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Protoc."},{"key":"10.1016\/j.bbamcr.2020.118763_bb0455","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.aninu.2015.08.004","article-title":"The profiles of mitochondrial respiration and glycolysis using extracellular flux analysis in porcine enterocyte IPEC-J2","volume":"1","author":"Tan","year":"2015","journal-title":"Anim Nutr"},{"key":"10.1016\/j.bbamcr.2020.118763_bb0460","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1016\/j.freeradbiomed.2011.08.005","article-title":"Assessing bioenergetic function in response to oxidative stress by metabolic profiling","volume":"51","author":"Dranka","year":"2011","journal-title":"Free Radic. Biol. 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Neurochem."},{"key":"10.1016\/j.bbamcr.2020.118763_bb0490","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.neuroscience.2008.06.015","article-title":"Subcellular localization of transporters along the rat blood-brain barrier and blood-cerebral-spinal fluid barrier by in vivo biotinylation","volume":"155","author":"Roberts","year":"2008","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbamcr.2020.118763_bb0495","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1038\/jcbfm.2011.21","article-title":"Differential axial localization along the mouse brain vascular tree of luminal sodium-dependent glutamine transporters Snat1 and Snat3","volume":"31","author":"Ruderisch","year":"2011","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.bbamcr.2020.118763_bb0500","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1007\/s00018-014-1771-4","article-title":"Iron transport across the blood-brain barrier: development, neurovascular regulation and cerebral amyloid angiopathy","volume":"72","author":"McCarthy","year":"2015","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.bbamcr.2020.118763_bb0505","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.cell.2010.06.028","article-title":"Two to tango: regulation of mammalian iron metabolism","volume":"142","author":"Hentze","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.bbamcr.2020.118763_bb0510","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.cell.2016.12.034","article-title":"A red carpet for Iron metabolism","volume":"168","author":"Muckenthaler","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.bbamcr.2020.118763_bb0515","first-page":"H1149","article-title":"Receptor-mediated transcytosis of transferrin through blood-brain barrier endothelial cells","volume":"270","author":"Descamps","year":"1996","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.bbamcr.2020.118763_bb0520","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.molcel.2018.11.035","article-title":"SubCellBarCode: proteome-wide mapping of protein localization and relocalization","volume":"73","author":"Orre","year":"2019","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bbamcr.2020.118763_bb0525","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1089\/ars.2007.1893","article-title":"Intracellular iron transport and storage: from molecular mechanisms to health implications","volume":"10","author":"MacKenzie","year":"2008","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.bbamcr.2020.118763_bb0530","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1042\/BJ20041853","article-title":"Characterization of nuclear ferritin and mechanism of translocation","volume":"388","author":"Surguladze","year":"2005","journal-title":"Biochem. J."},{"key":"10.1016\/j.bbamcr.2020.118763_bb0535","doi-asserted-by":"crossref","first-page":"23963","DOI":"10.1074\/jbc.M210050200","article-title":"Ferritoid, a tissue-specific nuclear transport protein for ferritin in corneal epithelial cells","volume":"278","author":"Millholland","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamcr.2020.118763_bb0540","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1091\/mbc.9.5.1037","article-title":"Nuclear ferritin protects DNA from UV damage in corneal epithelial cells","volume":"9","author":"Cai","year":"1998","journal-title":"Mol. Biol. 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Hematol."},{"key":"10.1016\/j.bbamcr.2020.118763_bb0560","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0152016","article-title":"Determining maximum glycolytic capacity using extracellular flux measurements","volume":"11","author":"Mookerjee","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.bbamcr.2020.118763_bb0565","doi-asserted-by":"crossref","first-page":"12608","DOI":"10.1038\/s41598-019-48676-2","article-title":"The role of glycolysis and mitochondrial respiration in the formation and functioning of endothelial tip cells during angiogenesis","volume":"9","author":"Yetkin-Arik","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbamcr.2020.118763_bb0570","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1093\/oxfordjournals.jbchem.a127334","article-title":"The use of oligomycin as an inhibitor of oxidative phosphorylation","volume":"49","author":"Huijing","year":"1961","journal-title":"J. Biochem."},{"key":"10.1016\/j.bbamcr.2020.118763_bb0575","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1186\/1476-4598-12-152","article-title":"Tumor glycolysis as a target for cancer therapy: progress and prospects","volume":"12","author":"Ganapathy-Kanniappan","year":"2013","journal-title":"Mol. 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Biophys. Acta"},{"key":"10.1016\/j.bbamcr.2020.118763_bb0610","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.cbpa.2011.01.006","article-title":"Iron-containing transcription factors and their roles as sensors","volume":"15","author":"Fleischhacker","year":"2011","journal-title":"Curr. Opin. Chem. Biol."},{"key":"10.1016\/j.bbamcr.2020.118763_bb0615","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1006\/jmbi.1997.1377","article-title":"Structure and dynamics of the iron responsive element RNA: implications for binding of the RNA by iron regulatory binding proteins","volume":"274","author":"Addess","year":"1997","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.bbamcr.2020.118763_bb0620","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/s13024-017-0218-4","article-title":"Iron regulatory protein (IRP)-iron responsive element (IRE) signaling pathway in human neurodegenerative diseases","volume":"12","author":"Zhou","year":"2017","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.bbamcr.2020.118763_bb0625","series-title":"Mitochondrial Respiratory States and Rates","author":"Frostner","year":"2019"},{"key":"10.1016\/j.bbamcr.2020.118763_bb0630","doi-asserted-by":"crossref","first-page":"2889","DOI":"10.1021\/cr950051s","article-title":"Heme\/copper terminal oxidases","volume":"96","author":"Ferguson-Miller","year":"1996","journal-title":"Chem. Rev."},{"key":"10.1016\/j.bbamcr.2020.118763_bb0635","doi-asserted-by":"crossref","first-page":"36","DOI":"10.3389\/fphys.2015.00036","article-title":"Mitochondrial uncoupling proteins and energy metabolism","volume":"6","author":"Busiello","year":"2015","journal-title":"Front. Physiol."},{"key":"10.1016\/j.bbamcr.2020.118763_bb0640","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1016\/j.bbabio.2011.04.003","article-title":"Uncoupled respiration, ROS production, acute lipotoxicity and oxidative damage in isolated skeletal muscle mitochondria from UCP3-ablated mice","volume":"1807","author":"Nabben","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbamcr.2020.118763_bb0645","doi-asserted-by":"crossref","unstructured":"M.B. Gerstein, A. Kundaje, M. Hariharan, S.G. Landt, K.-K. Yan, C. Cheng, X.J. Mu, E. Khurana, J. Rozowsky, R. Alexander, R. Min, P. Alves, A. Abyzov, N. Addleman, N. Bhardwaj, A.P. Boyle, P. Cayting, A. Charos, D.Z. Chen, Y. Cheng, D. Clarke, C. Eastman, G. Euskirchen, S. Frietze, Y. Fu, J. Gertz, F. Grubert, A. Harmanci, P. Jain, M. Kasowski, P. Lacroute, J. Leng, J. Lian, H. Monahan, H. O'Geen, Z. Ouyang, E.C. Partridge, D. Patacsil, F. Pauli, D. Raha, L. Ramirez, T.E. Reddy, B. Reed, M. Shi, T. Slifer, J. Wang, L. Wu, X. Yang, K.Y. Yip, G. Zilberman-Schapira, S. Batzoglou, A. Sidow, P.J. Farnham, R.M. Myers, S.M. Weissman, M. Snyder, Architecture of the human regulatory network derived from ENCODE data, Nature, 489 (2012) 91\u2013100.","DOI":"10.1038\/nature11245"},{"key":"10.1016\/j.bbamcr.2020.118763_bb0650","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.1101\/gr.139105.112","article-title":"Sequence features and chromatin structure around the genomic regions bound by 119 human transcription factors","volume":"22","author":"Wang","year":"2012","journal-title":"Genome Res."},{"key":"10.1016\/j.bbamcr.2020.118763_bb0655","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/nature09906","article-title":"Mapping and analysis of chromatin state dynamics in nine human cell types","volume":"473","author":"Ernst","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.bbamcr.2020.118763_bb0660","series-title":"GeneHancer: Genome-Wide Integration of Enhancers and Target Genes in GeneCards, Database (Oxford), 2017","author":"Fishilevich","year":"2017"},{"key":"10.1016\/j.bbamcr.2020.118763_bb0665","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/0022-2836(87)90689-9","article-title":"CpG islands in vertebrate genomes","volume":"196","author":"Gardiner-Garden","year":"1987","journal-title":"J. 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Gillespie, Perinuclear mitochondrial clustering creates an oxidant-rich nuclear domain required for hypoxia-induced transcription, Sci Signal, 5 (2012) ra47.","DOI":"10.1126\/scisignal.2002712"},{"key":"10.1016\/j.bbamcr.2020.118763_bb0685","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1111\/j.1476-5381.2010.00902.x","article-title":"Role of perinuclear mitochondria in the spatiotemporal dynamics of spontaneous Ca2+ waves in interstitial cells of Cajal-like cells of the rabbit urethra","volume":"161","author":"Hashitani","year":"2010","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bbamcr.2020.118763_bb0690","doi-asserted-by":"crossref","first-page":"22704","DOI":"10.1074\/jbc.M312366200","article-title":"Ca(2+) homeostasis during mitochondrial fragmentation and perinuclear clustering induced by hFis1","volume":"279","author":"Frieden","year":"2004","journal-title":"J. Biol. 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