{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T02:14:08Z","timestamp":1773195248522,"version":"3.50.1"},"reference-count":49,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"vor","delay-in-days":365,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"Tier-2 research","award":["MOE2013-T2-2-031"],"award-info":[{"award-number":["MOE2013-T2-2-031"]}]},{"name":"Ministry of Education, Singapore and AcRF Tier 1","award":["RG46\/13"],"award-info":[{"award-number":["RG46\/13"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Cell Research"],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.1016\/j.bbamcr.2016.12.011","type":"journal-article","created":{"date-parts":[[2016,12,10]],"date-time":"2016-12-10T18:19:59Z","timestamp":1481393999000},"page":"487-497","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Myogenic differentiation depends on the interplay of Grb2 and N-WASP"],"prefix":"10.1016","volume":"1864","author":[{"given":"Payal","family":"Mitra","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thirumaran","family":"Thanabalu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbamcr.2016.12.011_bb0005","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1083\/jcb.132.4.657","article-title":"Myogenin expression, cell cycle withdrawal, and phenotypic differentiation are temporally separable events that precede cell fusion upon myogenesis","volume":"132","author":"Andres","year":"1996","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.bbamcr.2016.12.011_bb0010","doi-asserted-by":"crossref","first-page":"e49","DOI":"10.1126\/scisignal.2003576","article-title":"Grb2, a double-edged sword of receptor tyrosine kinase signaling","volume":"5","author":"Belov","year":"2012","journal-title":"Sci. Signal."},{"key":"10.1016\/j.bbamcr.2016.12.011_bb0015","doi-asserted-by":"crossref","first-page":"3338","DOI":"10.1096\/fj.06-7070com","article-title":"Inhibition of myoblast migration by prostacyclin is associated with enhanced cell fusion","volume":"21","author":"Bondesen","year":"2007","journal-title":"FASEB J."},{"key":"10.1016\/j.bbamcr.2016.12.011_bb0020","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/0092-8674(93)90146-H","article-title":"Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor","volume":"73","author":"Buday","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.bbamcr.2016.12.011_bb0025","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.ejcb.2010.06.007","article-title":"Vinculin, an adapter protein in control of cell adhesion signalling","volume":"90","author":"Carisey","year":"2011","journal-title":"Eur. J. Cell Biol."},{"key":"10.1016\/j.bbamcr.2016.12.011_bb0030","doi-asserted-by":"crossref","first-page":"21946","DOI":"10.1074\/jbc.M000687200","article-title":"GRB2 links signaling to actin assembly by enhancing interaction of neural Wiskott-Aldrich syndrome protein (N-WASp) with actin-related protein (ARP2\/3) complex","volume":"275","author":"Carlier","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamcr.2016.12.011_bb0035","doi-asserted-by":"crossref","first-page":"957014","DOI":"10.1155\/2014\/957014","article-title":"Cellular players in skeletal muscle regeneration","volume":"2014","author":"Ceafalan","year":"2014","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.bbamcr.2016.12.011_bb0040","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0014-5793(95)00578-W","article-title":"The Grb2 adaptor","volume":"369","author":"Chardin","year":"1995","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bbamcr.2016.12.011_bb0045","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1152\/physrev.00019.2003","article-title":"Cellular and molecular regulation of muscle regeneration","volume":"84","author":"Charge","year":"2004","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.bbamcr.2016.12.011_bb0050","doi-asserted-by":"crossref","first-page":"16006","DOI":"10.1074\/jbc.M600738200","article-title":"A conformational switch in vinculin drives formation and dynamics of a talin-vinculin complex at focal adhesions","volume":"281","author":"Cohen","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamcr.2016.12.011_bb0055","doi-asserted-by":"crossref","first-page":"4011","DOI":"10.1002\/j.1460-2075.1994.tb06717.x","article-title":"Binding of the Grb2 SH2 domain to phosphotyrosine motifs does not change the affinity of its SH3 domains for Sos proline-rich motifs","volume":"13","author":"Cussac","year":"1994","journal-title":"EMBO J."},{"issue":"36","key":"10.1016\/j.bbamcr.2016.12.011_bb0060","article-title":"Kindlin-2 is required for myocyte elongation and is essential for myogenesis","volume":"9","author":"Dowling","year":"2008","journal-title":"BMC Cell Biol."},{"key":"10.1016\/j.bbamcr.2016.12.011_bb0065","doi-asserted-by":"crossref","first-page":"59","DOI":"10.3109\/10409238.2013.857291","article-title":"Signaling pathways controlling skeletal muscle mass","volume":"49","author":"Egerman","year":"2014","journal-title":"Crit. Rev. Biochem. Mol. Biol."},{"issue":"Suppl. 1","key":"10.1016\/j.bbamcr.2016.12.011_bb0070","first-page":"21","article-title":"Cytoskeletal reorganization in skeletal muscle differentiation: from cell morphology to gene expression","volume":"51","author":"Formigli","year":"2007","journal-title":"Eur. J. Histochem."},{"key":"10.1016\/j.bbamcr.2016.12.011_bb0075","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1016\/j.bbamcr.2014.05.008","article-title":"Myogenesis defect due to Toca-1 knockdown can be suppressed by expression of N-WASP","volume":"1843","author":"George","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbamcr.2016.12.011_bb0080","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1517\/14728222.12.8.1021","article-title":"Grb2 signaling in cell motility and cancer","volume":"12","author":"Giubellino","year":"2008","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.bbamcr.2016.12.011_bb0085","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1242\/jcs.092726","article-title":"N-WASP-mediated invadopodium formation is involved in intravasation and lung metastasis of mammary tumors","volume":"125","author":"Gligorijevic","year":"2012","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.bbamcr.2016.12.011_bb0090","doi-asserted-by":"crossref","first-page":"11211","DOI":"10.1073\/pnas.1116065109","article-title":"The actin regulator N-WASp is required for muscle-cell fusion in mice","volume":"109","author":"Gruenbaum-Cohen","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbamcr.2016.12.011_bb0095","doi-asserted-by":"crossref","first-page":"452","DOI":"10.4161\/cib.2.5.9158","article-title":"Cytoskeletal remodeling during myotube assembly and guidance: coordinating the actin and microtubule networks","volume":"2","author":"Guerin","year":"2009","journal-title":"Commun. Integr. Biol."},{"key":"10.1016\/j.bbamcr.2016.12.011_bb0100","doi-asserted-by":"crossref","first-page":"37307","DOI":"10.1074\/jbc.M103195200","article-title":"Rac1 inhibits myogenic differentiation by preventing the complete withdrawal of myoblasts from the cell cycle","volume":"276","author":"Heller","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamcr.2016.12.011_bb0105","first-page":"779","article-title":"Muscle regeneration: cellular and molecular events","volume":"23","author":"Karalaki","year":"2009","journal-title":"In Vivo"},{"key":"10.1016\/j.bbamcr.2016.12.011_bb0110","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.gde.2015.03.006","article-title":"Mechanisms of myoblast fusion during muscle development","volume":"32","author":"Kim","year":"2015","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.bbamcr.2016.12.011_bb0115","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.devcel.2007.02.019","article-title":"A critical function for the actin cytoskeleton in targeted exocytosis of prefusion vesicles during myoblast fusion","volume":"12","author":"Kim","year":"2007","journal-title":"Dev. Cell"},{"key":"10.1016\/j.bbamcr.2016.12.011_bb0120","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1091\/mbc.E04-06-0459","article-title":"Phospholipase D is involved in myogenic differentiation through remodeling of actin cytoskeleton","volume":"16","author":"Komati","year":"2005","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.bbamcr.2016.12.011_bb0125","doi-asserted-by":"crossref","first-page":"e71770","DOI":"10.1371\/journal.pone.0071770","article-title":"Epidermal growth factor receptor down-regulation triggers human myoblast differentiation","volume":"8","author":"Leroy","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.bbamcr.2016.12.011_bb0130","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1006\/excr.2002.5473","article-title":"Preferential binding of Grb2 or phosphatidylinositol 3-kinase to the met receptor has opposite effects on HGF-induced myoblast proliferation","volume":"274","author":"Leshem","year":"2002","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.bbamcr.2016.12.011_bb0135","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/363085a0","article-title":"Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling","volume":"363","author":"Li","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.bbamcr.2016.12.011_bb0140","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/34208","article-title":"Induction of filopodium formation by a WASP-related actin-depolymerizing protein N-WASP","volume":"391","author":"Miki","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.bbamcr.2016.12.011_bb0145","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1083\/jcb.111.3.1149","article-title":"Myogenic programs of mouse muscle cell lines: expression of myosin heavy chain isoforms, MyoD1, and myogenin","volume":"111","author":"Miller","year":"1990","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.bbamcr.2016.12.011_bb0150","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1016\/j.biocel.2012.02.020","article-title":"Insulin receptor substrate protein 53kDa (IRSp53) is a negative regulator of myogenic differentiation","volume":"44","author":"Misra","year":"2012","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.bbamcr.2016.12.011_bb0155","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1016\/j.bbrc.2007.10.086","article-title":"N-WASP plays a critical role in fibroblast adhesion and spreading","volume":"364","author":"Misra","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbamcr.2016.12.011_bb0160","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1530\/REP-10-0394","article-title":"Many routes to the same destination: lessons from skeletal muscle development","volume":"141","author":"Mok","year":"2011","journal-title":"Reproduction"},{"key":"10.1016\/j.bbamcr.2016.12.011_bb0170","doi-asserted-by":"crossref","first-page":"3282","DOI":"10.1242\/jcs.047597","article-title":"Nap1-mediated actin remodeling is essential for mammalian myoblast fusion","volume":"122","author":"Nowak","year":"2009","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.bbamcr.2016.12.011_bb0175","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.ydbio.2009.10.024","article-title":"Myoblast fusion: when it takes more to make one","volume":"341","author":"Rochlin","year":"2010","journal-title":"Dev. Biol."},{"key":"10.1016\/j.bbamcr.2016.12.011_bb0180","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0092-8674(00)80732-1","article-title":"The interaction between N-WASP and the Arp2\/3 complex links Cdc42-dependent signals to actin assembly","volume":"97","author":"Rohatgi","year":"1999","journal-title":"Cell"},{"key":"10.1016\/j.bbamcr.2016.12.011_bb0185","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1016\/j.ydbio.2007.01.015","article-title":"The Wiskott-Aldrich syndrome protein (WASP) is essential for myoblast fusion in Drosophila","volume":"304","author":"Schafer","year":"2007","journal-title":"Dev. Biol."},{"key":"10.1016\/j.bbamcr.2016.12.011_bb0190","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.bbamcr.2016.12.011_bb0195","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1091\/mbc.8.9.1709","article-title":"Wiskott-Aldrich syndrome protein is associated with the adapter protein Grb2 and the epidermal growth factor receptor in living cells","volume":"8","author":"She","year":"1997","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.bbamcr.2016.12.011_bb0200","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1002\/dvdy.10200","article-title":"Genome-wide examination of myoblast cell cycle withdrawal during differentiation","volume":"226","author":"Shen","year":"2003","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.bbamcr.2016.12.011_bb0205","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1126\/science.272.5267.1476","article-title":"Inhibition of myogenic bHLH and MEF2 transcription factors by the bHLH protein Twist","volume":"272","author":"Spicer","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.bbamcr.2016.12.011_bb0210","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/S0092-8674(00)81050-8","article-title":"Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization","volume":"84","author":"Symons","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.bbamcr.2016.12.011_bb0215","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/nrm2069","article-title":"The WASP-WAVE protein network: connecting the membrane to the cytoskeleton","volume":"8","author":"Takenawa","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bbamcr.2016.12.011_bb0220","doi-asserted-by":"crossref","first-page":"R224","DOI":"10.1016\/S0960-9822(02)00757-1","article-title":"Muscle differentiation: how two cells become one","volume":"12","author":"Taylor","year":"2002","journal-title":"Curr. Biol."},{"key":"10.1016\/j.bbamcr.2016.12.011_bb0225","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1002\/(SICI)1096-9896(199710)183:2<195::AID-PATH901>3.0.CO;2-Y","article-title":"Grb2 overexpression in nuclei and cytoplasm of human breast cells: a histochemical and biochemical study of normal and neoplastic mammary tissue specimens","volume":"183","author":"Verbeek","year":"1997","journal-title":"J. Pathol."},{"key":"10.1016\/j.bbamcr.2016.12.011_bb0230","doi-asserted-by":"crossref","first-page":"3519","DOI":"10.1242\/jcs.099523","article-title":"Actin nucleators in the nucleus: an emerging theme","volume":"125","author":"Weston","year":"2012","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.bbamcr.2016.12.011_bb0235","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.gdata.2015.04.009","article-title":"Contribution of nuclear actin to transcription regulation","volume":"4","author":"Yamazaki","year":"2015","journal-title":"Genomics Data"},{"key":"10.1016\/j.bbamcr.2016.12.011_bb0240","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1242\/jcs.115.9.1791","article-title":"Role of Grb2 in EGF-stimulated EGFR internalization","volume":"115","author":"Yamazaki","year":"2002","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.bbamcr.2016.12.011_bb0245","doi-asserted-by":"crossref","first-page":"7616","DOI":"10.1074\/jbc.M607596200","article-title":"A novel role of the actin-nucleating Arp2\/3 complex in the regulation of RNA polymerase II-dependent transcription","volume":"282","author":"Yoo","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamcr.2016.12.011_bb2000","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1006\/dbio.1995.1142","article-title":"Regulation of integrin alpha 5 beta 1 affinity during myogenic differentiation","volume":"169","author":"Boettiger","year":"1995","journal-title":"Developmental biology"}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167488916303366?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167488916303366?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,7,16]],"date-time":"2022-07-16T21:28:06Z","timestamp":1658006886000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167488916303366"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3]]},"references-count":49,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["S0167488916303366"],"URL":"https:\/\/doi.org\/10.1016\/j.bbamcr.2016.12.011","relation":{},"ISSN":["0167-4889"],"issn-type":[{"value":"0167-4889","type":"print"}],"subject":[],"published":{"date-parts":[[2017,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Myogenic differentiation depends on the interplay of Grb2 and N-WASP","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Cell Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbamcr.2016.12.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V.","name":"copyright","label":"Copyright"}]}}