{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T22:42:01Z","timestamp":1780526521895,"version":"3.54.1"},"reference-count":44,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100012001","name":"Al Jalila Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Cell Research"],"published-print":{"date-parts":[[2020,7]]},"DOI":"10.1016\/j.bbamcr.2020.118692","type":"journal-article","created":{"date-parts":[[2020,3,2]],"date-time":"2020-03-02T11:06:33Z","timestamp":1583147193000},"page":"118692","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Par-4 regulates autophagic cell death in human cancer cells via upregulating p53 and BNIP3"],"prefix":"10.1016","volume":"1867","author":[{"given":"Faisal","family":"Thayyullathil","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anees Rahman","family":"Cheratta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siraj","family":"Pallichankandy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karthikeyan","family":"Subburayan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saeed","family":"Tariq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivek M.","family":"Rangnekar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sehamuddin","family":"Galadari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbamcr.2020.118692_bb0005","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/S1534-5807(04)00099-1","article-title":"Development by self-digestion: molecular mechanisms and biological functions of autophagy","volume":"6","author":"Levine","year":"2004","journal-title":"Dev. Cell"},{"key":"10.1016\/j.bbamcr.2020.118692_bb0010","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1038\/nrc.2017.53","article-title":"Targeting autophagy in cancer","volume":"17","author":"Levy","year":"2017","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.bbamcr.2020.118692_bb0015","first-page":"2349","article-title":"Autophagy and cancer\u2014issues we need to digest","volume":"125","author":"Liu","year":"2012","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.bbamcr.2020.118692_bb0020","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.pharmthera.2011.03.009","article-title":"Targeting autophagy during cancer therapy to improve clinical outcomes","volume":"131","author":"Levy","year":"2011","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.bbamcr.2020.118692_bb0025","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.gde.2009.12.004","article-title":"Autophagy: an adaptable modifier of tumourigenesis","volume":"20","author":"Wilkinson","year":"2010","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.bbamcr.2020.118692_bb0030","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1111\/j.1750-3639.2011.00544.x","article-title":"Autophagy in brain tumors: a new target for therapeutic intervention","volume":"22","author":"Kaza","year":"2012","journal-title":"Brain Pathol."},{"key":"10.1016\/j.bbamcr.2020.118692_bb0035","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/j.fob.2014.08.005","article-title":"ROS-dependent prostate apoptosis response-4 (Par-4) up-regulation and ceramide generation are the prime signaling events associated with curcumin-induced autophagic cell death in human malignant glioma","volume":"4","author":"Thayyullathil","year":"2014","journal-title":"FEBS Open Bio"},{"key":"10.1016\/j.bbamcr.2020.118692_bb0040","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.freeradbiomed.2015.10.404","article-title":"ROS-dependent activation of autophagy is a critical mechanism for the induction of anti-glioma effect of sanguinarine","volume":"89","author":"Pallichankandy","year":"2015","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbamcr.2020.118692_bb0045","doi-asserted-by":"crossref","first-page":"3873","DOI":"10.1038\/onc.2010.141","article-title":"Cancer-selective apoptotic effects of extracellular and intracellular Par-4","volume":"29","author":"Shrestha-Bhattarai","year":"2010","journal-title":"Oncogene"},{"key":"10.1016\/j.bbamcr.2020.118692_bb0050","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1158\/0008-5472.CAN-06-2687","article-title":"Inactivation of the candidate tumor suppressor par-4 in endometrial cancer","volume":"67","author":"Moreno-Bueno","year":"2007","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbamcr.2020.118692_bb0055","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1038\/sj.onc.1202416","article-title":"Decreased expression of the pro-apoptotic protein Par-4 in renal cell carcinoma","volume":"18","author":"Cook","year":"1999","journal-title":"Oncogene"},{"key":"10.1016\/j.bbamcr.2020.118692_bb0060","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.ccr.2013.05.007","article-title":"Par-4 downregulation promotes breast cancer recurrence by preventing multinucleation following targeted therapy","volume":"24","author":"Alvarez","year":"2013","journal-title":"Cancer Cell"},{"key":"10.1016\/j.bbamcr.2020.118692_bb0065","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/sj.embor.7400421","article-title":"Tumour-suppression activity of the proapoptotic regulator Par4","volume":"6","author":"Garcia-Cao","year":"2005","journal-title":"EMBO Rep."},{"key":"10.1016\/j.bbamcr.2020.118692_bb0070","doi-asserted-by":"crossref","first-page":"9276","DOI":"10.1158\/0008-5472.CAN-07-2124","article-title":"Cancer resistance in transgenic mice expressing the SAC module of Par-4","volume":"67","author":"Zhao","year":"2007","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbamcr.2020.118692_bb0075","doi-asserted-by":"crossref","first-page":"5516","DOI":"10.1128\/MCB.23.16.5516-5525.2003","article-title":"Identification of a unique core domain of par-4 sufficient for selective apoptosis induction in cancer cells","volume":"23","author":"El-Guendy","year":"2003","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.bbamcr.2020.118692_bb0080","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1750-2187-8-2","article-title":"Caspase-3 mediated release of SAC domain containing fragment from Par-4 is necessary for the sphingosine-induced apoptosis in Jurkat cells","volume":"8","author":"Thayyullathil","year":"2013","journal-title":"J. Mol. Signal."},{"key":"10.1016\/j.bbamcr.2020.118692_bb0085","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1128\/MCB.06321-11","article-title":"Prostate apoptosis response 4 (Par-4), a novel substrate of caspase-3 during apoptosis activation","volume":"32","author":"Chaudhry","year":"2012","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.bbamcr.2020.118692_bb0090","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1038\/nrc2723","article-title":"The first 30 years of p53: growing ever more complex","volume":"9","author":"Levine","year":"2009","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.bbamcr.2020.118692_bb0095","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/nrm2147","article-title":"p53 in health and disease","volume":"8","author":"Vousden","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bbamcr.2020.118692_bb0100","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.canlet.2018.04.009","article-title":"Par-4-dependent p53 up-regulation plays a critical role in thymoquinone-induced cellular senescence in human malignant glioma cells","volume":"426","author":"Subburayan","year":"2018","journal-title":"Cancer Lett."},{"key":"10.1016\/j.bbamcr.2020.118692_bb0105","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1038\/cdd.2009.16","article-title":"Role of BNIP3 and NIX in cell death, autophagy, and mitophagy","volume":"16","author":"Zhang","year":"2009","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.bbamcr.2020.118692_bb0110","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1080\/15548627.2015.1085136","article-title":"Tumor suppressor functions of BNIP3 and mitophagy","volume":"11","author":"Chourasia","year":"2015","journal-title":"Autophagy"},{"key":"10.1016\/j.bbamcr.2020.118692_bb0115","doi-asserted-by":"crossref","first-page":"9082","DOI":"10.1073\/pnas.97.16.9082","article-title":"Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia","volume":"97","author":"Bruick","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbamcr.2020.118692_bb0120","first-page":"6669","article-title":"HIF-1-dependent regulation of hypoxic induction of the cell death factors BNIP3 and NIX in human tumors","volume":"61","author":"Sowter","year":"2001","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbamcr.2020.118692_bb0125","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.tibs.2010.07.007","article-title":"Regulation of autophagy by ROS: physiology and pathology","volume":"36","author":"Scherz-Shouval","year":"2011","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.bbamcr.2020.118692_bb0130","doi-asserted-by":"crossref","first-page":"2570","DOI":"10.1128\/MCB.00166-09","article-title":"Hypoxia-induced autophagy is mediated through hypoxia-inducible factor induction of BNIP3 and BNIP3L via their BH3 domains","volume":"29","author":"Bellot","year":"2009","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.bbamcr.2020.118692_bb0135","doi-asserted-by":"crossref","first-page":"2527","DOI":"10.1038\/sj.emboj.7601689","article-title":"Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1","volume":"26","author":"Maiuri","year":"2007","journal-title":"EMBO J."},{"key":"10.1016\/j.bbamcr.2020.118692_bb0140","doi-asserted-by":"crossref","first-page":"35803","DOI":"10.1074\/jbc.M705231200","article-title":"Bnip3 mediates the hypoxia-induced inhibition on mammalian target of rapamycin by interacting with Rheb","volume":"282","author":"Li","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamcr.2020.118692_bb0145","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1038\/sj.onc.1208095","article-title":"Arsenic trioxide induces autophagic cell death in malignant glioma cells by upregulation of mitochondrial cell death protein BNIP3","volume":"24","author":"Kanzawa","year":"2005","journal-title":"Oncogene"},{"key":"10.1016\/j.bbamcr.2020.118692_bb0150","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1007\/s10495-015-1109-1","article-title":"Tumor suppressive functions of ceramide: evidence and mechanisms","volume":"20","author":"Galadari","year":"2015","journal-title":"Apoptosis"},{"key":"10.1016\/j.bbamcr.2020.118692_bb0155","doi-asserted-by":"crossref","first-page":"18384","DOI":"10.1074\/jbc.M313561200","article-title":"Ceramide-mediated macroautophagy involves inhibition of protein kinase B and up-regulation of beclin 1","volume":"279","author":"Scarlatti","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamcr.2020.118692_bb0160","doi-asserted-by":"crossref","first-page":"4286","DOI":"10.1158\/0008-5472.CAN-03-3084","article-title":"Pivotal role of the cell death factor BNIP3 in ceramide-induced autophagic cell death in malignant glioma cells","volume":"64","author":"Daido","year":"2004","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbamcr.2020.118692_bb0165","doi-asserted-by":"crossref","first-page":"104022","DOI":"10.18632\/oncotarget.21955","article-title":"Overexpression of ceramide synthase 1 increases C18-ceramide and leads to lethal autophagy in human glioma","volume":"8","author":"Wang","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.bbamcr.2020.118692_bb0170","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.cell.2010.01.028","article-title":"Methods in mammalian autophagy research","volume":"140","author":"Mizushima","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.bbamcr.2020.118692_bb0175","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1038\/cdd.2016.8","article-title":"Cancer therapy in the necroptosis era","volume":"23","author":"Su","year":"2016","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.bbamcr.2020.118692_bb0180","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.tcb.2015.10.014","article-title":"Ferroptosis: death by lipid peroxidation","volume":"26","author":"Yang","year":"2016","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.bbamcr.2020.118692_bb0185","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.4161\/auto.28777","article-title":"New role for EMD (emerin), a key inner nuclear membrane protein, as an enhancer of autophagosome formation in the C16-ceramide autophagy pathway","volume":"10","author":"Deroyer","year":"2014","journal-title":"Autophagy"},{"key":"10.1016\/j.bbamcr.2020.118692_bb0190","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.cellsig.2013.10.004","article-title":"Yessotoxin induces ER-stress followed by autophagic cell death in glioma cells mediated by mTOR and BNIP3","volume":"26","author":"Rubiolo","year":"2014","journal-title":"Cell. Signal."},{"key":"10.1016\/j.bbamcr.2020.118692_bb0195","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1038\/nature07986","article-title":"Cytoplasmic functions of the tumour suppressor p53","volume":"458","author":"Green","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.bbamcr.2020.118692_bb0200","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1161\/HYPERTENSIONAHA.113.01028","article-title":"p53 mediates autophagy and cell death by a mechanism contingent on Bnip3","volume":"62","author":"Wang","year":"2013","journal-title":"Hypertension"},{"key":"10.1016\/j.bbamcr.2020.118692_bb0205","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1126\/science.1092472","article-title":"In vivo activation of the p53 pathway by small-molecule antagonists of MDM2","volume":"303","author":"Vassilev","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.bbamcr.2020.118692_bb0210","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.ajpath.2013.10.012","article-title":"Concomitant induction of apoptosis and autophagy by prostate apoptosis response-4 in hypopharyngeal carcinoma cells","volume":"184","author":"Wang","year":"2014","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bbamcr.2020.118692_bb0215","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1038\/emboj.2008.149","article-title":"Par-4 inhibits Akt and suppresses Ras-induced lung tumorigenesis","volume":"27","author":"Joshi","year":"2008","journal-title":"EMBO J."},{"key":"10.1016\/j.bbamcr.2020.118692_bb0220","doi-asserted-by":"crossref","first-page":"2518","DOI":"10.4161\/cc.8.16.9384","article-title":"The Par-4\/PTEN connection in tumor suppression","volume":"8","author":"Diaz-Meco","year":"2009","journal-title":"Cell Cycle"}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167488920300501?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167488920300501?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T19:53:11Z","timestamp":1759089191000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167488920300501"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":44,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["S0167488920300501"],"URL":"https:\/\/doi.org\/10.1016\/j.bbamcr.2020.118692","relation":{},"ISSN":["0167-4889"],"issn-type":[{"value":"0167-4889","type":"print"}],"subject":[],"published":{"date-parts":[[2020,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Par-4 regulates autophagic cell death in human cancer cells via upregulating p53 and BNIP3","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Cell Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbamcr.2020.118692","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"118692"}}