{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T21:32:26Z","timestamp":1775079146793,"version":"3.50.1"},"reference-count":32,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T00:00:00Z","timestamp":1698192000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Cell Research"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.bbamcr.2023.119607","type":"journal-article","created":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T06:01:28Z","timestamp":1697436088000},"page":"119607","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Regulatory role of RBM39 in acute myeloid leukemia: Mediation through the PI3K\/AKT pathway"],"prefix":"10.1016","volume":"1871","author":[{"given":"Xiaoyan","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaojun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziyuan","family":"Nie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Menghan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianyang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaqiong","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuxia","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenzhen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianmin","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbamcr.2023.119607_bb0005","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1056\/NEJMra1406184","article-title":"Acute myeloid leukemia","volume":"373","author":"D\u00f6hner","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbamcr.2023.119607_bb0010","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1056\/NEJMoa1301689","article-title":"Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia","volume":"368","author":"Network","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbamcr.2023.119607_bb0015","first-page":"62","article-title":"Hematopoietic stem cell transplantation for patients with aml in first complete remission","volume":"127","author":"Cornelissen","year":"2016","journal-title":"Blood, J. Am. Soc. Hematol."},{"key":"10.1016\/j.bbamcr.2023.119607_bb0020","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.ccell.2019.01.010","article-title":"Targeting an rna-binding protein network in acute myeloid leukemia","volume":"35","author":"Wang","year":"2019","journal-title":"Cancer Cell"},{"key":"10.1016\/j.bbamcr.2023.119607_bb0025","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/nrm760","article-title":"Messenger-rna-binding proteins and the messages they carry","volume":"3","author":"Dreyfuss","year":"2002","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bbamcr.2023.119607_bb0030","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/nature17988","article-title":"Imagebased detection and targeting of therapy resistance in pancreatic adenocarcinoma","volume":"534","author":"Fox","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.bbamcr.2023.119607_bb0035","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/nature10496","article-title":"Frequent pathway mutations of splicing machinery in myelodysplasia","volume":"478","author":"Yoshida","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.bbamcr.2023.119607_bb0040","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1074\/jbc.M110417200","article-title":"Molecular cloning and characterization of caper, a novel coactivator of activating protein-1 and estrogen receptors","volume":"277","author":"Jung","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamcr.2023.119607_bb0045","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1005116","article-title":"Caper is vital for energy and redox homeostasis by integrating glucose-induced mitochondrial functions via err-\u03b1-gabpa and stressinduced adaptive responses via nf-\u03bab-cmyc","volume":"11","author":"Kang","year":"2015","journal-title":"PLoS Genet."},{"key":"10.1016\/j.bbamcr.2023.119607_bb0050","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.4161\/cc.28156","article-title":"Caper, a novel regulator of human breast cancer progression","volume":"13","author":"Mercier","year":"2014","journal-title":"Cell Cycle"},{"key":"10.1016\/j.bbamcr.2023.119607_bb0055","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/s13402-012-0088-2","article-title":"Cse1l, dido1 and rbm39 in colorectal adenoma to carcinoma progression","volume":"35","author":"Sillars-Hardebol","year":"2012","journal-title":"Cell. Oncol."},{"key":"10.1016\/j.bbamcr.2023.119607_bb0060","doi-asserted-by":"crossref","first-page":"6311","DOI":"10.1007\/s13277-014-1819-y","article-title":"Overexpression of hcc1\/caper\u03b1 may play a role in lung cancer carcinogenesis","volume":"35","author":"Chai","year":"2014","journal-title":"Tumor Biol."},{"key":"10.1016\/j.bbamcr.2023.119607_bb0065","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/nature14610","article-title":"Lenalidomide induces ubiquitination and degradation of ck1\u03b1 in del (5q) mds","volume":"523","author":"Kr\u00f6nke","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.bbamcr.2023.119607_bb0070","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1038\/nchembio.2363","article-title":"Selective degradation of splicing factor caper\u03b1 by anticancer sulfonamides","volume":"13","author":"Uehara","year":"2017","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.bbamcr.2023.119607_bb0075","doi-asserted-by":"crossref","DOI":"10.1126\/science.aal3755","article-title":"Anticancer sulfonamides target splicing by inducing rbm39 degradation via recruitment to dcaf15","volume":"356","author":"Han","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.bbamcr.2023.119607_bb0080","doi-asserted-by":"crossref","first-page":"100703","DOI":"10.1016\/j.drup.2020.100703","article-title":"Genetic biomarkers of drug resistance: a compass of prognosis and targeted therapy in acute myeloid leukemia","volume":"52","author":"Long","year":"2020","journal-title":"Drug Resist. Updat."},{"key":"10.1016\/j.bbamcr.2023.119607_bb0085","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1038\/s41375-018-0068-2","article-title":"Mutation patterns identify adult patients with de novo acute myeloid leukemia aged 60 years or older who respond favorably to standard chemotherapy: an analysis of alliance studies","volume":"32","author":"Eisfeld","year":"2018","journal-title":"Leukemia"},{"key":"10.1016\/j.bbamcr.2023.119607_bb0090","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1097\/CCO.0000000000000404","article-title":"Relapsed\/refractory acute myeloid leukemia: any progress?","volume":"29","author":"Schlenk","year":"2017","journal-title":"Curr. Opin. Oncol."},{"key":"10.1016\/j.bbamcr.2023.119607_bb0095","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1080\/14656566.2017.1391216","article-title":"Cytarabine and daunorubicin for the treatment of acute myeloid leukemia","volume":"18","author":"Murphy","year":"2017","journal-title":"Expert. Opin. Pharmacother."},{"key":"10.1016\/j.bbamcr.2023.119607_bb0100","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1002\/ajh.24072","article-title":"Characteristics, clinical outcome, and prognostic significance of idh mutations in aml","volume":"90","author":"DiNardo","year":"2015","journal-title":"Am. J. Hematol."},{"key":"10.1016\/j.bbamcr.2023.119607_bb0105","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.drup.2012.07.002","article-title":"Antifolates in cancer therapy: structure, activity and mechanisms of drug resistance","volume":"15","author":"Gonen","year":"2012","journal-title":"Drug Resist. Updat."},{"key":"10.1016\/j.bbamcr.2023.119607_bb0110","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.drup.2014.12.001","article-title":"Molecular basis of resistance to proteasome inhibitors in hematological malignancies","volume":"18","author":"Niewerth","year":"2015","journal-title":"Drug Resist. Updat."},{"key":"10.1016\/j.bbamcr.2023.119607_bb0115","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.drup.2015.08.004","article-title":"Microenvironment acidity as a major determinant of tumor chemoresistance: Proton pump inhibitors (ppis) as a novel therapeutic approach","volume":"23","author":"Taylor","year":"2015","journal-title":"Drug Resist. Updat."},{"key":"10.1016\/j.bbamcr.2023.119607_bb0120","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.drup.2016.07.001","article-title":"Old drugs, novel ways out: drug resistance toward cytotoxic chemotherapeutics","volume":"28","author":"Wijdeven","year":"2016","journal-title":"Drug Resist. Updat."},{"key":"10.1016\/j.bbamcr.2023.119607_bb0125","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.jprot.2015.04.031","article-title":"The human rbpome: from genes and proteins to human disease","volume":"127","author":"Neelamraju","year":"2015","journal-title":"J. Proteome"},{"key":"10.1016\/j.bbamcr.2023.119607_bb0130","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1038\/nrg3813","article-title":"A census of human rna-binding proteins","volume":"15","author":"Gerstberger","year":"2014","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.bbamcr.2023.119607_bb0135","doi-asserted-by":"crossref","first-page":"10127","DOI":"10.1038\/ncomms10127","article-title":"The rna-binding proteomes from yeast to man harbour conserved enigmrbps","volume":"6","author":"Beckmann","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbamcr.2023.119607_bb0140","doi-asserted-by":"crossref","first-page":"107390","DOI":"10.1016\/j.pharmthera.2019.07.001","article-title":"Cancer the \u2018rbp\u2019eutics\u2013rna-binding proteins as therapeutic targets for cancer","volume":"203","author":"Mohibi","year":"2019","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.bbamcr.2023.119607_bb0145","doi-asserted-by":"crossref","first-page":"2419","DOI":"10.1172\/JCI116848","article-title":"Novel nuclear autoantigen with splicing factor motifs identified with antibody from hepatocellular carcinoma","volume":"92","author":"Imai","year":"1993","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbamcr.2023.119607_bb0150","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1136\/gutjnl-2011-301153","article-title":"Tpx2 and aurka promote 20q amplicondriven colorectal adenoma to carcinoma progression","volume":"61","author":"Sillars-Hardebol","year":"2012","journal-title":"Gut"},{"key":"10.1016\/j.bbamcr.2023.119607_bb0155","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/nature19830","article-title":"The mcl1 inhibitor s63845 is tolerable and effective in diverse cancer models","volume":"538","author":"Kotschy","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.bbamcr.2023.119607_bb0160","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1038\/s41420-021-00598-7","article-title":"Rna-binding protein 39: a promising therapeutic target for cancer","volume":"7","author":"Xu","year":"2021","journal-title":"Cell Death Dis."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167488923001805?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167488923001805?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T21:01:32Z","timestamp":1735765292000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167488923001805"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["S0167488923001805"],"URL":"https:\/\/doi.org\/10.1016\/j.bbamcr.2023.119607","relation":{},"ISSN":["0167-4889"],"issn-type":[{"value":"0167-4889","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Regulatory role of RBM39 in acute myeloid leukemia: Mediation through the PI3K\/AKT pathway","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Cell Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbamcr.2023.119607","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"119607"}}