{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T23:34:46Z","timestamp":1768692886364,"version":"3.49.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFD1300403"],"award-info":[{"award-number":["2022YFD1300403"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2019B1515210021"],"award-info":[{"award-number":["2019B1515210021"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31872389"],"award-info":[{"award-number":["31872389"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32072777"],"award-info":[{"award-number":["32072777"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Cell Research"],"published-print":{"date-parts":[[2023,3]]},"DOI":"10.1016\/j.bbamcr.2023.119431","type":"journal-article","created":{"date-parts":[[2023,1,9]],"date-time":"2023-01-09T12:20:25Z","timestamp":1673266825000},"page":"119431","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Heat stress disrupts intestinal stem cell migration and differentiation along the crypt\u2013villus axis through FAK signaling"],"prefix":"10.1016","volume":"1870","author":[{"given":"Geng-xiu","family":"Zan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying-chao","family":"Qin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-wen","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun-qi","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui-chao","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiu-qi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia-yi","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbamcr.2023.119431_bb0005","doi-asserted-by":"crossref","first-page":"5613","DOI":"10.1002\/jcp.29492","article-title":"Wnt\/beta-catenin-mediated heat exposure inhibits intestinal epithelial cell proliferation and stem cell expansion through endoplasmic reticulum stress","volume":"235","author":"Zhou","year":"2020","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.bbamcr.2023.119431_bb0010","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.3390\/antibiotics10111285","article-title":"Heat stress-mediated activation of immune-inflammatory pathways","volume":"10","author":"Cantet","year":"2021","journal-title":"Antibiotics"},{"key":"10.1016\/j.bbamcr.2023.119431_bb0015","doi-asserted-by":"crossref","first-page":"15495","DOI":"10.1021\/acs.jafc.1c03361","article-title":"Crosstalk between endoplasmic reticulum stress and oxidative stress in heat exposure-induced apoptosis is dependent on the ATF4-CHOP-CHAC1 signal pathway in IPEC-J2 cells","volume":"69","author":"Cui","year":"2021","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.bbamcr.2023.119431_bb0020","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.aninu.2020.11.008","article-title":"Xylooligosaccharide attenuates lipopolysaccharide-induced intestinal injury in piglets via suppressing inflammation and modulating cecal microbial communities","volume":"7","author":"Wang","year":"2021","journal-title":"Anim. Nutr."},{"key":"10.1016\/j.bbamcr.2023.119431_bb0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.jtherbio.2020.102539","article-title":"Responses of intestinal morphology and function in offspring to heat stress in primiparous sows during late gestation","volume":"89","author":"Guo","year":"2020","journal-title":"J. Therm. Biol."},{"key":"10.1016\/j.bbamcr.2023.119431_bb0030","doi-asserted-by":"crossref","first-page":"6435","DOI":"10.1007\/s11033-019-05090-1","article-title":"L-arginine alleviates heat stress-induced intestinal epithelial barrier damage by promoting expression of tight junction proteins via the AMPK pathway","volume":"46","author":"Xia","year":"2019","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.bbamcr.2023.119431_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.110572","article-title":"Microbes affect gut epithelial cell composition through immune-dependent regulation of intestinal stem cell differentiation","volume":"38","author":"Liu","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.bbamcr.2023.119431_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.110009","article-title":"CDC42 controlled apical-basal polarity regulates intestinal stem cell to transit amplifying cell fate transition via YAP-EGF-mTOR signaling","volume":"38","author":"Zhang","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.bbamcr.2023.119431_bb0045","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1016\/j.cell.2018.08.063","article-title":"Spatial reconstruction of single enterocytes uncovers broad zonation along the intestinal villus axis","volume":"175","author":"Moor","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.bbamcr.2023.119431_bb0050","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1126\/science.aau3429","article-title":"Active cell migration is critical for steady-state epithelial turnover in the gut","volume":"365","author":"Krndija","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.bbamcr.2023.119431_bb0055","doi-asserted-by":"crossref","first-page":"28478","DOI":"10.1074\/jbc.M114.567446","article-title":"Myosin light chain kinase (MLCK) regulates cell migration in a myosin regulatory light chain phosphorylation-independent mechanism","volume":"289","author":"Chen","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamcr.2023.119431_bb0060","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1093\/ecco-jcc\/jjy133","article-title":"Engulfment and cell motility protein 1 protects against DSS-induced colonic injury in mice via rac1 activation","volume":"13","author":"Zheng","year":"2019","journal-title":"J. Crohns Colitis"},{"key":"10.1016\/j.bbamcr.2023.119431_bb0065","first-page":"830","article-title":"Distraction-induced intestinal growth: the role of mechanotransduction mechanisms in a mouse model of short bowel syndrome","volume":"20","author":"Sueyoshi","year":"2014","journal-title":"Tissue Eng.A"},{"key":"10.1016\/j.bbamcr.2023.119431_bb0070","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.tcb.2016.02.001","article-title":"Endosomes: emerging platforms for integrin-mediated FAK signalling","volume":"26","author":"Alanko","year":"2016","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.bbamcr.2023.119431_bb0075","first-page":"1343","article-title":"Cell surface heat shock protein 90 modulates prostate cancer cell adhesion and invasion through the integrin-\u03b21\/focal adhesion kinase\/c-Src signaling pathway","volume":"25","author":"Liu","year":"2011","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.bbamcr.2023.119431_bb0080","first-page":"147","article-title":"Salidroside inhibits the proliferation and migration of gastric cancer cells via suppression of Srcassociated signaling pathway activation and heat shock protein 70 expression","volume":"18","author":"Qi","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.bbamcr.2023.119431_bb0085","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1111\/j.1460-9568.2010.07451.x","article-title":"Neuroprotective preconditioning of rat brain cultures with ethanol: potential transduction by PKC isoforms and focal adhesion kinase upstream of increases in effector heat shock proteins","volume":"32","author":"Sivaswamy","year":"2010","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.bbamcr.2023.119431_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2021.109640","article-title":"Lauric acid alleviates deoxynivalenol-induced intestinal stem cell damage by potentiating the Akt\/mTORC1\/S6K1 signaling axis","volume":"348","author":"Liu","year":"2021","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.bbamcr.2023.119431_bb0095","doi-asserted-by":"crossref","first-page":"H1480","DOI":"10.1152\/ajpheart.00857.2003","article-title":"Senescence alters blood flow responses to acute heat stress","volume":"286","author":"Kenney","year":"2004","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.bbamcr.2023.119431_bb0100","doi-asserted-by":"crossref","DOI":"10.1021\/acsinfecdis.1c00530","article-title":"Microbial imbalance induces inflammation by promoting salmonella penetration through the mucosal barrier","author":"Sharma","year":"2022","journal-title":"ACS Infect. Dis."},{"key":"10.1016\/j.bbamcr.2023.119431_bb0105","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1093\/brain\/aww028","article-title":"The heat shock response plays an important role in TDP-43 clearance: evidence for dysfunction in amyotrophic lateral sclerosis","volume":"139","author":"Chen","year":"2016","journal-title":"Brain"},{"key":"10.1016\/j.bbamcr.2023.119431_bb0110","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.stem.2013.11.008","article-title":"Lgr5+ stem cells are indispensable for radiation-induced intestinal regeneration","volume":"14","author":"Metcalfe","year":"2014","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.bbamcr.2023.119431_bb0115","doi-asserted-by":"crossref","first-page":"2675","DOI":"10.3382\/ps\/pey123","article-title":"Glutamine alleviates heat stress-induced impairment of intestinal morphology, intestinal inflammatory response, and barrier integrity in broilers","volume":"97","author":"Wu","year":"2018","journal-title":"Poult. Sci."},{"key":"10.1016\/j.bbamcr.2023.119431_bb0120","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1152\/physrev.00044.2005","article-title":"The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology","volume":"87","author":"Bedard","year":"2007","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.bbamcr.2023.119431_bb0125","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1152\/physrev.00040.2012","article-title":"Oxidative stress: an essential factor in the pathogenesis of gastrointestinal mucosal diseases","volume":"94","author":"Bhattacharyya","year":"2014","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.bbamcr.2023.119431_bb0130","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.3390\/ani11041135","article-title":"Adverse effects of heat stress on the intestinal integrity and function of pigs and the mitigation capacity of dietary antioxidants: a review","volume":"11","author":"Ortega","year":"2021","journal-title":"Animals"},{"key":"10.1016\/j.bbamcr.2023.119431_bb0135","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/s41575-018-0081-y","article-title":"Tales from the crypt: new insights into intestinal stem cells","volume":"16","author":"Gehart","year":"2019","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.bbamcr.2023.119431_bb0140","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1038\/s41422-021-00561-2","article-title":"Integrin alphaEbeta7(+) T cells direct intestinal stem cell fate decisions via adhesion signaling","volume":"31","author":"Chen","year":"2021","journal-title":"Cell Res."},{"key":"10.1016\/j.bbamcr.2023.119431_bb0145","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/s41580-020-0278-0","article-title":"Cell fate specification and differentiation in the adult mammalian intestine","volume":"22","author":"Beumer","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bbamcr.2023.119431_bb0150","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/mi.2013.84","article-title":"Redox signaling regulates commensal-mediated mucosal homeostasis and restitution and requires formyl peptide receptor 1","volume":"7","author":"Alam","year":"2014","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.bbamcr.2023.119431_bb0155","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1096\/fj.201801176R","article-title":"Stat3 is indispensable for damage-induced crypt regeneration but not for Wnt-driven intestinal tumorigenesis","volume":"33","author":"Oshima","year":"2019","journal-title":"FASEB J."},{"key":"10.1016\/j.bbamcr.2023.119431_bb0160","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.stem.2017.11.001","article-title":"YAP\/TAZ-dependent reprogramming of colonic epithelium links ECM remodeling to tissue regeneration","volume":"22","author":"Yui","year":"2018","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.bbamcr.2023.119431_bb0165","doi-asserted-by":"crossref","first-page":"6024","DOI":"10.1038\/srep06024","article-title":"FAK and paxillin dynamics at focal adhesions in the protrusions of migrating cells","volume":"4","author":"Hu","year":"2014","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbamcr.2023.119431_bb0170","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1053\/j.gastro.2008.01.079","article-title":"Current view: intestinal stem cells and signaling","volume":"134","author":"Scoville","year":"2008","journal-title":"Gastroenterology"}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167488923000022?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167488923000022?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T20:01:33Z","timestamp":1759089693000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167488923000022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":34,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["S0167488923000022"],"URL":"https:\/\/doi.org\/10.1016\/j.bbamcr.2023.119431","relation":{},"ISSN":["0167-4889"],"issn-type":[{"value":"0167-4889","type":"print"}],"subject":[],"published":{"date-parts":[[2023,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Heat stress disrupts intestinal stem cell migration and differentiation along the crypt\u2013villus axis through FAK signaling","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Cell Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbamcr.2023.119431","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"119431"}}