{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T00:34:45Z","timestamp":1792715685711,"version":"4.5.0"},"reference-count":44,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Cell Research"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.bbamcr.2020.118806","type":"journal-article","created":{"date-parts":[[2020,7,30]],"date-time":"2020-07-30T21:48:59Z","timestamp":1596145739000},"page":"118806","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"title":["Crosstalk between pleural mesothelial cell and lung fibroblast contributes to pulmonary fibrosis"],"prefix":"10.1016","volume":"1867","author":[{"given":"Fei","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Zhi","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei-Pei","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Mei","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai-Jun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin-Jie","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-Liang","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Bao","family":"Xin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan-Li","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbamcr.2020.118806_bb0005","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1164\/rccm.201011-1874OC","article-title":"BUILD-3: a randomized, controlled trial of bosentan in idiopathic pulmonary fibrosis","volume":"184","author":"King","year":"2011","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.bbamcr.2020.118806_bb0010","doi-asserted-by":"crossref","first-page":"e44","DOI":"10.1164\/rccm.201807-1255ST","article-title":"Latin American Thoracic, diagnosis of idiopathic pulmonary fibrosis. An official ATS\/ERS\/JRS\/ALAT clinical practice guideline","volume":"198","author":"Raghu","year":"2018","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.bbamcr.2020.118806_bb0015","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s40139-017-0134-x","article-title":"Heterogeneity of fibroblasts and myofibroblasts in pulmonary fibrosis","volume":"5","author":"Habiel","year":"2017","journal-title":"Curr Pathobiol Rep"},{"key":"10.1016\/j.bbamcr.2020.118806_bb0020","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1164\/rccm.200602-163OC","article-title":"Incidence and prevalence of idiopathic pulmonary fibrosis","volume":"174","author":"Raghu","year":"2006","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.bbamcr.2020.118806_bb0025","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1164\/rccm.201212-2297OC","article-title":"Role of lung pericytes and resident fibroblasts in the pathogenesis of pulmonary fibrosis","volume":"188","author":"Hung","year":"2013","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.bbamcr.2020.118806_bb0030","doi-asserted-by":"crossref","first-page":"L115","DOI":"10.1152\/ajplung.90587.2008","article-title":"Pleural mesothelial cell transformation into myofibroblasts and haptotactic migration in response to TGF-beta1 in vitro","volume":"297","author":"Nasreen","year":"2009","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.bbamcr.2020.118806_bb0035","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.taap.2015.01.004","article-title":"Bleomycin induced epithelial-mesenchymal transition (EMT) in pleural mesothelial cells","volume":"283","author":"Chen","year":"2015","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.bbamcr.2020.118806_bb0040","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1096\/fj.13-236828","article-title":"Wilms\u2019 tumor 1 (Wt1) regulates pleural mesothelial cell plasticity and transition into myofibroblasts in idiopathic pulmonary fibrosis","volume":"28","author":"Karki","year":"2014","journal-title":"FASEB J."},{"key":"10.1016\/j.bbamcr.2020.118806_bb0045","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1097\/MCP.0b013e328349ac2b","article-title":"Modeling pulmonary fibrosis with bleomycin","volume":"17","author":"Mouratis","year":"2011","journal-title":"Curr Opinion Pulm Med"},{"key":"10.1016\/j.bbamcr.2020.118806_bb0050","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1183\/09031936.00141010","article-title":"Parenchymal trafficking of pleural mesothelial cells in idiopathic pulmonary fibrosis","volume":"39","author":"Mubarak","year":"2012","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.bbamcr.2020.118806_bb0055","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1016\/j.bbamcr.2018.05.013","article-title":"Lethal (2) giant larvae regulates pleural mesothelial cell polarity in pleural fibrosis","volume":"1865","author":"Song","year":"2018","journal-title":"Biochim Biophys Acta Mol Cell Res"},{"key":"10.1016\/j.bbamcr.2020.118806_bb0060","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1016\/j.ajpath.2012.12.030","article-title":"Pleural mesothelial cell differentiation and invasion in fibrogenic lung injury","volume":"182","author":"Zolak","year":"2013","journal-title":"Am J Path"},{"key":"10.1016\/j.bbamcr.2020.118806_bb0065","doi-asserted-by":"crossref","first-page":"re8","DOI":"10.1126\/scisignal.2005189","article-title":"Signaling mechanisms of the epithelial-mesenchymal transition","volume":"7","author":"Gonzalez","year":"2014","journal-title":"Sci. Signal."},{"key":"10.1016\/j.bbamcr.2020.118806_bb0070","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/embor.2009.276","article-title":"Integrin-TGF-beta crosstalk in fibrosis, cancer and wound healing","volume":"11","author":"Margadant","year":"2010","journal-title":"EMBO Rep."},{"key":"10.1016\/j.bbamcr.2020.118806_bb0075","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1164\/rccm.201708-1580OC","article-title":"Increased extracellular vesicles mediate WNT-5A signaling in idiopathic pulmonary fibrosis","volume":"198","author":"Martin-Medina","year":"2018","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.bbamcr.2020.118806_bb0080","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1165\/rcmb.2008-0201OC","article-title":"WNT5A is a regulator of fibroblast proliferation and resistance to apoptosis","volume":"41","author":"Vuga","year":"2009","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.bbamcr.2020.118806_bb0085","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1080\/01902140600710512","article-title":"Increased extracellular matrix metalloproteinase inducer (EMMPRIN) expression in pulmonary fibrosis","volume":"32","author":"Guillot","year":"2006","journal-title":"Exp. Lung Res."},{"key":"10.1016\/j.bbamcr.2020.118806_bb0090","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1016\/j.bbadis.2015.06.008","article-title":"Crosstalk between calpain activation and TGF-beta1 augments collagen-I synthesis in pulmonary fibrosis","volume":"1852","author":"Li","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbamcr.2020.118806_bb0095","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.ymthe.2016.12.017","article-title":"miR-18a-5p inhibits sub-pleural pulmonary fibrosis by targeting TGF-beta receptor II","volume":"25","author":"Zhang","year":"2017","journal-title":"Mol. Ther."},{"key":"10.1016\/j.bbamcr.2020.118806_bb0100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.toxlet.2018.12.008","article-title":"Cigarette smoking aggravates bleomycin-induced experimental pulmonary fibrosis","volume":"303","author":"Zhou","year":"2019","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.bbamcr.2020.118806_bb0105","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/j.ebiom.2019.02.057","article-title":"miR-4739 mediates pleural fibrosis by targeting bone morphogenetic protein 7","volume":"41","author":"Wang","year":"2019","journal-title":"EBioMedicine"},{"key":"10.1016\/j.bbamcr.2020.118806_bb0110","doi-asserted-by":"crossref","first-page":"L145","DOI":"10.1152\/ajplung.00348.2015","article-title":"Activation of calpain by renin-angiotensin system in pleural mesothelial cells mediates tuberculous pleural fibrosis","volume":"311","author":"Yang","year":"2016","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.bbamcr.2020.118806_bb0115","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1111\/j.1524-475X.2011.00680.x","article-title":"Transforming growth factor-beta1 suppresses the up-regulation of matrix metalloproteinase-2 by lung fibroblasts in response to tumor necrosis factor-alpha","volume":"19","author":"Ye","year":"2011","journal-title":"Wound Repair Regen."},{"key":"10.1016\/j.bbamcr.2020.118806_bb0120","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1056\/NEJM199411103311907","article-title":"Transforming growth factor beta in tissue fibrosis","volume":"331","author":"Border","year":"1994","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbamcr.2020.118806_bb0125","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1016\/S0140-6736(11)60052-4","article-title":"Idiopathic pulmonary fibrosis","volume":"378","author":"King","year":"2011","journal-title":"Lancet"},{"key":"10.1016\/j.bbamcr.2020.118806_bb0130","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1084\/jem.20110551","article-title":"Integrating mechanisms of pulmonary fibrosis","volume":"208","author":"Wynn","year":"2011","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.bbamcr.2020.118806_bb0135","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1183\/09031936.03.00014703","article-title":"Cytokine profiles in idiopathic pulmonary fibrosis suggest an important role for TGF-beta and IL-10","volume":"22","author":"Bergeron","year":"2003","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.bbamcr.2020.118806_bb0140","doi-asserted-by":"crossref","first-page":"5390","DOI":"10.4049\/jimmunol.175.8.5390","article-title":"TGF-beta and Smad3 signaling link inflammation to chronic fibrogenesis","volume":"175","author":"Bonniaud","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.bbamcr.2020.118806_bb0145","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1164\/rccm.200405-612OC","article-title":"Progressive transforming growth factor beta1-induced lung fibrosis is blocked by an orally active ALK5 kinase inhibitor","volume":"171","author":"Bonniaud","year":"2005","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.bbamcr.2020.118806_bb0150","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1165\/ajrcmb\/5.2.155","article-title":"Increased production and immunohistochemical localization of transforming growth factor-beta in idiopathic pulmonary fibrosis","volume":"5","author":"Khalil","year":"1991","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.bbamcr.2020.118806_bb0155","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1172\/JCI119590","article-title":"Adenovector-mediated gene transfer of active transforming growth factor-beta1 induces prolonged severe fibrosis in rat lung","volume":"100","author":"Sime","year":"1997","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbamcr.2020.118806_bb0160","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1056\/NEJM200005043421807","article-title":"Role of transforming growth factor beta in human disease","volume":"342","author":"Blobe","year":"2000","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbamcr.2020.118806_bb0165","doi-asserted-by":"crossref","first-page":"12384","DOI":"10.1074\/jbc.M208544200","article-title":"Myofibroblast differentiation by transforming growth factor-beta1 is dependent on cell adhesion and integrin signaling via focal adhesion kinase","volume":"278","author":"Thannickal","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamcr.2020.118806_bb0170","doi-asserted-by":"crossref","first-page":"L525","DOI":"10.1152\/ajplung.00163.2007","article-title":"TGF-beta-induced EMT: mechanisms and implications for fibrotic lung disease","volume":"293","author":"Willis","year":"2007","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.bbamcr.2020.118806_bb0175","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/j.ajpath.2017.12.004","article-title":"A shared pattern of beta-catenin activation in bronchopulmonary dysplasia and idiopathic pulmonary fibrosis","volume":"188","author":"Sucre","year":"2018","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bbamcr.2020.118806_bb0180","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1016\/S0002-9440(10)64282-4","article-title":"Aberrant Wnt\/beta-catenin pathway activation in idiopathic pulmonary fibrosis","volume":"162","author":"Chilosi","year":"2003","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bbamcr.2020.118806_bb0185","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0002142","article-title":"Functional Wnt signaling is increased in idiopathic pulmonary fibrosis","volume":"3","author":"Konigshoff","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.bbamcr.2020.118806_bb0190","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-28968-9","article-title":"Inhibition of Wnt\/beta-catenin signaling suppresses myofibroblast differentiation of lung resident mesenchymal stem cells and pulmonary fibrosis","volume":"8","author":"Cao","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbamcr.2020.118806_bb0195","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.yexmp.2016.04.003","article-title":"Inhibition of Wnt\/beta-catenin signaling suppresses bleomycin-induced pulmonary fibrosis by attenuating the expression of TGF-beta1 and FGF-2","volume":"101","author":"Chen","year":"2016","journal-title":"Exp. Mol. Pathol."},{"key":"10.1016\/j.bbamcr.2020.118806_bb0200","doi-asserted-by":"crossref","first-page":"14309","DOI":"10.1073\/pnas.1001520107","article-title":"Inhibition of Wnt\/beta-catenin\/CREB binding protein (CBP) signaling reverses pulmonary fibrosis","volume":"107","author":"Henderson","year":"2010","journal-title":"Proc Nati Acad Sci U. S. A."},{"key":"10.1016\/j.bbamcr.2020.118806_bb0205","first-page":"434","article-title":"The human tumor cell-derived collagenase stimulatory factor (renamed EMMPRIN) is a member of the immunoglobulin superfamily","volume":"55","author":"Biswas","year":"1995","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbamcr.2020.118806_bb0210","doi-asserted-by":"crossref","unstructured":"D. Guindolet, E.E. Gabison, Role of CD147 (EMMPRIN\/Basigin) in Tissue Remodeling, Anat Rec (Hoboken) doi:https:\/\/doi.org\/10.1002\/ar.24089, Epub ahead of print (2019).","DOI":"10.1002\/ar.24089"},{"key":"10.1016\/j.bbamcr.2020.118806_bb0215","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1111\/j.1440-1827.2006.01972.x","article-title":"Emmprin (basigin\/CD147): matrix metalloproteinase modulator and multifunctional cell recognition molecule that plays a critical role in cancer progression","volume":"56","author":"Nabeshima","year":"2006","journal-title":"Pathol. Int."},{"key":"10.1016\/j.bbamcr.2020.118806_bb0220","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1189\/jlb.3RU0215-045R","article-title":"The role of EMMPRIN in T cell biology and immunological diseases","volume":"98","author":"Hahn","year":"2015","journal-title":"J. Leukoc. Biol."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167488920301646?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167488920301646?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T19:53:22Z","timestamp":1759089202000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167488920301646"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":44,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["S0167488920301646"],"URL":"https:\/\/doi.org\/10.1016\/j.bbamcr.2020.118806","relation":{},"ISSN":["0167-4889"],"issn-type":[{"value":"0167-4889","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Crosstalk between pleural mesothelial cell and lung fibroblast contributes to pulmonary fibrosis","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Cell Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbamcr.2020.118806","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"118806"}}