{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:12:45Z","timestamp":1791389565024,"version":"4.3.3"},"reference-count":190,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170300"],"award-info":[{"award-number":["82170300"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Cell Research"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1016\/j.bbamcr.2023.119488","type":"journal-article","created":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T02:35:14Z","timestamp":1684377314000},"page":"119488","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Kinases in cerebral cavernous malformations: Pathogenesis and therapeutic targets"],"prefix":"10.1016","volume":"1870","author":[{"given":"Chunxiao","family":"Qi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard Sean","family":"Bujaroski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Baell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangjian","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.bbamcr.2023.119488_bb0005","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1056\/NEJM198808113190605","article-title":"Cerebral cavernous malformations. Incidence and familial occurrence","volume":"319","author":"Rigamonti","year":"1988","journal-title":"N. Engl. J. Med."},{"issue":"1","key":"10.1016\/j.bbamcr.2023.119488_bb0010","doi-asserted-by":"crossref","first-page":"122","DOI":"10.3171\/2011.8.JNS101241","article-title":"Cerebral cavernous malformations: from genes to proteins to disease","volume":"116","author":"Cavalcanti","year":"2012","journal-title":"J. Neurosurg."},{"issue":"9","key":"10.1016\/j.bbamcr.2023.119488_bb0015","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1016\/j.mayocp.2019.11.005","article-title":"Cerebral cavernous malformation: what a practicing clinician should know","volume":"95","author":"Flemming","year":"2020","journal-title":"Mayo Clin. Proc."},{"issue":"3","key":"10.1016\/j.bbamcr.2023.119488_bb0020","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S1474-4422(07)70053-4","article-title":"Genetics of cavernous angiomas","volume":"6","author":"Labauge","year":"2007","journal-title":"Lancet Neurol."},{"issue":"4","key":"10.1016\/j.bbamcr.2023.119488_bb0025","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1227\/NEU.0000000000001842","article-title":"Natural history of spinal cord cavernous malformations: a multicenter cohort study","volume":"90","author":"Ren","year":"2022","journal-title":"Neurosurgery"},{"issue":"6","key":"10.1016\/j.bbamcr.2023.119488_bb0030","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1001\/archopht.124.6.885","article-title":"Frequency of retinal cavernomas in 60 patients with familial cerebral cavernomas: a clinical and genetic study","volume":"124","author":"Labauge","year":"2006","journal-title":"Arch. Ophthalmol."},{"issue":"2","key":"10.1016\/j.bbamcr.2023.119488_bb0035","doi-asserted-by":"crossref","first-page":"198","DOI":"10.3171\/2011.11.PEDS11390","article-title":"Natural history and imaging prevalence of cavernous malformations in children and young adults","volume":"9","author":"Al-Holou","year":"2012","journal-title":"J. Neurosurg. Pediatr."},{"issue":"18","key":"10.1016\/j.bbamcr.2023.119488_bb0040","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1056\/NEJMoa070972","article-title":"Incidental findings on brain MRI in the general population","volume":"357","author":"Vernooij","year":"2007","journal-title":"N. Engl. J. Med."},{"issue":"7","key":"10.1016\/j.bbamcr.2023.119488_bb0045","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/jamaneurol.2017.0439","article-title":"Population-based prevalence of cerebral cavernous malformations in older adults: Mayo Clinic Study of Aging","volume":"74","author":"Flemming","year":"2017","journal-title":"JAMA Neurol."},{"issue":"5","key":"10.1016\/j.bbamcr.2023.119488_bb0050","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1093\/neuros\/nyx091","article-title":"Synopsis of guidelines for the clinical management of cerebral cavernous malformations: consensus recommendations based on systematic literature review by the Angioma Alliance scientific advisory board clinical experts panel","volume":"80","author":"Akers","year":"2017","journal-title":"Neurosurgery"},{"issue":"12","key":"10.1016\/j.bbamcr.2023.119488_bb0055","doi-asserted-by":"crossref","first-page":"e1210","DOI":"10.1212\/WNL.0000000000012569","article-title":"Seizure incidence rates in children and adults with familial cerebral cavernous malformations","volume":"97","author":"Fox","year":"2021","journal-title":"Neurology"},{"issue":"3","key":"10.1016\/j.bbamcr.2023.119488_bb0060","doi-asserted-by":"crossref","first-page":"e027572","DOI":"10.1161\/JAHA.122.027572","article-title":"Intracranial hemorrhage rate and lesion burden in patients with familial cerebral cavernous malformation","volume":"12","author":"Weinsheimer","year":"2023","journal-title":"J. Am. Heart Assoc."},{"issue":"2","key":"10.1016\/j.bbamcr.2023.119488_bb0065","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1038\/13815","article-title":"Truncating mutations in CCM1, encoding KRIT1, cause hereditary cavernous angiomas","volume":"23","author":"Laberge-le Couteulx","year":"1999","journal-title":"Nat. Genet."},{"issue":"6","key":"10.1016\/j.bbamcr.2023.119488_bb0070","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1086\/380314","article-title":"Mutations in a gene encoding a novel protein containing a phosphotyrosine-binding domain cause type 2 cerebral cavernous malformations","volume":"73","author":"Liquori","year":"2003","journal-title":"Am. J. Hum. Genet."},{"issue":"2","key":"10.1016\/j.bbamcr.2023.119488_bb0075","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1086\/381718","article-title":"Mutations within the MGC4607 gene cause cerebral cavernous malformations","volume":"74","author":"Denier","year":"2004","journal-title":"Am. J. Hum. Genet."},{"issue":"5","key":"10.1016\/j.bbamcr.2023.119488_bb0080","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1093\/hmg\/ddn430","article-title":"Biallelic somatic and germline mutations in cerebral cavernous malformations (CCMs): evidence for a two-hit mechanism of CCM pathogenesis","volume":"18","author":"Akers","year":"2009","journal-title":"Hum. Mol. Genet."},{"issue":"5","key":"10.1016\/j.bbamcr.2023.119488_bb0085","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1016\/j.ajhg.2021.04.005","article-title":"Somatic MAP3K3 mutation defines a subclass of cerebral cavernous malformation","volume":"108","author":"Weng","year":"2021","journal-title":"Am. J. Hum. Genet."},{"issue":"7862","key":"10.1016\/j.bbamcr.2023.119488_bb0090","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/s41586-021-03562-8","article-title":"PIK3CA and CCM mutations fuel cavernomas through a cancer-like mechanism","volume":"594","author":"Ren","year":"2021","journal-title":"Nature"},{"issue":"9","key":"10.1016\/j.bbamcr.2023.119488_bb0095","doi-asserted-by":"crossref","first-page":"2648","DOI":"10.1093\/brain\/awab117","article-title":"Somatic MAP3K3 and PIK3CA mutations in sporadic cerebral and spinal cord cavernous malformations","volume":"144","author":"Hong","year":"2021","journal-title":"Brain"},{"issue":"11","key":"10.1016\/j.bbamcr.2023.119488_bb0100","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1056\/NEJMoa2100440","article-title":"Somatic PIK3CA mutations in sporadic cerebral cavernous malformations","volume":"385","author":"Peyre","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbamcr.2023.119488_bb0105","article-title":"Cerebral cavernous malformations arise from endothelial gain of MEKK3-KLF2\/4 signalling","author":"Zhou","year":"2016","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.bbamcr.2023.119488_bb0110","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/nm.1911","article-title":"The cerebral cavernous malformation signaling pathway promotes vascular integrity via rho GTPases","volume":"15","author":"Whitehead","year":"2009","journal-title":"Nat. Med."},{"issue":"4","key":"10.1016\/j.bbamcr.2023.119488_bb0115","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1084\/jem.20091258","article-title":"Cerebral cavernous malformations proteins inhibit rho kinase to stabilize vascular integrity","volume":"207","author":"Stockton","year":"2010","journal-title":"J. Exp. Med."},{"issue":"7455","key":"10.1016\/j.bbamcr.2023.119488_bb0120","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1038\/nature12207","article-title":"EndMT contributes to the onset and progression of cerebral cavernous malformations","volume":"498","author":"Maddaluno","year":"2013","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.bbamcr.2023.119488_bb0125","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1161\/CIRCRESAHA.117.312310","article-title":"Clonal expansion of endothelial cells contributes to ischemia-induced neovascularization","volume":"122","author":"Manavski","year":"2018","journal-title":"Circ. Res."},{"issue":"13","key":"10.1016\/j.bbamcr.2023.119488_bb0130","doi-asserted-by":"crossref","DOI":"10.1172\/JCI139570","article-title":"Astrocytes propel neurovascular dysfunction during cerebral cavernous malformation lesion formation","volume":"131","author":"Lopez-Ramirez","year":"2021","journal-title":"J. Clin. Invest."},{"issue":"11","key":"10.1016\/j.bbamcr.2023.119488_bb0135","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1161\/CIRCRESAHA.122.321129","article-title":"Neuroinflammation plays a critical role in cerebral cavernous malformation disease","volume":"131","author":"Lai","year":"2022","journal-title":"Circ. Res."},{"issue":"3","key":"10.1016\/j.bbamcr.2023.119488_bb0140","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.jsb.2015.10.006","article-title":"Structural analysis of the KRIT1 ankyrin repeat and FERM domains reveals a conformationally stable ARD-FERM interface","volume":"192","author":"Zhang","year":"2015","journal-title":"J. Struct. Biol."},{"issue":"5","key":"10.1016\/j.bbamcr.2023.119488_bb0145","doi-asserted-by":"crossref","first-page":"2842","DOI":"10.1074\/jbc.M114.616433","article-title":"Structural basis for the disruption of the cerebral cavernous malformations 2 (CCM2) interaction with Krev interaction trapped 1 (KRIT1) by disease-associated mutations","volume":"290","author":"Fisher","year":"2015","journal-title":"J. Biol. Chem."},{"issue":"33","key":"10.1016\/j.bbamcr.2023.119488_bb0150","doi-asserted-by":"crossref","first-page":"23639","DOI":"10.1074\/jbc.M113.462911","article-title":"The structure of the ternary complex of Krev interaction trapped 1 (KRIT1) bound to both the Rap1 GTPase and the heart of glass (HEG1) cytoplasmic tail","volume":"288","author":"Gingras","year":"2013","journal-title":"J. Biol. Chem."},{"issue":"21","key":"10.1016\/j.bbamcr.2023.119488_bb0155","doi-asserted-by":"crossref","first-page":"5518","DOI":"10.1111\/j.1742-4658.2007.06068.x","article-title":"Krit 1 interactions with microtubules and membranes are regulated by Rap1 and integrin cytoplasmic domain associated protein-1","volume":"274","author":"Beraud-Dufour","year":"2007","journal-title":"FEBS J."},{"issue":"4","key":"10.1016\/j.bbamcr.2023.119488_bb0160","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.molcel.2012.12.005","article-title":"Mechanism for KRIT1 release of ICAP1-mediated suppression of integrin activation","volume":"49","author":"Liu","year":"2013","journal-title":"Mol. Cell"},{"issue":"5","key":"10.1016\/j.bbamcr.2023.119488_bb0165","doi-asserted-by":"crossref","first-page":"1884","DOI":"10.1074\/jbc.M116.762393","article-title":"Nuclear localization of integrin cytoplasmic domain-associated Protein-1 (ICAP1) influences beta1 integrin activation and recruits Krev\/interaction Trapped-1 (KRIT1) to the nucleus","volume":"292","author":"Draheim","year":"2017","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.bbamcr.2023.119488_bb0170","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1083\/jcb.201303044","article-title":"CCM1-ICAP-1 complex controls beta1 integrin-dependent endothelial contractility and fibronectin remodeling","volume":"202","author":"Faurobert","year":"2013","journal-title":"J. Cell Biol."},{"issue":"3","key":"10.1016\/j.bbamcr.2023.119488_bb0175","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.jsb.2015.10.006","article-title":"Structural analysis of the KRIT1 ankyrin repeat and FERM domains reveals a conformationally stable ARD-FERM interface","volume":"192","author":"Zhang","year":"2015","journal-title":"J. Struct. Biol."},{"issue":"1","key":"10.1016\/j.bbamcr.2023.119488_bb0180","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1083\/jcb.201205109","article-title":"Structural basis of the junctional anchorage of the cerebral cavernous malformations complex","volume":"199","author":"Gingras","year":"2012","journal-title":"J. Cell Biol."},{"issue":"9","key":"10.1016\/j.bbamcr.2023.119488_bb0185","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1038\/sj.onc.1201268","article-title":"Association of Krev-1\/rap1a with Krit1, a novel ankyrin repeat-containing protein encoded by a gene mapping to 7q21-22","volume":"15","author":"Serebriiskii","year":"1997","journal-title":"Oncogene"},{"issue":"26","key":"10.1016\/j.bbamcr.2023.119488_bb0190","doi-asserted-by":"crossref","first-page":"22317","DOI":"10.1074\/jbc.M112.361295","article-title":"Structural basis for small G protein effector interaction of Ras-related protein 1 (Rap1) and adaptor protein Krev interaction trapped 1 (KRIT1)","volume":"287","author":"Li","year":"2012","journal-title":"J. Biol. Chem."},{"issue":"14","key":"10.1016\/j.bbamcr.2023.119488_bb0195","doi-asserted-by":"crossref","first-page":"2509","DOI":"10.1091\/mbc.e11-02-0157","article-title":"A mechanism of Rap1-induced stabilization of endothelial cell--cell junctions","volume":"22","author":"Liu","year":"2011","journal-title":"Mol. Biol. Cell"},{"issue":"2","key":"10.1016\/j.bbamcr.2023.119488_bb0200","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1083\/jcb.200705175","article-title":"KRIT-1\/CCM1 is a Rap1 effector that regulates endothelial cell cell junctions","volume":"179","author":"Glading","year":"2007","journal-title":"J. Cell Biol."},{"issue":"1\u20132","key":"10.1016\/j.bbamcr.2023.119488_bb0205","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1242\/dmm.003293","article-title":"Rap1 and its effector KRIT1\/CCM1 regulate beta-catenin signaling","volume":"3","author":"Glading","year":"2010","journal-title":"Dis. Model. Mech."},{"issue":"11","key":"10.1016\/j.bbamcr.2023.119488_bb0210","doi-asserted-by":"crossref","first-page":"200263","DOI":"10.1098\/rsob.200263","article-title":"Signalling through cerebral cavernous malformation protein networks","volume":"10","author":"Su","year":"2020","journal-title":"Open Biol."},{"issue":"16","key":"10.1016\/j.bbamcr.2023.119488_bb0215","doi-asserted-by":"crossref","first-page":"10677","DOI":"10.1073\/pnas.122354499","article-title":"KRIT1, a gene mutated in cerebral cavernous malformation, encodes a microtubule-associated protein","volume":"99","author":"Gunel","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"7","key":"10.1016\/j.bbamcr.2023.119488_bb0220","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1083\/jcb.201407129","article-title":"CCM2-CCM3 interaction stabilizes their protein expression and permits endothelial network formation","volume":"208","author":"Draheim","year":"2015","journal-title":"J. Cell Biol."},{"issue":"4","key":"10.1016\/j.bbamcr.2023.119488_bb0225","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1093\/hmg\/11.4.389","article-title":"KRIT1 association with the integrin-binding protein ICAP-1: a new direction in the elucidation of cerebral cavernous malformations (CCM1) pathogenesis","volume":"11","author":"Zawistowski","year":"2002","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbamcr.2023.119488_bb0230","doi-asserted-by":"crossref","first-page":"7937","DOI":"10.1038\/ncomms8937","article-title":"Structure and vascular function of MEKK3-cerebral cavernous malformations 2 complex","volume":"6","author":"Fisher","year":"2015","journal-title":"Nat. Commun."},{"issue":"11","key":"10.1016\/j.bbamcr.2023.119488_bb0235","doi-asserted-by":"crossref","first-page":"4343","DOI":"10.1021\/pr0704276","article-title":"Proteomic identification of the cerebral cavernous malformation signaling complex","volume":"6","author":"Hilder","year":"2007","journal-title":"J. Proteome Res."},{"issue":"7597","key":"10.1016\/j.bbamcr.2023.119488_bb0240","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1038\/nature17178","article-title":"Cerebral cavernous malformations arise from endothelial gain of MEKK3-KLF2\/4 signalling","volume":"532","author":"Zhou","year":"2016","journal-title":"Nature"},{"issue":"12","key":"10.1016\/j.bbamcr.2023.119488_bb0245","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1038\/ncb1071","article-title":"Rac-MEKK3-MKK3 scaffolding for p38 MAPK activation during hyperosmotic shock","volume":"5","author":"Uhlik","year":"2003","journal-title":"Nat. Cell Biol."},{"issue":"5651","key":"10.1016\/j.bbamcr.2023.119488_bb0250","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1126\/science.1090772","article-title":"Regulation of cell polarity and protrusion formation by targeting RhoA for degradation","volume":"302","author":"Wang","year":"2003","journal-title":"Science"},{"issue":"20","key":"10.1016\/j.bbamcr.2023.119488_bb0255","doi-asserted-by":"crossref","first-page":"13301","DOI":"10.1074\/jbc.C900009200","article-title":"Cerebral cavernous malformation 2 protein promotes smad ubiquitin regulatory factor 1-mediated RhoA degradation in endothelial cells","volume":"284","author":"Crose","year":"2009","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.bbamcr.2023.119488_bb0260","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/BF03183610","article-title":"cDNA cloning and expression of an apoptosis-related gene, humanTFAR15 gene","volume":"42","author":"Wang","year":"1999","journal-title":"Sci China C Life Sci"},{"issue":"31","key":"10.1016\/j.bbamcr.2023.119488_bb0265","doi-asserted-by":"crossref","first-page":"24099","DOI":"10.1074\/jbc.M110.128470","article-title":"Crystal structure of CCM3, a cerebral cavernous malformation protein critical for vascular integrity","volume":"285","author":"Li","year":"2010","journal-title":"J. Biol. Chem."},{"issue":"29","key":"10.1016\/j.bbamcr.2023.119488_bb0270","doi-asserted-by":"crossref","first-page":"26138","DOI":"10.1074\/jbc.M110.211250","article-title":"Molecular recognition of leucine-aspartate repeat (LD) motifs by the focal adhesion targeting homology domain of cerebral cavernous malformation 3 (CCM3)","volume":"286","author":"Li","year":"2011","journal-title":"J. Biol. Chem."},{"issue":"28","key":"10.1016\/j.bbamcr.2023.119488_bb0275","doi-asserted-by":"crossref","first-page":"25056","DOI":"10.1074\/jbc.M110.213777","article-title":"CCM3\/PDCD10 heterodimerizes with germinal center kinase III (GCKIII) proteins using a mechanism analogous to CCM3 homodimerization","volume":"286","author":"Ceccarelli","year":"2011","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.bbamcr.2023.119488_bb0280","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/j.str.2013.02.015","article-title":"Structural mechanism of CCM3 heterodimerization with GCKIII kinases","volume":"21","author":"Zhang","year":"2013","journal-title":"Structure"},{"issue":"28","key":"10.1016\/j.bbamcr.2023.119488_bb0285","doi-asserted-by":"crossref","first-page":"25065","DOI":"10.1074\/jbc.M110.214486","article-title":"Structure-function analysis of core STRIPAK proteins: a signaling complex implicated in Golgi polarization","volume":"286","author":"Kean","year":"2011","journal-title":"J. Biol. Chem."},{"issue":"Pt 8","key":"10.1016\/j.bbamcr.2023.119488_bb0290","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1242\/jcs.061341","article-title":"CCM3\/PDCD10 stabilizes GCKIII proteins to promote Golgi assembly and cell orientation","volume":"123","author":"Fidalgo","year":"2010","journal-title":"J. Cell Sci."},{"issue":"6","key":"10.1016\/j.bbamcr.2023.119488_bb0295","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1091\/mbc.e06-07-0608","article-title":"PDCD10 interacts with Ste20-related kinase MST4 to promote cell growth and transformation via modulation of the ERK pathway","volume":"18","author":"Ma","year":"2007","journal-title":"Mol. Biol. Cell"},{"issue":"1","key":"10.1016\/j.bbamcr.2023.119488_bb0300","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1074\/mcp.M800266-MCP200","article-title":"A PP2A phosphatase high-density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein","volume":"8","author":"Goudreault","year":"2009","journal-title":"Mol. Cell. Proteomics"},{"issue":"24","key":"10.1016\/j.bbamcr.2023.119488_bb0305","doi-asserted-by":"crossref","first-page":"4466","DOI":"10.1242\/jcs.198614","article-title":"RHO binding to FAM65A regulates Golgi reorientation during cell migration","volume":"129","author":"Mardakheh","year":"2016","journal-title":"J. Cell Sci."},{"issue":"1","key":"10.1016\/j.bbamcr.2023.119488_bb0310","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1074\/mcp.M800266-MCP200","article-title":"A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein","volume":"8","author":"Goudreault","year":"2009","journal-title":"Mol. Cell. Proteomics"},{"issue":"7","key":"10.1016\/j.bbamcr.2023.119488_bb0315","doi-asserted-by":"crossref","first-page":"e11740","DOI":"10.1371\/journal.pone.0011740","article-title":"Defining the functional domain of programmed cell death 10 through its interactions with phosphatidylinositol-3,4,5-trisphosphate","volume":"5","author":"Dibble","year":"2010","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.bbamcr.2023.119488_bb0320","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s10048-010-0261-6","article-title":"Evidence for anti-angiogenic and pro-survival functions of the cerebral cavernous malformation protein 3","volume":"12","author":"Schleider","year":"2011","journal-title":"Neurogenetics"},{"issue":"116","key":"10.1016\/j.bbamcr.2023.119488_bb0325","doi-asserted-by":"crossref","first-page":"ra26","DOI":"10.1126\/scisignal.2000722","article-title":"Stabilization of VEGFR2 signaling by cerebral cavernous malformation 3 is critical for vascular development","volume":"3","author":"He","year":"2010","journal-title":"Sci. Signal."},{"issue":"2","key":"10.1016\/j.bbamcr.2023.119488_bb0330","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.devcel.2014.12.009","article-title":"The cerebral cavernous malformation pathway controls cardiac development via regulation of endocardial MEKK3 signaling and KLF expression","volume":"32","author":"Zhou","year":"2015","journal-title":"Dev. Cell"},{"issue":"6","key":"10.1016\/j.bbamcr.2023.119488_bb0335","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1016\/j.str.2015.04.003","article-title":"Structural insights into the molecular recognition between cerebral cavernous malformation 2 and mitogen-activated protein kinase kinase kinase 3","volume":"23","author":"Wang","year":"2015","journal-title":"Structure"},{"issue":"46","key":"10.1016\/j.bbamcr.2023.119488_bb0340","doi-asserted-by":"crossref","first-page":"14284","DOI":"10.1073\/pnas.1510495112","article-title":"The cerebral cavernous malformation proteins CCM2L and CCM2 prevent the activation of the MAP kinase MEKK3","volume":"112","author":"Cullere","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.bbamcr.2023.119488_bb0345","doi-asserted-by":"crossref","first-page":"6","DOI":"10.15252\/emmm.201505433","article-title":"KLF4 is a key determinant in the development and progression of cerebral cavernous malformations","volume":"8","author":"Cuttano","year":"2016","journal-title":"EMBO Mol. Med."},{"issue":"1","key":"10.1016\/j.bbamcr.2023.119488_bb0350","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1038\/s41467-019-09829-z","article-title":"A conserved CCM complex promotes apoptosis non-autonomously by regulating zinc homeostasis","volume":"10","author":"Chapman","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbamcr.2023.119488_bb0355","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/1471-213X-13-40","article-title":"The Kruppel-like factor 2 and Kruppel-like factor 4 genes interact to maintain endothelial integrity in mouse embryonic vasculogenesis","volume":"13","author":"Chiplunkar","year":"2013","journal-title":"BMC Dev. Biol."},{"issue":"22","key":"10.1016\/j.bbamcr.2023.119488_bb0360","doi-asserted-by":"crossref","first-page":"2996","DOI":"10.1101\/gad.11.22.2996","article-title":"The LKLF transcription factor is required for normal tunica media formation and blood vessel stabilization during murine embryogenesis","volume":"11","author":"Kuo","year":"1997","journal-title":"Genes Dev."},{"issue":"4","key":"10.1016\/j.bbamcr.2023.119488_bb0365","doi-asserted-by":"crossref","first-page":"e91700","DOI":"10.1172\/jci.insight.91700","article-title":"KLF2 and KLF4 control endothelial identity and vascular integrity","volume":"2","author":"Sangwung","year":"2017","journal-title":"JCI Insight"},{"issue":"11","key":"10.1016\/j.bbamcr.2023.119488_bb0370","doi-asserted-by":"crossref","first-page":"eaau0731","DOI":"10.1126\/sciadv.aau0731","article-title":"Ponatinib (AP24534) inhibits MEKK3-KLF signaling and prevents formation and progression of cerebral cavernous malformations","volume":"4","author":"Choi","year":"2018","journal-title":"Sci. Adv."},{"issue":"30","key":"10.1016\/j.bbamcr.2023.119488_bb0375","doi-asserted-by":"crossref","first-page":"21013","DOI":"10.1074\/jbc.M512908200","article-title":"TLR8-mediated NF-kappaB and JNK activation are TAK1-independent and MEKK3-dependent","volume":"281","author":"Qin","year":"2006","journal-title":"J. Biol. Chem."},{"issue":"52","key":"10.1016\/j.bbamcr.2023.119488_bb0380","doi-asserted-by":"crossref","first-page":"43056","DOI":"10.1074\/jbc.M507807200","article-title":"TAK1 is recruited to the tumor necrosis factor-alpha (TNF-alpha) receptor 1 complex in a receptor-interacting protein (RIP)-dependent manner and cooperates with MEKK3 leading to NF-kappaB activation","volume":"280","author":"Blonska","year":"2005","journal-title":"J. Biol. Chem."},{"issue":"7654","key":"10.1016\/j.bbamcr.2023.119488_bb0385","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1038\/nature22075","article-title":"Endothelial TLR4 and the microbiome drive cerebral cavernous malformations","volume":"545","author":"Tang","year":"2017","journal-title":"Nature"},{"issue":"8","key":"10.1016\/j.bbamcr.2023.119488_bb0390","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1161\/CIRCRESAHA.118.314300","article-title":"CDC42 deletion elicits cerebral vascular malformations via increased MEKK3-dependent KLF4 expression","volume":"124","author":"Castro","year":"2019","journal-title":"Circ. Res."},{"issue":"4","key":"10.1016\/j.bbamcr.2023.119488_bb0395","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1161\/ATVBAHA.112.245563","article-title":"MiRrored regulation of KLF2 and KLF4","volume":"32","author":"Hamik","year":"2012","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"10","key":"10.1016\/j.bbamcr.2023.119488_bb0400","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20200140","article-title":"Cerebral cavernous malformations are driven by ADAMTS5 proteolysis of versican","volume":"217","author":"Hong","year":"2020","journal-title":"J. Exp. Med."},{"issue":"11","key":"10.1016\/j.bbamcr.2023.119488_bb0405","doi-asserted-by":"crossref","first-page":"3331","DOI":"10.1084\/jem.20171178","article-title":"Thrombospondin1 (TSP1) replacement prevents cerebral cavernous malformations","volume":"214","author":"Lopez-Ramirez","year":"2017","journal-title":"J. Exp. Med."},{"issue":"6","key":"10.1016\/j.bbamcr.2023.119488_bb0410","doi-asserted-by":"crossref","first-page":"e3000734","DOI":"10.1371\/journal.pbio.3000734","article-title":"Targeting miR-27a\/VE-cadherin interactions rescues cerebral cavernous malformations in mice","volume":"18","author":"Li","year":"2020","journal-title":"PLoS Biol."},{"issue":"3","key":"10.1016\/j.bbamcr.2023.119488_bb0415","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1182\/blood-2018-06-856062","article-title":"Cerebral cavernous malformations form an anticoagulant vascular domain in humans and mice","volume":"133","author":"Lopez-Ramirez","year":"2019","journal-title":"Blood"},{"issue":"27","key":"10.1016\/j.bbamcr.2023.119488_bb0420","doi-asserted-by":"crossref","first-page":"8421","DOI":"10.1073\/pnas.1501352112","article-title":"Sulindac metabolites decrease cerebrovascular malformations in CCM3-knockout mice","volume":"112","author":"Bravi","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"9","key":"10.1016\/j.bbamcr.2023.119488_bb0425","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1161\/CIRCULATIONAHA.114.013675","article-title":"Oxidative stress activates endothelial innate immunity via sterol regulatory element binding protein 2 (SREBP2) transactivation of microRNA-92a","volume":"131","author":"Chen","year":"2015","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.bbamcr.2023.119488_bb0430","doi-asserted-by":"crossref","first-page":"e1142640","DOI":"10.1080\/21675511.2016.1142640","article-title":"Beyond multiple mechanisms and a unique drug: defective autophagy as pivotal player in cerebral cavernous malformation pathogenesis and implications for targeted therapies","volume":"4","author":"Marchi","year":"2016","journal-title":"Rare Dis."},{"issue":"5","key":"10.1016\/j.bbamcr.2023.119488_bb0435","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1161\/CIRCULATIONAHA.111.043299","article-title":"Crippling of Kruppel (\u2212like factor 2) by bad flow portends a miRky day for endothelial function","volume":"124","author":"Irani","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.bbamcr.2023.119488_bb0440","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.freeradbiomed.2013.05.034","article-title":"Mechanosensitive microRNAs-role in endothelial responses to shear stress and redox state","volume":"64","author":"Marin","year":"2013","journal-title":"Free Radic. Biol. Med."},{"issue":"1","key":"10.1016\/j.bbamcr.2023.119488_bb0445","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.jhep.2016.07.051","article-title":"Cross-talk between autophagy and KLF2 determines endothelial cell phenotype and microvascular function in acute liver injury","volume":"66","author":"Guixe-Muntet","year":"2017","journal-title":"J. Hepatol."},{"issue":"9","key":"10.1016\/j.bbamcr.2023.119488_bb0450","doi-asserted-by":"crossref","first-page":"3461","DOI":"10.1172\/JCI79964","article-title":"Kruppel-like factor 4 is critical for transcriptional control of cardiac mitochondrial homeostasis","volume":"125","author":"Liao","year":"2015","journal-title":"J. Clin. Invest."},{"issue":"2","key":"10.1016\/j.bbamcr.2023.119488_bb0455","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.devcel.2014.12.016","article-title":"Regulation of beta1 integrin-Klf2-mediated angiogenesis by CCM proteins","volume":"32","author":"Renz","year":"2015","journal-title":"Dev. Cell"},{"issue":"2","key":"10.1016\/j.bbamcr.2023.119488_bb0460","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.258816","article-title":"Contribution of protein-protein interactions to the endothelial-barrier-stabilizing function of KRIT1","volume":"135","author":"Swamy","year":"2022","journal-title":"J. Cell Sci."},{"issue":"15","key":"10.1016\/j.bbamcr.2023.119488_bb0465","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.216093","article-title":"The CCM1-CCM2 complex controls complementary functions of ROCK1 and ROCK2 that are required for endothelial integrity","volume":"131","author":"Lisowska","year":"2018","journal-title":"J. Cell Sci."},{"issue":"8","key":"10.1016\/j.bbamcr.2023.119488_bb0470","doi-asserted-by":"crossref","first-page":"2795","DOI":"10.1172\/JCI39679","article-title":"CCM3 signaling through sterile 20-like kinases plays an essential role during zebrafish cardiovascular development and cerebral cavernous malformations","volume":"120","author":"Zheng","year":"2010","journal-title":"J. Clin. Invest."},{"issue":"6","key":"10.1016\/j.bbamcr.2023.119488_bb0475","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1038\/nrm1128","article-title":"Rocks: multifunctional kinases in cell behaviour","volume":"4","author":"Riento","year":"2003","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"16","key":"10.1016\/j.bbamcr.2023.119488_bb0480","doi-asserted-by":"crossref","first-page":"11760","DOI":"10.1074\/jbc.C109.097220","article-title":"Rho kinase inhibition rescues the endothelial cell cerebral cavernous malformation phenotype","volume":"285","author":"Borikova","year":"2010","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.bbamcr.2023.119488_bb0485","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1161\/STROKEAHA.118.024058","article-title":"Rho kinase inhibition blunts lesion development and hemorrhage in murine models of aggressive Pdcd10\/Ccm3 disease","volume":"50","author":"Shenkar","year":"2019","journal-title":"Stroke"},{"issue":"28","key":"10.1016\/j.bbamcr.2023.119488_bb0490","doi-asserted-by":"crossref","first-page":"11427","DOI":"10.1073\/pnas.1306595110","article-title":"Rasip1 mediates Rap1 regulation of rho in endothelial barrier function through ArhGAP29","volume":"110","author":"Post","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"4","key":"10.1016\/j.bbamcr.2023.119488_bb0495","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1007\/s10456-021-09809-2","article-title":"CCM2-deficient endothelial cells undergo a ROCK-dependent reprogramming into senescence-associated secretory phenotype","volume":"24","author":"Vannier","year":"2021","journal-title":"Angiogenesis"},{"issue":"14","key":"10.1016\/j.bbamcr.2023.119488_bb0500","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.1128\/MCB.01453-14","article-title":"Rap1 spatially controls ArhGAP29 to inhibit rho signaling during endothelial barrier regulation","volume":"35","author":"Post","year":"2015","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.bbamcr.2023.119488_bb0505","doi-asserted-by":"crossref","first-page":"e11394","DOI":"10.7554\/eLife.11394","article-title":"Heart of glass anchors Rasip1 at endothelial cell-cell junctions to support vascular integrity","volume":"5","author":"de Kreuk","year":"2016","journal-title":"Elife"},{"issue":"4","key":"10.1016\/j.bbamcr.2023.119488_bb0510","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.devcel.2011.02.010","article-title":"Blood vessel tubulogenesis requires Rasip1 regulation of GTPase signaling","volume":"20","author":"Xu","year":"2011","journal-title":"Dev. Cell"},{"issue":"17","key":"10.1016\/j.bbamcr.2023.119488_bb0515","doi-asserted-by":"crossref","first-page":"2521","DOI":"10.1093\/hmg\/ddi256","article-title":"CCM1 and CCM2 protein interactions in cell signaling: implications for cerebral cavernous malformations pathogenesis","volume":"14","author":"Zawistowski","year":"2005","journal-title":"Hum. Mol. Genet."},{"issue":"7","key":"10.1016\/j.bbamcr.2023.119488_bb0520","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1038\/s41556-021-00702-0","article-title":"CCM3 is a gatekeeper in focal adhesions regulating mechanotransduction and YAP\/TAZ signalling","volume":"23","author":"Wang","year":"2021","journal-title":"Nat. Cell Biol."},{"issue":"Pt 1","key":"10.1016\/j.bbamcr.2023.119488_bb0525","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1042\/bj3280105","article-title":"Mammalian actin-related protein 2\/3 complex localizes to regions of lamellipodial protrusion and is composed of evolutionarily conserved proteins","volume":"328 (Pt 1)","author":"Machesky","year":"1997","journal-title":"Biochem. J."},{"issue":"2","key":"10.1016\/j.bbamcr.2023.119488_bb0530","doi-asserted-by":"crossref","first-page":"146","DOI":"10.4161\/cam.28437","article-title":"CCM1 and the second life of proteins in adhesion complexes","volume":"8","author":"van den Berg","year":"2014","journal-title":"Cell Adhes. Migr."},{"issue":"9","key":"10.1016\/j.bbamcr.2023.119488_bb0535","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1038\/nm0901-1041","article-title":"NSAIDs inhibit alpha V beta 3 integrin-mediated and Cdc42\/Rac-dependent endothelial-cell spreading, migration and angiogenesis","volume":"7","author":"Dormond","year":"2001","journal-title":"Nat. Med."},{"issue":"17","key":"10.1016\/j.bbamcr.2023.119488_bb0540","first-page":"3058","article-title":"Cdc42 is required for cytoskeletal support of endothelial cell adhesion during blood vessel formation in mice","volume":"142","author":"Barry","year":"2015","journal-title":"Development"},{"key":"10.1016\/j.bbamcr.2023.119488_bb0545","doi-asserted-by":"crossref","first-page":"6449","DOI":"10.1038\/ncomms7449","article-title":"CCM-3\/STRIPAK promotes seamless tube extension through endocytic recycling","volume":"6","author":"Lant","year":"2015","journal-title":"Nat. Commun."},{"issue":"5","key":"10.1016\/j.bbamcr.2023.119488_bb0550","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1172\/JCI44393","article-title":"Mutations in 2 distinct genetic pathways result in cerebral cavernous malformations in mice","volume":"121","author":"Chan","year":"2011","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbamcr.2023.119488_bb0555","doi-asserted-by":"crossref","first-page":"850","DOI":"10.2741\/2107","article-title":"The GCK II and III subfamilies of the STE20 group kinases","volume":"12","author":"Pombo","year":"2007","journal-title":"Front. Biosci."},{"issue":"8","key":"10.1016\/j.bbamcr.2023.119488_bb0560","doi-asserted-by":"crossref","first-page":"e11905","DOI":"10.1371\/journal.pone.0011905","article-title":"Structural comparison of human mammalian ste20-like kinases","volume":"5","author":"Record","year":"2010","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.bbamcr.2023.119488_bb0565","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1016\/j.str.2013.04.007","article-title":"Structural basis for the unique heterodimeric assembly between cerebral cavernous malformation 3 and germinal center kinase III","volume":"21","author":"Xu","year":"2013","journal-title":"Structure"},{"issue":"5","key":"10.1016\/j.bbamcr.2023.119488_bb0570","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.devcel.2013.05.002","article-title":"Focal defects in single-celled tubes mutant for cerebral cavernous malformation 3, GCKIII, or NSF2","volume":"25","author":"Song","year":"2013","journal-title":"Dev. Cell"},{"issue":"7","key":"10.1016\/j.bbamcr.2023.119488_bb0575","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1083\/jcb.200310061","article-title":"YSK1 is activated by the Golgi matrix protein GM130 and plays a role in cell migration through its substrate 14-3-3zeta","volume":"164","author":"Preisinger","year":"2004","journal-title":"J. Cell Biol."},{"issue":"4","key":"10.1016\/j.bbamcr.2023.119488_bb0580","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/s10048-007-0098-9","article-title":"CCM3 interacts with CCM2 indicating common pathogenesis for cerebral cavernous malformations","volume":"8","author":"Voss","year":"2007","journal-title":"Neurogenetics"},{"issue":"4","key":"10.1016\/j.bbamcr.2023.119488_bb0585","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/S0092-8674(01)00471-8","article-title":"Integrin-mediated activation of Cdc42 controls cell polarity in migrating astrocytes through PKCzeta","volume":"106","author":"Etienne-Manneville","year":"2001","journal-title":"Cell"},{"issue":"9","key":"10.1016\/j.bbamcr.2023.119488_bb0590","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1038\/nm.4178","article-title":"Dysregulated exocytosis of angiopoietin-2 drives cerebral cavernous malformation","volume":"22","author":"Zhao","year":"2016","journal-title":"Nat. Med."},{"issue":"9","key":"10.1016\/j.bbamcr.2023.119488_bb0595","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1038\/nm.4169","article-title":"Endothelial exocytosis of angiopoietin-2 resulting from CCM3 deficiency contributes to cerebral cavernous malformation","volume":"22","author":"Jenny Zhou","year":"2016","journal-title":"Nat. Med."},{"issue":"4","key":"10.1016\/j.bbamcr.2023.119488_bb0600","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1001\/jamaneurol.2018.3634","article-title":"Emerging pharmacologic targets in cerebral cavernous malformation and potential strategies to Alter the natural history of a difficult disease: a review","volume":"76","author":"Chohan","year":"2019","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.bbamcr.2023.119488_bb0605","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.160372","article-title":"Release of STK24\/25 suppression on MEKK3 signaling in endothelial cells confers cerebral cavernous malformation","author":"Yang","year":"2023","journal-title":"JCI Insight"},{"issue":"2","key":"10.1016\/j.bbamcr.2023.119488_bb0610","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1084\/jem.20181353","article-title":"Somatic activating mutations in PIK3CA cause generalized lymphatic anomaly","volume":"216","author":"Rodriguez-Laguna","year":"2019","journal-title":"J. Exp. Med."},{"issue":"4","key":"10.1016\/j.bbamcr.2023.119488_bb0615","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1016\/j.jpeds.2014.12.069","article-title":"Lymphatic and other vascular malformative\/overgrowth disorders are caused by somatic mutations in PIK3CA","volume":"166","author":"Luks","year":"2015","journal-title":"J. Pediatr."},{"issue":"10","key":"10.1016\/j.bbamcr.2023.119488_bb0620","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.201809155","article-title":"Systematic pharmacological screens uncover novel pathways involved in cerebral cavernous malformations","volume":"10","author":"Otten","year":"2018","journal-title":"EMBO Mol. Med."},{"issue":"3","key":"10.1016\/j.bbamcr.2023.119488_bb0625","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1161\/STROKEAHA.115.011867","article-title":"Endothelial cells lining sporadic cerebral cavernous malformation Cavernomas undergo endothelial-to-mesenchymal transition","volume":"47","author":"Bravi","year":"2016","journal-title":"Stroke"},{"issue":"1","key":"10.1016\/j.bbamcr.2023.119488_bb0630","doi-asserted-by":"crossref","first-page":"8296","DOI":"10.1038\/s41598-017-08373-4","article-title":"Up-regulation of NADPH oxidase-mediated redox signaling contributes to the loss of barrier function in KRIT1 deficient endothelium","volume":"7","author":"Goitre","year":"2017","journal-title":"Sci. Rep."},{"issue":"11","key":"10.1016\/j.bbamcr.2023.119488_bb0635","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.15252\/emmm.201505316","article-title":"Defective autophagy is a key feature of cerebral cavernous malformations","volume":"7","author":"Marchi","year":"2015","journal-title":"EMBO Mol. Med."},{"issue":"1","key":"10.1016\/j.bbamcr.2023.119488_bb0640","doi-asserted-by":"crossref","first-page":"2761","DOI":"10.1038\/s41467-019-10707-x","article-title":"Endothelial cell clonal expansion in the development of cerebral cavernous malformations","volume":"10","author":"Malinverno","year":"2019","journal-title":"Nat. Commun."},{"issue":"10","key":"10.1016\/j.bbamcr.2023.119488_bb0645","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1161\/CIRCRESAHA.118.313970","article-title":"Cerebral cavernous malformations develop through clonal expansion of mutant endothelial cells","volume":"123","author":"Detter","year":"2018","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbamcr.2023.119488_bb0650","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.freeradbiomed.2016.01.008","article-title":"Cytochrome P450 and matrix metalloproteinase genetic modifiers of disease severity in cerebral cavernous malformation type 1","volume":"92","author":"Choquet","year":"2016","journal-title":"Free Radic. Biol. Med."},{"issue":"4","key":"10.1016\/j.bbamcr.2023.119488_bb0655","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1007\/s00018-022-04224-2","article-title":"Inflammation and neutrophil extracellular traps in cerebral cavernous malformation","volume":"79","author":"Yau","year":"2022","journal-title":"Cell. Mol. Life Sci."},{"issue":"11","key":"10.1016\/j.bbamcr.2023.119488_bb0660","doi-asserted-by":"crossref","first-page":"e0223089","DOI":"10.1371\/journal.pone.0223089","article-title":"Correction: KRIT1 regulates the homeostasis of intracellular reactive oxygen species","volume":"14","author":"staff","year":"2019","journal-title":"PLoS One"},{"issue":"11","key":"10.1016\/j.bbamcr.2023.119488_bb0665","doi-asserted-by":"crossref","first-page":"2702","DOI":"10.1161\/ATVBAHA.112.300115","article-title":"Decreased Krev interaction-trapped 1 expression leads to increased vascular permeability and modifies inflammatory responses in vivo","volume":"32","author":"Corr","year":"2012","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"2","key":"10.1016\/j.bbamcr.2023.119488_bb0670","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.jocn.2009.06.008","article-title":"Expressions of angiogenesis associated matrix metalloproteinases and extracellular matrix proteins in cerebral vascular malformations","volume":"17","author":"Bicer","year":"2010","journal-title":"J. Clin. Neurosci."},{"issue":"6","key":"10.1016\/j.bbamcr.2023.119488_bb0680","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1093\/neuros\/nyy539","article-title":"Atorvastatin treatment of cavernous Angiomas with symptomatic hemorrhage exploratory proof of concept (AT CASH EPOC) trial","volume":"85","author":"Polster","year":"2019","journal-title":"Neurosurgery"},{"issue":"3","key":"10.1016\/j.bbamcr.2023.119488_bb0685","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/s12975-019-00737-4","article-title":"Effect of simvastatin on permeability in cerebral cavernous malformation type 1 patients: results from a pilot small randomized controlled clinical trial","volume":"11","author":"Mabray","year":"2020","journal-title":"Transl. Stroke Res."},{"issue":"3","key":"10.1016\/j.bbamcr.2023.119488_bb0695","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s12975-019-00725-8","article-title":"A brain-targeted orally available ROCK2 inhibitor benefits mild and aggressive cavernous Angioma disease","volume":"11","author":"McKerracher","year":"2020","journal-title":"Transl. Stroke Res."},{"issue":"12","key":"10.1016\/j.bbamcr.2023.119488_bb0700","doi-asserted-by":"crossref","first-page":"2230","DOI":"10.1177\/0271678X221105995","article-title":"Cerebral cavernous malformation development in chronic mouse models driven by dual recombinases induced gene deletion in brain endothelial cells","volume":"42","author":"Yang","year":"2022","journal-title":"J. Cereb. Blood Flow Metab."},{"issue":"28","key":"10.1016\/j.bbamcr.2023.119488_bb0705","doi-asserted-by":"crossref","first-page":"12640","DOI":"10.1073\/pnas.1000132107","article-title":"Cerebral cavernous malformation protein CCM1 inhibits sprouting angiogenesis by activating DELTA-NOTCH signaling","volume":"107","author":"Wustehube","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.bbamcr.2023.119488_bb0710","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/s41467-020-20774-0","article-title":"Caveolae-mediated Tie2 signaling contributes to CCM pathogenesis in a brain endothelial cell-specific Pdcd10-deficient mouse model","volume":"12","author":"Zhou","year":"2021","journal-title":"Nat. Commun."},{"issue":"4","key":"10.1016\/j.bbamcr.2023.119488_bb0715","doi-asserted-by":"crossref","first-page":"e83","DOI":"10.1016\/j.jaad.2013.11.006","article-title":"Successful treatment of multifocal intracerebral and spinal hemangiomas with propranolol","volume":"70","author":"Miquel","year":"2014","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.bbamcr.2023.119488_bb0720","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.jns.2016.04.053","article-title":"Propranolol stops progressive multiple cerebral cavernoma in an adult patient","volume":"367","author":"Reinhard","year":"2016","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.bbamcr.2023.119488_bb0725","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.wneu.2015.11.003","article-title":"Propranolol treatment of cavernous malformations with symptomatic hemorrhage","volume":"88","author":"Zabramski","year":"2016","journal-title":"World Neurosurg."},{"issue":"4","key":"10.1016\/j.bbamcr.2023.119488_bb0730","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1161\/STROKEAHA.120.029676","article-title":"Propranolol reduces the development of lesions and rescues barrier function in cerebral cavernous malformations: a preclinical study","volume":"52","author":"Oldenburg","year":"2021","journal-title":"Stroke"},{"issue":"1","key":"10.1016\/j.bbamcr.2023.119488_bb0735","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S1474-4422(22)00409-4","article-title":"Safety and efficacy of propranolol for treatment of familial cerebral cavernous malformations (Treat_CCM): a randomised, open-label, blinded-endpoint, phase 2 pilot trial","volume":"22","author":"Lanfranconi","year":"2023","journal-title":"Lancet Neurol."},{"issue":"3","key":"10.1016\/j.bbamcr.2023.119488_bb0740","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1161\/CIRCULATIONAHA.114.010403","article-title":"Strategy for identifying repurposed drugs for the treatment of cerebral cavernous malformation","volume":"131","author":"Gibson","year":"2015","journal-title":"Circulation"},{"issue":"21","key":"10.1016\/j.bbamcr.2023.119488_bb0745","doi-asserted-by":"crossref","first-page":"5503","DOI":"10.1073\/pnas.1702942114","article-title":"Combined HMG-COA reductase and prenylation inhibition in treatment of CCM","volume":"114","author":"Nishimura","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"2","key":"10.1016\/j.bbamcr.2023.119488_bb0750","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1159\/000316851","article-title":"Ccm1 regulates microvascular morphogenesis during angiogenesis","volume":"48","author":"Liu","year":"2011","journal-title":"J. Vasc. Res."},{"issue":"2","key":"10.1016\/j.bbamcr.2023.119488_bb0755","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1007\/s12975-010-0010-z","article-title":"Ccm1 assures microvascular integrity during angiogenesis","volume":"1","author":"Liu","year":"2010","journal-title":"Transl. Stroke Res."},{"key":"10.1016\/j.bbamcr.2023.119488_bb0760","doi-asserted-by":"crossref","first-page":"9584819","DOI":"10.1155\/2017\/9584819","article-title":"Tempol, a superoxide dismutase mimetic agent, inhibits superoxide anion-induced inflammatory pain in mice","volume":"2017","author":"Bernardy","year":"2017","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.bbamcr.2023.119488_bb0765","doi-asserted-by":"crossref","first-page":"181","DOI":"10.3389\/fonc.2013.00181","article-title":"COX-independent mechanisms of cancer chemoprevention by anti-inflammatory drugs","volume":"3","author":"Gurpinar","year":"2013","journal-title":"Front. Oncol."},{"issue":"2","key":"10.1016\/j.bbamcr.2023.119488_bb0770","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.atherosclerosis.2008.12.023","article-title":"Statins inhibit rho kinase activity in patients with atherosclerosis","volume":"205","author":"Nohria","year":"2009","journal-title":"Atherosclerosis"},{"issue":"4","key":"10.1016\/j.bbamcr.2023.119488_bb0775","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.amjcard.2008.10.008","article-title":"Comparison of effects of rosuvastatin (10 mg) versus atorvastatin (40 mg) on rho kinase activity in caucasian men with a previous atherosclerotic event","volume":"103","author":"Rawlings","year":"2009","journal-title":"Am. J. Cardiol."},{"issue":"8","key":"10.1016\/j.bbamcr.2023.119488_bb0780","doi-asserted-by":"crossref","first-page":"e43","DOI":"10.2105\/AJPH.2014.302034","article-title":"Meta-analysis of all-cause mortality according to serum 25-hydroxyvitamin D","volume":"104","author":"Garland","year":"2014","journal-title":"Am. J. Public Health"},{"issue":"4","key":"10.1016\/j.bbamcr.2023.119488_bb0785","article-title":"Vitamin D deficiency and the risk of cerebrovascular disease","volume":"9","author":"Kim","year":"2020","journal-title":"Antioxidants (Basel)"},{"issue":"3","key":"10.1016\/j.bbamcr.2023.119488_bb0790","doi-asserted-by":"crossref","first-page":"255","DOI":"10.2217\/bmm.15.118","article-title":"Peripheral plasma vitamin D and non-HDL cholesterol reflect the severity of cerebral cavernous malformation disease","volume":"10","author":"Girard","year":"2016","journal-title":"Biomark. Med"},{"issue":"24","key":"10.1016\/j.bbamcr.2023.119488_bb0795","doi-asserted-by":"crossref","first-page":"2649","DOI":"10.1056\/NEJMc0708819","article-title":"Propranolol for severe hemangiomas of infancy","volume":"358","author":"Leaute-Labreze","year":"2008","journal-title":"N. Engl. J. Med."},{"issue":"5","key":"10.1016\/j.bbamcr.2023.119488_bb0800","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1177\/0883073810363917","article-title":"Propranolol treatment for a giant infantile brain cavernoma","volume":"25","author":"Moschovi","year":"2010","journal-title":"J. Child Neurol."},{"issue":"1","key":"10.1016\/j.bbamcr.2023.119488_bb0805","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1186\/s12967-022-03360-4","article-title":"Propranolol as therapy for cerebral cavernous malformations: a cautionary note","volume":"20","author":"Shenkar","year":"2022","journal-title":"J. Transl. Med."},{"issue":"520","key":"10.1016\/j.bbamcr.2023.119488_bb0810","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aaw3521","article-title":"Distinct cellular roles for PDCD10 define a gut-brain axis in cerebral cavernous malformation","volume":"11","author":"Tang","year":"2019","journal-title":"Sci. Transl. Med."},{"issue":"10","key":"10.1016\/j.bbamcr.2023.119488_bb0815","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1080\/17474086.2016.1232163","article-title":"Ponatinib in the therapy of chronic myeloid leukemia","volume":"9","author":"Poch Martell","year":"2016","journal-title":"Expert. Rev. Hematol."},{"issue":"12","key":"10.1016\/j.bbamcr.2023.119488_bb0820","doi-asserted-by":"crossref","first-page":"4701","DOI":"10.1021\/jm100395q","volume":"53","author":"Huang","year":"2010","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bbamcr.2023.119488_bb0825","series-title":"Antisense Modulation of MEKK3 Expression","author":"Gaarde","year":"2002"},{"key":"10.1016\/j.bbamcr.2023.119488_bb0830","series-title":"Screening for Modulators of MEKK2 and MEKK3","author":"Qin","year":"2005"},{"issue":"30","key":"10.1016\/j.bbamcr.2023.119488_bb0835","doi-asserted-by":"crossref","first-page":"E7129","DOI":"10.1073\/pnas.1721298115","article-title":"Different roles of myocardial ROCK1 and ROCK2 in cardiac dysfunction and postcapillary pulmonary hypertension in mice","volume":"115","author":"Sunamura","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.bbamcr.2023.119488_bb0840","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1161\/STROKEAHA.116.015013","article-title":"RhoA kinase inhibition with Fasudil versus simvastatin in murine models of cerebral cavernous malformations","volume":"48","author":"Shenkar","year":"2017","journal-title":"Stroke"},{"issue":"4","key":"10.1016\/j.bbamcr.2023.119488_bb0845","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1097\/FJC.0b013e3182a3718f","article-title":"Rho kinases in cardiovascular physiology and pathophysiology: the effect of fasudil","volume":"62","author":"Shi","year":"2013","journal-title":"J. Cardiovasc. Pharmacol."},{"issue":"1","key":"10.1016\/j.bbamcr.2023.119488_bb0850","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1002\/acn3.19","article-title":"Selective ROCK2 inhibition in focal cerebral ischemia","volume":"1","author":"Lee","year":"2014","journal-title":"Ann. Clin. Transl. Neurol."},{"key":"10.1016\/j.bbamcr.2023.119488_bb0855","series-title":"Rho Kinase Inhibitor Ba-1049 (r) and Active Metabolites Thereof","author":"Rosen","year":"2017"},{"issue":"6","key":"10.1016\/j.bbamcr.2023.119488_bb0860","doi-asserted-by":"crossref","DOI":"10.3390\/molecules25061369","article-title":"Determination of KD025 (SLx-2119), a selective ROCK2 inhibitor, in rat plasma by high-performance liquid chromatography-tandem mass spectrometry and its pharmacokinetic application","volume":"25","author":"Yoon","year":"2020","journal-title":"Molecules"},{"issue":"7","key":"10.1016\/j.bbamcr.2023.119488_bb0865","doi-asserted-by":"crossref","DOI":"10.3390\/molecules23071791","article-title":"Synthesis and PI3 kinase inhibition activity of a Wortmannin-leucine derivative","volume":"23","author":"Cantrell","year":"2018","journal-title":"Molecules"},{"issue":"5","key":"10.1016\/j.bbamcr.2023.119488_bb0870","doi-asserted-by":"crossref","first-page":"538","DOI":"10.4161\/cbt.4.5.1660","article-title":"PWT-458, a novel pegylated-17-hydroxywortmannin, inhibits phosphatidylinositol 3-kinase signaling and suppresses growth of solid tumors","volume":"4","author":"Yu","year":"2005","journal-title":"Cancer Biol. Ther."},{"issue":"5","key":"10.1016\/j.bbamcr.2023.119488_bb0875","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.ejca.2008.12.007","article-title":"Antiangiogenic effect of ZSTK474, a novel phosphatidylinositol 3-kinase inhibitor","volume":"45","author":"Kong","year":"2009","journal-title":"Eur. J. Cancer"},{"issue":"1","key":"10.1016\/j.bbamcr.2023.119488_bb0880","doi-asserted-by":"crossref","first-page":"3194","DOI":"10.1038\/s41467-019-11174-0","article-title":"A novel rapamycin analog is highly selective for mTORC1 in vivo","volume":"10","author":"Schreiber","year":"2019","journal-title":"Nat. Commun."},{"issue":"4","key":"10.1016\/j.bbamcr.2023.119488_bb0885","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/j.jid.2019.10.001","article-title":"Theranostic advances in vascular malformations","volume":"140","author":"Dekeuleneer","year":"2020","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.bbamcr.2023.119488_bb0890","doi-asserted-by":"crossref","first-page":"394257","DOI":"10.1155\/2015\/394257","article-title":"mTOR kinase: a possible pharmacological target in the management of chronic pain","volume":"2015","author":"Lisi","year":"2015","journal-title":"Biomed. Res. Int."},{"issue":"10","key":"10.1016\/j.bbamcr.2023.119488_bb0895","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1089\/ars.2010.3809","article-title":"ULK1, mammalian target of rapamycin, and mitochondria: linking nutrient availability and autophagy","volume":"14","author":"Kundu","year":"2011","journal-title":"Antioxid. Redox Signal."},{"issue":"51","key":"10.1016\/j.bbamcr.2023.119488_bb0900","doi-asserted-by":"crossref","first-page":"84736","DOI":"10.18632\/oncotarget.12450","article-title":"A phase 1 study of oral ridaforolimus in pediatric patients with advanced solid tumors","volume":"7","author":"Pearson","year":"2016","journal-title":"Oncotarget"},{"issue":"6","key":"10.1016\/j.bbamcr.2023.119488_bb0905","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1158\/1535-7163.MCT-10-0792","article-title":"Ridaforolimus (AP23573; MK-8669), a potent mTOR inhibitor, has broad antitumor activity and can be optimally administered using intermittent dosing regimens","volume":"10","author":"Rivera","year":"2011","journal-title":"Mol. Cancer Ther."},{"issue":"10","key":"10.1016\/j.bbamcr.2023.119488_bb0910","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1038\/s41589-021-00813-7","article-title":"Selective inhibitors of mTORC1 activate 4EBP1 and suppress tumor growth","volume":"17","author":"Lee","year":"2021","journal-title":"Nat. Chem. Biol."},{"issue":"1","key":"10.1016\/j.bbamcr.2023.119488_bb0915","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1128\/MCB.00800-07","article-title":"Single and combined silencing of ERK1 and ERK2 reveals their positive contribution to growth signaling depending on their expression levels","volume":"28","author":"Lefloch","year":"2008","journal-title":"Mol. Cell. Biol."},{"issue":"8","key":"10.1016\/j.bbamcr.2023.119488_bb0920","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1038\/sj.embor.7400755","article-title":"MAPK signalling: ERK5 versus ERK1\/2","volume":"7","author":"Nishimoto","year":"2006","journal-title":"EMBO Rep."},{"key":"10.1016\/j.bbamcr.2023.119488_bb0925","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/j.ejmech.2013.10.052","article-title":"Structural determinants for ERK5 (MAPK7) and leucine rich repeat kinase 2 activities of benzo[e]pyrimido-[5,4-b]diazepine-6(11H)-ones","volume":"70","author":"Deng","year":"2013","journal-title":"Eur. J. Med. Chem."},{"issue":"391","key":"10.1016\/j.bbamcr.2023.119488_bb0930","doi-asserted-by":"crossref","first-page":"ra86","DOI":"10.1126\/scisignal.aaa3206","article-title":"Extracellular signal-regulated kinase 5 promotes acute cellular and systemic inflammation","volume":"8","author":"Wilhelmsen","year":"2015","journal-title":"Sci. Signal."},{"issue":"5","key":"10.1016\/j.bbamcr.2023.119488_bb0935","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1042\/BST20190338","article-title":"Small molecule ERK5 kinase inhibitors paradoxically activate ERK5 signalling: be careful what you wish for","volume":"48","author":"Cook","year":"2020","journal-title":"Biochem. Soc. Trans."},{"issue":"12","key":"10.1016\/j.bbamcr.2023.119488_bb0940","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1038\/nm1216-1502c","article-title":"Erratum: endothelial exocytosis of angiopoietin-2 resulting from CCM3 deficiency contributes to cerebral cavernous malformation","volume":"22","author":"Zhou","year":"2016","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbamcr.2023.119488_bb0945","doi-asserted-by":"crossref","first-page":"174021","DOI":"10.1016\/j.ejphar.2021.174021","article-title":"Angiopoietin inhibitors: a review on targeting tumor angiogenesis","volume":"899","author":"Parmar","year":"2021","journal-title":"Eur. J. Pharmacol."},{"issue":"2","key":"10.1016\/j.bbamcr.2023.119488_bb0950","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1159\/000488542","article-title":"Cabozantinib as a second-line agent in advanced hepatocellular carcinoma","volume":"7","author":"Kudo","year":"2018","journal-title":"Liver Cancer"},{"issue":"6","key":"10.1016\/j.bbamcr.2023.119488_bb0955","doi-asserted-by":"crossref","first-page":"2337","DOI":"10.1158\/1078-0432.CCR-04-1900","article-title":"Antiangiogenic treatment with the three thrombospondin-1 type 1 repeats recombinant protein in an orthotopic human pancreatic cancer model","volume":"11","author":"Zhang","year":"2005","journal-title":"Clin. Cancer Res."},{"issue":"10","key":"10.1016\/j.bbamcr.2023.119488_bb0960","doi-asserted-by":"crossref","first-page":"3129","DOI":"10.1158\/1535-7163.MCT-08-0013","article-title":"Preclinical overview of sorafenib, a multikinase inhibitor that targets both Raf and VEGF and PDGF receptor tyrosine kinase signaling","volume":"7","author":"Wilhelm","year":"2008","journal-title":"Mol. Cancer Ther."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167488923000605?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167488923000605?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T21:56:26Z","timestamp":1722549386000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167488923000605"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":190,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["S0167488923000605"],"URL":"https:\/\/doi.org\/10.1016\/j.bbamcr.2023.119488","relation":{},"ISSN":["0167-4889"],"issn-type":[{"value":"0167-4889","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Kinases in cerebral cavernous malformations: Pathogenesis and therapeutic targets","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Cell Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbamcr.2023.119488","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"119488"}}