{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T19:50:19Z","timestamp":1784663419014,"version":"3.55.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Cell Research"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1016\/j.bbamcr.2021.119200","type":"journal-article","created":{"date-parts":[[2021,12,27]],"date-time":"2021-12-27T11:30:44Z","timestamp":1640604644000},"page":"119200","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Suppression of LMCD1 ameliorates renal fibrosis by blocking the activation of ERK pathway"],"prefix":"10.1016","volume":"1869","author":[{"given":"Rui","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zixia","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongzhe","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beiru","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbamcr.2021.119200_bb0005","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/S0140-6736(20)30045-3","article-title":"Global, regional, and national burden of chronic kidney disease, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017","volume":"395","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.bbamcr.2021.119200_bb0010","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18051039","article-title":"Chronic kidney disease and exposure to nephrotoxic metals","volume":"18","author":"Orr","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbamcr.2021.119200_bb0015","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-981-13-8871-2_1","article-title":"Prevalence and disease burden of chronic kidney disease","volume":"1165","author":"Lv","year":"2019","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.bbamcr.2021.119200_bb0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.biocel.2005.09.005","article-title":"The renal cortical fibroblast in renal tubulointerstitial fibrosis","volume":"38","author":"Qi","year":"2006","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.bbamcr.2021.119200_bb0025","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1369\/0022155414568019","article-title":"Epigallocatechin-3-gallate attenuates unilateral ureteral obstruction-induced renal interstitial fibrosis in mice","volume":"63","author":"Wang","year":"2015","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.bbamcr.2021.119200_bb0030","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1681\/ASN.2010080793","article-title":"Mechanisms of tubulointerstitial fibrosis","volume":"21","author":"Zeisberg","year":"2010","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.bbamcr.2021.119200_bb0035","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1006\/geno.1999.6049","article-title":"Identification of a novel LIM domain gene, LMCD1, and chromosomal localization in human and mouse","volume":"63","author":"Bespalova","year":"2000","journal-title":"Genomics"},{"key":"10.1016\/j.bbamcr.2021.119200_bb0040","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1038\/nrm1499","article-title":"The LIM domain: from the cytoskeleton to the nucleus","volume":"5","author":"Kadrmas","year":"2004","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bbamcr.2021.119200_bb0045","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1038\/s41419-019-1876-7","article-title":"LMCD1 promotes osteogenic differentiation of human bone marrow stem cells by regulating BMP signaling","volume":"10","author":"Zhu","year":"2019","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bbamcr.2021.119200_bb0050","doi-asserted-by":"crossref","first-page":"3088","DOI":"10.1074\/jbc.RA117.000866","article-title":"LIM and cysteine-rich domains 1 is required for thrombin-induced smooth muscle cell proliferation and promotes atherogenesis","volume":"293","author":"Janjanam","year":"2018","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamcr.2021.119200_bb0055","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.1002\/cam4.719","article-title":"Transcriptome profiling reveals novel gene expression signatures and regulating transcription factors of TGF\u03b2-induced epithelial-to-mesenchymal transition","volume":"5","author":"Du","year":"2016","journal-title":"Cancer Med."},{"key":"10.1016\/j.bbamcr.2021.119200_bb0060","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1161\/HYPERTENSIONAHA.109.135665","article-title":"LIM and cysteine-rich domains 1 regulates cardiac hypertrophy by targeting calcineurin\/nuclear factor of activated T cells signaling","volume":"55","author":"Bian","year":"2010","journal-title":"Hypertension"},{"key":"10.1016\/j.bbamcr.2021.119200_bb0065","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1128\/MMBR.68.2.320-344.2004","article-title":"ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions","volume":"68","author":"Roux","year":"2004","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"10.1016\/j.bbamcr.2021.119200_bb0070","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1161\/01.HYP.31.1.152","article-title":"Growth factors and mitogen-activated protein kinases","volume":"31","author":"Force","year":"1998","journal-title":"Hypertension"},{"key":"10.1016\/j.bbamcr.2021.119200_bb0075","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1172\/JCI119568","article-title":"Activation of extracellular signal-regulated kinase in proliferative glomerulonephritis in rats","volume":"100","author":"Bokemeyer","year":"1997","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbamcr.2021.119200_bb0080","doi-asserted-by":"crossref","first-page":"6551","DOI":"10.1096\/fj.201801865RR","article-title":"C-reactive protein exacerbates epithelial-mesenchymal transition through Wnt\/\u03b2-catenin and ERK signaling in streptozocin-induced diabetic nephropathy","volume":"33","author":"Zhang","year":"2019","journal-title":"FASEB J."},{"key":"10.1016\/j.bbamcr.2021.119200_bb0085","first-page":"4054","article-title":"HMGB1-TLR4 signaling participates in renal ischemia reperfusion injury and could be attenuated by dexamethasone-mediated inhibition of the ERK\/NF-\u03baB pathway","volume":"8","author":"Zhang","year":"2016","journal-title":"Am. J. Transl. Res."},{"key":"10.1016\/j.bbamcr.2021.119200_bb0090","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1159\/000368485","article-title":"Fluorofenidone attenuates oxidative stress and renal fibrosis in obstructive nephropathy via blocking NOX2 (gp91phox) expression and inhibiting ERK\/MAPK signaling pathway","volume":"40","author":"Qin","year":"2015","journal-title":"Kidney Blood Press. Res."},{"key":"10.1016\/j.bbamcr.2021.119200_bb0095","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1080\/10715762.2016.1181757","article-title":"Apocynin attenuates renal fibrosis via inhibition of NOXs-ROS-ERK-myofibroblast accumulation in UUO rats","volume":"50","author":"Cheng","year":"2016","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.bbamcr.2021.119200_bb0100","doi-asserted-by":"crossref","first-page":"102","DOI":"10.15252\/emmm.201404127","article-title":"Caveolin-1 deficiency induces a MEK-ERK1\/2-Snail-1-dependent epithelial-mesenchymal transition and fibrosis during peritoneal dialysis","volume":"7","author":"Strippoli","year":"2015","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.bbamcr.2021.119200_bb0105","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1111\/j.1523-1755.2005.00157.x","article-title":"Activation of ERK in renal fibrosis after unilateral ureteral obstruction: modulation by antioxidants","volume":"67","author":"Pat","year":"2005","journal-title":"Kidney Int."},{"key":"10.1016\/j.bbamcr.2021.119200_bb0110","doi-asserted-by":"crossref","DOI":"10.3390\/biom9040141","article-title":"Unilateral ureteral obstruction as a model to investigate fibrosis-attenuating treatments","volume":"9","author":"Mart\u00ednez-Klimova","year":"2019","journal-title":"Biomolecules"},{"key":"10.1016\/j.bbamcr.2021.119200_bb0115","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.tem.2016.06.004","article-title":"Partial epithelial-to-mesenchymal transition and other new mechanisms of kidney fibrosis","volume":"27","author":"Lovisa","year":"2016","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.bbamcr.2021.119200_bb0120","doi-asserted-by":"crossref","DOI":"10.1111\/apha.13247","article-title":"Cardiotrophin-1 opposes renal fibrosis in mice: potential prevention of chronic kidney disease","volume":"226","author":"Perretta-Tejedor","year":"2019","journal-title":"Acta Physiol. (Oxf.)"},{"key":"10.1016\/j.bbamcr.2021.119200_bb0125","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1016\/S0002-9440(10)61109-1","article-title":"Interaction between the transforming growth factor-beta type II receptor\/Smad pathway and beta-catenin during transforming growth factor-beta1-mediated adherens junction disassembly","volume":"160","author":"Tian","year":"2002","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bbamcr.2021.119200_bb0130","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1016\/S0002-9440(10)63247-6","article-title":"Integrity of cell-cell contacts is a critical regulator of TGF-beta 1-induced epithelial-to-myofibroblast transition: role for beta-catenin","volume":"165","author":"Masszi","year":"2004","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bbamcr.2021.119200_bb0135","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1016\/j.cellsig.2008.02.012","article-title":"ERK activation is regulated by E2F1 and is essential for E2F1-induced S phase entry","volume":"20","author":"Korotayev","year":"2008","journal-title":"Cell. Signal."},{"key":"10.1016\/j.bbamcr.2021.119200_bb0140","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1172\/JCI200319270","article-title":"Targeted disruption of TGF-beta1\/Smad3 signaling protects against renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction","volume":"112","author":"Sato","year":"2003","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbamcr.2021.119200_bb0145","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1146\/annurev-physiol-022516-034227","article-title":"Mechanisms of renal fibrosis","volume":"80","author":"Humphreys","year":"2018","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.bbamcr.2021.119200_bb0150","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.matbio.2017.12.013","article-title":"Renal fibrosis: recent translational aspects","volume":"68\u201369","author":"Fran\u00e7ois","year":"2018","journal-title":"Matrix Biol."},{"key":"10.1016\/j.bbamcr.2021.119200_bb0155","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/sj.ki.5000054","article-title":"Renal fibrosis: new insights into the pathogenesis and therapeutics","volume":"69","author":"Liu","year":"2006","journal-title":"Kidney Int."},{"key":"10.1016\/j.bbamcr.2021.119200_bb0160","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a021873","article-title":"TGF-\u03b2 and the TGF-\u03b2 family: context-dependent roles in cell and tissue physiology","volume":"8","author":"Morikawa","year":"2016","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.bbamcr.2021.119200_bb0165","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s13395-019-0214-1","article-title":"LIM and cysteine-rich domains 1 (LMCD1) regulates skeletal muscle hypertrophy, calcium handling, and force","volume":"9","author":"Ferreira","year":"2019","journal-title":"Skelet. Muscle"},{"key":"10.1016\/j.bbamcr.2021.119200_bb0170","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1161\/ATVBAHA.120.314147","article-title":"Myristoylation of LMCD1 leads to its species-specific derepression of E2F1 and NFATc1 in the modulation of CDC6 and IL-33 expression during development of vascular lesions","volume":"40","author":"Govatati","year":"2020","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.bbamcr.2021.119200_bb0175","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1161\/ATVBAHA.119.312729","article-title":"NFATc1-E2F1-LMCD1-mediated IL-33 expression by thrombin is required for injury-induced neointima formation","volume":"39","author":"Govatati","year":"2019","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.bbamcr.2021.119200_bb0180","doi-asserted-by":"crossref","first-page":"2640","DOI":"10.1038\/onc.2011.440","article-title":"Somatic LMCD1 mutations promoted cell migration and tumor metastasis in hepatocellular carcinoma","volume":"31","author":"Chang","year":"2012","journal-title":"Oncogene"},{"key":"10.1016\/j.bbamcr.2021.119200_bb0185","doi-asserted-by":"crossref","first-page":"F4","DOI":"10.1152\/ajprenal.00045.2005","article-title":"Evidence that inhibition of tubular cell apoptosis protects against renal damage and development of fibrosis following ureteric obstruction","volume":"290","author":"Docherty","year":"2006","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.bbamcr.2021.119200_bb0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.109741","article-title":"Interleukin-17A induces renal fibrosis through the ERK and Smad signaling pathways","volume":"123","author":"Weng","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.bbamcr.2021.119200_bb0195","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18050855","article-title":"Renalase protects against renal fibrosis by inhibiting the activation of the ERK signaling pathways","volume":"18","author":"Wu","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbamcr.2021.119200_bb0200","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1681\/ASN.2014010065","article-title":"Evidence of a role for fibroblast transient receptor potential canonical 3 Ca2+ channel in renal fibrosis","volume":"26","author":"Saliba","year":"2015","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.bbamcr.2021.119200_bb0205","doi-asserted-by":"crossref","first-page":"8864","DOI":"10.1128\/MCB.25.20.8864-8873.2005","article-title":"LMCD1\/Dyxin is a novel transcriptional cofactor that restricts GATA6 function by inhibiting DNA binding","volume":"25","author":"Rath","year":"2005","journal-title":"Mol. Cell. Biol."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167488921002548?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167488921002548?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T19:57:25Z","timestamp":1759089445000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167488921002548"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":41,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["S0167488921002548"],"URL":"https:\/\/doi.org\/10.1016\/j.bbamcr.2021.119200","relation":{},"ISSN":["0167-4889"],"issn-type":[{"value":"0167-4889","type":"print"}],"subject":[],"published":{"date-parts":[[2022,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Suppression of LMCD1 ameliorates renal fibrosis by blocking the activation of ERK pathway","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Cell Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbamcr.2021.119200","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"119200"}}