{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T20:18:01Z","timestamp":1784233081843,"version":"3.55.0"},"reference-count":180,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB877"],"award-info":[{"award-number":["SFB877"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["ME2108\/9-1"],"award-info":[{"award-number":["ME2108\/9-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB1192"],"award-info":[{"award-number":["SFB1192"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Cell Research"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1016\/j.bbamcr.2021.119165","type":"journal-article","created":{"date-parts":[[2021,10,25]],"date-time":"2021-10-25T08:56:28Z","timestamp":1635152188000},"page":"119165","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Ectodomain shedding by ADAM proteases as a central regulator in kidney physiology and disease"],"prefix":"10.1016","volume":"1869","author":[{"given":"Catherine","family":"Meyer-Schwesinger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Seipold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Saftig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbamcr.2021.119165_bb0005","doi-asserted-by":"crossref","first-page":"7962","DOI":"10.1073\/pnas.96.14.7962","article-title":"Nephrin is specifically located at the slit diaphragm of glomerular podocytes","volume":"96","author":"Ruotsalainen","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0010","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s00232-001-0036-y","article-title":"Changes in sodium or glucose filtration rate modulate expression of glucose transporters in renal proximal tubular cells of rat","volume":"182","author":"Vestri","year":"2001","journal-title":"J. Membr. Biol."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0015","article-title":"Shedding of Klotho: functional implications in chronic kidney disease and associated vascular disease","volume":"7","author":"Saar-Kovrov","year":"2020"},{"key":"10.1016\/j.bbamcr.2021.119165_bb0020","series-title":"The evolving complexity of the collecting duct renin-angiotensin system in hypertension","author":"Prieto","year":"2021"},{"key":"10.1016\/j.bbamcr.2021.119165_bb0025","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1038\/ki.1994.230","article-title":"The glomerular response to injury: progression or resolution?","volume":"45","author":"Johnson","year":"1994","journal-title":"Kidney Int."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0030","first-page":"847","article-title":"Expression of smooth muscle cell phenotype by rat mesangial cells in immune complex nephritis.Alpha-smooth muscle actin is a marker of mesangial cell proliferation","volume":"87","author":"Johnson","year":"1991"},{"key":"10.1016\/j.bbamcr.2021.119165_bb0035","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1046\/j.1523-1755.2003.00255.x","article-title":"Plasticity of kidney cells: role in kidney remodeling and scarring","volume":"64","author":"El-Nahas","year":"2003","journal-title":"Kidney Int."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0040","first-page":"F378","article-title":"Patterns of differentiation of renin lineage cells during nephrogenesis","volume":"321","author":"Kessel","year":"2021"},{"key":"10.1016\/j.bbamcr.2021.119165_bb0045","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1016\/j.kint.2018.01.014","article-title":"Detection of renin lineage cell transdifferentiation to podocytes in the kidney glomerulus with dual lineage tracing","volume":"93","author":"Eng","year":"2018","journal-title":"Kidney Int."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0050","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1046\/j.1523-1755.2002.00226.x","article-title":"Nitric oxide and glomerulonephritis","volume":"61","author":"Cattell","year":"2002","journal-title":"Kidney Int."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0055","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1097\/00041552-200301000-00008","article-title":"Vascular endothelial growth factor: a new player in the pathogenesis of renal fibrosis","volume":"12","author":"Kang","year":"2003","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0060","doi-asserted-by":"crossref","first-page":"S190","DOI":"10.1681\/ASN.V210s190","article-title":"The activated mesangial cell: a glomerular \"myofibroblast\"?","volume":"2","author":"Johnson","year":"1992","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0065","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1002\/(SICI)1096-9896(199909)189:1<105::AID-PATH388>3.0.CO;2-0","article-title":"CD34 expression as a novel marker of transformed mesangial cells in biopsied glomerular diseases","volume":"189","author":"Naruse","year":"1999","journal-title":"J. Pathol."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0070","doi-asserted-by":"crossref","first-page":"2848","DOI":"10.1182\/blood.V78.11.2848.2848","article-title":"CD34 expression by stromal precursors in normal human adult bone marrow","volume":"78","author":"Simmons","year":"1991","journal-title":"Blood"},{"key":"10.1016\/j.bbamcr.2021.119165_bb0075","doi-asserted-by":"crossref","first-page":"3313","DOI":"10.1242\/dev.125.17.3313","article-title":"Paracrine PDGF-B\/PDGF-rbeta signaling controls mesangial cell development in kidney glomeruli","volume":"125","author":"Lindahl","year":"1998","journal-title":"Development"},{"key":"10.1016\/j.bbamcr.2021.119165_bb0080","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/nm1731","article-title":"The Notch pathway in podocytes plays a role in the development of glomerular disease","volume":"14","author":"Niranjan","year":"2008","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0085","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1038\/ki.2011.255","article-title":"Canonical Wnt\/beta-catenin signaling mediates transforming growth factor-beta1-driven podocyte injury and proteinuria","volume":"80","author":"Wang","year":"2011","journal-title":"Kidney Int."},{"issue":"Suppl 1","key":"10.1016\/j.bbamcr.2021.119165_bb0090","doi-asserted-by":"crossref","first-page":"i9","DOI":"10.1093\/ndt\/gft491","article-title":"mTOR controls kidney epithelia in health and disease","volume":"29","author":"Grahammer","year":"2014","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0095","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.1016\/j.biocel.2013.06.013","article-title":"Podocyte energy metabolism and glomerular diseases","volume":"45","author":"Imasawa","year":"2013","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0100","first-page":"2511","article-title":"Alterations in the ubiquitin proteasome system in persistent but not reversible proteinuric diseases","volume":"25","author":"Beeken","year":"2014"},{"key":"10.1016\/j.bbamcr.2021.119165_bb0105","first-page":"3","article-title":"Proteinuria: detection and role in native renal disease progression","volume":"26","author":"Gorriz","year":"2012"},{"key":"10.1016\/j.bbamcr.2021.119165_bb0110","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1046\/j.1523-1755.1999.00656.x","article-title":"Transforming growth factor-beta regulates tubular epithelial-myofibroblast transdifferentiation in vitro","volume":"56","author":"Fan","year":"1999","journal-title":"Kidney Int."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0115","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1097\/00041552-200105000-00004","article-title":"Renal fibrosis: an update","volume":"10","author":"Zeisberg","year":"2001","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0120","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1046\/j.1523-1755.2002.00333.x","article-title":"Role of basic fibroblast growth factor-2 in epithelial-mesenchymal transformation","volume":"61","author":"Strutz","year":"2002","journal-title":"Kidney Int."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0125","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1038\/ki.1997.481","article-title":"Effects of integrins on proliferation and apoptosis of renal epithelial cells after acute injury","volume":"52","author":"Wijesekera","year":"1997","journal-title":"Kidney Int."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0130","doi-asserted-by":"crossref","first-page":"2216","DOI":"10.1093\/ndt\/13.9.2216","article-title":"Cellular apoptosis and proliferation in experimental renal fibrosis","volume":"13","author":"Thomas","year":"1998","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0135","doi-asserted-by":"crossref","DOI":"10.15252\/embj.201899456","article-title":"Proteolytic ectodomain shedding of membrane proteins in mammals-hardware, concepts, and recent developments","volume":"37","author":"Lichtenthaler","year":"2018","journal-title":"EMBO J."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0140","doi-asserted-by":"crossref","first-page":"3693","DOI":"10.1242\/dev.076398","article-title":"Ectodomain shedding and ADAMs in development","volume":"139","author":"Weber","year":"2012","journal-title":"Development"},{"key":"10.1016\/j.bbamcr.2021.119165_bb0145","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/0014-4827(73)90500-4","article-title":"Natural shedding of carbohydrate-containing macromolecules from cell surfaces","volume":"79","author":"Kapeller","year":"1973","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0150","doi-asserted-by":"crossref","first-page":"e15","DOI":"10.1182\/blood-2010-05-283838","article-title":"Deciphering the human platelet sheddome","volume":"117","author":"Fong","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.bbamcr.2021.119165_bb0155","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0065-230X(08)60361-9","article-title":"Shedding from the cell surface of normal and cancer cells","volume":"32","author":"Black","year":"1980","journal-title":"Adv. Cancer Res."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0160","doi-asserted-by":"crossref","first-page":"37743","DOI":"10.1074\/jbc.M105677200","article-title":"The disintegrins ADAM10 and TACE contribute to the constitutive and phorbol ester-regulated normal cleavage of the cellular prion protein","volume":"276","author":"Vincent","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0165","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202002385RR","article-title":"GPR37 is processed in the N-terminal ectodomain by ADAM10 and furin","volume":"35","author":"Mattila","year":"2021","journal-title":"FASEB J."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0170","first-page":"14","article-title":"Activation of the epithelial sodium channel by the metalloprotease meprin beta subunit","volume":"5","author":"Garcia-Caballero","year":"2011"},{"key":"10.1016\/j.bbamcr.2021.119165_bb0175","first-page":"F480","article-title":"Experimental nephrotic syndrome leads to proteolytic activation of the epithelial Na(+) channel in the mouse kidney","volume":"321","author":"Bohnert","year":"2021"},{"key":"10.1016\/j.bbamcr.2021.119165_bb0180","article-title":"Urokinase-type plasminogen activator contributes to amiloride-sensitive sodium retention in nephrotic range glomerular proteinuria in mice","volume":"227","author":"Hinrichs","year":"2019"},{"key":"10.1016\/j.bbamcr.2021.119165_bb0185","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1042\/BJ20090549","article-title":"Active-site determinants of substrate recognition by the metalloproteinases TACE and ADAM10","volume":"424","author":"Caescu","year":"2009","journal-title":"Biochem. J."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0190","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.semcdb.2020.05.019","article-title":"The substrate repertoire of gamma-secretase\/presenilin","volume":"105","author":"Guner","year":"2020","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0195","doi-asserted-by":"crossref","first-page":"2959","DOI":"10.1007\/s00018-020-03470-6","article-title":"Physiological functions of SPP\/SPPL intramembrane proteases","volume":"77","author":"Mentrup","year":"2020","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0200","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S0092-8674(00)80675-3","article-title":"Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans","volume":"100","author":"Brown","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.bbamcr.2021.119165_bb0205","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1101\/gad.1039703","article-title":"The ADAMs family of metalloproteases: multidomain proteins with multiple functions","volume":"17","author":"Seals","year":"2003","journal-title":"Genes Dev."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0210","first-page":"122","article-title":"A disintegrin and metalloprotease (ADAM): historical overview of their functions","volume":"8","author":"Giebeler","year":"2016"},{"key":"10.1016\/j.bbamcr.2021.119165_bb0215","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/356248a0","article-title":"A potential fusion peptide and an integrin ligand domain in a protein active in sperm-egg fusion","volume":"356","author":"Blobel","year":"1992","journal-title":"Nature"},{"key":"10.1016\/j.bbamcr.2021.119165_bb0220","first-page":"870","article-title":"The ADAMs family of proteases as targets for the treatment of cancer","volume":"17","author":"Mullooly","year":"2016"},{"key":"10.1016\/j.bbamcr.2021.119165_bb0225","first-page":"1510","article-title":"Domain integration of ADAM family proteins: emerging themes from structural studies","volume":"244","author":"Seegar","year":"2019"},{"key":"10.1016\/j.bbamcr.2021.119165_bb0230","first-page":"2071","article-title":"The metalloproteinase ADAM10: a useful therapeutic target?","volume":"2017","author":"Wetzel","year":"1864"},{"key":"10.1016\/j.bbamcr.2021.119165_bb0235","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/0014-5793(93)80312-I","article-title":"Astacins, serralysins, snake venom and matrix metalloproteinases exhibit identical zinc-binding environments (HEXXHXXGXXH and met-turn) and topologies and should be grouped into a common family, the 'metzincins'","volume":"331","author":"Bode","year":"1993","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0240","doi-asserted-by":"crossref","first-page":"35712","DOI":"10.1074\/jbc.M703231200","article-title":"The ADAM10 prodomain is a specific inhibitor of ADAM10 proteolytic activity and inhibits cellular shedding events","volume":"282","author":"Moss","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0245","first-page":"13427","article-title":"Regulation of human ADAM 12 protease by the prodomain.Evidence for a functional cysteine switch","volume":"274","author":"Loechel","year":"1999"},{"key":"10.1016\/j.bbamcr.2021.119165_bb0250","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1080\/09537104.2016.1184751","article-title":"Regulation of a disintegrin and metalloproteinase (ADAM) family sheddases ADAM10 and ADAM17: the emerging role of tetraspanins and rhomboids","volume":"28","author":"Matthews","year":"2017","journal-title":"Platelets"},{"key":"10.1016\/j.bbamcr.2021.119165_bb0255","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.tibs.2005.05.006","article-title":"Shedding light on ADAM metalloproteinases","volume":"30","author":"Huovila","year":"2005","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0260","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1186\/gb-2011-12-11-233","article-title":"Tissue inhibitors of metalloproteinases","volume":"12","author":"Murphy","year":"2011","journal-title":"Genome Biol."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0265","doi-asserted-by":"crossref","first-page":"11738","DOI":"10.1074\/jbc.M805894200","article-title":"ADAM10, the rate-limiting protease of regulated intramembrane proteolysis of notch and other proteins, is processed by ADAMS-9, ADAMS-15, and the gamma-secretase","volume":"284","author":"Tousseyn","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0270","doi-asserted-by":"crossref","first-page":"2523","DOI":"10.1172\/JCI65401","article-title":"Endocytosis of synaptic ADAM10 in neuronal plasticity and Alzheimer's disease","volume":"123","author":"Marcello","year":"2013","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0275","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1074\/mcp.M115.048298","article-title":"Secretome analysis identifies novel signal peptide peptidase-like 3 (sppl3) substrates and reveals a role of sppl3 in multiple golgi glycosylation pathways","volume":"14","author":"Kuhn","year":"2015","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.bbamcr.2021.119165_bb0280","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.mam.2008.08.001","article-title":"The ADAM metalloproteinases","volume":"29","author":"Edwards","year":"2008","journal-title":"Mol. Asp. Med."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0285","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.ceb.2003.08.001","article-title":"ADAMs: modulators of cell-cell and cell-matrix interactions","volume":"15","author":"White","year":"2003","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0290","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1523\/JNEUROSCI.3439-06.2007","article-title":"Synapse-associated protein-97 mediates alpha-secretase ADAM10 trafficking and promotes its activity","volume":"27","author":"Marcello","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0295","doi-asserted-by":"crossref","first-page":"46029","DOI":"10.1074\/jbc.M306393200","article-title":"PACSIN3 binds ADAM12\/meltrin alpha and up-regulates ectodomain shedding of heparin-binding epidermal growth factor-like growth factor","volume":"278","author":"Mori","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0300","doi-asserted-by":"crossref","first-page":"12822","DOI":"10.1074\/jbc.RA120.012601","article-title":"The tetraspanin Tspan15 is an essential subunit of an ADAM10 scissor complex","volume":"295","author":"Koo","year":"2020","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0305","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1111\/j.1749-6632.2003.tb03207.x","article-title":"TACE\/ADAM17 processing of EGFR ligands indicates a role as a physiological convertase","volume":"995","author":"Lee","year":"2003","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0310","first-page":"32","article-title":"ADAMs: key components in EGFR signalling and development","volume":"6","author":"Blobel","year":"2005"},{"key":"10.1016\/j.bbamcr.2021.119165_bb0315","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1101\/gad.942302","article-title":"Kuzbanian-mediated cleavage of Drosophila Notch","volume":"16","author":"Lieber","year":"2002","journal-title":"Genes Dev."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0320","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1172\/JCI20864","volume":"113","author":"Postina","year":"2004","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0325","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/978-1-4614-0899-4_2","article-title":"The role of Adams in notch signaling","volume":"727","author":"Groot","year":"2012","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0330","doi-asserted-by":"crossref","first-page":"2615","DOI":"10.1093\/hmg\/11.21.2615","article-title":"The disintegrin\/metalloprotease ADAM 10 is essential for notch signalling but not for alpha-secretase activity in fibroblasts","volume":"11","author":"Hartmann","year":"2002","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0335","article-title":"Systematic substrate identification indicates a central role for the metalloprotease ADAM10 in axon targeting and synapse function","volume":"5","author":"Kuhn","year":"2016"},{"key":"10.1016\/j.bbamcr.2021.119165_bb0340","doi-asserted-by":"crossref","first-page":"149","DOI":"10.3389\/fnmol.2016.00149","article-title":"The emerging role of tetraspanins in the proteolytic processing of the amyloid precursor protein","volume":"9","author":"Seipold","year":"2016","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0345","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1091\/mbc.e08-11-1135","article-title":"ADAMs 10 and 17 represent differentially regulated components of a general shedding machinery for membrane proteins such as transforming growth factor alpha, L-selectin, and tumor necrosis factor alpha","volume":"20","author":"Le Gall","year":"2009","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.bbamcr.2021.119165_bb0350","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1126\/science.282.5392.1281","article-title":"An essential role for ectodomain shedding in mammalian development","volume":"282","author":"Peschon","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.bbamcr.2021.119165_bb0355","first-page":"2059","article-title":"The shedding protease ADAM17: physiology and pathophysiology","volume":"2017","author":"Zunke","year":"1864"},{"key":"10.1016\/j.bbamcr.2021.119165_bb0360","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.it.2011.05.005","article-title":"ADAM17: a molecular switch to control inflammation and tissue regeneration","volume":"32","author":"Scheller","year":"2011","journal-title":"Trends Immunol."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0365","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1084\/jem.20092366","article-title":"Critical role of the disintegrin metalloprotease ADAM17 for intestinal inflammation and regeneration in mice","volume":"207","author":"Chalaris","year":"2010","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0370","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1016\/j.bbamcr.2019.06.017","article-title":"Status update on iRhom and ADAM17: it's still complicated","volume":"1866","author":"Dusterhoft","year":"2019","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0375","doi-asserted-by":"crossref","first-page":"11523","DOI":"10.1038\/ncomms11523","article-title":"Phosphatidylserine exposure is required for ADAM17 sheddase function","volume":"7","author":"Sommer","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0380","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1021\/pr100556z","article-title":"Active metalloproteases of the A Disintegrin and Metalloprotease (ADAM) family: biological function and structure","volume":"10","author":"Klein","year":"2011","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0385","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1293\/tox.2017-0006","article-title":"A brief review of kidney development, maturation, developmental abnormalities, and drug toxicity: juvenile animal relevancy","volume":"30","author":"Seely","year":"2017","journal-title":"J. Toxicol. Pathol."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0390","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0140-6736(13)60311-6","article-title":"Effect of fetal and child health on kidney development and long-term risk of hypertension and kidney disease","volume":"382","author":"Luyckx","year":"2013","journal-title":"Lancet"},{"key":"10.1016\/j.bbamcr.2021.119165_bb0395","first-page":"149","article-title":"Adam10 mediates the choice between principal cells and intercalated cells in the kidney","volume":"26","author":"Guo","year":"2015"},{"key":"10.1016\/j.bbamcr.2021.119165_bb0400","first-page":"3290","article-title":"Inactivation of Notch signaling in the renal collecting duct causes nephrogenic diabetes insipidus in mic","volume":"119","author":"Jeong","year":"2009","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0405","first-page":"zqab024","article-title":"Loss of Adam10 disrupts ion transport in immortalized kidney collecting duct cells","volume":"2","author":"Assmus","year":"2021"},{"key":"10.1016\/j.bbamcr.2021.119165_bb0410","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1182\/blood-2011-04-348557","article-title":"Deletion of Adam10 in endothelial cells leads to defects in organ-specific vascular structures","volume":"118","author":"Glomski","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.bbamcr.2021.119165_bb0415","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1161\/CIRCRESAHA.115.307738","article-title":"ADAM10-dependent signaling through Notch1 and Notch4 controls development of organ-specific vascular beds","volume":"119","author":"Alabi","year":"2016","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0420","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/s10456-018-9599-4","article-title":"Glomerular endothelial cell maturation depends on ADAM10, a key regulator of notch signaling","volume":"21","author":"Farber","year":"2018","journal-title":"Angiogenesis"},{"key":"10.1016\/j.bbamcr.2021.119165_bb0425","first-page":"1389","article-title":"ADAM10-mediated ectodomain shedding is an essential driver of podocyte damage","volume":"32","author":"Sachs","year":"2021"},{"key":"10.1016\/j.bbamcr.2021.119165_bb0430","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1002\/path.5517","article-title":"ADAM10 mediates ectopic proximal tubule development and renal fibrosis through notch signalling","volume":"252","author":"Li","year":"2020","journal-title":"J. Pathol."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0435","first-page":"F333","article-title":"Role of ADAM17 in kidney disease","volume":"317","author":"Palau","year":"2019"},{"key":"10.1016\/j.bbamcr.2021.119165_bb0440","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1093\/ndt\/gfr583","article-title":"ADAM17 up-regulation in renal transplant dysfunction and non-transplant-related renal fibrosis","volume":"27","author":"Mulder","year":"2012","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0445","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1053\/j.jrn.2017.05.007","article-title":"ADAM17, a new player in the pathogenesis of chronic kidney disease-mineral and bone disorder","volume":"27","author":"Perna","year":"2017","journal-title":"J. Ren. Nutr."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0450","first-page":"C1366","article-title":"A disintegrin and metalloprotease 10 activity sheds the ectodomain of the amyloid precursor-like protein 2 and regulates protein expression in proximal tubule cells","volume":"300","author":"Cong","year":"2011"},{"key":"10.1016\/j.bbamcr.2021.119165_bb0455","doi-asserted-by":"crossref","first-page":"13308","DOI":"10.1074\/jbc.M114.559088","article-title":"ADAM10 is the major sheddase responsible for the release of membrane-associated meprin a","volume":"289","author":"Herzog","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0460","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1292\/jvms.17-0439","article-title":"Immunolocalization of beta-catenin, E-cadherin and N-cadherin in neonate and adult rat kidney","volume":"79","author":"Terada","year":"2017","journal-title":"J. Vet. Med. Sci."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0465","doi-asserted-by":"crossref","first-page":"7416","DOI":"10.1074\/jbc.M114.603753","article-title":"The cytoplasmic domain of a disintegrin and metalloproteinase 10 (ADAM10) regulates its constitutive activity but is dispensable for stimulated ADAM10-dependent shedding","volume":"290","author":"Maretzky","year":"2015","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0470","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.bbrc.2011.11.140","article-title":"Tumor suppressor cell adhesion molecule 1 (CADM1) is cleaved by a disintegrin and metalloprotease 10 (ADAM10) and subsequently cleaved by gamma-secretase complex","volume":"417","author":"Nagara","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0475","first-page":"F388","article-title":"Cell adhesion molecule-1 shedding induces apoptosis of renal epithelial cells and exacerbates human nephropathies","volume":"314","author":"Kato","year":"2018"},{"key":"10.1016\/j.bbamcr.2021.119165_bb0480","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.2353\/ajpath.2009.080960","article-title":"CXCL16 is expressed in podocytes and acts as a scavenger receptor for oxidized low-density lipoprotein","volume":"174","author":"Gutwein","year":"2009","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0485","article-title":"ACE2: evidence of role as entry receptor for SARS-CoV-2 and implications in comorbidities","volume":"9","author":"Zamorano Cuervo","year":"2020"},{"key":"10.1016\/j.bbamcr.2021.119165_bb0490","first-page":"1","article-title":"Angiotensin-converting enzyme 2 and COVID-19 in cardiorenal diseases","volume":"135","author":"Sharma","year":"2021"},{"key":"10.1016\/j.bbamcr.2021.119165_bb0495","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCULATIONAHA.110.955369","article-title":"Angiotensin-converting enzyme 2 suppresses pathological hypertrophy, myocardial fibrosis, and cardiac dysfunction","volume":"122","author":"Zhong","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.bbamcr.2021.119165_bb0500","doi-asserted-by":"crossref","first-page":"14838","DOI":"10.1074\/jbc.M200581200","article-title":"Hydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxypeptidase","volume":"277","author":"Vickers","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0505","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1111\/bph.12159","article-title":"ACE2, angiotensin-(1-7) and Mas receptor axis in inflammation and fibrosis","volume":"169","author":"Simoes e Silva","year":"2013","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0510","doi-asserted-by":"crossref","first-page":"33678","DOI":"10.1038\/srep33678","article-title":"Neprilysin is a mediator of alternative renin-angiotensin-system activation in the murine and human kidney","volume":"6","author":"Domenig","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0515","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1161\/CIRCRESAHA.119.316151","article-title":"Critical role of neprilysin in kidney angiotensin metabolism","volume":"127","author":"Kaltenecker","year":"2020","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0520","doi-asserted-by":"crossref","first-page":"19796","DOI":"10.1073\/pnas.0709805104","volume":"104","author":"Chen","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0525","first-page":"F359","article-title":"Shedding of klotho by ADAMs in the kidney","volume":"309","author":"van Loon","year":"2015"},{"key":"10.1016\/j.bbamcr.2021.119165_bb0530","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1126\/science.1114245","article-title":"The beta-glucuronidase klotho hydrolyzes and activates the TRPV5 channel","volume":"310","author":"Chang","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.bbamcr.2021.119165_bb0535","doi-asserted-by":"crossref","first-page":"3438","DOI":"10.1096\/fj.10-154765","article-title":"Klotho: a novel phosphaturic substance acting as an autocrine enzyme in the renal proximal tubule","volume":"24","author":"Hu","year":"2010","journal-title":"FASEB J."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0540","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1038\/nature05315","article-title":"Klotho converts canonical FGF receptor into a specific receptor for FGF23","volume":"444","author":"Urakawa","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.bbamcr.2021.119165_bb0545","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.bone.2016.09.010","article-title":"FGF23-klotho signaling axis in the kidney","volume":"100","author":"Erben","year":"2017","journal-title":"Bone"},{"key":"10.1016\/j.bbamcr.2021.119165_bb0550","doi-asserted-by":"crossref","first-page":"6120","DOI":"10.1074\/jbc.C500457200","article-title":"Regulation of fibroblast growth factor-23 signaling by klotho","volume":"281","author":"Kurosu","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0555","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1124\/mol.109.055780","article-title":"Regulation of renal outer medullary potassium channel and renal K(+) excretion by Klotho","volume":"76","author":"Cha","year":"2009","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0560","doi-asserted-by":"crossref","first-page":"3397","DOI":"10.1093\/ndt\/gfn291","article-title":"The beta-glucuronidase klotho exclusively activates the epithelial Ca2+ channels TRPV5 and TRPV6","volume":"23","author":"Lu","year":"2008","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0565","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1055\/s-0038-1660479","article-title":"A disintegrin and metalloproteases (ADAMs) in cardiovascular, metabolic and inflammatory diseases: aspects for theranostic approaches","volume":"118","author":"van der Vorst","year":"2018","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0570","first-page":"F205","article-title":"Accelerated receptor shedding inhibits kidney injury molecule-1 (KIM-1)-mediated efferocytosis","volume":"307","author":"Gandhi","year":"2014"},{"key":"10.1016\/j.bbamcr.2021.119165_bb0575","doi-asserted-by":"crossref","first-page":"30113","DOI":"10.1074\/jbc.M505111200","volume":"280","author":"Lambert","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0580","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/978-1-4939-6625-7_8","volume":"1527","author":"Xiao","year":"2017","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0585","series-title":"Key metalloproteinase-mediated pathways in the kidney","author":"Wozniak","year":"2021"},{"key":"10.1016\/j.bbamcr.2021.119165_bb0590","doi-asserted-by":"crossref","first-page":"153","DOI":"10.3389\/fcell.2018.00153","article-title":"Renal ADAM10 and 17: their physiological and medical meanings","volume":"6","author":"Kato","year":"2018","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0595","article-title":"Historical overview of the interleukin-6 family cytokine","volume":"217","author":"Kang","year":"2020","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0600","doi-asserted-by":"crossref","first-page":"405","DOI":"10.3389\/fimmu.2017.00405","article-title":"Interleukin-6 signaling pathway and its role in kidney disease: an update","volume":"8","author":"Su","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0605","first-page":"1597","article-title":"Inflammation-induced IL-6 functions as a natural brake on macrophages and limits GN","volume":"26","author":"Luig","year":"2015"},{"key":"10.1016\/j.bbamcr.2021.119165_bb0610","first-page":"1106","article-title":"IL-6\/IL-6R axis plays a critical role in acute kidney injury","volume":"19","author":"Nechemia-Arbely","year":"2008"},{"key":"10.1016\/j.bbamcr.2021.119165_bb0615","doi-asserted-by":"crossref","first-page":"38829","DOI":"10.1074\/jbc.M210584200","volume":"278","author":"Matthews","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0620","first-page":"132","article-title":"IL-6 trans-signaling drives murine crescentic GN","volume":"27","author":"Braun","year":"2016"},{"key":"10.1016\/j.bbamcr.2021.119165_bb0625","doi-asserted-by":"crossref","first-page":"2691","DOI":"10.1002\/art.38061","article-title":"Interleukin-6 trans-signaling exacerbates inflammation and renal pathology in lupus-prone mice","volume":"65","author":"Tsantikos","year":"2013","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0630","doi-asserted-by":"crossref","first-page":"3980","DOI":"10.7150\/thno.32352","article-title":"Blocking interleukin-6 trans-signaling protects against renal fibrosis by suppressing STAT3 activation","volume":"9","author":"Chen","year":"2019","journal-title":"Theranostics"},{"key":"10.1016\/j.bbamcr.2021.119165_bb0635","doi-asserted-by":"crossref","first-page":"7219","DOI":"10.4049\/jimmunol.0901929","article-title":"Differences in wound healing in mice with deficiency of IL-6 versus IL-6 receptor","volume":"184","author":"McFarland-Mancini","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0640","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1083\/jcb.200307137","article-title":"Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands","volume":"164","author":"Sahin","year":"2004","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0645","first-page":"3147","article-title":"Importance of functional EGF receptors in recovery from acute nephrotoxic injury","volume":"14","author":"Wang","year":"2003"},{"key":"10.1016\/j.bbamcr.2021.119165_bb0650","first-page":"854","article-title":"Genetic or pharmacologic blockade of EGFR inhibits renal fibrosis","volume":"23","author":"Liu","year":"2012"},{"key":"10.1016\/j.bbamcr.2021.119165_bb0655","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.87023","article-title":"ADAM17 substrate release in proximal tubule drives kidney fibrosis","volume":"1","author":"Kefaloyianni","year":"2016","journal-title":"JCI Insight"},{"key":"10.1016\/j.bbamcr.2021.119165_bb0660","first-page":"1996","article-title":"Amphiregulin aggravates glomerulonephritis via recruitment and activation of myeloid cells","volume":"31","author":"Melderis","year":"2020"},{"key":"10.1016\/j.bbamcr.2021.119165_bb0665","first-page":"2370","article-title":"Proximal tubule-derived amphiregulin amplifies and integrates profibrotic EGF receptor signals in kidney fibrosis","volume":"30","author":"Kefaloyianni","year":"2019"},{"key":"10.1016\/j.bbamcr.2021.119165_bb0670","first-page":"F1005","article-title":"Tumor necrosis factor-alpha, kidney function, and hypertension","volume":"313","author":"Mehaffey","year":"2017"},{"key":"10.1016\/j.bbamcr.2021.119165_bb0675","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1038\/ki.2009.142","article-title":"Immunoregulatory role of TNFalpha in inflammatory kidney diseases","volume":"76","author":"Ernandez","year":"2009","journal-title":"Kidney Int."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0680","doi-asserted-by":"crossref","DOI":"10.1155\/2010\/182958","article-title":"TNF superfamily: a growing saga of kidney injury modulators","volume":"2010","author":"Sanchez-Nino","year":"2010","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0685","first-page":"F1836","article-title":"Tumor necrosis factor-alpha induces renal vasoconstriction as well as natriuresis in mice","volume":"295","author":"Shahid","year":"2008"},{"key":"10.1016\/j.bbamcr.2021.119165_bb0690","doi-asserted-by":"crossref","first-page":"37993","DOI":"10.1074\/jbc.M106434200","volume":"276","author":"Garton","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0695","doi-asserted-by":"crossref","first-page":"6362","DOI":"10.4049\/jimmunol.172.10.6362","article-title":"The transmembrane CXC-chemokine ligand 16 is induced by IFN-gamma and TNF-alpha and shed by the activity of the disintegrin-like metalloproteinase ADAM10","volume":"172","author":"Abel","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0700","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1161\/HYPERTENSIONAHA.113.01837","article-title":"Critical role of CXCL16 in hypertensive kidney injury and fibrosis","volume":"62","author":"Xia","year":"2013","journal-title":"Hypertension"},{"key":"10.1016\/j.bbamcr.2021.119165_bb0705","doi-asserted-by":"crossref","first-page":"442","DOI":"10.2174\/1566523218666180214092536","article-title":"CX3CL1\/CX3CR1 axis, as the therapeutic potential in renal diseases: friend or foe?","volume":"17","author":"Zhuang","year":"2017","journal-title":"Curr. Gene Ther."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0710","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/s00441-021-03473-0","article-title":"Regulation and function of CX3CR1 and its ligand CX3CL1 in kidney disease","volume":"385","author":"von Vietinghoff","year":"2021","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0715","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.bbrc.2008.03.088","article-title":"The role of CXCL16 and its processing metalloproteinases ADAM10 and ADAM17 in the proliferation and migration of human mesangial cells","volume":"370","author":"Schramme","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0720","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1038\/ki.2008.181","article-title":"Characterization of CXCL16 and ADAM10 in the normal and transplanted kidney","volume":"74","author":"Schramme","year":"2008","journal-title":"Kidney Int."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0725","first-page":"722","article-title":"Notch signalling in context","volume":"17","author":"Bray","year":"2016"},{"issue":"2014","key":"10.1016\/j.bbamcr.2021.119165_bb0730","first-page":"91","article-title":"Kick it up a notch: notch signaling and kidney fibrosis","volume":"4","author":"Sweetwyne","year":"2011","journal-title":"Kidney Int. Suppl."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0735","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1038\/ki.2010.172","article-title":"Expression of notch pathway proteins correlates with albuminuria, glomerulosclerosis, and renal function","volume":"78","author":"Murea","year":"2010","journal-title":"Kidney Int."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0740","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1007\/s11255-018-1956-0","article-title":"PAX2 may induce ADAM10 expression in renal tubular epithelial cells and contribute to epithelial-to-mesenchymal transition","volume":"50","author":"Hou","year":"2018","journal-title":"Int. Urol. Nephrol."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0745","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1038\/nm.4419","article-title":"ADAM10-mediated ephrin-B2 shedding promotes myofibroblast activation and organ fibrosis","volume":"23","author":"Lagares","year":"2017","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0750","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/s00018-012-1106-2","article-title":"The substrate degradome of meprin metalloproteases reveals an unexpected proteolytic link between meprin beta and ADAM10","volume":"70","author":"Jefferson","year":"2013","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0755","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1046\/j.1523-1755.2002.00209.x","article-title":"Meprin, a brush-border enzyme, plays an important role in hypoxic\/ischemic acute renal tubular injury in rats","volume":"61","author":"Carmago","year":"2002","journal-title":"Kidney Int."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0760","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1097\/SHK.0b013e3181ec39cc","article-title":"Actinonin, a meprin a inhibitor, protects the renal microcirculation during sepsis","volume":"35","author":"Wang","year":"2011","journal-title":"Shock"},{"key":"10.1016\/j.bbamcr.2021.119165_bb0765","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1038\/ki.2012.184","article-title":"The receptor of advanced glycation end products plays a central role in advanced oxidation protein products-induced podocyte apoptosis","volume":"82","author":"Zhou","year":"2012","journal-title":"Kidney Int."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0770","first-page":"3067","article-title":"Glomerular localization and expression of angiotensin-converting enzyme 2 and angiotensin-converting enzyme: implications for albuminuria in diabetes","volume":"17","author":"Ye","year":"2006"},{"key":"10.1016\/j.bbamcr.2021.119165_bb0775","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0062833","article-title":"Rosiglitazone treatment of type 2 diabetic db\/db mice attenuates urinary albumin and angiotensin converting enzyme 2 excretion","volume":"8","author":"Chodavarapu","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.bbamcr.2021.119165_bb0780","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1111\/jth.13315","article-title":"Renal endothelial protein C receptor expression and shedding during diabetic nephropathy","volume":"14","author":"Lattenist","year":"2016","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0785","doi-asserted-by":"crossref","first-page":"17286","DOI":"10.1074\/jbc.M412427200","article-title":"Activated protein C mediates novel lung endothelial barrier enhancement: role of sphingosine 1-phosphate receptor transactivation","volume":"280","author":"Finigan","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0790","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1038\/nm1667","article-title":"Activated protein C protects against diabetic nephropathy by inhibiting endothelial and podocyte apoptosis","volume":"13","author":"Isermann","year":"2007","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0795","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1074\/jbc.M109.059394","article-title":"A disintegrin and metalloproteinase 17 (ADAM17) mediates inflammation-induced shedding of syndecan-1 and -4 by lung epithelial cells","volume":"285","author":"Pruessmeyer","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0800","doi-asserted-by":"crossref","first-page":"3783","DOI":"10.1007\/s00018-015-1912-4","article-title":"A transmembrane C-terminal fragment of syndecan-1 is generated by the metalloproteinase ADAM17 and promotes lung epithelial tumor cell migration and lung metastasis formation","volume":"72","author":"Pasqualon","year":"2015","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0805","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/j.kint.2019.09.035","article-title":"Blocking matrix metalloproteinase-mediated syndecan-4 shedding restores the endothelial glycocalyx and glomerular filtration barrier function in early diabetic kidney disease","volume":"97","author":"Ramnath","year":"2020","journal-title":"Kidney Int."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0810","doi-asserted-by":"crossref","first-page":"e331","DOI":"10.1097\/TP.0000000000002170","article-title":"Syndecan-1 shedding inhibition to protect against ischemic acute kidney injury through HGF target signaling pathway","volume":"102","author":"Lu","year":"2018","journal-title":"Transplantation"},{"key":"10.1016\/j.bbamcr.2021.119165_bb0815","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1124\/pr.59.3.3","article-title":"The intrarenal renin-angiotensin system: from physiology to the pathobiology of hypertension and kidney disease","volume":"59","author":"Kobori","year":"2007","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0820","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1038\/nm1275","article-title":"Angiotensin II and EGF receptor cross-talk in chronic kidney diseases: a new therapeutic approach","volume":"11","author":"Lautrette","year":"2005","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0825","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1038\/sj.ki.5002373","article-title":"ACE2 inhibition worsens glomerular injury in association with increased ACE expression in streptozotocin-induced diabetic mice","volume":"72","author":"Soler","year":"2007","journal-title":"Kidney Int."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0830","doi-asserted-by":"crossref","first-page":"F629","DOI":"10.1152\/ajprenal.00516.2013","article-title":"Insulin treatment attenuates renal ADAM17 and ACE2 shedding in diabetic Akita mice","volume":"306","author":"Salem","year":"2014","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.bbamcr.2021.119165_bb0835","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1007\/s00125-008-0988-x","article-title":"Urinary mRNA expression of ACE and ACE2 in human type 2 diabetic nephropathy","volume":"51","author":"Wang","year":"2008","journal-title":"Diabetologia"},{"key":"10.1016\/j.bbamcr.2021.119165_bb0840","doi-asserted-by":"crossref","first-page":"3809","DOI":"10.1111\/j.1582-4934.2009.00761.x","article-title":"CXCL16 and oxLDL are induced in the onset of diabetic nephropathy","volume":"13","author":"Gutwein","year":"2009","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0845","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1006\/bbrc.1998.8485","article-title":"The metallo-disintegrin ADAM10 (MADM) from bovine kidney has type IV collagenase activity in vitro","volume":"245","author":"Millichip","year":"1998","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0850","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1038\/s41467-017-00498-4","article-title":"Sirt6 deficiency exacerbates podocyte injury and proteinuria through targeting Notch signaling","volume":"8","author":"Liu","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0855","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1007\/s00125-010-1978-3","article-title":"Association analysis of notch pathway signalling genes in diabetic nephropathy","volume":"54","author":"Kavanagh","year":"2011","journal-title":"Diabetologia"},{"key":"10.1016\/j.bbamcr.2021.119165_bb0860","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1007\/s00441-021-03429-4","article-title":"Perspectives in membranous nephropathy","volume":"385","author":"Tomas","year":"2021","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0865","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1369\/0022155415611708","article-title":"Avian podocytes, which lack nephrin, use adherens junction proteins at intercellular junctions","volume":"64","author":"Yaoita","year":"2016","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0870","first-page":"1997","article-title":"Wnt\/beta-catenin signaling promotes podocyte dysfunction and albuminuria","volume":"20","author":"Dai","year":"2009"},{"key":"10.1016\/j.bbamcr.2021.119165_bb0875","doi-asserted-by":"crossref","first-page":"26003","DOI":"10.1074\/jbc.M111.223164","article-title":"Wnt\/beta-catenin pathway in podocytes integrates cell adhesion, differentiation, and survival","volume":"286","author":"Kato","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0880","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1038\/sj.emboj.7600548","article-title":"ADAM10 cleavage of N-cadherin and regulation of cell-cell adhesion and beta-catenin nuclear signalling","volume":"24","author":"Reiss","year":"2005","journal-title":"EMBO J."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0885","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1146\/annurev.med.60.101707.125712","article-title":"Polycystic kidney disease","volume":"60","author":"Harris","year":"2009","journal-title":"Annu. Rev. Med."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0890","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1152\/physiolgenomics.00090.2014","article-title":"Polycystin-1 and Galpha12 regulate the cleavage of E-cadherin in kidney epithelial cells","volume":"47","author":"Xu","year":"2015","journal-title":"Physiol. Genomics"},{"key":"10.1016\/j.bbamcr.2021.119165_bb0895","doi-asserted-by":"crossref","first-page":"F551","DOI":"10.1152\/ajprenal.00218.2014","article-title":"ADAM17 promotes proliferation of collecting duct kidney epithelial cells through ERK activation and increased glycolysis in polycystic kidney disease","volume":"307","author":"Beck Gooz","year":"2014","journal-title":"Am. J. Physiol. Renal. Physiol."},{"key":"10.1016\/j.bbamcr.2021.119165_bb0900","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1007\/s00018-020-03507-w","article-title":"The metalloproteinase ADAM10 requires its activity to sustain surface expression","volume":"78","author":"Seifert","year":"2021","journal-title":"Cell. Mol. Life Sci."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167488921002196?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167488921002196?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T11:32:34Z","timestamp":1778671954000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167488921002196"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":180,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["S0167488921002196"],"URL":"https:\/\/doi.org\/10.1016\/j.bbamcr.2021.119165","relation":{},"ISSN":["0167-4889"],"issn-type":[{"value":"0167-4889","type":"print"}],"subject":[],"published":{"date-parts":[[2022,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ectodomain shedding by ADAM proteases as a central regulator in kidney physiology and disease","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Cell Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbamcr.2021.119165","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"119165"}}