{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T04:05:36Z","timestamp":1783483536353,"version":"3.55.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["R21EY024388"],"award-info":[{"award-number":["R21EY024388"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81272926"],"award-info":[{"award-number":["81272926"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81572753"],"award-info":[{"award-number":["81572753"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31660332"],"award-info":[{"award-number":["31660332"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004543","name":"China Scholar Council","doi-asserted-by":"crossref","award":["201507040075"],"award-info":[{"award-number":["201507040075"]}],"id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004543","name":"China Scholar Council","doi-asserted-by":"crossref","award":["201506820020"],"award-info":[{"award-number":["201506820020"]}],"id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Jiangxi Province Bureau of Foreign Experts","award":["2016"],"award-info":[{"award-number":["2016"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Cell Research"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1016\/j.bbamcr.2017.08.009","type":"journal-article","created":{"date-parts":[[2017,8,26]],"date-time":"2017-08-26T03:00:23Z","timestamp":1503716423000},"page":"2369-2377","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"title":["AMPK downregulates ALK2 via increasing the interaction between Smurf1 and Smad6, leading to inhibition of osteogenic differentiation"],"prefix":"10.1016","volume":"1864","author":[{"given":"Hui","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Ying","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan-Yuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan-Shan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deqinag","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingyu","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye-Guang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis C.","family":"Gerstenfeld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijun","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbamcr.2017.08.009_bb0005","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.abb.2014.07.011","article-title":"Bone morphogenetic proteins: structure, biological function and therapeutic applications","volume":"561","author":"Carreira","year":"2014","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.bbamcr.2017.08.009_bb0010","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1002\/biof.1177","article-title":"Bone morphogenetic proteins: a powerful osteoinductive compound with non-negligible side effects and limitations","volume":"40","author":"Oryan","year":"2014","journal-title":"Biofactors"},{"key":"10.1016\/j.bbamcr.2017.08.009_bb0015","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1095\/biolreprod.114.125203","article-title":"Inhibitory SMADs: potential regulators of ovarian function","volume":"92","author":"Li","year":"2015","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.bbamcr.2017.08.009_bb0020","doi-asserted-by":"crossref","first-page":"3569","DOI":"10.1074\/jbc.M506761200","article-title":"Smad6 interacts with Runx2 and mediates Smad ubiquitin regulatory factor 1-induced Runx2 degradation","volume":"281","author":"Shen","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamcr.2017.08.009_bb0025","doi-asserted-by":"crossref","first-page":"2809","DOI":"10.1091\/mbc.e02-07-0441","article-title":"Cooperative inhibition of bone morphogenetic protein signaling by Smurf1 and inhibitory Smads","volume":"14","author":"Murakami","year":"2003","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.bbamcr.2017.08.009_bb0030","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1242\/dmm.010280","article-title":"Fibrodysplasia ossificans progressiva: mechanisms and models of skeletal metamorphosis","volume":"5","author":"Kaplan","year":"2012","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.bbamcr.2017.08.009_bb0035","first-page":"1281","article-title":"Molecular and cellular mechanisms of heterotopic ossification","volume":"29","author":"Ramirez","year":"2014","journal-title":"Histol. Histopathol."},{"key":"10.1016\/j.bbamcr.2017.08.009_bb0040","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/ng1783","article-title":"A recurrent mutation in the BMP type I receptor ACVR1 causes inherited and sporadic fibrodysplasia ossificans progressiva","volume":"38","author":"Shore","year":"2006","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbamcr.2017.08.009_bb0045","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.ydbio.2015.02.011","article-title":"BMP signaling mediated by constitutively active Activin type 1 receptor (ACVR1) results in ectopic bone formation localized to distal extremity joints","volume":"400","author":"Agarwal","year":"2015","journal-title":"Dev. Biol."},{"key":"10.1016\/j.bbamcr.2017.08.009_bb0050","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.1002\/jbmr.1637","article-title":"An Acvr1 R206H knock-in mouse has fibrodysplasia ossificans progressiva","volume":"27","author":"Chakkalakal","year":"2012","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bbamcr.2017.08.009_bb0055","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aac4358","article-title":"ACVR1R206H receptor mutation causes fibrodysplasia ossificans progressiva by imparting responsiveness to activin A","volume":"7","author":"Hatsell","year":"2015","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.bbamcr.2017.08.009_bb0060","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1016\/S0002-9440(10)63372-X","article-title":"Transgenic mice overexpressing BMP4 develop a fibrodysplasia ossificans progressiva (FOP)-like phenotype","volume":"165","author":"Kan","year":"2004","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bbamcr.2017.08.009_bb0065","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ceb.2014.09.004","article-title":"AMPK: positive and negative regulation, and its role in whole-body energy homeostasis","volume":"33","author":"Hardie","year":"2015","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.bbamcr.2017.08.009_bb0070","doi-asserted-by":"crossref","first-page":"2164","DOI":"10.2337\/db13-0368","article-title":"AMPK: a target for drugs and natural products with effects on both diabetes and cancer","volume":"62","author":"Hardie","year":"2013","journal-title":"Diabetes"},{"key":"10.1016\/j.bbamcr.2017.08.009_bb0075","doi-asserted-by":"crossref","first-page":"457","DOI":"10.2217\/fon.09.174","article-title":"AMPK as a metabolic tumor suppressor: control of metabolism and cell growth","volume":"6","author":"Luo","year":"2010","journal-title":"Future Oncol."},{"key":"10.1016\/j.bbamcr.2017.08.009_bb0080","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.bone.2010.04.596","article-title":"AMP-activated protein kinase (AMPK) activation regulates in vitro bone formation and bone mass","volume":"47","author":"Shah","year":"2010","journal-title":"Bone"},{"key":"10.1016\/j.bbamcr.2017.08.009_bb0085","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.bone.2012.10.024","article-title":"Coordinated time-dependent modulation of AMPK\/Akt\/mTOR signaling and autophagy controls osteogenic differentiation of human mesenchymal stem cells","volume":"52","author":"Pantovic","year":"2013","journal-title":"Bone"},{"key":"10.1016\/j.bbamcr.2017.08.009_bb0090","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1530\/JOE-11-0306","article-title":"AMP-activated protein kinase pathway and bone metabolism","volume":"212","author":"Jeyabalan","year":"2012","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.bbamcr.2017.08.009_bb0095","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1002\/jcp.22892","article-title":"Human mesenchymal stem cell differentiation to the osteogenic or adipogenic lineage is regulated by AMP-activated protein kinase","volume":"227","author":"Kim","year":"2012","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.bbamcr.2017.08.009_bb0100","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.bbrc.2015.03.168","article-title":"Adiponectin enhances osteogenic differentiation in human adipose-derived stem cells by activating the APPL1-AMPK signaling pathway","volume":"461","author":"Chen","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbamcr.2017.08.009_bb0105","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.bbrc.2008.08.034","article-title":"Metformin enhances the differentiation and mineralization of osteoblastic MC3T3-E1 cells via AMP kinase activation as well as eNOS and BMP-2 expression","volume":"375","author":"Kanazawa","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbamcr.2017.08.009_bb0110","doi-asserted-by":"crossref","first-page":"E139","DOI":"10.1152\/ajpendo.90677.2008","article-title":"Activation of AMP kinase and inhibition of Rho kinase induce the mineralization of osteoblastic MC3T3-E1 cells through endothelial NOS and BMP-2 expression","volume":"296","author":"Kanazawa","year":"2009","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.bbamcr.2017.08.009_bb0115","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1002\/jcp.21917","article-title":"Osteoblast differentiation is functionally associated with decreased AMP kinase activity","volume":"221","author":"Kasai","year":"2009","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.bbamcr.2017.08.009_bb0120","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1016\/j.cell.2015.05.029","article-title":"Glucose uptake and Runx2 synergize to orchestrate osteoblast differentiation and bone formation","volume":"161","author":"Wei","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.bbamcr.2017.08.009_bb0125","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1530\/JOE-12-0184","article-title":"Mice lacking AMP-activated protein kinase alpha1 catalytic subunit have increased bone remodelling and modified skeletal responses to hormonal challenges induced by ovariectomy and intermittent PTH treatment","volume":"214","author":"Jeyabalan","year":"2012","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.bbamcr.2017.08.009_bb0130","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1016\/j.bone.2010.08.001","article-title":"AMP kinase acts as a negative regulator of RANKL in the differentiation of osteoclasts","volume":"47","author":"Lee","year":"2010","journal-title":"Bone"},{"key":"10.1016\/j.bbamcr.2017.08.009_bb0135","doi-asserted-by":"crossref","first-page":"12187","DOI":"10.1074\/jbc.M112.430389","article-title":"Genetic deletion of catalytic subunits of AMP-activated protein kinase increases osteoclasts and reduces bone mass in young adult mice","volume":"288","author":"Kang","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamcr.2017.08.009_bb0140","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1124\/mol.115.099549","article-title":"AMPK inhibits the stimulatory effects of TGF-beta on Smad2\/3 activity, cell migration, and epithelial-to-mesenchymal transition","volume":"88","author":"Lin","year":"2015","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.bbamcr.2017.08.009_bb0145","first-page":"75","article-title":"Lowering of amyloid beta peptide production with a small molecule inhibitor of amyloid-beta precursor protein dimerization","volume":"1","author":"So","year":"2012","journal-title":"Am. J. Neurodegener. Dis."},{"key":"10.1016\/j.bbamcr.2017.08.009_bb0150","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1038\/nmeth.1591","article-title":"A more efficient method to generate integration-free human iPS cells","volume":"8","author":"Okita","year":"2011","journal-title":"Nat. Methods"},{"key":"10.1016\/j.bbamcr.2017.08.009_bb0155","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1016\/j.bone.2007.01.001","article-title":"Autogenous regulation of a network of bone morphogenetic proteins (BMPs) mediates the osteogenic differentiation in murine marrow stromal cells","volume":"40","author":"Edgar","year":"2007","journal-title":"Bone"},{"key":"10.1016\/j.bbamcr.2017.08.009_bb0160","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1038\/nm.1888","article-title":"BMP type I receptor inhibition reduces heterotopic [corrected] ossification","volume":"14","author":"Yu","year":"2008","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbamcr.2017.08.009_bb0165","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1038\/nm.2252","article-title":"Conversion of vascular endothelial cells into multipotent stem-like cells","volume":"16","author":"Medici","year":"2010","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbamcr.2017.08.009_bb0170","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/gt.2011.190","article-title":"Allele-specific RNA interference in FOP silencing the FOP gene","volume":"19","author":"Lowery","year":"2012","journal-title":"Gene Ther."},{"key":"10.1016\/j.bbamcr.2017.08.009_bb0175","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1038\/nm.2334","article-title":"Potent inhibition of heterotopic ossification by nuclear retinoic acid receptor-gamma agonists","volume":"17","author":"Shimono","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbamcr.2017.08.009_bb0180","doi-asserted-by":"crossref","DOI":"10.1242\/dmm.027573","article-title":"High throughput screening for modulators of ACVR1 transcription potentially applicable to the treatment of Fibrodysplasia ossificans progressiva","author":"Cappato","year":"2016","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.bbamcr.2017.08.009_bb0185","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1002\/stem.1981","article-title":"New protocol to optimize iPS cells for genome analysis of Fibrodysplasia ossificans progressiva","volume":"33","author":"Matsumoto","year":"2015","journal-title":"Stem Cells"},{"key":"10.1016\/j.bbamcr.2017.08.009_bb0190","doi-asserted-by":"crossref","DOI":"10.1038\/emm.2016.43","article-title":"Concurrent progress of reprogramming and gene correction to overcome therapeutic limitation of mutant ALK2-iPSC","volume":"48","author":"Kim","year":"2016","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.bbamcr.2017.08.009_bb0195","doi-asserted-by":"crossref","first-page":"32794","DOI":"10.18632\/oncotarget.15825","article-title":"Metformin inhibits ALK1-mediated angiogenesis via activation of AMPK","volume":"8","author":"Ying","year":"2017","journal-title":"Oncotarget"}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167488917302252?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167488917302252?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T20:17:19Z","timestamp":1659385039000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167488917302252"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12]]},"references-count":39,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["S0167488917302252"],"URL":"https:\/\/doi.org\/10.1016\/j.bbamcr.2017.08.009","relation":{},"ISSN":["0167-4889"],"issn-type":[{"value":"0167-4889","type":"print"}],"subject":[],"published":{"date-parts":[[2017,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"AMPK downregulates ALK2 via increasing the interaction between Smurf1 and Smad6, leading to inhibition of osteogenic differentiation","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Cell Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbamcr.2017.08.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V.","name":"copyright","label":"Copyright"}]}}