{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T00:26:18Z","timestamp":1793147178160,"version":"4.5.0"},"reference-count":81,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,9,11]],"date-time":"2020-09-11T00:00:00Z","timestamp":1599782400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["FDN 143278"],"award-info":[{"award-number":["FDN 143278"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["FDN 374958"],"award-info":[{"award-number":["FDN 374958"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008572","name":"University of Ottawa","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008572","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Cell Research"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.bbamcr.2020.118854","type":"journal-article","created":{"date-parts":[[2020,9,11]],"date-time":"2020-09-11T11:35:27Z","timestamp":1599824127000},"page":"118854","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["Altered mitochondrial fusion drives defensive glutathione synthesis in cells able to switch to glycolytic ATP production"],"prefix":"10.1016","volume":"1868","author":[{"given":"David A.","family":"Patten","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shawn","family":"McGuirk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ujval","family":"Anilkumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghadi","family":"Antoun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karan","family":"Gandhi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaganvir","family":"Parmar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed Ariff","family":"Iqbal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard B.","family":"Richardson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"St-Pierre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth S.","family":"Slack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary-Ellen","family":"Harper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbamcr.2020.118854_bb0005","first-page":"505","article-title":"Mito-Morphosis: mitochondrial fusion","volume":"78","author":"Pernas","year":"2016","journal-title":"Fission, and Cristae Remodeling as Key Mediators of Cellular Function, Annu Rev Physiol"},{"issue":"2","key":"10.1016\/j.bbamcr.2020.118854_bb0010","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1083\/jcb.200211046","article-title":"Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development","volume":"160","author":"Chen","year":"2003","journal-title":"J. Cell Biol."},{"issue":"2","key":"10.1016\/j.bbamcr.2020.118854_bb0015","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.cell.2006.09.021","article-title":"Mitochondrial inner-membrane fusion and crista maintenance requires the dynamin-related GTPase Mgm1","volume":"127","author":"Meeusen","year":"2006","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.bbamcr.2020.118854_bb0020","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1091\/mbc.e12-10-0721","article-title":"Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in mitochondrial fission","volume":"24","author":"Loson","year":"2013","journal-title":"Mol. Biol. Cell"},{"issue":"5","key":"10.1016\/j.bbamcr.2020.118854_bb0025","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/13014","article-title":"The dynamin-related GTPase Dnm1 regulates mitochondrial fission in yeast","volume":"1","author":"Bleazard","year":"1999","journal-title":"Nat. Cell Biol."},{"issue":"8","key":"10.1016\/j.bbamcr.2020.118854_bb0030","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.1091\/mbc.12.8.2245","article-title":"Dynamin-related protein Drp1 is required for mitochondrial division in mammalian cells","volume":"12","author":"Smirnova","year":"2001","journal-title":"Mol. Biol. Cell"},{"issue":"2","key":"10.1016\/j.bbamcr.2020.118854_bb0035","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/79944","article-title":"OPA1, encoding a dynamin-related GTPase, is mutated in autosomal dominant optic atrophy linked to chromosome 3q28","volume":"26","author":"Alexander","year":"2000","journal-title":"Nat. Genet."},{"issue":"2","key":"10.1016\/j.bbamcr.2020.118854_bb0040","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/79936","article-title":"Nuclear gene OPA1, encoding a mitochondrial dynamin-related protein, is mutated in dominant optic atrophy","volume":"26","author":"Delettre","year":"2000","journal-title":"Nat. Genet."},{"issue":"5","key":"10.1016\/j.bbamcr.2020.118854_bb0045","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1038\/ng1341","article-title":"Mutations in the mitochondrial GTPase mitofusin 2 cause Charcot-Marie-tooth neuropathy type 2A","volume":"36","author":"Zuchner","year":"2004","journal-title":"Nat. Genet."},{"issue":"7","key":"10.1016\/j.bbamcr.2020.118854_bb0050","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1016\/j.cell.2006.06.010","article-title":"Mitochondria: dynamic organelles in disease, aging, and development","volume":"125","author":"Chan","year":"2006","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.bbamcr.2020.118854_bb0055","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.cmet.2013.03.002","article-title":"Mitochondrial dynamics in the regulation of nutrient utilization and energy expenditure","volume":"17","author":"Liesa","year":"2013","journal-title":"Cell Metab."},{"issue":"R2","key":"10.1016\/j.bbamcr.2020.118854_bb0060","doi-asserted-by":"crossref","first-page":"R169","DOI":"10.1093\/hmg\/ddp326","article-title":"Mitochondrial dynamics\u2014fusion, fission, movement, and mitophagy\u2014in neurodegenerative diseases","volume":"18","author":"Chen","year":"2009","journal-title":"Hum. Mol. Genet."},{"issue":"23","key":"10.1016\/j.bbamcr.2020.118854_bb0065","doi-asserted-by":"crossref","first-page":"2236","DOI":"10.1056\/NEJMra1215233","article-title":"Mitochondrial dynamics\u2014mitochondrial fission and fusion in human diseases","volume":"369","author":"Archer","year":"2013","journal-title":"N. Engl. J. Med."},{"issue":"5","key":"10.1016\/j.bbamcr.2020.118854_bb0070","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1177\/1535370213493069","article-title":"Oxidative stress response elicited by mitochondrial dysfunction: implication in the pathophysiology of aging","volume":"238","author":"Wang","year":"2013","journal-title":"Exp Biol Med (Maywood)"},{"key":"10.1016\/j.bbamcr.2020.118854_bb0075","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.redox.2014.02.006","article-title":"Hydrogen peroxide sensing, signaling and regulation of transcription factors","volume":"2","author":"Marinho","year":"2014","journal-title":"Redox Biol."},{"key":"10.1016\/j.bbamcr.2020.118854_bb0080","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.redox.2016.12.035","article-title":"Hydrogen peroxide as a central redox signaling molecule in physiological oxidative stress: oxidative eustress","volume":"11","author":"Sies","year":"2017","journal-title":"Redox Biol."},{"issue":"14","key":"10.1016\/j.bbamcr.2020.118854_bb0085","doi-asserted-by":"crossref","first-page":"4668","DOI":"10.1073\/pnas.82.14.4668","article-title":"Origin and turnover of mitochondrial glutathione","volume":"82","author":"Griffith","year":"1985","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbamcr.2020.118854_bb0090","doi-asserted-by":"crossref","first-page":"68","DOI":"10.3389\/fcell.2014.00068","article-title":"S-glutathionylation reactions in mitochondrial function and disease","volume":"2","author":"Mailloux","year":"2014","journal-title":"Front Cell Dev Biol"},{"key":"10.1016\/j.bbamcr.2020.118854_bb0095","first-page":"95","article-title":"Regulation of glutathione synthesis","volume":"36","author":"Lu","year":"2000","journal-title":"Curr. Top. Cell. Regul."},{"issue":"3","key":"10.1016\/j.bbamcr.2020.118854_bb0100","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1016\/S0021-9258(19)40057-4","article-title":"Amino acid sequence of rat kidney gamma-glutamylcysteine synthetase","volume":"265","author":"Yan","year":"1990","journal-title":"J. Biol. Chem."},{"issue":"12","key":"10.1016\/j.bbamcr.2020.118854_bb0105","first-page":"5184","article-title":"Glutathione synthetase","volume":"254","author":"Oppenheimer","year":"1979","journal-title":"Purification from rat kidney and mapping of the substrate binding sites, The Journal of biological chemistry"},{"issue":"9","key":"10.1016\/j.bbamcr.2020.118854_bb0110","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1091\/mbc.8.9.1699","article-title":"Glutathione synthetase is dispensable for growth under both normal and oxidative stress conditions in the yeast Saccharomyces cerevisiae due to an accumulation of the dipeptide gamma-glutamylcysteine","volume":"8","author":"Grant","year":"1997","journal-title":"Mol. Biol. Cell"},{"issue":"10","key":"10.1016\/j.bbamcr.2020.118854_bb0115","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1016\/j.freeradbiomed.2004.06.040","article-title":"Genetically altered mice to evaluate glutathione homeostasis in health and disease","volume":"37","author":"Dalton","year":"2004","journal-title":"Free Radic. Biol. Med."},{"issue":"10","key":"10.1016\/j.bbamcr.2020.118854_bb0120","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1038\/embor.2012.128","article-title":"The intracellular redox state is a core determinant of mitochondrial fusion","volume":"13","author":"Shutt","year":"2012","journal-title":"EMBO Rep."},{"issue":"5","key":"10.1016\/j.bbamcr.2020.118854_bb0125","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1083\/jcb.200704110","article-title":"OPA1 processing controls mitochondrial fusion and is regulated by mRNA splicing, membrane potential, and Yme1L","volume":"178","author":"Song","year":"2007","journal-title":"J. Cell Biol."},{"issue":"22","key":"10.1016\/j.bbamcr.2020.118854_bb0130","doi-asserted-by":"crossref","first-page":"2676","DOI":"10.15252\/embj.201488349","article-title":"OPA1-dependent cristae modulation is essential for cellular adaptation to metabolic demand","volume":"33","author":"Patten","year":"2014","journal-title":"EMBO J."},{"issue":"13","key":"10.1016\/j.bbamcr.2020.118854_bb0135","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.1091\/mbc.e10-12-0933","article-title":"The dynamin-related GTPase Opa1 is required for glucose-stimulated ATP production in pancreatic beta cells","volume":"22","author":"Zhang","year":"2011","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.bbamcr.2020.118854_bb0140","doi-asserted-by":"crossref","first-page":"3550","DOI":"10.1038\/ncomms4550","article-title":"Acidosis overrides oxygen deprivation to maintain mitochondrial function and cell survival","volume":"5","author":"Khacho","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbamcr.2020.118854_bb0145","doi-asserted-by":"crossref","unstructured":"R.J. Mailloux, J.Y. Xuan, S. McBride, W. Maharsy, S. Thorn, C.E. Holterman, C.R. Kennedy, P. Rippstein, R. deKemp, J. da Silva, M. Nemer, M. Lou, M.E. Harper, Glutaredoxin-2 is required to control oxidative phosphorylation in cardiac muscle by mediating deglutathionylation reactions, The Journal of biological chemistry 289(21) (2014) 14812\u201328.","DOI":"10.1074\/jbc.M114.550574"},{"issue":"12","key":"10.1016\/j.bbamcr.2020.118854_bb0150","doi-asserted-by":"crossref","first-page":"8365","DOI":"10.1074\/jbc.M112.442905","article-title":"Glutaredoxin-2 is required to control proton leak through uncoupling protein-3","volume":"288","author":"Mailloux","year":"2013","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.bbamcr.2020.118854_bb0155","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1038\/nprot.2006.478","article-title":"Organelle isolation: functional mitochondria from mouse liver, muscle and cultured fibroblasts","volume":"2","author":"Frezza","year":"2007","journal-title":"Nat. Protoc."},{"issue":"3","key":"10.1016\/j.bbamcr.2020.118854_bb0160","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0152016","article-title":"Determining maximum glycolytic capacity using extracellular flux measurements","volume":"11","author":"Mookerjee","year":"2016","journal-title":"PLoS One"},{"issue":"17","key":"10.1016\/j.bbamcr.2020.118854_bb0165","doi-asserted-by":"crossref","first-page":"7189","DOI":"10.1074\/jbc.M116.774471","article-title":"Quantifying intracellular rates of glycolytic and oxidative ATP production and consumption using extracellular flux measurements","volume":"292","author":"Mookerjee","year":"2017","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.bbamcr.2020.118854_bb0170","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.bbabio.2014.10.005","article-title":"The contributions of respiration and glycolysis to extracellular acid production","volume":"1847","author":"Mookerjee","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbamcr.2020.118854_bb0175","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/978-1-4939-3801-8_20","article-title":"Metabolomics analyses of Cancer cells in controlled microenvironments","volume":"1458","author":"Gravel","year":"2016","journal-title":"Methods Mol. Biol."},{"issue":"1","key":"10.1016\/j.bbamcr.2020.118854_bb0180","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/2049-3002-1-22","article-title":"PGC-1alpha supports glutamine metabolism in breast cancer","volume":"1","author":"McGuirk","year":"2013","journal-title":"Cancer Metab"},{"issue":"1","key":"10.1016\/j.bbamcr.2020.118854_bb0185","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.cell.2006.06.025","article-title":"OPA1 controls apoptotic cristae remodeling independently from mitochondrial fusion","volume":"126","author":"Frezza","year":"2006","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.bbamcr.2020.118854_bb0190","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.cell.2013.08.032","article-title":"Mitochondrial cristae shape determines respiratory chain supercomplexes assembly and respiratory efficiency","volume":"155","author":"Cogliati","year":"2013","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.bbamcr.2020.118854_bb0195","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1083\/jcb.201110034","article-title":"Mitochondrial division ensures the survival of postmitotic neurons by suppressing oxidative damage","volume":"197","author":"Kageyama","year":"2012","journal-title":"J. Cell Biol."},{"issue":"9","key":"10.1016\/j.bbamcr.2020.118854_bb0200","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0003257","article-title":"Preventing mitochondrial fission impairs mitochondrial function and leads to loss of mitochondrial DNA","volume":"3","author":"Parone","year":"2008","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.bbamcr.2020.118854_bb0205","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/sj.emboj.7601963","article-title":"Fission and selective fusion govern mitochondrial segregation and elimination by autophagy","volume":"27","author":"Twig","year":"2008","journal-title":"EMBO J."},{"issue":"11","key":"10.1016\/j.bbamcr.2020.118854_bb0210","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1002\/oby.21654","article-title":"Reactive oxygen species and oxidative stress in obesity-recent findings and empirical approaches","volume":"24","author":"McMurray","year":"2016","journal-title":"Obesity (Silver Spring)"},{"issue":"1","key":"10.1016\/j.bbamcr.2020.118854_bb0215","doi-asserted-by":"crossref","first-page":"11528","DOI":"10.1038\/s41598-018-29972-9","article-title":"The Metabolomic bioenergetic signature of Opa1-disrupted mouse embryonic fibroblasts highlights aspartate deficiency","volume":"8","author":"Bocca","year":"2018","journal-title":"Sci. Rep."},{"issue":"28","key":"10.1016\/j.bbamcr.2020.118854_bb0220","doi-asserted-by":"crossref","first-page":"26185","DOI":"10.1074\/jbc.M503062200","article-title":"Disruption of fusion results in mitochondrial heterogeneity and dysfunction","volume":"280","author":"Chen","year":"2005","journal-title":"J. Biol. Chem."},{"issue":"47","key":"10.1016\/j.bbamcr.2020.118854_bb0225","doi-asserted-by":"crossref","first-page":"33627","DOI":"10.1074\/jbc.274.47.33627","article-title":"Regulation of gamma-glutamylcysteine synthetase subunit gene expression by the transcription factor Nrf2","volume":"274","author":"Wild","year":"1999","journal-title":"J. Biol. Chem."},{"issue":"7","key":"10.1016\/j.bbamcr.2020.118854_bb0230","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.3390\/jcm4071428","article-title":"Mitochondrial glutathione in diabetic nephropathy","volume":"4","author":"Lash","year":"2015","journal-title":"J. Clin. Med."},{"issue":"5","key":"10.1016\/j.bbamcr.2020.118854_bb0235","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.febslet.2015.01.027","article-title":"The mitochondrial dicarboxylate and 2-oxoglutarate carriers do not transport glutathione","volume":"589","author":"Booty","year":"2015","journal-title":"FEBS Lett."},{"issue":"20","key":"10.1016\/j.bbamcr.2020.118854_bb0240","doi-asserted-by":"crossref","first-page":"14850","DOI":"10.1016\/S0021-9258(18)82411-5","article-title":"The quantitative contributions of mitochondrial proton leak and ATP turnover reactions to the changed respiration rates of hepatocytes from rats of different thyroid status","volume":"268","author":"Harper","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamcr.2020.118854_bb0245","doi-asserted-by":"crossref","unstructured":"J.M. Buescher, M.R. Antoniewicz, L.G. Boros, S.C. Burgess, H. Brunengraber, C.B. Clish, R.J. DeBerardinis, O. Feron, C. Frezza, B. Ghesquiere, E. Gottlieb, K. Hiller, R.G. Jones, J.J. Kamphorst, R.G. Kibbey, A.C. Kimmelman, J.W. Locasale, S.Y. Lunt, O.D. Maddocks, C. Malloy, C.M. Metallo, E.J. Meuillet, J. Munger, K. Noh, J.D. Rabinowitz, M. Ralser, U. Sauer, G. Stephanopoulos, J. St-Pierre, D.A. Tennant, C. Wittmann, M.G. Vander Heiden, A. Vazquez, K. Vousden, J.D. Young, N. Zamboni, S.M. Fendt, A roadmap for interpreting (13)C metabolite labeling patterns from cells, Current opinion in biotechnology 34 (2015) 189\u2013201.","DOI":"10.1016\/j.copbio.2015.02.003"},{"key":"10.1016\/j.bbamcr.2020.118854_bb0250","doi-asserted-by":"crossref","first-page":"2236","DOI":"10.1038\/ncomms3236","article-title":"Reductive glutamine metabolism is a function of the alpha-ketoglutarate to citrate ratio in cells","volume":"4","author":"Fendt","year":"2013","journal-title":"Nat. Commun."},{"issue":"5","key":"10.1016\/j.bbamcr.2020.118854_bb0255","doi-asserted-by":"crossref","first-page":"3143","DOI":"10.1016\/j.bbagen.2012.09.008","article-title":"Glutathione synthesis","volume":"1830","author":"Lu","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbamcr.2020.118854_bb0260","doi-asserted-by":"crossref","unstructured":"G.L. Semenza, Hypoxia-inducible factor 1 (HIF-1) pathway, Sci STKE 2007(407) (2007) cm8.","DOI":"10.1126\/stke.4072007cm8"},{"key":"10.1016\/j.bbamcr.2020.118854_bb0265","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1146\/annurev.pharmtox.46.120604.141046","article-title":"Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway","volume":"47","author":"Kensler","year":"2007","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"issue":"2","key":"10.1016\/j.bbamcr.2020.118854_bb0270","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.cell.2006.09.024","article-title":"Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators","volume":"127","author":"St-Pierre","year":"2006","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.bbamcr.2020.118854_bb0275","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1093\/hmg\/dds500","article-title":"LKB1-regulated adaptive mechanisms are essential for neuronal survival following mitochondrial dysfunction","volume":"22","author":"Germain","year":"2013","journal-title":"Hum. Mol. Genet."},{"issue":"8","key":"10.1016\/j.bbamcr.2020.118854_bb0280","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1038\/nrc2676","article-title":"The LKB1-AMPK pathway: metabolism and growth control in tumour suppression","volume":"9","author":"Shackelford","year":"2009","journal-title":"Nat. Rev. Cancer"},{"issue":"5","key":"10.1016\/j.bbamcr.2020.118854_bb0285","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1038\/ncb2220","article-title":"During autophagy mitochondria elongate, are spared from degradation and sustain cell viability","volume":"13","author":"Gomes","year":"2011","journal-title":"Nat. Cell Biol."},{"issue":"3","key":"10.1016\/j.bbamcr.2020.118854_bb0290","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.cmet.2013.02.002","article-title":"In vivo HIF-mediated reductive carboxylation is regulated by citrate levels and sensitizes VHL-deficient cells to glutamine deprivation","volume":"17","author":"Gameiro","year":"2013","journal-title":"Cell Metab."},{"issue":"27","key":"10.1016\/j.bbamcr.2020.118854_bb0295","doi-asserted-by":"crossref","first-page":"E6283","DOI":"10.1073\/pnas.1711888115","article-title":"Early loss of mitochondrial complex I and rewiring of glutathione metabolism in renal oncocytoma","volume":"115","author":"Gopal","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbamcr.2020.118854_bb0300","series-title":"Activation of the NRF2 Antioxidant Program Generates an Imbalance in Central Carbon Metabolism in Cancer, Elife 6","author":"Sayin","year":"2017"},{"issue":"2","key":"10.1016\/j.bbamcr.2020.118854_bb0305","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.stem.2016.04.015","article-title":"Mitochondrial dynamics impacts stem cell identity and fate decisions by regulating a nuclear transcriptional program","volume":"19","author":"Khacho","year":"2016","journal-title":"Cell Stem Cell"},{"issue":"1","key":"10.1016\/j.bbamcr.2020.118854_bb0310","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.ccr.2012.05.016","article-title":"Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming","volume":"22","author":"Mitsuishi","year":"2012","journal-title":"Cancer Cell"},{"issue":"19","key":"10.1016\/j.bbamcr.2020.118854_bb0315","doi-asserted-by":"crossref","first-page":"6543","DOI":"10.1074\/jbc.RA119.010983","article-title":"The short variant of optic atrophy 1 (OPA1) improves cell survival under oxidative stress","volume":"295","author":"Lee","year":"2020","journal-title":"J. Biol. Chem."},{"issue":"24","key":"10.1016\/j.bbamcr.2020.118854_bb0320","doi-asserted-by":"crossref","first-page":"21865","DOI":"10.1074\/jbc.M111.240242","article-title":"Glutathionylation acts as a control switch for uncoupling proteins UCP2 and UCP3","volume":"286","author":"Mailloux","year":"2011","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.bbamcr.2020.118854_bb0325","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0192801","article-title":"Protein S-glutathionylation lowers superoxide\/hydrogen peroxide release from skeletal muscle mitochondria through modification of complex I and inhibition of pyruvate uptake","volume":"13","author":"Gill","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.bbamcr.2020.118854_bb0330","doi-asserted-by":"crossref","first-page":"151","DOI":"10.3389\/fphar.2014.00151","article-title":"Glutathione and mitochondria","volume":"5","author":"Ribas","year":"2014","journal-title":"Front. Pharmacol."},{"issue":"7","key":"10.1016\/j.bbamcr.2020.118854_bb0335","doi-asserted-by":"crossref","first-page":"3747","DOI":"10.1016\/S0021-9258(18)34844-0","article-title":"Status of the mitochondrial pool of glutathione in the isolated hepatocyte","volume":"257","author":"Meredith","year":"1982","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.bbamcr.2020.118854_bb0340","doi-asserted-by":"crossref","first-page":"3317","DOI":"10.1016\/j.bbagen.2012.10.018","article-title":"Mitochondrial glutathione: features, regulation and role in disease","volume":"1830","author":"Mari","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"issue":"2","key":"10.1016\/j.bbamcr.2020.118854_bb0345","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/S0022-3565(24)37484-1","article-title":"Evidence for mitochondrial uptake of glutathione by dicarboxylate and 2-oxoglutarate carriers","volume":"285","author":"Chen","year":"1998","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"2","key":"10.1016\/j.bbamcr.2020.118854_bb0350","doi-asserted-by":"crossref","first-page":"C497","DOI":"10.1152\/ajpcell.00058.2010","article-title":"Dicarboxylate carrier-mediated glutathione transport is essential for reactive oxygen species homeostasis and normal respiration in rat brain mitochondria","volume":"299","author":"Kamga","year":"2010","journal-title":"Am J Physiol Cell Physiol"},{"issue":"3","key":"10.1016\/j.bbamcr.2020.118854_bb0355","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1093\/hmg\/ddx419","article-title":"SLC25A10 biallelic mutations in intractable epileptic encephalopathy with complex I deficiency","volume":"27","author":"Punzi","year":"2018","journal-title":"Hum. Mol. Genet."},{"issue":"2","key":"10.1016\/j.bbamcr.2020.118854_bb0360","first-page":"114","article-title":"Clinical applications of N-acetylcysteine","volume":"3","author":"Kelly","year":"1998","journal-title":"Altern. Med. Rev."},{"issue":"1\u20132","key":"10.1016\/j.bbamcr.2020.118854_bb0365","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.mam.2008.05.005","article-title":"Regulation of glutathione synthesis","volume":"30","author":"Lu","year":"2009","journal-title":"Mol. Asp. Med."},{"key":"10.1016\/j.bbamcr.2020.118854_bb0370","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.freeradbiomed.2017.12.007","article-title":"N-acetylcysteine supplementation increases exercise performance and reduces oxidative stress only in individuals with low levels of glutathione","volume":"115","author":"Paschalis","year":"2018","journal-title":"Free Radic. Biol. Med."},{"issue":"4","key":"10.1016\/j.bbamcr.2020.118854_bb0375","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.cmet.2016.01.019","article-title":"Mitochondrial DNA replication defects disturb cellular dNTP pools and remodel one-carbon metabolism","volume":"23","author":"Nikkanen","year":"2016","journal-title":"Cell Metab."},{"key":"10.1016\/j.bbamcr.2020.118854_bb0380","doi-asserted-by":"crossref","unstructured":"A.E. Rodriguez, G.S. Ducker, L.K. Billingham, C.A. Martinez, N. Mainolfi, V. Suri, A. Friedman, M.G. Manfredi, S.E. Weinberg, J.D. Rabinowitz, N.S. Chandel, Serine Metabolism Supports Macrophage IL-1beta Production, Cell Metab 29(4) (2019) 1003\u20131011 e4.","DOI":"10.1016\/j.cmet.2019.01.014"},{"issue":"10","key":"10.1016\/j.bbamcr.2020.118854_bb0385","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1097\/00004647-200110000-00001","article-title":"An energy budget for signaling in the grey matter of the brain","volume":"21","author":"Attwell","year":"2001","journal-title":"J. Cereb. Blood Flow Metab."},{"issue":"2","key":"10.1016\/j.bbamcr.2020.118854_bb0390","doi-asserted-by":"crossref","first-page":"C641","DOI":"10.1152\/ajpcell.00222.2006","article-title":"Mitochondria and neuronal activity","volume":"292","author":"Kann","year":"2007","journal-title":"Am J Physiol Cell Physiol"},{"issue":"6","key":"10.1016\/j.bbamcr.2020.118854_bb0395","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1038\/ncb1881","article-title":"The bioenergetic and antioxidant status of neurons is controlled by continuous degradation of a key glycolytic enzyme by APC\/C-Cdh1","volume":"11","author":"Herrero-Mendez","year":"2009","journal-title":"Nat. Cell Biol."},{"issue":"5","key":"10.1016\/j.bbamcr.2020.118854_bb0400","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1002\/jnr.10044","article-title":"Pyruvate carboxylation in neurons","volume":"66","author":"Hassel","year":"2001","journal-title":"J. Neurosci. Res."},{"issue":"2","key":"10.1016\/j.bbamcr.2020.118854_bb0405","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1002\/brb3.208","article-title":"N-acetylcysteine (NAC) in neurological disorders: mechanisms of action and therapeutic opportunities","volume":"4","author":"Bavarsad Shahripour","year":"2014","journal-title":"Brain Behav"}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167488920302123?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167488920302123?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T22:08:21Z","timestamp":1777500501000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167488920302123"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":81,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["S0167488920302123"],"URL":"https:\/\/doi.org\/10.1016\/j.bbamcr.2020.118854","relation":{},"ISSN":["0167-4889"],"issn-type":[{"value":"0167-4889","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Altered mitochondrial fusion drives defensive glutathione synthesis in cells able to switch to glycolytic ATP production","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Cell Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbamcr.2020.118854","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"118854"}}