{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T15:37:51Z","timestamp":1790437071778,"version":"4.1.0"},"reference-count":42,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31873030"],"award-info":[{"award-number":["31873030"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Shandong Province Natural Science Foundation","doi-asserted-by":"publisher","award":["ZR2018BC048"],"award-info":[{"award-number":["ZR2018BC048"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Funds of Shandong \u201cDouble Tops\u201d Program"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Cell Research"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1016\/j.bbamcr.2018.12.002","type":"journal-article","created":{"date-parts":[[2018,12,4]],"date-time":"2018-12-04T11:56:48Z","timestamp":1543924608000},"page":"713-726","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":68,"title":["Activation of PERK-eIF2\u03b1-ATF4-CHOP axis triggered by excessive ER stress contributes to lead-induced nephrotoxicity"],"prefix":"10.1016","volume":"1866","author":[{"given":"Min-Ge","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui-Feng","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Hui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Du-Bao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen-Yong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbamcr.2018.12.002_bb0005","doi-asserted-by":"crossref","first-page":"2074","DOI":"10.1038\/sj.ki.5001809","article-title":"Lead-related nephrotoxicity: a review of the epidemiologic evidence","volume":"70","author":"Ekong","year":"2006","journal-title":"Kidney Int."},{"key":"10.1016\/j.bbamcr.2018.12.002_bb0010","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2017.262","article-title":"Autophagy blockade and lysosomal membrane permeabilization contribute to lead-induced nephrotoxicity in primary rat proximal tubular cells","volume":"8","author":"Song","year":"2017","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bbamcr.2018.12.002_bb0015","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.ecoenv.2017.02.017","article-title":"Effects of selenium-lead interaction on the gene expression of inflammatory factors and selenoproteins in chicken neutrophils","volume":"139","author":"Li","year":"2017","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.bbamcr.2018.12.002_bb0020","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.chemosphere.2017.03.130","article-title":"The antagonistic effect of selenium on lead-induced apoptosis via mitochondrial dynamics pathway in the chicken kidney","volume":"180","author":"Jin","year":"2017","journal-title":"Chemosphere"},{"key":"10.1016\/j.bbamcr.2018.12.002_bb0025","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.etap.2016.11.001","article-title":"Lead accumulation and metallothionein content in female rats of different ages and generations after daily intake of Pb-contaminated food","volume":"48","author":"Nascimento","year":"2016","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.bbamcr.2018.12.002_bb0030","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.toxlet.2013.02.005","article-title":"Nephroprotective effect of calcium channel blockers against toxicity of lead exposure in mice","volume":"218","author":"Zhang","year":"2013","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.bbamcr.2018.12.002_bb0035","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1080\/15287390801988962","article-title":"The use of cultured primary bovine colon epithelial cells as a screening model to detect genotoxic effects of heterocyclic aromatic amines in the comet assay","volume":"71","author":"Follmann","year":"2008","journal-title":"J. Toxicol. Environ. Health A"},{"key":"10.1016\/j.bbamcr.2018.12.002_bb0040","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1007\/s00204-015-1547-0","article-title":"Mitochondrial permeability transition and its regulatory components are implicated in apoptosis of primary cultures of rat proximal tubular cells exposed to lead","volume":"90","author":"Liu","year":"2016","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.bbamcr.2018.12.002_bb0045","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1038\/nrneph.2017.129","article-title":"Endoplasmic reticulum stress, the unfolded protein response and autophagy in kidney diseases","volume":"13","author":"Cybulsky","year":"2017","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.bbamcr.2018.12.002_bb0050","doi-asserted-by":"crossref","first-page":"74","DOI":"10.3389\/fphys.2017.00074","article-title":"Stress signal network between hypoxia and ER stress in chronic kidney disease","volume":"8","author":"Maekawa","year":"2017","journal-title":"Front. Physiol."},{"key":"10.1016\/j.bbamcr.2018.12.002_bb0055","first-page":"1","article-title":"Endoplasmic reticulum stress in ischemic and nephrotoxic acute kidney injury","author":"Yan","year":"2018","journal-title":"Ann. Med."},{"key":"10.1016\/j.bbamcr.2018.12.002_bb0060","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/j.envpol.2017.12.102","article-title":"Role of autophagy in environmental neurotoxicity","volume":"235","author":"Pellacani","year":"2018","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.bbamcr.2018.12.002_bb0065","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1126\/science.1209038","article-title":"The unfolded protein response: from stress pathway to homeostatic regulation","volume":"334","author":"Walter","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.bbamcr.2018.12.002_bb0070","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2016.78","article-title":"Endoplasmic reticulum stress eIF2alpha-ATF4 pathway-mediated cyclooxygenase-2 induction regulates cadmium-induced autophagy in kidney","volume":"7","author":"Luo","year":"2016","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bbamcr.2018.12.002_bb0075","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1002\/jcb.25261","article-title":"Numb protects human renal tubular epithelial cells from bovine serum albumin-induced apoptosis through antagonizing CHOP\/PERK pathway","volume":"117","author":"Ding","year":"2016","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.bbamcr.2018.12.002_bb0080","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1038\/aps.2017.30","article-title":"Chrysin ameliorates podocyte injury and slit diaphragm protein loss via inhibition of the PERK-eIF2alpha-ATF-CHOP pathway in diabetic mice","volume":"38","author":"Kang","year":"2017","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.bbamcr.2018.12.002_bb0085","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1007\/s00018-017-2639-1","article-title":"Autophagy in diabetic kidney disease: regulation, pathological role and therapeutic potential","volume":"75","author":"Yang","year":"2018","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.bbamcr.2018.12.002_bb0090","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/j.envpol.2017.09.015","article-title":"Excessive ER stress and the resulting autophagic flux dysfunction contribute to fluoride-induced neurotoxicity","volume":"233","author":"Niu","year":"2018","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.bbamcr.2018.12.002_bb0095","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.tox.2017.03.016","article-title":"Cadmium disrupts autophagic flux by inhibiting cytosolic Ca(2+)-dependent autophagosome-lysosome fusion in primary rat proximal tubular cells","volume":"383","author":"Liu","year":"2017","journal-title":"Toxicology"},{"key":"10.1016\/j.bbamcr.2018.12.002_bb0100","doi-asserted-by":"crossref","first-page":"91162","DOI":"10.18632\/oncotarget.20035","article-title":"CaMKII is involved in subcellular Ca(2+) redistribution-induced endoplasmic reticulum stress leading to apoptosis in primary cultures of rat proximal tubular cells exposed to lead","volume":"8","author":"Wang","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.bbamcr.2018.12.002_bb0105","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.1080\/15548627.2015.1091141","article-title":"ER stress: autophagy induction, inhibition and selection","volume":"11","author":"Rashid","year":"2015","journal-title":"Autophagy"},{"key":"10.1016\/j.bbamcr.2018.12.002_bb0110","doi-asserted-by":"crossref","first-page":"831","DOI":"10.3109\/0886022X.2016.1160724","article-title":"Endoplasmic reticulum stress and its effects on renal tubular cells apoptosis in ischemic acute kidney injury","volume":"38","author":"Xu","year":"2016","journal-title":"Ren. Fail."},{"key":"10.1016\/j.bbamcr.2018.12.002_bb0115","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/S1097-2765(00)80330-5","article-title":"Essential for translational regulation and cell survival during the unfolded protein response","volume":"5","author":"Harding","year":"2000","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bbamcr.2018.12.002_bb0120","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/s41419-018-0427-y","article-title":"Inhibition of Sec61-dependent translocation by mycolactone uncouples the integrated stress response from ER stress, driving cytotoxicity via translational activation of ATF4","volume":"9","author":"Ogbechi","year":"2018","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bbamcr.2018.12.002_bb0125","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.113.000238","article-title":"PERK-eIF2alpha-ATF4-CHOP signaling contributes to TNFalpha-induced vascular calcification","volume":"2","author":"Masuda","year":"2013","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.bbamcr.2018.12.002_bb0130","doi-asserted-by":"crossref","first-page":"3202","DOI":"10.1038\/s41419-017-0002-y","article-title":"HRD1 prevents apoptosis in renal tubular epithelial cells by mediating eIF2alpha ubiquitylation and degradation","volume":"8","author":"Huang","year":"2017","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bbamcr.2018.12.002_bb0135","doi-asserted-by":"crossref","first-page":"4896","DOI":"10.1093\/hmg\/ddx370","article-title":"The role of the ER stress-response protein PERK in rhodopsin retinitis pigmentosa","volume":"26","author":"Athanasiou","year":"2017","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbamcr.2018.12.002_bb0140","first-page":"1708","article-title":"Afatinib down-regulates MCL-1 expression through the PERK-eIF2\u03b1-ATF4 axis and leads to apoptosis in head and neck squamous cell carcinoma","volume":"6","author":"Liu","year":"2016","journal-title":"Am. J. Cancer Res."},{"key":"10.1016\/j.bbamcr.2018.12.002_bb0145","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1002\/mc.22284","article-title":"Autophagy and protein kinase RNA-like endoplasmic reticulum kinase (PERK)\/eukaryotic initiation factor 2 alpha kinase (eIF2\u03b1) pathway protect ovarian cancer cells from metformin-induced apoptosis","volume":"55","author":"Moon","year":"2016","journal-title":"Mol. Carcinog."},{"key":"10.1016\/j.bbamcr.2018.12.002_bb0150","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1016\/j.ajpath.2016.03.004","article-title":"PERK activation promotes medulloblastoma tumorigenesis by attenuating premalignant granule cell precursor apoptosis","volume":"186","author":"Ho","year":"2016","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bbamcr.2018.12.002_bb0155","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.tox.2017.01.002","article-title":"Pyrazinamide-induced hepatotoxicity is alleviated by 4-PBA via inhibition of the PERK-eIF2alpha-ATF4-CHOP pathway","volume":"378","author":"Guo","year":"2017","journal-title":"Toxicology"},{"key":"10.1016\/j.bbamcr.2018.12.002_bb0160","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.redox.2015.01.001","article-title":"Oxidative stress and autophagy: crucial modulators of kidney injury","volume":"4","author":"Sureshbabu","year":"2015","journal-title":"Redox Biol."},{"key":"10.1016\/j.bbamcr.2018.12.002_bb0165","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1089\/ars.2013.5363","article-title":"Autophagy in kidney health and disease","volume":"20","author":"Wang","year":"2014","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.bbamcr.2018.12.002_bb0170","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1038\/ncb1991","article-title":"A subdomain of the endoplasmic reticulum forms a cradle for autophagosome formation","volume":"11","author":"Hayashi-Nishino","year":"2009","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.bbamcr.2018.12.002_bb0175","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2015.409","article-title":"Dengue-induced autophagy, virus replication and protection from cell death require ER stress (PERK) pathway activation","volume":"7","author":"Datan","year":"2016","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bbamcr.2018.12.002_bb0180","doi-asserted-by":"crossref","first-page":"3867","DOI":"10.1002\/jcp.26137","article-title":"Crosstalk of ER stress-mediated autophagy and ER-phagy: involvement of UPR and the core autophagy machinery","volume":"233","author":"Song","year":"2018","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.bbamcr.2018.12.002_bb0185","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/s41419-017-0121-5","article-title":"Dysfunctional autophagy following exposure to pro-inflammatory cytokines contributes to pancreatic beta-cell apoptosis","volume":"9","author":"Lambelet","year":"2018","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bbamcr.2018.12.002_bb0190","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1172\/JCI40027","article-title":"The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5","volume":"120","author":"Rouschop","year":"2010","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbamcr.2018.12.002_bb0195","doi-asserted-by":"crossref","first-page":"3616","DOI":"10.1128\/MCB.05164-11","article-title":"PERK integrates autophagy and oxidative stress responses to promote survival during extracellular matrix detachment","volume":"31","author":"Avivar-Valderas","year":"2011","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.bbamcr.2018.12.002_bb0200","doi-asserted-by":"crossref","first-page":"803","DOI":"10.7150\/ijbs.11100","article-title":"PERK-mediated autophagy in osteosarcoma cells resists ER stress-induced cell apoptosis","volume":"11","author":"Ji","year":"2015","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.bbamcr.2018.12.002_bb0205","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18010058","article-title":"View of life-and-death decision with respect to endoplasmic reticulum stress-the role of PERK pathway","volume":"18","author":"Marton","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbamcr.2018.12.002_bb0210","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.jinorgbio.2018.02.015","article-title":"Interplay between autophagy and apoptosis in lead(II)-induced cytotoxicity of primary rat proximal tubular cells","volume":"182","author":"Chu","year":"2018","journal-title":"J. Inorg. Biochem."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167488918302131?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167488918302131?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T19:48:39Z","timestamp":1759088919000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167488918302131"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":42,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["S0167488918302131"],"URL":"https:\/\/doi.org\/10.1016\/j.bbamcr.2018.12.002","relation":{},"ISSN":["0167-4889"],"issn-type":[{"value":"0167-4889","type":"print"}],"subject":[],"published":{"date-parts":[[2019,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Activation of PERK-eIF2\u03b1-ATF4-CHOP axis triggered by excessive ER stress contributes to lead-induced nephrotoxicity","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Cell Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbamcr.2018.12.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V.","name":"copyright","label":"Copyright"}]}}