11","key":"10.1016\/j.bbamcr.2016.02.016_bb0645","first-page":"3298","article-title":"Stromal cells promote angiogenesis and growth of human prostate tumors in a differential reactive stroma (DRS) xenograft model","volume":"62","author":"Tuxhorn","year":"2002","journal-title":"Cancer Res."},{"issue":"4","key":"10.1016\/j.bbamcr.2016.02.016_bb0650","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1016\/S0022-5347(17)37506-7","article-title":"Prostate and bone fibroblasts induce human prostate cancer growth in vivo: implications for bidirectional tumor\u2013stromal cell interaction in prostate carcinoma growth and metastasis","volume":"147","author":"Gleave","year":"1992","journal-title":"J. Urol."},{"issue":"7223","key":"10.1016\/j.bbamcr.2016.02.016_bb0655","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1038\/nature07427","article-title":"Generation of a prostate from a single adult stem cell","volume":"456","author":"Leong","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.bbamcr.2016.02.016_bb0660","article-title":"Identification of CD166 as a surface marker for enriching prostate stem\/progenitor and cancer initiating cells","author":"Jiao","year":"2012","journal-title":"PLoS One"},{"issue":"7263","key":"10.1016\/j.bbamcr.2016.02.016_bb0665","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/nature08361","article-title":"A luminal epithelial stem cell that is a cell of origin for prostate cancer","volume":"461","author":"Wang","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.bbamcr.2016.02.016_bb0670","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1038\/ncb3047","article-title":"Single luminal epithelial progenitors can generate prostate organoids in culture.","volume":"16","author":"Chua","year":"2014","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.bbamcr.2016.02.016_bb0675","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2014.08.002","article-title":"Luminal cells are favored as the cell of origin for prostate cancer","author":"Wang","year":"2014","journal-title":"Cell Rep."},{"key":"10.1016\/j.bbamcr.2016.02.016_bb0680","doi-asserted-by":"crossref","DOI":"10.1038\/ncb2600","article-title":"Multipotent and unipotent progenitors contribute to prostate postnatal development","volume":"14","author":"Ousset","year":"2012","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.bbamcr.2016.02.016_bb0685","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.ccr.2012.01.005","article-title":"Adult murine prostate basal and luminal cells are self-sustained lineages that can both serve as targets for prostate cancer initiation","volume":"21","author":"Choi","year":"2012","journal-title":"Cancer Cell"},{"key":"10.1016\/j.bbamcr.2016.02.016_bb0690","article-title":"Symmetrical and asymmetrical division analysis provides evidence for a hierarchy of prostate epithelial cell lineages","volume":"5","author":"Wang","year":"2014","journal-title":"Nat. Commun."},{"issue":"14","key":"10.1016\/j.bbamcr.2016.02.016_bb0695","doi-asserted-by":"crossref","first-page":"6796","DOI":"10.1158\/0008-5472.CAN-07-0490","article-title":"Hierarchical organization of prostate cancer cells in xenograft tumors: the CD44+alpha2beta1+ cell population is enriched in tumor-initiating cells","volume":"67","author":"Patrawala","year":"2007","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbamcr.2016.02.016_bb0700","doi-asserted-by":"crossref","DOI":"10.1038\/sj.bjc.6604242","article-title":"CD44+ CD24(\u2212) prostate cells are early cancer progenitor\/stem cells that provide a model for patients with poor prognosis","author":"Hurt","year":"2008","journal-title":"Br. J. Cancer"},{"issue":"5","key":"10.1016\/j.bbamcr.2016.02.016_bb0705","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.stem.2012.03.009","article-title":"The PSA(\u2212\/lo) prostate cancer cell population harbors self-renewing long-term tumor-propagating cells that resist castration","volume":"10","author":"Qin","year":"2012","journal-title":"Cell Stem Cell"},{"issue":"6","key":"10.1016\/j.bbamcr.2016.02.016_bb0710","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1002\/stem.1087","article-title":"Stem-like cells with luminal progenitor phenotype survive castration in human prostate cancer","volume":"30","author":"Germann","year":"2012","journal-title":"Stem Cells"},{"issue":"4","key":"10.1016\/j.bbamcr.2016.02.016_bb0715","first-page":"293","article-title":"Comparative pathology of benign prostatic hyperplasia and prostate cancer","volume":"11","author":"Maini","year":"1997","journal-title":"In Vivo (Brooklyn)"},{"issue":"38","key":"10.1016\/j.bbamcr.2016.02.016_bb0720","doi-asserted-by":"crossref","first-page":"5349","DOI":"10.1038\/sj.onc.1203037","article-title":"Mouse models of prostate cancer","volume":"18","author":"Sharma","year":"1999","journal-title":"Oncogene"},{"issue":"4","key":"10.1016\/j.bbamcr.2016.02.016_bb0725","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.cell.2007.01.029","article-title":"The epigenomics of cancer","volume":"128","author":"Jones","year":"2007","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.bbamcr.2016.02.016_bb0730","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.cell.2007.02.005","article-title":"Chromatin modifications and their function","volume":"128","author":"Kouzarides","year":"2007","journal-title":"Cell"},{"issue":"7143","key":"10.1016\/j.bbamcr.2016.02.016_bb0735","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/nature05918","article-title":"Stability and flexibility of epigenetic gene regulation in mammalian development","volume":"447","author":"Reik","year":"2007","journal-title":"Nature"},{"issue":"8","key":"10.1016\/j.bbamcr.2016.02.016_bb0740","doi-asserted-by":"crossref","first-page":"823","DOI":"10.4161\/epi.21141","article-title":"Judge, jury and executioner of stem cell fate","volume":"7","author":"Tollervey","year":"2012","journal-title":"Epigenetics"},{"key":"10.1016\/j.bbamcr.2016.02.016_bb0745","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.ccr.2010.05.026","article-title":"Integrative genomic profiling of human prostate cancer program in Computational Biology 2 Program in Human Oncology and Pathogenesis (HOPP)","volume":"18","author":"Taylor","year":"2010","journal-title":"Cancer Cell"},{"key":"10.1016\/j.bbamcr.2016.02.016_bb0750","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/nature11125","article-title":"The mutational landscape of lethal castration-resistant prostate cancer","author":"Grasso","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.bbamcr.2016.02.016_bb0755","doi-asserted-by":"crossref","first-page":"e1324","DOI":"10.1038\/cddis.2014.283","article-title":"Integrative epigenome analysis identifies a polycomb-targeted differentiation program as a tumor-suppressor event epigenetically inactivated in colorectal cancer","volume":"5","author":"Tan","year":"2014","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bbamcr.2016.02.016_bb0760","doi-asserted-by":"crossref","first-page":"3617","DOI":"10.1158\/0008-5472.CAN-13-3147","article-title":"Activation of cancer-promoting genes in colorectal tumors loss of the polycomb mark from bivalent promoters leads to loss of the polycomb mark from bivalent promoters leads to activation of cancer-promoting genes in colorectal tumors","volume":"74","author":"Hahn","year":"2014","journal-title":"Cancer Res."},{"issue":"38","key":"10.1016\/j.bbamcr.2016.02.016_bb0765","doi-asserted-by":"crossref","first-page":"4586","DOI":"10.1038\/onc.2012.477","article-title":"Chromatin H3K27me3\/H3K4me3 histone marks define gene sets in high-grade serous ovarian cancer that distinguish malignant, tumour-sustaining and chemo-resistant ovarian tumour cells","volume":"32","author":"Chapman-Rothe","year":"2013","journal-title":"Oncogene"},{"issue":"5","key":"10.1016\/j.bbamcr.2016.02.016_bb0770","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1038\/cdd.2013.202","article-title":"DNA hypermethylation in prostate cancer is a consequence of aberrant epithelial differentiation and hyperproliferation","volume":"21","author":"Pellacani","year":"2014","journal-title":"Cell Death Differ."},{"issue":"45","key":"10.1016\/j.bbamcr.2016.02.016_bb0775","doi-asserted-by":"crossref","first-page":"6560","DOI":"10.1038\/sj.onc.1210472","article-title":"Hypomethylation of WNT5A, CRIP1 and S100P in prostate cancer","volume":"26","author":"Wang","year":"2007","journal-title":"Oncogene"},{"key":"10.1016\/j.bbamcr.2016.02.016_bb0780","doi-asserted-by":"crossref","first-page":"6094","DOI":"10.1038\/ncomms7094","article-title":"Site- and allele-specific polycomb dysregulation in T-cell leukaemia","volume":"6","author":"Navarro","year":"2015","journal-title":"Nat. Commun."},{"issue":"14","key":"10.1016\/j.bbamcr.2016.02.016_bb0785","doi-asserted-by":"crossref","first-page":"2036","DOI":"10.1038\/onc.2009.496","article-title":"Wnt5a signaling is involved in the aggressiveness of prostate cancer and expression of metalloproteinase","volume":"29","author":"Yamamoto","year":"2010","journal-title":"Oncogene"},{"issue":"6254","key":"10.1016\/j.bbamcr.2016.02.016_bb0790","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1126\/science.aab0917","article-title":"RNA-Seq of single prostate CTCs implicates noncanonical Wnt signaling in antiandrogen resistance.","volume":"349","author":"Miyamoto","year":"2015","journal-title":"Science"},{"issue":"8","key":"10.1016\/j.bbamcr.2016.02.016_bb0795","doi-asserted-by":"crossref","first-page":"716","DOI":"10.4161\/epi.5.8.13014","article-title":"Multivalent epigenetic marks confer microenvironment-responsive epigenetic plasticity to ovarian cancer cells","volume":"5","author":"Bapat","year":"2010","journal-title":"Epigenetics"},{"issue":"6119","key":"10.1016\/j.bbamcr.2016.02.016_bb0800","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1126\/science.1227670","article-title":"Variable clonal repopulation dynamics influence chemotherapy response in colorectal cancer","volume":"339","author":"Kreso","year":"2013","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.bbamcr.2016.02.016_bb0805","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1101\/gr.161034.113","article-title":"From single-cell to cell-pool transcriptomes: stochasticity in gene expression and RNA splicing","volume":"24","author":"Marinov","year":"2014","journal-title":"Genome Res."},{"key":"10.1016\/j.bbamcr.2016.02.016_bb0810","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1404656111","article-title":"Single-cell analyses of transcriptional heterogeneity during drug tolerance transition in cancer cells by RNA sequencing","author":"Lee","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbamcr.2016.02.016_bb0815","first-page":"1905","article-title":"Single-cell RNA sequencing identifies extracellular matrix gene expression by pancreatic circulating tumor cells","volume":"8","author":"Ting","year":"2014","journal-title":"CELREP"},{"key":"10.1016\/j.bbamcr.2016.02.016_bb0820","doi-asserted-by":"crossref","DOI":"10.1126\/science.1254257","article-title":"Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma","author":"Patel","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.bbamcr.2016.02.016_bb0825","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.gde.2013.12.004","article-title":"Single cell analysis of cancer genomes","volume":"24","author":"Van","year":"2014","journal-title":"Curr. Opin. Genet. Dev."},{"issue":"4","key":"10.1016\/j.bbamcr.2016.02.016_bb0830","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.devcel.2014.01.016","article-title":"Developmental dynamics and disease potential of random monoallelic gene expression","volume":"28","author":"Gendrel","year":"2014","journal-title":"Dev. Cell"},{"key":"10.1016\/j.bbamcr.2016.02.016_bb0835","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.devcel.2014.01.017","article-title":"Random monoallelic gene expression increases upon embryonic stem cell differentiation","volume":"28","author":"Lanie","year":"2014","journal-title":"Dev. Cell"},{"issue":"8","key":"10.1016\/j.bbamcr.2016.02.016_bb0840","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1101\/gr.1006603","article-title":"Allelic variation in gene expression is common in the human genome","volume":"13","author":"Lo","year":"2003","journal-title":"Genome Res."},{"issue":"5853","key":"10.1016\/j.bbamcr.2016.02.016_bb0845","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1126\/science.1148910","article-title":"Widespread monoallelic expression on human autosomes","volume":"318","author":"Gimelbrant","year":"2007","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.bbamcr.2016.02.016_bb0850","first-page":"1","article-title":"Chromatin signature of widespread monoallelic expression","volume":"2013","author":"Nag","year":"2013","journal-title":"Elife"},{"issue":"10","key":"10.1016\/j.bbamcr.2016.02.016_bb0855","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.4161\/15592294.2014.970052","article-title":"Using RNA sequencing for identifying gene imprinting and random monoallelic expression in human placenta","volume":"9","author":"Metsalu","year":"2014","journal-title":"Epigenetics"},{"issue":"1","key":"10.1016\/j.bbamcr.2016.02.016_bb0860","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.ajhg.2014.12.001","article-title":"Biased allelic expression in human primary fibroblast single cells","volume":"96","author":"Borel","year":"2015","journal-title":"Am. J. Hum. Genet."},{"issue":"11","key":"10.1016\/j.bbamcr.2016.02.016_bb0865","doi-asserted-by":"crossref","first-page":"e13843","DOI":"10.1371\/journal.pone.0013843","article-title":"Dual DNA methylation patterns in the CNS reveal developmentally poised chromatin and monoallelic expression of critical genes","volume":"5","author":"Wang","year":"2010","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.bbamcr.2016.02.016_bb0870","first-page":"1","article-title":"Passive and active DNA methylation and the interplay with genetic variation in gene regulation","volume":"2013","author":"Gutierrez-Arcelus","year":"2013","journal-title":"Elife"},{"issue":"8","key":"10.1016\/j.bbamcr.2016.02.016_bb0875","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1534\/g3.115.018853","article-title":"Chromatin signature identifies monoallelic gene expression across mammalian cell types.","volume":"5","author":"Nag","year":"2015","journal-title":"G3 Genes|Genomes|Genetics."},{"issue":"2","key":"10.1016\/j.bbamcr.2016.02.016_bb0880","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.cell.2006.02.041","article-title":"A bivalent chromatin structure marks key developmental genes in embryonic stem cells.","volume":"21;125","author":"Bernstein","year":"2006","journal-title":"Cell."},{"key":"10.1016\/j.bbamcr.2016.02.016_bb0885","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.scr.2014.12.002","article-title":"Cryosectioning the intestinal crypt-villus axis: an ex vivo method to study the dynamics of epigenetic modifications from stem cells to differentiated cells","volume":"14","author":"Vincent","year":"2015","journal-title":"Stem Cell Res."},{"issue":"2","key":"10.1016\/j.bbamcr.2016.02.016_bb0890","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/ng1972","article-title":"A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and silencing in adult cancers","volume":"39","author":"Ohm","year":"2007","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbamcr.2016.02.016_bb0895","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2014.283","article-title":"Integrative epigenome analysis identifies a polycomb-targeted differentiation program as a tumor-suppressor event epigenetically inactivated in colorectal cancer","volume":"5","author":"Tan","year":"2014","journal-title":"Cell Death Dis."},{"issue":"50","key":"10.1016\/j.bbamcr.2016.02.016_bb0900","doi-asserted-by":"crossref","first-page":"19809","DOI":"10.1073\/pnas.0810133105","article-title":"Bivalent domains enforce transcriptional memory of DNA methylated genes in cancer cells.","volume":"16;105","author":"Rodriguez","year":"2008","journal-title":"PNAS"},{"key":"10.1016\/j.bbamcr.2016.02.016_bb0905","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.4161\/epi.6.11.18021","article-title":"Bivalent histone modifications in stem cells poise miRNA loci for CpG island hypermethylation in human cancer","volume":"611","author":"Iliou","year":"2011","journal-title":"Outi Hovatta Manel Esteller Epigenetics"},{"issue":"7","key":"10.1016\/j.bbamcr.2016.02.016_bb0910","doi-asserted-by":"crossref","DOI":"10.18632\/oncotarget.3030","article-title":"Global analysis of H3K4me3 and H3K27me3 profiles in glioblastoma stem cells and identification of SLC17A7 as a bivalent tumor suppressor gene","volume":"6","author":"Lin","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.bbamcr.2016.02.016_bb0915","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2007.03.043","article-title":"Downregulation of death-associated protein kinase 1 (DAPK1) in chronic lymphocytic leukemia","author":"Raval","year":"2007","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.bbamcr.2016.02.016_bb0920","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/j.cell.2013.03.021","article-title":"Punctuated evolution of prostate cancer genomes","volume":"153","author":"Baca","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.bbamcr.2016.02.016_bb0925","doi-asserted-by":"crossref","DOI":"10.1038\/nrc2090","article-title":"Inflammation in prostate carcinogenesis","author":"De Marzo","year":"2007","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.bbamcr.2016.02.016_bb0930","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1002\/jcb.21843","article-title":"Inflammation as the primary aetiological agent of human prostate cancer: a stem cell connection?","volume":"105","author":"Maitland","year":"2008","journal-title":"J. Cell. Biochem."},{"issue":"3","key":"10.1016\/j.bbamcr.2016.02.016_bb0935","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/S0090-4295(99)80034-X","article-title":"Interleukin-6: a candidate mediator of human prostate cancer morbidity","volume":"45","author":"Twillie","year":"1995","journal-title":"Urology"},{"issue":"1","key":"10.1016\/j.bbamcr.2016.02.016_bb0940","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/S0022-5347(01)62092-5","article-title":"Elevated levels of circulating interleukin-6 and transforming growth factor-beta1 in patients with metastatic prostatic carcinoma","volume":"161","author":"Adler","year":"1999","journal-title":"J. Urol."},{"issue":"7","key":"10.1016\/j.bbamcr.2016.02.016_bb0945","first-page":"2702","article-title":"Serum interleukin 6 as a prognostic factor in patients with prostate cancer","volume":"6","author":"Nakashima","year":"2000","journal-title":"Clin. Cancer Res."},{"issue":"16","key":"10.1016\/j.bbamcr.2016.02.016_bb0950","doi-asserted-by":"crossref","first-page":"5288","DOI":"10.1158\/0008-5472.CAN-13-0874","article-title":"JAK-STAT blockade inhibits tumor initiation and clonogenic recovery of prostate cancer stem-like cells","volume":"73","author":"Kroon","year":"2013","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbamcr.2016.02.016_bb0955","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.cell.2009.10.014","article-title":"An epigenetic switch involving NF-kappaB, Lin28, Let-7 MicroRNA, and IL6 links inflammation to cell transformation","author":"Iliopoulos","year":"2009","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.bbamcr.2016.02.016_bb0960","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1158\/0008-5472.CAN-13-0594","article-title":"Loss of androgen receptor expression promotes a stem-like cell phenotype in prostate cancer through STAT3 signaling","volume":"74","author":"Schroeder","year":"2014","journal-title":"Cancer Res."},{"issue":"4","key":"10.1016\/j.bbamcr.2016.02.016_bb0965","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.ccr.2011.03.004","article-title":"Nonreceptor tyrosine kinase BMX maintains self-renewal and tumorigenic potential of glioblastoma stem cells by activating STAT3","volume":"19","author":"Guryanova","year":"2011","journal-title":"Cancer Cell"},{"issue":"18","key":"10.1016\/j.bbamcr.2016.02.016_bb0970","doi-asserted-by":"crossref","first-page":"8416","DOI":"10.18632\/oncotarget.2314","article-title":"Inhibition of STAT3 signaling targets both tumor-initiating and differentiated cell populations in prostate cancer","volume":"5","author":"Han","year":"2014","journal-title":"Oncotarget"},{"issue":"23","key":"10.1016\/j.bbamcr.2016.02.016_bb0975","doi-asserted-by":"crossref","first-page":"15969","DOI":"10.1074\/jbc.M114.564252","article-title":"Galiellalactone is a direct inhibitor of the transcription factor STAT3 in prostate cancer cells","volume":"289","author":"Don-Doncow","year":"2014","journal-title":"J. Biol. Chem."},{"issue":"7369","key":"10.1016\/j.bbamcr.2016.02.016_bb0980","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/nature10525","article-title":"A vascular niche and a VEGF-Nrp1 loop regulate the initiation and stemness of skin tumours","volume":"478","author":"Beck","year":"2011","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.bbamcr.2016.02.016_bb0985","doi-asserted-by":"crossref","first-page":"e60983","DOI":"10.1371\/journal.pone.0060983","article-title":"Activation of NF-kappa B signaling promotes growth of prostate cancer cells in bone","volume":"8","author":"Jin","year":"2013","journal-title":"PLoS One"},{"issue":"8","key":"10.1016\/j.bbamcr.2016.02.016_bb0990","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1038\/ni.2060","article-title":"Inflammation meets cancer, with NF-\u03baB as the matchmaker","volume":"12","author":"Ben-Neriah","year":"2011","journal-title":"Nat. Immunol."},{"issue":"2","key":"10.1016\/j.bbamcr.2016.02.016_bb0995","doi-asserted-by":"crossref","first-page":"531","DOI":"10.3390\/cancers4020531","article-title":"The stroma-a key regulator in prostate function and malignancy","volume":"4","author":"H\u00e4ggl\u00f6f","year":"2012","journal-title":"Cancers (Basel)"},{"issue":"1","key":"10.1016\/j.bbamcr.2016.02.016_bb1000","first-page":"58","article-title":"Primary prostate stromal cells modulate the morphology and migration of primary prostate epithelial cells in type 1 collagen gels","volume":"62","author":"Hall","year":"2002","journal-title":"Cancer Res."},{"issue":"1","key":"10.1016\/j.bbamcr.2016.02.016_bb1005","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.semcdb.2009.10.010","article-title":"Cancer associated fibroblasts in cancer pathogenesis","volume":"21","author":"Franco","year":"2010","journal-title":"Semin. Cell Dev. Biol."},{"issue":"9","key":"10.1016\/j.bbamcr.2016.02.016_bb1010","doi-asserted-by":"crossref","first-page":"4244","DOI":"10.1158\/0008-5472.CAN-06-3946","article-title":"Cross-talk between paracrine-acting cytokine and chemokine pathways promotes malignancy in benign human prostatic epithelium","volume":"67","author":"Ao","year":"2007","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbamcr.2016.02.016_bb1015","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1677\/ERC-09-0109","article-title":"Emerging roles of chemokines in prostate cancer","volume":"16","author":"Vindrieux","year":"2009","journal-title":"Endocr. Relat. Cancer"},{"key":"10.1016\/j.bbamcr.2016.02.016_bb1020","doi-asserted-by":"crossref","first-page":"128","DOI":"10.3389\/fonc.2015.00128","article-title":"Immune infiltration and prostate cancer","volume":"5","author":"Strasner","year":"2015","journal-title":"Front Oncol."},{"issue":"15","key":"10.1016\/j.bbamcr.2016.02.016_bb1025","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1002\/pros.21020","article-title":"Human prostate-infiltrating CD8+ T lymphocytes are oligoclonal and PD-1+","volume":"69","author":"Sfanos","year":"2009","journal-title":"Prostate"},{"issue":"9","key":"10.1016\/j.bbamcr.2016.02.016_bb1030","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1016\/j.ejca.2009.02.015","article-title":"Prostate cancer lesions are surrounded by FOXP3+, PD-1+ and B7-H1+ lymphocyte clusters","volume":"45","author":"Ebelt","year":"2009","journal-title":"Eur. J. Cancer"},{"issue":"12","key":"10.1016\/j.bbamcr.2016.02.016_bb1035","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.1111\/j.1464-410X.2010.09804.x","article-title":"Infiltration of tumour-associated macrophages in prostate biopsy specimens is predictive of disease progression after hormonal therapy for prostate cancer","volume":"107","author":"Nonomura","year":"2011","journal-title":"BJU Int."},{"issue":"1\u20132","key":"10.1016\/j.bbamcr.2016.02.016_bb1040","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.jim.2009.06.004","article-title":"Characterization of the intra-prostatic immune cell infiltration in androgen-deprived prostate cancer patients","volume":"348","author":"Gannon","year":"2009","journal-title":"J. Immunol. Methods"},{"issue":"1","key":"10.1016\/j.bbamcr.2016.02.016_bb1045","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/1479-5876-12-30","article-title":"Tumor infiltrating B-cells are increased in prostate cancer tissue","volume":"12","author":"Woo","year":"2014","journal-title":"J. Transl. Med."},{"issue":"13","key":"10.1016\/j.bbamcr.2016.02.016_bb1050","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1101\/gad.220202.113","article-title":"An IKK\u03b1-E2F1-BMI1 cascade activated by infiltrating B cells controls prostate regeneration and tumor recurrence","volume":"27","author":"Ammirante","year":"2013","journal-title":"Genes Dev."},{"issue":"6835","key":"10.1016\/j.bbamcr.2016.02.016_bb1055","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1038\/35077256","article-title":"Cancer epidemiology in the last century and the next decade","volume":"411","author":"Peto","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.bbamcr.2016.02.016_bb1060","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/978-3-642-38007-5_4","article-title":"The diet as a cause of human prostate cancer","volume":"159","author":"Nelson","year":"2014","journal-title":"Cancer Treat. Res."},{"issue":"23","key":"10.1016\/j.bbamcr.2016.02.016_bb1065","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1093\/jnci\/91.23.2038","article-title":"Heterocyclic amine content of cooked meat and risk of prostate cancer","volume":"91","author":"Norrish","year":"1999","journal-title":"J. Natl. Cancer Inst."},{"issue":"6","key":"10.1016\/j.bbamcr.2016.02.016_bb1070","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1023\/A:1011256201044","article-title":"A prospective study on intake of animal products and risk of prostate cancer","volume":"12","author":"Michaud","year":"2001","journal-title":"Cancer Causes Control"},{"issue":"April","key":"10.1016\/j.bbamcr.2016.02.016_bb1075","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1158\/1055-9965.EPI-06-0973","article-title":"Grilled meat consumption and PhIP-DNA adducts in prostate carcinogenesis","volume":"16","author":"Tang","year":"2007","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"issue":"4","key":"10.1016\/j.bbamcr.2016.02.016_bb1080","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1111\/j.1349-7006.2004.tb03205.x","article-title":"Heterocyclic amines: mutagens\/carcinogens produced during cooking of meet and fish","volume":"95","author":"Sugimura","year":"2004","journal-title":"Cancer Sci."},{"issue":"11","key":"10.1016\/j.bbamcr.2016.02.016_bb1085","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1111\/j.1349-7006.2003.tb01387.x","article-title":"High susceptibility of the ACI and spontaneously hypertensive rat (SHR) strains to 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) prostate carcinogenesis","volume":"94","author":"Inaguma","year":"2003","journal-title":"Cancer Sci."},{"issue":"3","key":"10.1016\/j.bbamcr.2016.02.016_bb1090","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1158\/0008-5472.CAN-06-1336","article-title":"The dietary charred meat carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine acts as both a tumor initiator and promoter in the rat ventral prostate","volume":"67","author":"Nakai","year":"2007","journal-title":"Cancer Res."},{"issue":"8","key":"10.1016\/j.bbamcr.2016.02.016_bb1095","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1158\/1940-6207.CAPR-15-0090","article-title":"Bacterial prostatitis enhances 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced cancer at multiple sites","volume":"8","author":"Sfanos","year":"2015","journal-title":"Cancer Prev. Res."},{"issue":"4","key":"10.1016\/j.bbamcr.2016.02.016_bb1100","first-page":"858","article-title":"Interleukin-6 promotes dietary carcinogen-induced DNA damage in colorectal cancer cells","volume":"4","author":"Patel","year":"2015","journal-title":"R. Soc. Chem."},{"issue":"2","key":"10.1016\/j.bbamcr.2016.02.016_bb1105","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1093\/clinids\/10.2.239","article-title":"Prostatic abscess in the antibiotic era","volume":"10","author":"Weinberger","year":"1988","journal-title":"Rev. Infect. Dis."},{"issue":"12","key":"10.1016\/j.bbamcr.2016.02.016_bb1110","doi-asserted-by":"crossref","first-page":"3120","DOI":"10.1128\/JCM.34.12.3120-3128.1996","article-title":"Prokaryotic DNA sequences in patients with chronic idiopathic prostatitis","volume":"34","author":"Krieger","year":"1996","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.bbamcr.2016.02.016_bb1115","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1002\/(SICI)1096-9071(199705)52:1<8::AID-JMV2>3.0.CO;2-8","article-title":"Analysis of prostate tissue DNA for the presence of human papillomavirus by polymerase chain reaction, cloning, and automated sequencing","volume":"52","author":"Anderson","year":"1997","journal-title":"J. Med. Virol."},{"issue":"1","key":"10.1016\/j.bbamcr.2016.02.016_bb1120","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/1471-2407-11-53","article-title":"Serum antibodies against genitourinary infectious agents in prostate cancer and benign prostate hyperplasia patients: a case\u2013control study","volume":"11","author":"Hrbacek","year":"2011","journal-title":"BMC Cancer"},{"issue":"4","key":"10.1016\/j.bbamcr.2016.02.016_bb1125","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.canep.2014.06.002","article-title":"Sexually transmitted infections and prostate cancer risk: a systematic review and meta-analysis","volume":"38","author":"Caini","year":"2014","journal-title":"Cancer Epidemiol."},{"issue":"12","key":"10.1016\/j.bbamcr.2016.02.016_bb1130","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1586\/eri.11.137","article-title":"Propionibacterium acnes: infection beyond the skin","volume":"9","author":"Perry","year":"2011","journal-title":"Expert Rev. Anti-Infect. Ther."},{"issue":"6","key":"10.1016\/j.bbamcr.2016.02.016_bb1135","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1097\/01.ju.0000158161.15277.78","article-title":"Propionibacterium acnes associated with inflammation in radical prostatectomy specimens: a possible link to cancer evolution?","volume":"173","author":"Cohen","year":"2005","journal-title":"J. Urol."},{"issue":"5","key":"10.1016\/j.bbamcr.2016.02.016_bb1140","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1002\/pros.22936","article-title":"Expression profile analysis of microRNAs in prostate cancer by next-generation sequencing.","volume":"1;75","author":"Song","year":"2015","journal-title":"Prostate"},{"issue":"1","key":"10.1016\/j.bbamcr.2016.02.016_bb1145","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.ijmm.2010.08.014","article-title":"Prevalence of Propionibacterium acnes in diseased prostates and its inflammatory and transforming activity on prostate epithelial cells","volume":"301","author":"Fassi Fehri","year":"2011","journal-title":"Int. J. Med. Microbiol."},{"issue":"9","key":"10.1016\/j.bbamcr.2016.02.016_bb1150","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1002\/pros.22648","article-title":"A mouse model of chronic prostatic inflammation using a human prostate cancer-derived isolate of Propionibacterium acnes","volume":"73","author":"Shinohara","year":"2013","journal-title":"Prostate"},{"issue":"6","key":"10.1016\/j.bbamcr.2016.02.016_bb1155","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1155\/2013\/735843","article-title":"Is human papillomavirus associated with prostate cancer survival?","volume":"35","author":"Pascale","year":"2013","journal-title":"Dis. Markers"},{"key":"10.1016\/j.bbamcr.2016.02.016_bb1160","doi-asserted-by":"crossref","first-page":"7822","DOI":"10.1038\/srep07822","article-title":"Implication of high risk Human papillomavirus HR-HPV infection in prostate cancer in Indian population \u2014 A pioneering case\u2013control analysis","volume":"5","author":"Singh","year":"2015","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.bbamcr.2016.02.016_bb1165","first-page":"137","article-title":"No link between viral findings in the prostate and subsequent cancer development","volume":"96","author":"Bergh","year":"2007","journal-title":"Cancer Res. UK"},{"issue":"4","key":"10.1016\/j.bbamcr.2016.02.016_bb1170","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1097\/00008469-199808000-00006","article-title":"A survey of human papillomavirus 16 antibodies in patients with epithelial cancers","volume":"7","author":"Strickler","year":"1998","journal-title":"Eur. J. Cancer Prev."},{"key":"10.1016\/j.bbamcr.2016.02.016_bb1175","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1158\/1078-0432.CCR-0670-3","article-title":"Epstein\u2013Barr virus and cancer","volume":"10","author":"Thompson","year":"2004","journal-title":"Clin. Cancer Res."},{"issue":"3","key":"10.1016\/j.bbamcr.2016.02.016_bb1180","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1002\/pros.22562","article-title":"Human papillomavirus and Epstein Barr virus in prostate cancer: koilocytes indicate potential oncogenic influences of human papillomavirus in prostate cancer","volume":"73","author":"Whitaker","year":"2013","journal-title":"Prostate"},{"issue":"4","key":"10.1016\/j.bbamcr.2016.02.016_bb1185","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1002\/pros.10157","article-title":"Detection of human polyomaviruses and papillomaviruses in prostatic tissue reveals the prostate as a habitat for multiple viral infections","volume":"53","author":"Zambrano","year":"2002","journal-title":"Prostate"},{"issue":"6","key":"10.1016\/j.bbamcr.2016.02.016_bb1190","doi-asserted-by":"crossref","first-page":"2705","DOI":"10.1128\/JVI.02461-07","article-title":"BK virus as a cofactor in the etiology of prostate cancer in its early stages","volume":"82","author":"Das","year":"2008","journal-title":"J. Virol."},{"issue":"8","key":"10.1016\/j.bbamcr.2016.02.016_bb1195","doi-asserted-by":"crossref","DOI":"10.18632\/oncotarget.3363","article-title":"Antibody response to BK polyomavirus as a prognostic biomarker and potential therapeutic target in prostate cancer","volume":"6","author":"Keller","year":"2015","journal-title":"Oncotarget"},{"issue":"6","key":"10.1016\/j.bbamcr.2016.02.016_bb1200","doi-asserted-by":"crossref","first-page":"e0128955","DOI":"10.1371\/journal.pone.0128955","article-title":"Identification of pathogen signatures in prostate cancer using RNA-seq","volume":"10","author":"Chen","year":"2015","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.bbamcr.2016.02.016_bb1205","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1128\/JCM.36.6.1646-1652.1998","article-title":"Diverse and related 16S rRNA-encoding DNA sequences in prostate tissues of men with chronic prostatitis","volume":"36","author":"Riley","year":"1998","journal-title":"J. Clin. Microbiol."},{"issue":"4","key":"10.1016\/j.bbamcr.2016.02.016_bb1210","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1016\/S0022-5347(05)67145-5","article-title":"Bacterial DNA sequences in prostate tissue from patients with prostate cancer and chronic prostatitis","volume":"164","author":"Krieger","year":"2000","journal-title":"J. Urol."},{"issue":"3","key":"10.1016\/j.bbamcr.2016.02.016_bb1215","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1002\/pros.20680","article-title":"A molecular analysis of prokaryotic and viral DNA sequences in prostate tissue from patients with prostate cancer indicates the presence of multiple and diverse microorganisms","volume":"68","author":"Sfanos","year":"2008","journal-title":"Prostate"},{"issue":"2","key":"10.1016\/j.bbamcr.2016.02.016_bb1220","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1002\/ijc.2910600209","article-title":"Cancer risk after renal transplantation in the Nordic countries, 1964\u20131986","volume":"60","author":"Birkeland","year":"1995","journal-title":"Int. J. Cancer"},{"issue":"1","key":"10.1016\/j.bbamcr.2016.02.016_bb1225","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/sj.bjc.6601416","article-title":"Prostate cancer and use of nonsteroidal anti-inflammatory drugs: systematic review and meta-analysis","volume":"90","author":"Mahmud","year":"2004","journal-title":"Br. J. Cancer"},{"issue":"2","key":"10.1016\/j.bbamcr.2016.02.016_bb1230","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1158\/1055-9965.EPI-04-0532","article-title":"Nonsteroidal anti-inflammatory drugs and risk of prostate cancer in the Baltimore Longitudinal Study of Aging","volume":"14","author":"Platz","year":"2005","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"issue":"4","key":"10.1016\/j.bbamcr.2016.02.016_bb1235","doi-asserted-by":"crossref","first-page":"323","DOI":"10.5489\/cuaj.1129","article-title":"Nonsteroidal anti-inflammatory drugs and prostate cancer: a systematic review of the literature and meta-analysis","volume":"3","author":"Jafari","year":"2009","journal-title":"Can. Urol. Assoc. J."},{"issue":"5","key":"10.1016\/j.bbamcr.2016.02.016_bb1240","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1158\/1055-9965.EPI-13-1126","article-title":"Chronic inflammation in benign prostate tissue is associated with high-grade prostate cancer in the placebo arm of the prostate cancer prevention trial.","volume":"23","author":"Gurel","year":"2014","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"issue":"1","key":"10.1016\/j.bbamcr.2016.02.016_bb1245","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1111\/j.1365-2559.2011.04033.x","article-title":"Prostate cancer and inflammation: the evidence","volume":"60","author":"Sfanos","year":"2012","journal-title":"Histopathology"},{"issue":"5","key":"10.1016\/j.bbamcr.2016.02.016_bb1250","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1016\/S0090-4295(00)00776-7","article-title":"Morphologic transitions between proliferative inflammatory atrophy and high-grade prostatic intraepithelial neoplasia","volume":"56","author":"Putzi","year":"2000","journal-title":"Urology"},{"issue":"6","key":"10.1016\/j.bbamcr.2016.02.016_bb1255","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1016\/S0002-9440(10)65517-4","article-title":"Proliferative inflammatory atrophy of the prostate: implications for prostatic carcinogenesis","volume":"155","author":"De Marzo","year":"1999","journal-title":"Am. J. Pathol."},{"issue":"21","key":"10.1016\/j.bbamcr.2016.02.016_bb1260","doi-asserted-by":"crossref","first-page":"10683","DOI":"10.1158\/0008-5472.CAN-06-0963","article-title":"Decreased NKX3.1 protein expression in focal prostatic atrophy, prostatic intraepithelial neoplasia, and adenocarcinoma: association with Gleason score and chromosome 8p deletion","volume":"66","author":"Bethel","year":"2006","journal-title":"Cancer Res."},{"issue":"9","key":"10.1016\/j.bbamcr.2016.02.016_bb1265","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1097\/00000478-199809000-00005","article-title":"Histology and cellular kinetics of prostatic atrophy","volume":"22","author":"Ruska","year":"1998","journal-title":"Am. J. Surg. Pathol."},{"issue":"1","key":"10.1016\/j.bbamcr.2016.02.016_bb1270","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/nrg1748","article-title":"The epigenetic progenitor origin of human cancer","volume":"7","author":"Feinberg","year":"2006","journal-title":"Nat. Rev. Genet."},{"issue":"2","key":"10.1016\/j.bbamcr.2016.02.016_bb1275","first-page":"142","article-title":"Epigenetic field for cancerization","volume":"40","author":"Ushijima","year":"2007","journal-title":"J. Biochem. Mol. Biol."},{"issue":"6","key":"10.1016\/j.bbamcr.2016.02.016_bb1280","doi-asserted-by":"crossref","first-page":"1950","DOI":"10.3892\/ijo.2012.1646","article-title":"Topographic and quantitative relationship between prostate inflammation, proliferative inflammatory atrophy and low-grade prostate intraepithelial neoplasia: a biopsy study in chronic prostatitis patients","volume":"41","author":"Vral","year":"2012","journal-title":"Int. J. Oncol."},{"issue":"February","key":"10.1016\/j.bbamcr.2016.02.016_bb1285","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1002\/pros.22660","article-title":"High-grade prostatic intraepithelial neoplasia (HGPIN) and topographical distribution in 1374 prostatectomy specimens: existence of HGPIN near prostate cancer","volume":"73","author":"Eminaga","year":"2013","journal-title":"Prostate"},{"issue":"3","key":"10.1016\/j.bbamcr.2016.02.016_bb1290","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1038\/modpathol.3800053","article-title":"High-grade prostatic intraepithelial neoplasia","volume":"17","author":"Bostwick","year":"2004","journal-title":"Mod. Pathol."},{"issue":"2 Pt 1","key":"10.1016\/j.bbamcr.2016.02.016_bb1295","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/S0022-5347(17)35487-3","article-title":"The frequency of carcinoma and intraepithelial neoplasia of the prostate in young male patients","volume":"150","author":"Sakr","year":"1993","journal-title":"J. Urol."},{"issue":"6","key":"10.1016\/j.bbamcr.2016.02.016_bb1300","doi-asserted-by":"crossref","first-page":"376","DOI":"10.3322\/canjclin.39.6.376","article-title":"The pathology of early prostate cancer","volume":"39","author":"Bostwick","year":"1989","journal-title":"CA - Cancer J. Clin."},{"key":"10.1016\/j.bbamcr.2016.02.016_bb1305","article-title":"Molecular evidence that invasive adenocarcinoma can mimic prostatic intraepithelial neoplasia (PIN) and intraductal carcinoma through retrograde glandular colonization","author":"Haffner","year":"2015","journal-title":"J. Pathol."},{"issue":"6","key":"10.1016\/j.bbamcr.2016.02.016_bb1310","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1097\/01.pas.0000213424.38503.aa","article-title":"TMPRSS2-ERG fusion prostate cancer: an early molecular event associated with invasion","volume":"31","author":"Perner","year":"2007","journal-title":"Am. J. Surg. Pathol."},{"key":"10.1016\/j.bbamcr.2016.02.016_bb1315","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/ng.2279","article-title":"Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer.","volume":"44","author":"Barbieri","year":"2012","journal-title":"Nat. Genet."},{"issue":"1","key":"10.1016\/j.bbamcr.2016.02.016_bb1320","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0022-5347(05)00064-9","article-title":"Risk of prostate cancer on first re-biopsy within 1year following a diagnosis of high grade prostatic intraepithelial neoplasia is related to the number of cores sampled","volume":"175","author":"Herawi","year":"2006","journal-title":"J. Urol."},{"issue":"3","key":"10.1016\/j.bbamcr.2016.02.016_bb1325","doi-asserted-by":"crossref","DOI":"10.1016\/S0022-5347(17)72260-4","article-title":"On the frequency of occurrence of occult carcinoma of the prostate","volume":"33","author":"Rich","year":"1935","journal-title":"J. Urol."},{"issue":"2","key":"10.1016\/j.bbamcr.2016.02.016_bb1330","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1002\/path.1700680233","article-title":"Latent carcinoma of the prostate","volume":"68","author":"Franks","year":"1954","journal-title":"J. Pathol. Bacteriol."},{"key":"10.1016\/j.bbamcr.2016.02.016_bb1335","article-title":"The worldwide epidemiology of prostate cancer: perspectives from autopsy studies","author":"Haas","year":"2008","journal-title":"Can. J. Urol."},{"issue":"4","key":"10.1016\/j.bbamcr.2016.02.016_bb1340","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1200\/JCO.2006.06.9351","article-title":"Long-term prediction of prostate cancer up to 25years before diagnosis of prostate cancer using prostate kallikreins measured at age 44 to 50years","volume":"25","author":"Lilja","year":"2007","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.bbamcr.2016.02.016_bb1345","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.eururo.2011.07.067","article-title":"Baseline prostate-specific antigen testing at a young age","volume":"61","author":"Loeb","year":"2012","journal-title":"Eur. Urol."},{"key":"10.1016\/j.bbamcr.2016.02.016_bb1350","doi-asserted-by":"crossref","DOI":"10.1093\/ije\/dym049","article-title":"Commentary: prostate cancer is omnipresent, but should we screen for it?","author":"Martin","year":"2007","journal-title":"Int. J. Epidemiol."},{"key":"10.1016\/j.bbamcr.2016.02.016_bb1355","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/j.eursup.2009.11.002","article-title":"Benign prostatic hyperplasia and its aetiologies","volume":"8","author":"Briganti","year":"2009","journal-title":"Eur. Urol. Suppl."},{"issue":"5","key":"10.1016\/j.bbamcr.2016.02.016_bb1360","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1002\/1097-0142(197805)41:5<1857::AID-CNCR2820410529>3.0.CO;2-T","article-title":"Basal cell proliferation in benign prostatic hyperplasia","volume":"41","author":"Dermer","year":"1978","journal-title":"Cancer"},{"key":"10.1016\/j.bbamcr.2016.02.016_bb1365","article-title":"Telomerase activity and telomere length in human benign prostatic hyperplasia stem-like cells and their progeny implies the existence of distinct basal and luminal cell lineages","author":"Rane","year":"2015","journal-title":"Eur. Urol."},{"issue":"3","key":"10.1016\/j.bbamcr.2016.02.016_bb1370","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1038\/nrm2848","article-title":"Telomeres: protecting chromosomes against genome instability","volume":"11","author":"O'Sullivan","year":"2010","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bbamcr.2016.02.016_bb1375","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2012.01.039","article-title":"Telomerase reactivation following telomere dysfunction yields murine prostate tumors with bone metastases","author":"Ding","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.bbamcr.2016.02.016_bb1380","first-page":"218","article-title":"Telomerase activity \u2014 a prevalent marker of malignant prostate cancer","volume":"56","author":"Sommerfeld","year":"1996","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbamcr.2016.02.016_bb1385","article-title":"Telomerase activity in prostate cancer, prostatic intraepithelial neoplasia, and benign prostatic epithelium","author":"Zhang","year":"1998","journal-title":"Cancer Res."},{"issue":"5","key":"10.1016\/j.bbamcr.2016.02.016_bb1390","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1016\/S0022-5347(05)68239-0","article-title":"Association between outcome and telomere DNA content in prostate cancer","volume":"162","author":"Donaldson","year":"1999","journal-title":"J. Urol."},{"key":"10.1016\/j.bbamcr.2016.02.016_bb1395","article-title":"Telomere shortening is an early somatic DNA alteration in human prostate tumorigenesis","author":"Meeker","year":"2002","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbamcr.2016.02.016_bb1400","doi-asserted-by":"crossref","DOI":"10.1046\/j.1365-2362.2000.00636.x","article-title":"Telomerase activity in needle biopsies from prostate cancer and benign prostates","author":"Wymenga","year":"2000","journal-title":"Eur. J. Clin. Investig."},{"issue":"2","key":"10.1016\/j.bbamcr.2016.02.016_bb1405","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1146\/annurev.med.51.1.65","article-title":"Role of telomerase in cell senescence and oncogenesis","volume":"51","author":"Urquidi","year":"2000","journal-title":"Annu. Rev. Med."},{"issue":"10","key":"10.1016\/j.bbamcr.2016.02.016_bb1410","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1158\/2159-8290.CD-13-0135","article-title":"Prostate cancer cell telomere length variability and stromal cell telomere length as prognostic markers for metastasis and death","volume":"3","author":"Heaphy","year":"2013","journal-title":"Cancer Discov."},{"key":"10.1016\/j.bbamcr.2016.02.016_bb1415","doi-asserted-by":"crossref","unstructured":"Rane JK, Simms MS, Maitland NJ. Re: Yves Allorya, Willemien Beukers, Ana Sagrera, et al. Telomerase Reverse Transcriptase Promoter Mutations in Bladder Cancer: High Frequency Across Stages, Detection in Urine, and Lack of Association with Outcome. Eur. Urol. 2014;65(6):e85\u20136.","DOI":"10.1016\/j.eururo.2014.02.030"},{"issue":"19","key":"10.1016\/j.bbamcr.2016.02.016_bb1420","doi-asserted-by":"crossref","first-page":"2410","DOI":"10.1101\/gad.819500","article-title":"Molecular genetics of prostate cancer","volume":"14","author":"Abate-Shen","year":"2000","journal-title":"Genes Dev."},{"issue":"5","key":"10.1016\/j.bbamcr.2016.02.016_bb1425","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1038\/nrg2763","article-title":"Alternative lengthening of telomeres: models, mechanisms and implications","volume":"11","author":"Cesare","year":"2010","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.bbamcr.2016.02.016_bb1430","doi-asserted-by":"crossref","DOI":"10.1038\/nature07943","article-title":"The cancer genome","author":"Stratton","year":"2009","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.bbamcr.2016.02.016_bb1435","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1073\/pnas.1421839112","article-title":"Only three driver gene mutations are required for the development of lung and colorectal cancers.","volume":"6;112","author":"Tomasetti","year":"2015","journal-title":"PNAS"},{"issue":"4","key":"10.1016\/j.bbamcr.2016.02.016_bb1440","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1007\/s00432-012-1367-z","article-title":"Predictors of early distant metastasis in women with breast cancer","volume":"139","author":"Rosa Mendoza","year":"2013","journal-title":"J. Cancer Res. Clin. Oncol."},{"issue":"2","key":"10.1016\/j.bbamcr.2016.02.016_bb1445","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.cell.2011.09.024","article-title":"Tumor metastasis: molecular insights and evolving paradigms","volume":"147","author":"Valastyan","year":"2012","journal-title":"Cell"},{"issue":"9","key":"10.1016\/j.bbamcr.2016.02.016_bb1450","doi-asserted-by":"crossref","first-page":"e1001162","DOI":"10.1371\/journal.pbio.1001162","article-title":"Mesenchymal transition and dissemination of cancer cells is driven by myeloid-derived suppressor cells infiltrating the primary tumor","volume":"9","author":"Toh","year":"2011","journal-title":"PLoS Biol."},{"issue":"10","key":"10.1016\/j.bbamcr.2016.02.016_bb1455","doi-asserted-by":"crossref","first-page":"4417","DOI":"10.1128\/JVI.63.10.4417-4421.1989","article-title":"The E6 and E7 genes of the human papillomavirus type 16 together are necessary and sufficient for transformation of primary human keratinocytes","volume":"63","author":"Munger","year":"1989","journal-title":"J. Virol."},{"issue":"21","key":"10.1016\/j.bbamcr.2016.02.016_bb1460","doi-asserted-by":"crossref","first-page":"497","DOI":"10.4049\/jimmunol.167.1.497","article-title":"Both E6 and E7 oncoproteins of human papillomavirus 16 inhibit IL-18-induced IFN-gamma production in human peripheral blood mononuclear and NK cells","volume":"167","author":"Lee","year":"2001","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.bbamcr.2016.02.016_bb1465","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-2567.2007.02587.x","article-title":"Cancer immunoediting from immune surveillance to immune escape","volume":"121","author":"Kim","year":"2007","journal-title":"Immunology"},{"issue":"3","key":"10.1016\/j.bbamcr.2016.02.016_bb1470","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1016\/j.cell.2015.05.001","article-title":"Integrative clinical genomics of advanced prostate cancer","volume":"161","author":"Dan Robinson","year":"2015","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.bbamcr.2016.02.016_bb1475","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/S0090-4295(99)80018-1","article-title":"Frequency and characterization of p53 mutations in clinically localized prostate cancer","volume":"45","author":"Hall","year":"1995","journal-title":"Urology"},{"issue":"August","key":"10.1016\/j.bbamcr.2016.02.016_bb1480","first-page":"2082","article-title":"Inactivation of the p53 pathway in prostate cancer: impact on tumor progression","volume":"5","author":"Osman","year":"1999","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.bbamcr.2016.02.016_bb1485","article-title":"Massively parallel sequencing fails to detect minor resistant subclones in tissue samples prior to tyrosine kinase inhibitor therapy","volume":"15","author":"Heydt","year":"2011","journal-title":"BMC Cancer"},{"issue":"1","key":"10.1016\/j.bbamcr.2016.02.016_bb1490","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/bjc.1954.1","article-title":"The age distribution of cancer and a multi-stage theory of carcinogenesis","volume":"8","author":"Armitage","year":"1954","journal-title":"Br. J. Cancer"},{"issue":"1","key":"10.1016\/j.bbamcr.2016.02.016_bb1495","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/0002-9343(77)90124-3","article-title":"Chronic myelocytic leukemia: clonal origin in a stem cell common to the granulocyte, erythrocyte, platelet and monocyte\/macrophage","volume":"63","author":"Fialkow","year":"1977","journal-title":"Am. J. Med."},{"key":"10.1016\/j.bbamcr.2016.02.016_bb1500","unstructured":"Berger MF, Lawrence MS, Demichelis F, Drier Y, Cibulskis K, Sivachenko AY, et al. The genomic complexity of primary human prostate cancer. Ashutosh Tewari [Internet]. 1121314(15). Available from: http:\/\/www.nature.com\/authors\/editorial_policies\/license.html#terms"},{"key":"10.1016\/j.bbamcr.2016.02.016_bb1505","doi-asserted-by":"crossref","DOI":"10.1038\/nature11125","article-title":"The mutational landscape of lethal castration-resistant prostate cancer","author":"Grasso","year":"2012","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.bbamcr.2016.02.016_bb1510","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.ccr.2010.03.018","article-title":"An integrated network of androgen receptor, polycomb, and TMPRSS2-ERG gene fusions in prostate cancer progression","volume":"17","author":"Yu","year":"2010","journal-title":"Cancer Cell"},{"issue":"5","key":"10.1016\/j.bbamcr.2016.02.016_bb1515","doi-asserted-by":"crossref","first-page":"e10547","DOI":"10.1371\/journal.pone.0010547","article-title":"ETS transcription factors control transcription of EZH2 and epigenetic silencing of the tumor suppressor gene Nkx3.1 in prostate cancer","volume":"5","author":"Kunderfranco","year":"2010","journal-title":"PLoS One"},{"issue":"10","key":"10.1016\/j.bbamcr.2016.02.016_bb1520","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1038\/cr.2007.83","article-title":"JMJD3 is a histone H3K27 demethylase","volume":"17","author":"Xiang","year":"2007","journal-title":"Cell Res."},{"issue":"49","key":"10.1016\/j.bbamcr.2016.02.016_bb1525","doi-asserted-by":"crossref","first-page":"19226","DOI":"10.1073\/pnas.0700735104","article-title":"JARID1B is a histone H3 lysine 4 demethylase up-regulated in prostate cancer","volume":"104","author":"Xiang","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"7100","key":"10.1016\/j.bbamcr.2016.02.016_bb1530","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/nature04837","article-title":"The putative oncogene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3","volume":"442","author":"Cloos","year":"2006","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.bbamcr.2016.02.016_bb1535","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1002\/mc.10033","article-title":"DNA methyltransferase and demethylase in human prostate cancer","volume":"33","author":"Patra","year":"2002","journal-title":"Mol. Carcinog."},{"issue":"5","key":"10.1016\/j.bbamcr.2016.02.016_bb1540","first-page":"297","article-title":"Molecular mechanisms and potential functions of histone demethylases","volume":"13","author":"Kooistra","year":"2012","journal-title":"Nat. Publ. Group"},{"issue":"3","key":"10.1016\/j.bbamcr.2016.02.016_bb1545","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0004687","article-title":"Genome-wide profiling of Histone H3 Lysine 4 and Lysine 27 trimethylation reveals an epigenetic signature in prostate carcinogenesis","volume":"4","author":"Ke","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.bbamcr.2016.02.016_bb1550","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1186\/1471-2164-11-669","article-title":"Global profiling of histone and DNA methylation reveals epigenetic-based regulation of gene expression during epithelial to mesenchymal transition in prostate cells","volume":"11","author":"Ke","year":"2010","journal-title":"BMC Genomics"},{"issue":"5748","key":"10.1016\/j.bbamcr.2016.02.016_bb1555","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1126\/science.1117679","article-title":"Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer","volume":"310","author":"Tomlins","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.bbamcr.2016.02.016_bb1560","doi-asserted-by":"crossref","DOI":"10.1158\/0008-5472.CAN-12-1342","article-title":"CHD1 Is a 5q21 tumor suppressor required for ERG rearrangement in prostate cancer","author":"Burkhardt","year":"2013","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbamcr.2016.02.016_bb1565","article-title":"Assembly of methylated KDM1A and CHD1 drives androgen receptor-dependent transcription and translocation","author":"Metzger","year":"2016","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.bbamcr.2016.02.016_bb1570","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.molcel.2015.07.025","article-title":"Truncated ERG oncoproteins from TMPRSS2-ERG fusions are resistant to SPOP-mediated proteasome degradation","volume":"59","author":"An","year":"2015","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bbamcr.2016.02.016_bb1575","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.molcel.2015.07.026","article-title":"SPOP promotes ubiquitination and degradation of the ERG oncoprotein to suppress prostate cancer progression","volume":"59","author":"Gan","year":"2015","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bbamcr.2016.02.016_bb1580","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.09207","article-title":"SPOP mutation leads to genomic instability in prostate cancer","author":"Boysen","year":"2015","journal-title":"Elife"},{"key":"10.1016\/j.bbamcr.2016.02.016_bb1585","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2015.07.017","article-title":"Integration of copy number and transcriptomics provides risk stratification in prostate cancer: a discovery and validation cohort study","author":"Ross-Adams","year":"2015","journal-title":"EBioMedicine"},{"issue":"3","key":"10.1016\/j.bbamcr.2016.02.016_bb1590","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1073\/pnas.0304146101","article-title":"Gene expression profiling identifies clinically relevant subtypes of prostate cancer","volume":"20;101","author":"Lapointe","year":"2004","journal-title":"PNAS"},{"key":"10.1016\/j.bbamcr.2016.02.016_bb1595","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1016\/j.cell.2015.10.025","article-title":"The molecular taxonomy of primary prostate cancer","volume":"163","author":"Network","year":"2015","journal-title":"Cell"},{"issue":"10","key":"10.1016\/j.bbamcr.2016.02.016_bb1600","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1056\/NEJMoa1113205","article-title":"Intratumor heterogeneity and branched evolution revealed by multiregion sequencing","volume":"36610366","author":"Gerlinger","year":"2012","journal-title":"N. Engl. J. Med."},{"issue":"7319","key":"10.1016\/j.bbamcr.2016.02.016_bb1605","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1038\/nature09515","article-title":"Distant metastasis occurs late during the genetic evolution of pancreatic cancer","volume":"467","author":"Yachida","year":"2010","journal-title":"Nature"},{"issue":"11","key":"10.1016\/j.bbamcr.2016.02.016_bb1610","doi-asserted-by":"crossref","DOI":"10.1172\/JCI70354","article-title":"Tracking the clonal origin of lethal prostate cancer","volume":"123","author":"Haffner","year":"2013","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.bbamcr.2016.02.016_bb1615","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms7605","article-title":"Tracking the origins and drivers of subclonal metastatic expansion in prostate cancer","volume":"6","author":"Hong","year":"2015","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.bbamcr.2016.02.016_bb1620","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1002\/ar.1091750108","article-title":"The role of androgens in the epithelio-mesenchymal interactions involved in prostatic morphogenesis in embryonic mice'","volume":"175","author":"Cunha","year":"1973","journal-title":"Anat. Rec."},{"key":"10.1016\/j.bbamcr.2016.02.016_bb1625","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s00441-005-1121-9","article-title":"Early prostate development and its association with late-life prostate disease","volume":"322","author":"Risbridger","year":"2005","journal-title":"Cell Tissue Res."},{"issue":"2","key":"10.1016\/j.bbamcr.2016.02.016_bb1630","first-page":"209","article-title":"The effects of castration on advanced carcinoma of the prostate gland","volume":"43","author":"Huggins","year":"1941","journal-title":"JAMA Surg."},{"issue":"5957","key":"10.1016\/j.bbamcr.2016.02.016_bb1635","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1126\/science.1178124","article-title":"Induced chromosomal proximity and the genesis of gene fusions in prostate cancer.","volume":"27;326","author":"Mani","year":"2009","journal-title":"Science (80)"},{"issue":"1396","key":"10.1016\/j.bbamcr.2016.02.016_bb1640","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1016\/j.cell.2009.11.030","article-title":"Nuclear receptor-induced chromosomal proximity and DNA breaks underlie specific translocations in cancer","volume":"11","author":"Lin","year":"2009","journal-title":"Cell"},{"issue":"8","key":"10.1016\/j.bbamcr.2016.02.016_bb1645","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1038\/ng.613","article-title":"Androgen-induced TOP2B mediated double strand breaks and prostate cancer gene rearrangements","volume":"42","author":"Haffner","year":"2010","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbamcr.2016.02.016_bb1650","series-title":"TMPRSS2:ERG blocks neuroendocrine and luminal cell differentiation to maintain prostate cancer proliferation","author":"Mounir","year":"2014"},{"issue":"4","key":"10.1016\/j.bbamcr.2016.02.016_bb1655","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1038\/ng0495-401","article-title":"In vivo amplification of the androgen receptor gene and progression of human prostate cancer","volume":"9","author":"Visakorpi","year":"1995","journal-title":"Nat. Genet."},{"issue":"12","key":"10.1016\/j.bbamcr.2016.02.016_bb1660","first-page":"1541","article-title":"Mutant androgen receptor detected in an advanced-stage prostatic carcinoma is activated by adrenal androgens and progesterone","volume":"7","author":"Culig","year":"1993","journal-title":"Mol. Endocrinol."},{"issue":"13","key":"10.1016\/j.bbamcr.2016.02.016_bb1665","doi-asserted-by":"crossref","first-page":"5469","DOI":"10.1158\/0008-5472.CAN-08-0594","article-title":"Splicing of a novel androgen receptor exon generates a constitutively active androgen receptor that mediates prostate cancer therapy resistance","volume":"68","author":"Dehm","year":"2008","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbamcr.2016.02.016_bb1670","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.celrep.2014.01.013","article-title":"Destruction of full-length androgen receptor by wild-type SPOP, but not prostate-cancer-associated mutants","volume":"6","author":"An","year":"2014","journal-title":"Cell Rep."},{"issue":"4","key":"10.1016\/j.bbamcr.2016.02.016_bb1675","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.ccr.2009.02.021","article-title":"Regulation of androgen receptor transcriptional activity and specificity by RNF6-induced ubiquitination","volume":"15","author":"Xu","year":"2009","journal-title":"Cancer Cell"},{"issue":"3","key":"10.1016\/j.bbamcr.2016.02.016_bb1680","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1002\/jcp.21154","article-title":"The role of androgen in determining differentiation and regulation of androgen receptor expression in the human prostatic epithelium transient amplifying population","volume":"212","author":"Heer","year":"2007","journal-title":"J. Cell. Physiol."},{"issue":"5","key":"10.1016\/j.bbamcr.2016.02.016_bb1685","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: the next generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"issue":"February","key":"10.1016\/j.bbamcr.2016.02.016_bb1690","first-page":"1","article-title":"DNA damage response and prostate cancer: defects, regulation and therapeutic implications","author":"Karanika","year":"2014","journal-title":"Oncogene"},{"key":"10.1016\/j.bbamcr.2016.02.016_bb1695","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms5988","article-title":"Complex MSH2 and MSH6 mutations in hypermutated microsatellite unstable advanced prostate cancer","volume":"5","author":"Pritchard","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbamcr.2016.02.016_bb1700","doi-asserted-by":"crossref","DOI":"10.1038\/bjc.2012.146","article-title":"Germline BRCA1 mutations increase prostate cancer risk","volume":"106","author":"Leongamornlert","year":"2012","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.bbamcr.2016.02.016_bb1705","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1136\/jmg.2004.028829","article-title":"Cancer risks in BRCA2 families: estimates for sites other than breast and ovary","volume":"42","author":"Van Asperen","year":"2005","journal-title":"J. Med. Genet."},{"issue":"2","key":"10.1016\/j.bbamcr.2016.02.016_bb1710","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1086\/346094","article-title":"Mutations in CHEK2 associated with prostate cancer risk","volume":"72","author":"Dong","year":"2003","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.bbamcr.2016.02.016_bb1715","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1007\/978-1-59745-416-2_18","article-title":"Single nucleotide polymorphisms in DNA repair genes and prostate cancer risk","volume":"471","author":"Park","year":"2009","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.bbamcr.2016.02.016_bb1720","doi-asserted-by":"crossref","unstructured":"Beltran H, Yelensky R, Frampton GM, Park K, Downing SR, Macdonald TY, et al. Targeted next-generation sequencing of advanced prostate cancer identifies potential therapeutic targets and disease heterogeneity. Available from: http:\/\/dx.doi.org\/10.1016\/j.eururo.2012.08.053","DOI":"10.1016\/j.eururo.2012.08.053"},{"issue":"10","key":"10.1016\/j.bbamcr.2016.02.016_bb1725","first-page":"435","article-title":"PTEN losses exhibit heterogeneity in multifocal prostatic adenocarcinoma and are associated with higher Gleason grade","volume":"26","author":"Yoshimoto","year":"2012","journal-title":"Mod. Pathol."},{"issue":"49","key":"10.1016\/j.bbamcr.2016.02.016_bb1730","doi-asserted-by":"crossref","first-page":"5501","DOI":"10.1038\/onc.2013.206","article-title":"Prostate cancer progression after androgen deprivation therapy: mechanisms of castrate resistance and novel therapeutic approaches","volume":"32","author":"Karantanos","year":"2013","journal-title":"Oncogene"},{"issue":"12","key":"10.1016\/j.bbamcr.2016.02.016_bb1735","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1158\/2159-8290.CD-12-0120","article-title":"Dual roles of PARP-1 promote cancer growth and progression","volume":"2","author":"Schiewer","year":"2012","journal-title":"Cancer Discov."},{"issue":"11","key":"10.1016\/j.bbamcr.2016.02.016_bb1740","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1158\/2159-8290.CD-13-0108","article-title":"A hormone-DNA repair circuit governs the response to genotoxic insult","volume":"3","author":"Goodwin","year":"2013","journal-title":"Cancer Discov."},{"issue":"11","key":"10.1016\/j.bbamcr.2016.02.016_bb1745","doi-asserted-by":"crossref","first-page":"3030","DOI":"10.1158\/1055-9965.EPI-09-0772","article-title":"Predisposition for TMPRSS2-ERG fusion in prostate cancer by variants in DNA repair genes","volume":"18","author":"Luedeke","year":"2009","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"issue":"4","key":"10.1016\/j.bbamcr.2016.02.016_bb1750","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1038\/sj.bjc.6604242","article-title":"CD44+ CD24(\u2212) prostate cells are early cancer progenitor\/stem cells that provide a model for patients with poor prognosis","volume":"98","author":"Hurt","year":"2008","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.bbamcr.2016.02.016_bb1755","series-title":"Cancer Stem Cells: Mirage or Reality?","author":"Gupta","year":"2009"},{"issue":"6","key":"10.1016\/j.bbamcr.2016.02.016_bb1760","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1016\/j.celrep.2014.08.029","article-title":"Single-cell RNA sequencing identifies extracellular matrix gene expression by pancreatic circulating tumor cells","volume":"8","author":"Ting","year":"2014","journal-title":"Cell Rep."},{"issue":"17","key":"10.1016\/j.bbamcr.2016.02.016_bb1765","doi-asserted-by":"crossref","first-page":"8337","DOI":"10.1158\/0008-5472.CAN-06-1482","article-title":"TMPRSS2:ERG fusion-associated deletions provide insight into the heterogeneity of prostate cancer","volume":"66","author":"Perner","year":"2006","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbamcr.2016.02.016_bb1770","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.cell.2014.08.016","article-title":"Organoid cultures derived from patients with advanced prostate cancer","volume":"159","author":"Gao","year":"2014","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.bbamcr.2016.02.016_bb1775","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1002\/(SICI)1097-0045(19990501)39:2<135::AID-PROS9>3.0.CO;2-S","article-title":"Neuroendocrine differentiation in prostatic carcinoma","volume":"39","author":"Abrahamsson","year":"1999","journal-title":"Prostate"},{"issue":"6","key":"10.1016\/j.bbamcr.2016.02.016_bb1780","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1002\/pros.20910","article-title":"Shared TP53 gene mutation in morphologically and phenotypically distinct concurrent primary small cell neuroendocrine carcinoma and adenocarcinoma of the prostate","volume":"69","author":"Hansel","year":"2009","journal-title":"Prostate"},{"key":"10.1016\/j.bbamcr.2016.02.016_bb1785","first-page":"487","volume":"Vol. 1(6)","author":"Beltran","year":"2011"},{"key":"10.1016\/j.bbamcr.2016.02.016_bb1790","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1038\/sj.bjc.6690684","article-title":"Switch from antagonist to agonist of the androgen receptor bicalutamide is associated with prostate tumour progression in a new model system","volume":"81","author":"Culig","year":"1999","journal-title":"Br. J. Cancer"},{"issue":"9","key":"10.1016\/j.bbamcr.2016.02.016_bb1795","doi-asserted-by":"crossref","first-page":"4904","DOI":"10.1073\/pnas.081565498","article-title":"Crystallographic structures of the ligand-binding domains of the androgen receptor and its T877A mutant complexed with the natural agonist dihydrotestosterone","volume":"24;98","author":"Sack","year":"2001","journal-title":"PNAS"},{"issue":"12","key":"10.1016\/j.bbamcr.2016.02.016_bb1800","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1038\/labinvest.3780378","article-title":"Androgen receptor alterations in prostate cancer relapsed during a combined androgen blockade by orchiectomy and bicalutamide","volume":"81","author":"Haapala","year":"2001","journal-title":"Lab. Investig."},{"issue":"2","key":"10.1016\/j.bbamcr.2016.02.016_bb1805","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1677\/erc.0.0100209","article-title":"Androgen receptor involvement in the progression of prostate cancer","volume":"10","author":"Suzuki","year":"2003","journal-title":"Endocr Relat Cancer."},{"issue":"21","key":"10.1016\/j.bbamcr.2016.02.016_bb1810","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1056\/NEJM199505253322101","article-title":"Mutation of the androgen-receptor gene in metastatic androgen-independent prostate cancer","volume":"332","author":"Taplin","year":"1995","journal-title":"N. Engl. J. Med."},{"issue":"9","key":"10.1016\/j.bbamcr.2016.02.016_bb1815","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1158\/2159-8290.CD-13-0226","article-title":"A clinically relevant androgen receptor mutation confers resistance to second-generation antiandrogens enzalutamide and ARN-509","volume":"3","author":"Joseph","year":"2013","journal-title":"Cancer Discov."},{"issue":"9","key":"10.1016\/j.bbamcr.2016.02.016_bb1820","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1158\/2159-8290.CD-13-0142","article-title":"An F876l mutation in androgen receptor confers genetic and phenotypic resistance to MDV3100 (Enzalutamide)","volume":"3","author":"Korpal","year":"2013","journal-title":"Cancer Discov."},{"issue":"4","key":"10.1016\/j.bbamcr.2016.02.016_bb1825","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.neo.2015.03.004","article-title":"Development and validation of a scalable next-generation sequencing system for assessing relevant somatic variants in solid tumors","volume":"17","author":"Hovelson","year":"2015","journal-title":"Neoplasia"},{"issue":"2","key":"10.1016\/j.bbamcr.2016.02.016_bb1830","doi-asserted-by":"crossref","first-page":"489","DOI":"10.2353\/ajpath.2009.080727","article-title":"NF-kappaB regulates androgen receptor expression and prostate cancer growth","volume":"175","author":"Zhang","year":"2009","journal-title":"Am. J. Pathol."},{"issue":"12","key":"10.1016\/j.bbamcr.2016.02.016_bb1835","doi-asserted-by":"crossref","first-page":"4478","DOI":"10.1172\/JCI44239","article-title":"The retinoblastoma tumor suppressor controls androgen signaling and human prostate cancer progression","volume":"120","author":"Sharma","year":"2010","journal-title":"J. Clin. Invest."},{"issue":"6254","key":"10.1016\/j.bbamcr.2016.02.016_bb1840","article-title":"Tumor clone dynamics in lethal prostate cancer HHS Public Access","volume":"17","author":"Carreira","year":"2014","journal-title":"Sci. Transl. Med. Sept."},{"issue":"7547","key":"10.1016\/j.bbamcr.2016.02.016_bb1845","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/nature14347","article-title":"The evolutionary history of lethal metastatic prostate cancer","volume":"520","author":"Gundem","year":"2015","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.bbamcr.2016.02.016_bb1850","first-page":"803","article-title":"Survey of gene amplifications during prostate cancer progression by high-throughout fluorescence in situ hybridization on tissue microarrays","volume":"59","author":"Bubendorf","year":"1999","journal-title":"Cancer Res."},{"issue":"22","key":"10.1016\/j.bbamcr.2016.02.016_bb1855","first-page":"6606","article-title":"Characterization of a novel androgen receptor mutation in a relapsed CWR22 prostate cancer xenograft and cell line","volume":"62","author":"Tepper","year":"2002","journal-title":"Cancer Res."},{"issue":"6","key":"10.1016\/j.bbamcr.2016.02.016_bb1860","doi-asserted-by":"crossref","first-page":"2305","DOI":"10.1158\/0008-5472.CAN-08-3795","article-title":"A novel androgen receptor splice variant is up-regulated during prostate cancer progression and promotes androgen depletion-resistant growth","volume":"69","author":"Guo","year":"2009","journal-title":"Cancer Res."},{"issue":"1","key":"10.1016\/j.bbamcr.2016.02.016_bb1865","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1158\/0008-5472.CAN-08-2764","article-title":"Ligand-independent androgen receptor variants derived from splicing of cryptic exons signify hormone-refractory prostate cancer","volume":"69","author":"Hu","year":"2009","journal-title":"Cancer Res."},{"issue":"2","key":"10.1016\/j.bbamcr.2016.02.016_bb1870","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1158\/0008-5472.CAN-12-3630","article-title":"Androgen receptor splice variants mediate enzalutamide resistance in castration-resistant prostate cancer cell lines","volume":"73","author":"Li","year":"2013","journal-title":"Cancer Res."},{"issue":"11","key":"10.1016\/j.bbamcr.2016.02.016_bb1875","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1056\/NEJMoa1315815","article-title":"AR-V7 and resistance to enzalutamide and abiraterone in prostate cancer","volume":"371","author":"Antonarakis","year":"2014","journal-title":"N. Engl. J. Med."},{"issue":"6","key":"10.1016\/j.bbamcr.2016.02.016_bb1880","doi-asserted-by":"crossref","first-page":"T209","DOI":"10.1530\/ERC-15-0217","article-title":"Androgen receptor and prostate cancer stem cells: biological mechanisms and clinical implications","volume":"22","author":"Deng","year":"2015","journal-title":"Endocr. Relat. Cancer."},{"key":"10.1016\/j.bbamcr.2016.02.016_bb1885","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1002\/path.4274","article-title":"Somatic copy number alterations by whole-exome sequencing implicates YWHAZ and PTK2 in castration-resistant prostate cancer","volume":"231","author":"Menon","year":"2013","journal-title":"J. Pathol."},{"issue":"2","key":"10.1016\/j.bbamcr.2016.02.016_bb1890","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.eururo.2013.08.011","article-title":"Platinum priority \u2013 prostate cancer next-generation sequencing of advanced prostate cancer treated with androgen-deprivation therapy","volume":"66","author":"Rajan","year":"2014","journal-title":"Eur. Urol."},{"issue":"5","key":"10.1016\/j.bbamcr.2016.02.016_bb1895","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1038\/cr.2008.50","article-title":"Prostate cancer and metastasis initiating stem cells","volume":"18","author":"Kelly","year":"2008","journal-title":"Cell Res."},{"issue":"6","key":"10.1016\/j.bbamcr.2016.02.016_bb1900","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1002\/jso.21806","article-title":"Prostate cancer stem cells and their potential roles in metastasis","volume":"103","author":"Li","year":"2011","journal-title":"J. Surg. Oncol."},{"key":"10.1016\/j.bbamcr.2016.02.016_bb1905","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.eururo.2014.09.005","article-title":"MicroRNA expression profile of primary prostate cancer stem cells as a source of biomarkers and therapeutic targets","volume":"67","author":"Rane","year":"2015","journal-title":"Eur. Urol."},{"issue":"47","key":"10.1016\/j.bbamcr.2016.02.016_bb1910","doi-asserted-by":"crossref","first-page":"E6544","DOI":"10.1073\/pnas.1518007112","article-title":"A basal stem cell signature identifies aggressive prostate cancer phenotypes","volume":"24;112","author":"Smith","year":"2015","journal-title":"PNAS"}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167488916300416?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167488916300416?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,6,5]],"date-time":"2022-06-05T05:17:52Z","timestamp":1654406272000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167488916300416"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6]]},"references-count":382,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["S0167488916300416"],"URL":"https:\/\/doi.org\/10.1016\/j.bbamcr.2016.02.016","relation":{},"ISSN":["0167-4889"],"issn-type":[{"value":"0167-4889","type":"print"}],"subject":[],"published":{"date-parts":[[2016,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The molecular and cellular origin of human prostate cancer","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Cell Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbamcr.2016.02.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V.","name":"copyright","label":"Copyright"}]}}