{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T10:50:47Z","timestamp":1789901447068,"version":"4.0.1"},"reference-count":34,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"vor","delay-in-days":365,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"FONDECYT\/CONICYT","award":["1120923"],"award-info":[{"award-number":["1120923"]}]},{"name":"FONDECYT\/CONICYT","award":["1151031"],"award-info":[{"award-number":["1151031"]}]},{"name":"FONDAP\/CONICYT","award":["15130011"],"award-info":[{"award-number":["15130011"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Cell Research"],"published-print":{"date-parts":[[2016,6]]},"DOI":"10.1016\/j.bbamcr.2016.03.009","type":"journal-article","created":{"date-parts":[[2016,3,11]],"date-time":"2016-03-11T07:45:32Z","timestamp":1457682332000},"page":"1200-1207","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"PA","title":["Rapamycin requires AMPK activity and p27 expression for promoting autophagy-dependent Tsc2 -null cell survival"],"prefix":"10.1016","volume":"1863","author":[{"given":"Tania","family":"Campos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javiera","family":"Ziehe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Fuentes-Villalobos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orlando","family":"Riquelme","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Pe\u00f1a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"Troncoso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Lavandero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Violeta","family":"Morin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roxana","family":"Pincheira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariel F.","family":"Castro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbamcr.2016.03.009_bb0005","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s004390000348","article-title":"Molecular genetic advances in tuberous sclerosis","volume":"107","author":"Cheadle","year":"2000","journal-title":"Hum. Genet."},{"key":"10.1016\/j.bbamcr.2016.03.009_bb0010","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1086\/316951","article-title":"Mutational analysis in a cohort of 224 tuberous sclerosis patients indicates increased severity of TSC2, compared with TSC1, disease in multiple organs","volume":"68","author":"Dabora","year":"2001","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.bbamcr.2016.03.009_bb0015","doi-asserted-by":"crossref","first-page":"6085","DOI":"10.1073\/pnas.97.11.6085","article-title":"Mutations in the tuberous sclerosis complex gene TSC2 are a cause of sporadic pulmonary lymphangioleiomyomatosis","volume":"97","author":"Carsillo","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbamcr.2016.03.009_bb0020","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.ccr.2006.01.021","article-title":"TORgeting oncogene addiction for cancer therapy","volume":"9","author":"Choo","year":"2006","journal-title":"Cancer Cell"},{"key":"10.1016\/j.bbamcr.2016.03.009_bb0025","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1016\/S0140-6736(03)13044-9","article-title":"Mutation in TSC2 and activation of mammalian target of rapamycin signalling pathway in renal angiomyolipoma","volume":"361","author":"El-Hashemite","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.bbamcr.2016.03.009_bb0030","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/1476-4598-8-38","article-title":"Equivalent benefit of mTORC1 blockade and combined PI3K-mTOR blockade in a mouse model of tuberous sclerosis","volume":"8","author":"Pollizzi","year":"2009","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.bbamcr.2016.03.009_bb0035","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1056\/NEJMoa063564","article-title":"Sirolimus for angiomyolipoma in tuberous sclerosis complex or lymphangioleiomyomatosis","volume":"358","author":"Bissler","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbamcr.2016.03.009_bb0040","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1056\/NEJMe0707153","article-title":"Efficacy of sirolimus in treating tuberous sclerosis and lymphangioleiomyomatosis","volume":"358","author":"Paul","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbamcr.2016.03.009_bb0045","doi-asserted-by":"crossref","first-page":"12455","DOI":"10.1073\/pnas.1104361108","article-title":"Tumorigenesis in tuberous sclerosis complex is autophagy and p62\/sequestosome 1 (SQSTM1)-dependent","volume":"108","author":"Parkhitko","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbamcr.2016.03.009_bb0050","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1002\/path.2694","article-title":"Autophagy: assays and artifacts","volume":"221","author":"Barth","year":"2010","journal-title":"J. Pathol."},{"key":"10.1016\/j.bbamcr.2016.03.009_bb0055","doi-asserted-by":"crossref","first-page":"9349","DOI":"10.1158\/0008-5472.CAN-06-1597","article-title":"Autophagy in cancer: good, bad, or both?","volume":"66","author":"Hippert","year":"2006","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbamcr.2016.03.009_bb0060","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1101\/gad.1565707","article-title":"Autophagy mitigates metabolic stress and genome damage in mammary tumorigenesis","volume":"21","author":"Karantza-Wadsworth","year":"2007","journal-title":"Genes Dev."},{"key":"10.1016\/j.bbamcr.2016.03.009_bb0065","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: the next generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.bbamcr.2016.03.009_bb0070","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1101\/sqb.2012.76.011015","article-title":"Autophagy, stress, and cancer metabolism: what doesn't kill you makes you stronger","volume":"76","author":"Mathew","year":"2011","journal-title":"Cold Spring Harb. Symp. Quant. Biol."},{"key":"10.1016\/j.bbamcr.2016.03.009_bb0075","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1038\/nrc1692","article-title":"The role of autophagy in cancer development and response to therapy","volume":"5","author":"Kondo","year":"2005","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.bbamcr.2016.03.009_bb0080","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1172\/JCI28833","article-title":"Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma","volume":"117","author":"Amaravadi","year":"2007","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbamcr.2016.03.009_bb0085","doi-asserted-by":"crossref","first-page":"124","DOI":"10.4161\/auto.23323","article-title":"The ULK1 complex: sensing nutrient signals for autophagy activation","volume":"9","author":"Wong","year":"2013","journal-title":"Autophagy"},{"key":"10.1016\/j.bbamcr.2016.03.009_bb0090","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1128\/MCB.06159-11","article-title":"Role of AMPK-mTOR-Ulk1\/2 in the regulation of autophagy: cross talk, shortcuts, and feedbacks","volume":"32","author":"Alers","year":"2012","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.bbamcr.2016.03.009_bb0095","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1101\/gad.1110003","article-title":"Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling","volume":"17","author":"Inoki","year":"2003","journal-title":"Genes Dev."},{"key":"10.1016\/j.bbamcr.2016.03.009_bb0100","doi-asserted-by":"crossref","first-page":"6496","DOI":"10.1158\/0008-5472.CAN-07-5756","article-title":"AMP-activated protein kinase signaling results in cytoplasmic sequestration of p27","volume":"68","author":"Short","year":"2008","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbamcr.2016.03.009_bb0105","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1038\/ncb1537","article-title":"The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis","volume":"9","author":"Liang","year":"2007","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.bbamcr.2016.03.009_bb0110","article-title":"Rheb promotes cancer cell survival through p27Kip1-dependent activation of autophagy","author":"Campos","year":"2015","journal-title":"Mol. Carcinog."},{"key":"10.1016\/j.bbamcr.2016.03.009_bb0115","doi-asserted-by":"crossref","first-page":"445","DOI":"10.4161\/auto.19496","article-title":"Guidelines for the use and interpretation of assays for monitoring autophagy","volume":"8","author":"Klionsky","year":"2012","journal-title":"Autophagy"},{"key":"10.1016\/j.bbamcr.2016.03.009_bb0120","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1002\/jcb.24997","article-title":"The combination of rapamycin and resveratrol blocks autophagy and induces apoptosis in breast cancer cells","volume":"116","author":"Alayev","year":"2015","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.bbamcr.2016.03.009_bb0125","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1158\/1541-7786.MCR-13-0258-T","article-title":"Autophagy-dependent metabolic reprogramming sensitizes TSC2-deficient cells to the antimetabolite 6-aminonicotinamide","volume":"12","author":"Parkhitko","year":"2014","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.bbamcr.2016.03.009_bb0130","doi-asserted-by":"crossref","first-page":"6543","DOI":"10.1038\/onc.2010.393","article-title":"Rheb activates AMPK and reduces p27Kip1 levels in Tsc2-null cells via mTORC1-independent mechanisms: implications for cell proliferation and tumorigenesis","volume":"29","author":"Lacher","year":"2010","journal-title":"Oncogene"},{"key":"10.1016\/j.bbamcr.2016.03.009_bb0135","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/S0140-6736(12)61767-X","article-title":"Everolimus for angiomyolipoma associated with tuberous sclerosis complex or sporadic lymphangioleiomyomatosis (EXIST-2): a multicentre, randomised, double-blind, placebo-controlled trial","volume":"381","author":"Bissler","year":"2013","journal-title":"Lancet"},{"key":"10.1016\/j.bbamcr.2016.03.009_bb0140","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1056\/NEJMoa1100391","article-title":"Efficacy and safety of sirolimus in lymphangioleiomyomatosis","volume":"364","author":"McCormack","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbamcr.2016.03.009_bb0145","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1038\/sj.bjc.6600862","article-title":"Antitumour effect of cyclin-dependent kinase inhibitors (p16(INK4A), p18(INK4C), p19(INK4D), p21(WAF1\/CIP1) and p27(KIP1)) on malignant glioma cells","volume":"88","author":"Komata","year":"2003","journal-title":"Br. J. Cancer"},{"issue":"24","key":"10.1016\/j.bbamcr.2016.03.009_bb0150","doi-asserted-by":"crossref","first-page":"16924","DOI":"10.1074\/jbc.M113.542795","article-title":"p27 protects metabolically-stressed cardiomyocytes from apoptosis by promoting autophagy","volume":"289","author":"Sun","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamcr.2016.03.009_bb0155","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.molcel.2010.05.009","article-title":"Negative regulation of Vps34 by Cdk mediated phosphorylation","volume":"38","author":"Furuya","year":"2010","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bbamcr.2016.03.009_bb0160","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.pneurobio.2013.10.004","article-title":"Autophagy and apoptosis dysfunction in neurodegenerative disorders","volume":"112","author":"Ghavami","year":"2014","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.bbamcr.2016.03.009_bb0165","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s00005-012-0205-y","article-title":"Autophagy, apoptosis, mitoptosis and necrosis: interdependence between those pathways and effects on cancer","volume":"61","author":"Chaabane","year":"2013","journal-title":"Arch. Immunol. Ther. Exp."},{"key":"10.1016\/j.bbamcr.2016.03.009_bb0170","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/nature11066","article-title":"AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress","volume":"485","author":"Jeon","year":"2012","journal-title":"Nature"}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167488916300623?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167488916300623?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,14]],"date-time":"2018-09-14T11:23:32Z","timestamp":1536924212000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167488916300623"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6]]},"references-count":34,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["S0167488916300623"],"URL":"https:\/\/doi.org\/10.1016\/j.bbamcr.2016.03.009","relation":{},"ISSN":["0167-4889"],"issn-type":[{"value":"0167-4889","type":"print"}],"subject":[],"published":{"date-parts":[[2016,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Rapamycin requires AMPK activity and p27 expression for promoting autophagy-dependent Tsc2-null cell survival","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Cell Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbamcr.2016.03.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V.","name":"copyright","label":"Copyright"}]}}