{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T16:46:55Z","timestamp":1782492415723,"version":"3.54.5"},"reference-count":45,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"vor","delay-in-days":365,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81072641"],"award-info":[{"award-number":["81072641"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81273499"],"award-info":[{"award-number":["81273499"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81473205"],"award-info":[{"award-number":["81473205"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81400359"],"award-info":[{"award-number":["81400359"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81673433"],"award-info":[{"award-number":["81673433"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"crossref","award":["S2011030003190"],"award-info":[{"award-number":["S2011030003190"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Major Project of Guangdong Provincial Department of Science and Technology","award":["2013B090700010"],"award-info":[{"award-number":["2013B090700010"]}]},{"name":"Major Project of Platform Construction Education Department of Guangdong Province","award":["2014GKPT002"],"award-info":[{"award-number":["2014GKPT002"]}]},{"name":"Special Program for Applied Science and Technology of Guangdong Province","award":["2015B020232009"],"award-info":[{"award-number":["2015B020232009"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Cell Research"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1016\/j.bbamcr.2016.09.019","type":"journal-article","created":{"date-parts":[[2016,10,31]],"date-time":"2016-10-31T10:00:18Z","timestamp":1477908018000},"page":"3027-3039","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"title":["The poly(ADP-ribosyl)ation of FoxO3 mediated by PARP1 participates in isoproterenol-induced cardiac hypertrophy"],"prefix":"10.1016","volume":"1863","author":[{"given":"Jing","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renwei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiqi","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuolong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duanping","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuya","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolei","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiantao","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuoming","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5433-0302","authenticated-orcid":false,"given":"Peiqing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbamcr.2016.09.019_bb0005","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.phrs.2010.07.003","article-title":"Multifarious molecular signaling cascades of cardiac hypertrophy: can the muddy waters be cleared?","volume":"62","author":"Balakumar","year":"2010","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.bbamcr.2016.09.019_bb0010","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1038\/nrd2193","article-title":"Small-molecule therapies for cardiac hypertrophy: moving beneath the cell surface","volume":"6","author":"McKinsey","year":"2007","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.bbamcr.2016.09.019_bb0015","doi-asserted-by":"crossref","first-page":"11389","DOI":"10.1073\/pnas.1513047112","article-title":"Mitochondrial calcium overload is a key determinant in heart failure","volume":"112","author":"Santulli","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbamcr.2016.09.019_bb0020","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1146\/annurev-physiol-021909-135931","article-title":"The FoxO family in cardiac function and dysfunction","volume":"72","author":"Ronnebaum","year":"2010","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.bbamcr.2016.09.019_bb0025","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/S0092-8674(00)80595-4","article-title":"Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor","volume":"96","author":"Brunet","year":"1999","journal-title":"Cell"},{"key":"10.1016\/j.bbamcr.2016.09.019_bb0030","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1093\/cvr\/cvr144","article-title":"FoxO3 induces reversible cardiac atrophy and autophagy in a transgenic mouse model","volume":"91","author":"Schips","year":"2011","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.bbamcr.2016.09.019_bb0035","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1161\/CIRCULATIONAHA.106.637124","article-title":"Foxo transcription factors blunt cardiac hypertrophy by inhibiting calcineurin signaling","volume":"114","author":"Ni","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.bbamcr.2016.09.019_bb0040","doi-asserted-by":"crossref","first-page":"29730","DOI":"10.1074\/jbc.M805514200","article-title":"Foxo3a inhibits cardiomyocyte hypertrophy through transactivating catalase","volume":"283","author":"Tan","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamcr.2016.09.019_bb0045","doi-asserted-by":"crossref","first-page":"28319","DOI":"10.1074\/jbc.M109.024406","article-title":"FoxO transcription factors promote autophagy in cardiomyocytes","volume":"284","author":"Sengupta","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamcr.2016.09.019_bb0050","doi-asserted-by":"crossref","first-page":"20814","DOI":"10.1074\/jbc.M500528200","article-title":"The FOXO3a transcription factor regulates cardiac myocyte size downstream of AKT signaling","volume":"280","author":"Skurk","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamcr.2016.09.019_bb0055","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1038\/embor.2012.25","article-title":"Lysine methylation of FOXO3 regulates oxidative stress-induced neuronal cell death","volume":"13","author":"Xie","year":"2012","journal-title":"EMBO Rep."},{"key":"10.1016\/j.bbamcr.2016.09.019_bb0060","doi-asserted-by":"crossref","first-page":"C587","DOI":"10.1152\/ajpcell.00142.2011","article-title":"Posttranslational modifications control FoxO3 activity during denervation","volume":"302","author":"Bertaggia","year":"2012","journal-title":"Am. J. Phys. Cell Physiol."},{"key":"10.1016\/j.bbamcr.2016.09.019_bb0065","doi-asserted-by":"crossref","first-page":"2918","DOI":"10.3390\/ijms13032918","article-title":"Computational identification and modeling of crosstalk between phosphorylation, O-beta-glycosylation and methylation of FoxO3 and implications for cancer therapeutics","volume":"13","author":"Butt","year":"2012","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbamcr.2016.09.019_bb0070","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1073\/pnas.1319703111","article-title":"Essential role of poly(ADP-ribosyl)ation in cocaine action","volume":"111","author":"Scobie","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbamcr.2016.09.019_bb0075","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.bbrc.2009.03.022","article-title":"Regulation of FOXO1-mediated transcription and cell proliferation by PARP-1","volume":"382","author":"Sakamaki","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbamcr.2016.09.019_bb0080","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1038\/ncb1638","article-title":"Inhibition of Crm1-p53 interaction and nuclear export of p53 by poly(ADP-ribosyl)ation","volume":"9","author":"Kanai","year":"2007","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.bbamcr.2016.09.019_bb0085","doi-asserted-by":"crossref","first-page":"2860","DOI":"10.1128\/MCB.01746-07","article-title":"Regulation of transcription factor NFAT by ADP-ribosylation","volume":"28","author":"Olabisi","year":"2008","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.bbamcr.2016.09.019_bb0090","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/j.cell.2004.11.017","article-title":"Activating the PARP-1 sensor component of the groucho\/TLE1 corepressor complex mediates a CaMKinase IIdelta-dependent neurogenic gene activation pathway","volume":"119","author":"Ju","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.bbamcr.2016.09.019_bb0095","doi-asserted-by":"crossref","first-page":"28675","DOI":"10.1074\/jbc.M115.661611","article-title":"Poly(ADP-ribosyl)ation of FOXP3 protein mediated by PARP-1 protein regulates the function of regulatory T cells","volume":"290","author":"Luo","year":"2015","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamcr.2016.09.019_bb0100","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.molcel.2010.10.029","article-title":"PARP-1 attenuates Smad-mediated transcription","volume":"40","author":"Lonn","year":"2010","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bbamcr.2016.09.019_bb0105","doi-asserted-by":"crossref","first-page":"H1545","DOI":"10.1152\/ajpheart.01124.2005","article-title":"Poly(ADP-ribose) polymerase-1-deficient mice are protected from angiotensin II-induced cardiac hypertrophy","volume":"291","author":"Pillai","year":"2006","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.bbamcr.2016.09.019_bb0110","doi-asserted-by":"crossref","first-page":"2852","DOI":"10.1111\/bph.13091","article-title":"The orphan receptor NOR1 participates in isoprenaline-induced cardiac hypertrophy by regulating PARP-1","volume":"172","author":"Feng","year":"2015","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bbamcr.2016.09.019_bb0115","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.mce.2014.05.010","article-title":"AG-690\/11026014, a novel PARP-1 inhibitor, protects cardiomyocytes from AngII-induced hypertrophy","volume":"392","author":"Liu","year":"2014","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.bbamcr.2016.09.019_bb0120","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.bbrc.2014.01.045","article-title":"Salvianolic acid B protects cardiomyocytes from angiotensin II-induced hypertrophy via inhibition of PARP-1","volume":"444","author":"Liu","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbamcr.2016.09.019_bb0125","doi-asserted-by":"crossref","first-page":"2901","DOI":"10.1021\/pr050456l","article-title":"Proteomic analysis of hypertrophied myocardial protein patterns in renovascularly hypertensive and spontaneously hypertensive rats","volume":"5","author":"Zhou","year":"2006","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.bbamcr.2016.09.019_bb0130","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.trsl.2016.03.002","article-title":"SIRT6 suppresses isoproterenol-induced cardiac hypertrophy through activation of autophagy","volume":"172","author":"Lu","year":"2016","journal-title":"Transl. Res."},{"key":"10.1016\/j.bbamcr.2016.09.019_bb0135","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1254\/jphs.14013FP","article-title":"Cyclovirobuxine D induces autophagy-associated cell death via the Akt\/mTOR pathway in MCF-7 human breast cancer cells","volume":"125","author":"Lu","year":"2014","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.bbamcr.2016.09.019_bb0140","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.yjmcc.2013.02.012","article-title":"Left ventricular mechanical and energetic changes in long-term isoproterenol-induced hypertrophied hearts of SERCA2a transgenic rats","volume":"59","author":"Mitsuyama","year":"2013","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.bbamcr.2016.09.019_bb0145","doi-asserted-by":"crossref","first-page":"H1267","DOI":"10.1152\/ajpheart.00352.2012","article-title":"Nebivolol prevents desensitization of beta-adrenoceptor signaling and induction of cardiac hypertrophy in response to isoprenaline beyond beta1-adrenoceptor blockage","volume":"304","author":"Ozakca","year":"2013","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.bbamcr.2016.09.019_bb0150","doi-asserted-by":"crossref","first-page":"26107","DOI":"10.1074\/jbc.M114.582809","article-title":"Kruppel-like factor 4 protein regulates isoproterenol-induced cardiac hypertrophy by modulating myocardin expression and activity","volume":"289","author":"Yoshida","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamcr.2016.09.019_bb0155","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1097\/SHK.0b013e3181c4fb08","article-title":"Therapeutic injection of PARP inhibitor INO-1001 preserves cardiac function in porcine myocardial ischemia and reperfusion without reducing infarct size","volume":"33","author":"Roesner","year":"2010","journal-title":"Shock"},{"key":"10.1016\/j.bbamcr.2016.09.019_bb0160","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1007\/s11239-008-0230-1","volume":"27","author":"Morrow","year":"2009","journal-title":"J. Thromb. Thrombolysis"},{"key":"10.1016\/j.bbamcr.2016.09.019_bb0165","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.canlet.2003.10.029","article-title":"Radiosensitization of human and rodent cell lines by INO-1001, a novel inhibitor of poly(ADP-ribose) polymerase","volume":"205","author":"Brock","year":"2004","journal-title":"Cancer Lett."},{"key":"10.1016\/j.bbamcr.2016.09.019_bb0170","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10637-007-9072-5","article-title":"INO-1001, a novel inhibitor of poly(ADP-ribose) polymerase, enhances tumor response to doxorubicin","volume":"26","author":"Mason","year":"2008","journal-title":"Investig. New Drugs"},{"key":"10.1016\/j.bbamcr.2016.09.019_bb0175","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1002\/bies.1115","article-title":"Physiology and pathophysiology of poly(ADP-ribosyl)ation","volume":"23","author":"Burkle","year":"2001","journal-title":"BioEssays"},{"key":"10.1016\/j.bbamcr.2016.09.019_bb0180","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1111\/j.1527-3466.2007.00018.x","article-title":"Role of poly(ADP-ribose) polymerase 1 (PARP-1) in cardiovascular diseases: the therapeutic potential of PARP inhibitors","volume":"25","author":"Pacher","year":"2007","journal-title":"Cardiovasc. Drug Rev."},{"key":"10.1016\/j.bbamcr.2016.09.019_bb0185","doi-asserted-by":"crossref","first-page":"2276","DOI":"10.1038\/onc.2008.21","article-title":"The FoxO code","volume":"27","author":"Calnan","year":"2008","journal-title":"Oncogene"},{"key":"10.1016\/j.bbamcr.2016.09.019_bb0190","first-page":"1938","article-title":"FoxO transcription factors; regulation by AKT and 14-3-3 proteins","volume":"1813","author":"Tzivion","year":"2011","journal-title":"BBA Mol. Cell Res."},{"key":"10.1016\/j.bbamcr.2016.09.019_bb0195","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1083\/jcb.200112059","article-title":"14-3-3 transits to the nucleus and participates in dynamic nucleocytoplasmic transport","volume":"156","author":"Brunet","year":"2002","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.bbamcr.2016.09.019_bb0200","doi-asserted-by":"crossref","first-page":"11608","DOI":"10.1021\/bi050618r","article-title":"14-3-3 protein interacts with nuclear localization sequence of forkhead transcription factor FoxO4","volume":"44","author":"Obsilova","year":"2005","journal-title":"Biochemistry"},{"key":"10.1016\/j.bbamcr.2016.09.019_bb0205","doi-asserted-by":"crossref","first-page":"7665","DOI":"10.1093\/nar\/gkm933","article-title":"Feedback-regulated poly(ADP-ribosyl)ation by PARP-1 is required for rapid response to DNA damage in living cells","volume":"35","author":"Mortusewicz","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bbamcr.2016.09.019_bb0210","doi-asserted-by":"crossref","first-page":"359","DOI":"10.2119\/molmed.2011.00203","article-title":"Poly(ADP-Ribosyl)ation of high mobility group box 1 (HMGB1) protein enhances inhibition of efferocytosis","volume":"18","author":"Davis","year":"2012","journal-title":"Mol. Med."},{"key":"10.1016\/j.bbamcr.2016.09.019_bb0215","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.mad.2010.04.003","article-title":"Enzyme characteristics of recombinant poly(ADP-ribose) polymerases-1 of rat and human origin mirror the correlation between cellular poly(ADP-ribosyl)ation capacity and species-specific life span","volume":"131","author":"Beneke","year":"2010","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.bbamcr.2016.09.019_bb0220","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1095\/biolreprod.114.123661","article-title":"Spermatid head elongation with normal nuclear shaping requires ADP-ribosyltransferase PARP11 (ARTD11) in mice","volume":"92","author":"Meyer-Ficca","year":"2015","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.bbamcr.2016.09.019_bb0225","doi-asserted-by":"crossref","first-page":"3723","DOI":"10.1093\/nar\/gkp229","article-title":"Molecular mechanism of poly(ADP-ribosyl)ation by PARP1 and identification of lysine residues as ADP-ribose acceptor sites","volume":"37","author":"Altmeyer","year":"2009","journal-title":"Nucleic Acids Res."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167488916302488?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167488916302488?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,7]],"date-time":"2018-09-07T00:50:25Z","timestamp":1536281425000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167488916302488"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":45,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["S0167488916302488"],"URL":"https:\/\/doi.org\/10.1016\/j.bbamcr.2016.09.019","relation":{},"ISSN":["0167-4889"],"issn-type":[{"value":"0167-4889","type":"print"}],"subject":[],"published":{"date-parts":[[2016,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The poly(ADP-ribosyl)ation of FoxO3 mediated by PARP1 participates in isoproterenol-induced cardiac hypertrophy","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Cell Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbamcr.2016.09.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}