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Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbamcr.2021.119098_bb0010","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1126\/science.186.4162.449","article-title":"Cyclic guanosine monophosphate: elevation in degenerating photoreceptor cells of the C3H mouse retina","volume":"186","author":"Farber","year":"1974","journal-title":"Science"},{"key":"10.1016\/j.bbamcr.2021.119098_bb0015","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1002\/cne.902290307","article-title":"Cell death during differentiation of the retina in the mouse","volume":"229","author":"Young","year":"1984","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.bbamcr.2021.119098_bb0020","first-page":"358","article-title":"Linkage of photoreceptor degeneration by apoptosis with inherited defect in phototransduction","volume":"35","author":"Lolley","year":"1994","journal-title":"Invest. Ophthalmol. Vis. 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Eye Res."},{"key":"10.1016\/j.bbamcr.2021.119098_bb0040","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/S0014-4835(02)00332-9","article-title":"Activated microglia in human retinitis pigmentosa, late-onset retinal degeneration, and age-related macular degeneration","volume":"76","author":"Gupta","year":"2003","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.bbamcr.2021.119098_bb0045","first-page":"460","article-title":"Retinoid X receptors in macrophage biology, Trends Endocrinol","volume":"24","author":"R\u0151szer","year":"2013","journal-title":"Metab."},{"key":"10.1016\/j.bbamcr.2021.119098_bb0050","doi-asserted-by":"crossref","first-page":"e5","DOI":"10.1016\/j.ophtha.2012.07.008","article-title":"Laboratory evidence of sustained chronic inflammatory reaction in retinitis pigmentosa","volume":"120","author":"Yoshida","year":"2013","journal-title":"Ophthalmology"},{"key":"10.1016\/j.bbamcr.2021.119098_bb0055","first-page":"2992","article-title":"Identification of sequential events and factors associated with microglial activation, migration, and cytotoxicity in retinal degeneration in rd mice, Investig","volume":"46","author":"Zeng","year":"2005","journal-title":"Opthalmology Vis. Sci."},{"key":"10.1016\/j.bbamcr.2021.119098_bb0060","first-page":"397","article-title":"M\u00fcller cells in the healthy and diseased retina, Prog","volume":"25","author":"Bringmann","year":"2006","journal-title":"Retin. Eye Res."},{"key":"10.1016\/j.bbamcr.2021.119098_bb0065","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12974-017-0855-0","article-title":"Microglia activation is essential for BMP7-mediated retinal reactive gliosis","volume":"14","author":"Dharmarajan","year":"2017","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.bbamcr.2021.119098_bb0070","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0165-5728(94)90141-4","article-title":"Differential tumor necrosis factor expression by resident retinal cells from experimental uveitis-susceptible and -resistant rat strains","volume":"55","author":"de Kozak","year":"1994","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.bbamcr.2021.119098_bb0075","doi-asserted-by":"crossref","first-page":"85","DOI":"10.3109\/09273949709085056","article-title":"Tumor necrosis factor and nitric oxide production by resident retinal glial cells from rats presenting hereditary retinal degeneration","volume":"5","author":"de Kozak","year":"1997","journal-title":"Ocul. Immunol. Inflamm."},{"key":"10.1016\/j.bbamcr.2021.119098_bb0080","doi-asserted-by":"crossref","first-page":"8693","DOI":"10.1523\/JNEUROSCI.20-23-08693.2000","article-title":"Increased production of tumor necrosis factor-alpha by glial cells exposed to simulated ischemia or elevated hydrostatic pressure induces apoptosis in cocultured retinal ganglion cells","volume":"20","author":"Tezel","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbamcr.2021.119098_bb0085","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1002\/(SICI)1097-4547(19960315)43:6<639::AID-JNR1>3.0.CO;2-F","article-title":"Heterologous retinal cultured neurons and cell adhesion molecules induce clustering of acetylcholine receptors and polynucleation in mouse muscle BC3H-1 clonal cell line","volume":"43","author":"Politi","year":"1996","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.bbamcr.2021.119098_bb0090","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1002\/jnr.22747","article-title":"M\u00fcller glial cells induce stem cell properties in retinal progenitors in vitro and promote their further differentiation into photoreceptors","volume":"90","author":"Sim\u00f3n","year":"2012","journal-title":"J. Neurosci. 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Cell Res. 1863 (2016) 1134\u20131145. doi:https:\/\/doi.org\/10.1016\/j.bbamcr.2016.02.010.","DOI":"10.1016\/j.bbamcr.2016.02.010"},{"key":"10.1016\/j.bbamcr.2021.119098_bb0180","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0022817","article-title":"Genome-wide analysis of M\u00fcller glial differentiation reveals a requirement for notch signaling in postmitotic cells to maintain the glial fate","volume":"6","author":"Nelson","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.bbamcr.2021.119098_bb0185","first-page":"5808","article-title":"Sphingosine-1-phosphate is a crucial signal for migration of retina M\u00fcller glial cells, Investig","volume":"56","author":"Sim\u00f3n","year":"2015","journal-title":"Opthalmology Vis. Sci."},{"key":"10.1016\/j.bbamcr.2021.119098_bb0190","first-page":"3017","article-title":"Docosahexaenoic acid promotes photoreceptor differentiation without altering Crx expression, Investig","volume":"47","author":"Garelli","year":"2006","journal-title":"Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.bbamcr.2021.119098_bb0195","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1248\/bpb.32.1177","article-title":"Docosahexaenoic acid induces adipose differentiation-related protein through activation of retinoid X receptor in human choriocarcinoma BeWo cells","volume":"32","author":"Suzuki","year":"2009","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.bbamcr.2021.119098_bb0200","doi-asserted-by":"crossref","first-page":"4222","DOI":"10.1021\/jm9704309","article-title":"Regulation of retinoidal actions by diazepinylbenzoic acids. Retinoid synergists which activate the RXR-RAR heterodimers","volume":"40","author":"Umemiya","year":"1997","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bbamcr.2021.119098_bb0205","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1248\/cpb.48.1504","article-title":"Retinoidal pyrimidinecarboxylic acids. Unexpected diaza-substituent effects in retinobenzoic acids","volume":"48","author":"Ohta","year":"2000","journal-title":"Chem. Pharm. Bull. (Tokyo)."},{"key":"10.1016\/j.bbamcr.2021.119098_bb0210","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0181055","article-title":"Suppressive effects of RXR agonist PA024 on adrenal CYP11B2 expression, aldosterone secretion and blood pressure","volume":"12","author":"Suzuki","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.bbamcr.2021.119098_bb0215","doi-asserted-by":"crossref","first-page":"3327","DOI":"10.1021\/jm0255320","article-title":"Novel retinoid X receptor antagonists: specific inhibition of retinoid synergism in RXR-RAR heterodimer actions","volume":"45","author":"Takahashi","year":"2002","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bbamcr.2021.119098_bb0220","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1523\/JNEUROSCI.17-04-01397.1997","article-title":"p53 expression induces apoptosis in hippocampal pyramidal neuron cultures","volume":"17","author":"Jord\u00e1n","year":"1997","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbamcr.2021.119098_bb0225","first-page":"611","article-title":"The MIQE guidelines: minimum information for publication of quantitative real-time PCR experiments, Clin","volume":"55","author":"Bustin","year":"2009","journal-title":"Chem."},{"key":"10.1016\/j.bbamcr.2021.119098_bb0230","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat. 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Vis. Sci."},{"key":"10.1016\/j.bbamcr.2021.119098_bb0255","doi-asserted-by":"crossref","first-page":"4691","DOI":"10.1242\/dev.125.23.4691","article-title":"The RXRalpha ligand-dependent activation function 2 (AF-2) is important for mouse development","volume":"125","author":"Mascrez","year":"1998","journal-title":"Development"},{"key":"10.1016\/j.bbamcr.2021.119098_bb0260","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1038\/26515","article-title":"Retinoid-X receptor signalling in the developing spinal cord","volume":"395","author":"Solomin","year":"1998","journal-title":"Nature."},{"key":"10.1016\/j.bbamcr.2021.119098_bb0265","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/0925-4773(94)90023-X","article-title":"Developmental expression of murine retinoid X receptor (RXR) genes","volume":"45","author":"Doll\u00e9","year":"1994","journal-title":"Mech. 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Neurosci."},{"key":"10.1016\/j.bbamcr.2021.119098_bb0275","doi-asserted-by":"crossref","first-page":"3821","DOI":"10.1016\/j.febslet.2011.03.048","article-title":"Regulation of remyelination in multiple sclerosis","volume":"585","author":"Hanafy","year":"2011","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bbamcr.2021.119098_bb0280","article-title":"Neuronally-directed effects of RXR activation in a mouse model of Alzheimer\u2019s disease, Sci","volume":"7","author":"Mariani","year":"2017","journal-title":"Rep."},{"key":"10.1016\/j.bbamcr.2021.119098_bb0285","doi-asserted-by":"crossref","first-page":"7916","DOI":"10.4049\/jimmunol.175.12.7916","article-title":"Retinoid X receptor agonists increase Bcl2a1 expression and decrease apoptosis of naive T lymphocytes","volume":"175","author":"Rasooly","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.bbamcr.2021.119098_bb0290","first-page":"3555","article-title":"Activation of Bax in three models of retinitis pigmentosa, Investig","volume":"55","author":"Comitato","year":"2014","journal-title":"Opthalmology Vis. Sci."},{"key":"10.1016\/j.bbamcr.2021.119098_bb0295","doi-asserted-by":"crossref","unstructured":"T. Chitnis, H.L. Weiner, CNS inflammation and neurodegeneration, in: J. Clin. Invest., American Society for Clinical Investigation, 2017: pp. 3577\u20133587. doi:https:\/\/doi.org\/10.1172\/JCI90609.","DOI":"10.1172\/JCI90609"},{"key":"10.1016\/j.bbamcr.2021.119098_bb0300","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1002\/jnr.20518","article-title":"Agonists for the peroxisome proliferator-activated receptor-alpha and the retinoid X receptor inhibit inflammatory responses of microglia","volume":"81","author":"Xu","year":"2005","journal-title":"J. Neurosci. 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Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.bbamcr.2021.119098_bb0335","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1006\/exer.2001.1078","article-title":"Neurotrophic signaling in normal and degenerating rodent retinas, Exp","volume":"73","author":"Wahlin","year":"2001","journal-title":"Eye Res."},{"key":"10.1016\/j.bbamcr.2021.119098_bb0340","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/S0896-6273(00)81185-X","article-title":"Modification of glial-neuronal cell interactions prevents photoreceptor apoptosis during light-induced retinal degeneration","volume":"26","author":"Harada","year":"2000","journal-title":"Neuron"},{"key":"10.1016\/j.bbamcr.2021.119098_bb0345","doi-asserted-by":"crossref","first-page":"7024","DOI":"10.1073\/pnas.94.13.7024","article-title":"Glutamine synthetase protects against neuronal degeneration in injured retinal tissue, Proc","volume":"94","author":"Gorovits","year":"1997","journal-title":"Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbamcr.2021.119098_bb0350","article-title":"The role of peroxisome proliferator-activated receptor and effects of its agonist, pioglitazone","volume":"8","author":"Zhu","year":"2013","journal-title":"on a rat model of optic nerve crush: PPAR\u03b3 in retinal neuroprotection, PLoS One."},{"key":"10.1016\/j.bbamcr.2021.119098_bb0355","doi-asserted-by":"crossref","first-page":"32068","DOI":"10.18632\/oncotarget.16643","article-title":"Activation of liver X receptor delayed the retinal degeneration of rd1 mice through modulation of the immunological function of glia","volume":"8","author":"He","year":"2017","journal-title":"Oncotarget."},{"key":"10.1016\/j.bbamcr.2021.119098_bb0360","doi-asserted-by":"crossref","DOI":"10.1186\/s12974-016-0763-8","article-title":"Balancing the immune response in the brain: IL-10 and its regulation","volume":"13","author":"Lobo-Silva","year":"2016","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.bbamcr.2021.119098_bb0365","first-page":"695","article-title":"Decreased interleukin-10 and increased interleukin- 12p40 mRNA are associated with disease activity and characterize different disease stages in multiple sclerosis, Ann","volume":"45","author":"Boxel-Dezaire","year":"1999","journal-title":"Neurol."},{"key":"10.1016\/j.bbamcr.2021.119098_bb0370","first-page":"894","article-title":"Interleukin-10 protects against inflammation-mediated degeneration of dopaminergic neurons in substantia nigra, Neurobiol","volume":"28","author":"Arimoto","year":"2007","journal-title":"Aging."},{"key":"10.1016\/j.bbamcr.2021.119098_bb0375","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1111\/j.1468-1331.2010.03116.x","article-title":"Disease protection and interleukin-10 induction by endogenous interferon-\u03b2 in multiple sclerosis?","volume":"18","author":"Hesse","year":"2011","journal-title":"Eur. J. Neurol."},{"key":"10.1016\/j.bbamcr.2021.119098_bb0380","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1038\/gt.2011.126","article-title":"AAV serotype 2\/1-mediated gene delivery of anti-inflammatory interleukin-10 enhances neurogenesis and cognitive function in APPPS1 mice","volume":"19","author":"Kiyota","year":"2012","journal-title":"Gene Ther."},{"key":"10.1016\/j.bbamcr.2021.119098_bb0385","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1111\/j.1365-2567.2010.03379.x","article-title":"Retinal cells suppress intraocular inflammation (uveitis) through production of interleukin-27 and interleukin-10","volume":"132","author":"Lee","year":"2011","journal-title":"Immunology."},{"key":"10.1016\/j.bbamcr.2021.119098_bb0390","doi-asserted-by":"crossref","unstructured":"K.W. Moore, R. de Waal Malefyt, R.L. Coffman, A. O'Garra, I NTERLEUKIN -10 AND THE I NTERLEUKIN -10 R ECEPTOR , Annu. Rev. 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Neurosci."},{"key":"10.1016\/j.bbamcr.2021.119098_bb0405","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1002\/glia.22647","article-title":"TGF\u03b2 produced by IL-10 redirected astrocytes attenuates microglial activation","volume":"62","author":"Norden","year":"2014","journal-title":"Glia."},{"key":"10.1016\/j.bbamcr.2021.119098_bb0410","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1111\/j.1471-4159.2009.06263.x","article-title":"Interleukin-10 provides direct trophic support to neurons","volume":"110","author":"Zhou","year":"2009","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbamcr.2021.119098_bb0415","first-page":"183","article-title":"IL-10 promotes neuronal survival following spinal cord injury, Exp","volume":"220","author":"Zhou","year":"2009","journal-title":"Neurol."},{"key":"10.1016\/j.bbamcr.2021.119098_bb0420","article-title":"IL-10 regulates adult neurogenesis by modulating ERK and STAT3 activity, Front","volume":"9","author":"Pereira","year":"2015","journal-title":"Cell. Neurosci."},{"key":"10.1016\/j.bbamcr.2021.119098_bb0425","first-page":"4208","article-title":"Interleukin-10 regulates progenitor differentiation and modulates neurogenesis in adult brain","volume":"126","author":"Perez-Asensio","year":"2013","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.bbamcr.2021.119098_bb0430","doi-asserted-by":"crossref","unstructured":"E.L. Berson, B. Rosner, M.A. Sandberg, C. Weigel-DiFranco, A. Moser, R.J. Brockhurst, K.C. Hayes, C.A. Johnson, E.J. Anderson, A.R. Gaudio, W.C. Willett, E.J. Schaefer, Clinical trial of docosahexaenoic acid in patients with retinitis pigmentosa receiving vitamin A treatment., Arch. Ophthalmol. (Chicago, Ill. 1960). 122 (2004) 1297\u2013305. doi:https:\/\/doi.org\/10.1001\/archopht.122.9.1297.","DOI":"10.1001\/archopht.122.9.1297"},{"key":"10.1016\/j.bbamcr.2021.119098_bb0435","first-page":"1306","article-title":"Further evaluation of docosahexaenoic acid in patients with retinitis pigmentosa receiving vitamin A treatment: subgroup analyses., Arch","volume":"122","author":"Berson","year":"2004","journal-title":"Ophthalmol."},{"key":"10.1016\/j.bbamcr.2021.119098_bb0440","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1001\/jamaophthalmol.2014.1634","article-title":"Four-year placebo-controlled trial of docosahexaenoic acid in X-linked retinitis pigmentosa (DHAX Trial): a randomized clinical trial","volume":"132","author":"Hoffman","year":"2014","journal-title":"JAMA Ophthalmol."},{"key":"10.1016\/j.bbamcr.2021.119098_bb0445","doi-asserted-by":"crossref","unstructured":"S. Rayapudi, S.G. Schwartz, X. Wang, P. Chavis, Vitamin A and fish oils for retinitis pigmentosa, Cochrane Database Syst. Rev. 2013 (2013). doi:https:\/\/doi.org\/10.1002\/14651858.CD008428.pub2.","DOI":"10.1002\/14651858.CD008428.pub2"},{"key":"10.1016\/j.bbamcr.2021.119098_bb0450","first-page":"6646","article-title":"Docosahexaenoic acid slows visual field progression in X-linked retinitis pigmentosa: ancillary outcomes of the DHAX trial, Investig","volume":"56","author":"Hoffman","year":"2015","journal-title":"Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.bbamcr.2021.119098_bb0455","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1002\/jcp.20346","article-title":"Oxidative damage is a potential cause of cone cell death in retinitis pigmentosa","volume":"203","author":"Shen","year":"2005","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.bbamcr.2021.119098_bb0460","first-page":"1751","article-title":"Amelioration of retinal photic injury in albino rats by dimethylthiourea, Arch","volume":"108","author":"Lam","year":"1990","journal-title":"Ophthalmol."},{"key":"10.1016\/j.bbamcr.2021.119098_bb0465","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1006\/excr.1998.4421","article-title":"Reactive oxygen species as mediators of photoreceptor apoptosis in vitro, Exp","volume":"248","author":"Carmody","year":"1999","journal-title":"Cell Res."},{"key":"10.1016\/j.bbamcr.2021.119098_bb0470","first-page":"2929","article-title":"Identification of gene expression changes associated with the progression of retinal degeneration in the rd1 mouse, Investig","volume":"45","author":"Hackam","year":"2004","journal-title":"Ophthalmol. Vis. 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