{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T17:22:24Z","timestamp":1778260944626,"version":"3.51.4"},"reference-count":79,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T00:00:00Z","timestamp":1721606400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Cell Research"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1016\/j.bbamcr.2024.119798","type":"journal-article","created":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T01:49:34Z","timestamp":1721612974000},"page":"119798","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["GPR176 promotes fibroblast-to-myofibroblast transition in organ fibrosis progression"],"prefix":"10.1016","volume":"1871","author":[{"given":"Yasuo","family":"Okamoto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keisuke","family":"Kitakaze","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiro","family":"Takenouchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rena","family":"Matsui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Koga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryo","family":"Miyashima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hironobu","family":"Ishimaru","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhito","family":"Tsuboi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbamcr.2024.119798_bb0005","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1038\/s41586-020-2938-9","article-title":"Fibrosis: from mechanisms to medicines","volume":"587","author":"Henderson","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.bbamcr.2024.119798_bb0010","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.tips.2012.03.007","article-title":"Structure-based drug screening for G-protein-coupled receptors","volume":"33","author":"Shoichet","year":"2012","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.bbamcr.2024.119798_bb0015","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.tips.2019.12.008","article-title":"Targeting GPCR signaling for idiopathic pulmonary fibrosis therapies","volume":"41","author":"Haak","year":"2020","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.bbamcr.2024.119798_bb0020","article-title":"Targeting GPCRs to treat cardiac fibrosis","volume":"9","author":"Zhang","year":"2022","journal-title":"Front. Cadiovasc. Med."},{"key":"10.1016\/j.bbamcr.2024.119798_bb0025","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202301091","article-title":"GPCRs and fibroblast heterogeneity in fibroblast-associated diseases","volume":"37","author":"Dwivedi","year":"2023","journal-title":"FASEB J."},{"key":"10.1016\/j.bbamcr.2024.119798_bb0030","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/nm1685","article-title":"The lysophosphatidic acid receptor LPA1 links pulmonary fibrosis to lung injury by mediating fibroblast recruitment and vascular leak","volume":"14","author":"Tager","year":"2008","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbamcr.2024.119798_bb0035","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1172\/JCI200112214","article-title":"Critical role for the chemokine MCP-1\/CCR2 in the pathogenesis of bronchiolitis obliterans syndrome","volume":"108","author":"Belperio","year":"2001","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbamcr.2024.119798_bb0040","article-title":"Sphingosine-1-phosphate receptor-2 facilitates pulmonary fibrosis through potentiating IL-13 pathway in macrophages","volume":"13","author":"Zhao","year":"2018","journal-title":"PloS One"},{"key":"10.1016\/j.bbamcr.2024.119798_bb0045","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1124\/mol.117.111062","article-title":"G protein-coupled receptors as targets for approved drugs: how many targets and how many drugs?","volume":"93","author":"Sriram","year":"2018","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.bbamcr.2024.119798_bb0050","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1038\/nrd.2017.178","article-title":"Trends in GPCR drug discovery: new agents, targets and indications","volume":"16","author":"Hauser","year":"2017","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.bbamcr.2024.119798_bb0055","doi-asserted-by":"crossref","first-page":"2707","DOI":"10.1091\/mbc.e03-12-0902","article-title":"Endothelin-1 promotes myofibroblast induction through the ETA receptor via a rac\/phosphoinositide 3-kinase\/Akt-dependent pathway and is essential for the enhanced contractile phenotype of fibrotic fibroblasts","volume":"15","author":"Shi-Wen","year":"2004","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.bbamcr.2024.119798_bb0060","first-page":"185","article-title":"Sphingosine-1-phosphate as a mediator involved in development of fibrotic diseases","volume":"2013","author":"Takuwa","year":"1831","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbamcr.2024.119798_bb0065","doi-asserted-by":"crossref","first-page":"5644","DOI":"10.4049\/jimmunol.174.9.5644","article-title":"Bleomycin-induced E prostanoid receptor changes alter fibroblast responses to prostaglandin E2","volume":"174","author":"Moore","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.bbamcr.2024.119798_bb0070","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.773432","article-title":"Role of G protein-coupled receptors in hepatic stellate cells and approaches to anti-fibrotic treatment of non-alcoholic fatty liver disease","volume":"12","author":"Kimura","year":"2021","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.bbamcr.2024.119798_bb0075","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/0167-4781(95)00002-X","article-title":"cDNA cloning of a putative G protein-coupled receptor from brain","volume":"1261","author":"Hata","year":"1995","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbamcr.2024.119798_bb0080","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/0167-4781(94)90007-8","article-title":"Molecular cloning of a novel putative G protein-coupled receptor from rat aortic smooth muscle. Downregulation of the mRNA level by the cyclic AMP messenger pathway","volume":"1218","author":"Ishizaka","year":"1994","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbamcr.2024.119798_bb0085","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms10583","article-title":"Gpr176 is a Gz-linked orphan G-protein-coupled receptor that sets the pace of circadian behaviour","volume":"7","author":"Doi","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbamcr.2024.119798_bb0090","doi-asserted-by":"crossref","first-page":"4429","DOI":"10.1038\/s41598-020-61370-y","article-title":"Identification and functional characterisation of N-linked glycosylation of the orphan G protein-coupled receptor Gpr176","volume":"10","author":"Wang","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbamcr.2024.119798_bb0095","doi-asserted-by":"crossref","first-page":"8063","DOI":"10.1038\/s41598-018-26429-x","article-title":"Transcriptomic response of breast cancer cells to anacardic acid","volume":"8","author":"Schultz","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbamcr.2024.119798_bb0100","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.pathol.2021.01.010","article-title":"Histopathological typing in diffuse malignant epithelioid mesothelioma: implication for prognosis and molecular basis","volume":"53","author":"Forest","year":"2021","journal-title":"Pathology"},{"key":"10.1016\/j.bbamcr.2024.119798_bb0105","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2022.925231","article-title":"Identification of a gene signature of cancer-associated fibroblasts to predict prognosis in ovarian cancer","volume":"13","author":"Zeng","year":"2022","journal-title":"Front. Genet."},{"key":"10.1016\/j.bbamcr.2024.119798_bb0110","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/5813522","article-title":"Prognostic model and immune infiltration of ferroptosis subcluster-related modular genes in gastric cancer","volume":"2022","author":"Deng","year":"2022","journal-title":"J. Oncol."},{"key":"10.1016\/j.bbamcr.2024.119798_bb0115","article-title":"GPR176 promotes cancer progression by interacting with G protein GNAS to restrain cell mitophagy in colorectal cancer","volume":"10","author":"Tang","year":"2023","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10.1016\/j.bbamcr.2024.119798_bb0120","doi-asserted-by":"crossref","first-page":"3042","DOI":"10.1007\/s12094-023-03174-w","article-title":"Oncogenic roles of GPR176 in breast cancer: a potential marker of aggressiveness and a potential target of gene therapy","volume":"25","author":"Yun","year":"2023","journal-title":"Clin. Transl. Oncol."},{"key":"10.1016\/j.bbamcr.2024.119798_bb0125","doi-asserted-by":"crossref","DOI":"10.1155\/2023\/7123568","article-title":"GPR176 is a biomarker for predicting prognosis and immune infiltration in stomach adenocarcinoma","volume":"2023","author":"Ni","year":"2023","journal-title":"Mediators Inflamm."},{"key":"10.1016\/j.bbamcr.2024.119798_bb0130","first-page":"519","article-title":"Exploring the correlation between GPR176, a potential target gene of gastric cancer, and immune cell infiltration","volume":"16","author":"Gu","year":"2023","journal-title":"Pharmacogenomics Pers. Med."},{"key":"10.1016\/j.bbamcr.2024.119798_bb0135","doi-asserted-by":"crossref","first-page":"9360","DOI":"10.1038\/s41598-023-36586-3","article-title":"High expression of GPR176 predicts poor prognosis of gastric cancer patients and promotes the proliferation, migration, and invasion of gastric cancer cells","volume":"13","author":"Zhang","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbamcr.2024.119798_bb0140","doi-asserted-by":"crossref","first-page":"14641","DOI":"10.1007\/s00432-023-05256-2","article-title":"The promoting effects of GPR176 expression on proliferation, chemoresistance, lipogenesis and invasion of oesophageal cancer","volume":"149","author":"Yun","year":"2023","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"10.1016\/j.bbamcr.2024.119798_bb0145","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1080\/15257770.2020.1780437","article-title":"Diabetic nephropathy produces alterations in the tissue expression profile of the orphan receptors GPR149, GPR153, GPR176, TAAR3, TRRR5 and TAAR9 in Wister rats","volume":"39","author":"Ruiz-Helrn\u00e1ndez","year":"2020","journal-title":"Nucleosides Nucleotides Nucleic Acids"},{"key":"10.1016\/j.bbamcr.2024.119798_bb0150","doi-asserted-by":"crossref","DOI":"10.3389\/fragi.2021.803482","article-title":"Adipocyte-specific ablation of PU.1 promotes energy expenditure and ameliorates metabolic syndrome in aging mice","volume":"2","author":"Chen","year":"2022","journal-title":"Front. Aging"},{"key":"10.1016\/j.bbamcr.2024.119798_bb0155","author":"GeneNetwork"},{"key":"10.1016\/j.bbamcr.2024.119798_bb0160","doi-asserted-by":"crossref","first-page":"D1083","DOI":"10.1093\/nar\/gkt1031","article-title":"The ChEMBL bioactivity database: an update","volume":"42","author":"Bento","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bbamcr.2024.119798_bb0165","doi-asserted-by":"crossref","first-page":"W573","DOI":"10.1093\/nar\/gkm297","article-title":"firestar\u2014prediction of functionally important residues using structural templates and alignment reliability","volume":"35","author":"L\u00f3pez","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bbamcr.2024.119798_bb0170","doi-asserted-by":"crossref","first-page":"W235","DOI":"10.1093\/nar\/gkr437","article-title":"Firestar\u2014advances in the prediction of functionally important residues","volume":"39","author":"Lopez","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bbamcr.2024.119798_bb0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2020.112010","article-title":"Growth differentiation factor 15 facilitates lung fibrosis by activating macrophages and fibroblasts","volume":"391","author":"Takenouchi","year":"2020","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.bbamcr.2024.119798_bb0180","doi-asserted-by":"crossref","first-page":"8801","DOI":"10.1038\/s41598-017-08054-2","article-title":"Infiltration of M1, but not M2, macrophages is impaired after unilateral ureter obstruction in Nrf2-deficeint mice","volume":"7","author":"Sogawa","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbamcr.2024.119798_bb0185","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0152153","article-title":"Unilateral renal ischemia-reperfusion as a robust model for acute to chronic kidney injury in mice","volume":"11","author":"Le Clef","year":"2016","journal-title":"PloS One"},{"key":"10.1016\/j.bbamcr.2024.119798_bb0190","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1161\/01.HYP.0000128621.68160.dd","article-title":"Role of osteopontin in cardiac fibrosis and remodeling in angiotensin II-induced cardiac hypertrophy","volume":"43","author":"Matsui","year":"2004","journal-title":"Hypertension"},{"key":"10.1016\/j.bbamcr.2024.119798_bb0195","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/978-1-0716-1382-5_23","article-title":"Mouse models of liver fibrosis","volume":"2299","author":"Ravichandra","year":"2021","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.bbamcr.2024.119798_bb0200","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1016\/j.jaci.2013.07.026","article-title":"Sphingosine-1-phosphate receptor 2 protects against anaphylactic shock through suppression of endothelial nitric oxide synthase in mice","volume":"132","author":"Cui","year":"2013","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.bbamcr.2024.119798_bb0205","first-page":"2","article-title":"Sphingosine-1-phosphate receptor type 2 (S1P2) inhibits bleomycin-induced cellular senescence in murine lung fibroblasts","volume":"125","author":"Zhao","year":"2016","journal-title":"J. Juzen Med. Soc."},{"key":"10.1016\/j.bbamcr.2024.119798_bb0210","first-page":"13","article-title":"The efficient detection of membrane protein with immunoblotting: lessons from cold-temperature denaturation","volume":"47","author":"Miyano","year":"2021","journal-title":"Kawasaki Med. J."},{"key":"10.1016\/j.bbamcr.2024.119798_bb0215","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1016\/j.bbalip.2007.10.002","article-title":"Proteolytic activation and glycosylation of N-acylethanolamine-hydrolyzing acid amidase, a lysosomal enzyme involved in the endocannabinoid metabolism","volume":"1771","author":"Zhao","year":"2007","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbamcr.2024.119798_bb0220","doi-asserted-by":"crossref","first-page":"F50","DOI":"10.1152\/ajprenal.00077.2021","article-title":"Landscape of GPCR expression along the mouse nephron","volume":"321","author":"Poll","year":"2021","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.bbamcr.2024.119798_bb0225","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1074\/jbc.271.1.486","article-title":"Molecular cloning of F4\/80, a murine macrophage-restricted cell surface glycoprotein with homology to the G-protein-linked transmembrane 7 hormone receptor family","volume":"271","author":"McKnight","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamcr.2024.119798_bb0230","first-page":"1858","article-title":"CCR1 and CCR5 promote hepatic fibrosis in mice","volume":"119","author":"Seki","year":"2009","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbamcr.2024.119798_bb0235","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0021381","article-title":"Interleukin-8 is activated in patients with chronic liver diseases and associated with hepatic macrophage accumulation in human liver fibrosis","volume":"6","author":"Zimmermann","year":"2011","journal-title":"PloS One"},{"key":"10.1016\/j.bbamcr.2024.119798_bb0240","doi-asserted-by":"crossref","first-page":"2880","DOI":"10.1111\/bph.15408","article-title":"Role of intracellular complement activation in kidney fibrosis","volume":"178","author":"Portilla","year":"2021","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bbamcr.2024.119798_bb0245","series-title":"Efficient Renal Recruitment of Macrophages and T Cells in Mice Lacking the Duffy Antigen\/receptor for Chemokines","first-page":"119","volume":"175","author":"Vielhauer","year":"2009"},{"key":"10.1016\/j.bbamcr.2024.119798_bb0250","doi-asserted-by":"crossref","DOI":"10.1038\/srep26235","article-title":"Whole-transcriptome analysis of UUO mouse model of renal fibrosis reveals new molecular players in kidney diseases","volume":"6","author":"Arvaniti","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbamcr.2024.119798_bb0255","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1038\/nri3073","article-title":"Protective and pathogenic functions of macrophage subsets","volume":"11","author":"Murray","year":"2011","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.bbamcr.2024.119798_bb0260","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-50685-0","article-title":"The serum amyloid A3 promoter-driven luciferase reporter mice is a valuable tool to image early renal fibrosis development and shows the therapeutic effect of glucosyl-hesperidin treatment","volume":"9","author":"Kumrungsee","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbamcr.2024.119798_bb0265","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s40851-018-0109-8","article-title":"A novel photic entrainment mechanism for the circadian clock in an insect: involvement of c-fos and cryptochromes","volume":"4","author":"Kutaragi","year":"2018","journal-title":"Zool. Lett."},{"key":"10.1016\/j.bbamcr.2024.119798_bb0270","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1038\/s42003-023-04900-4","article-title":"GDE7 produces cyclic phosphatidic acid in the ER lumen functioning as a lysophospholipid mediator","volume":"6","author":"Kitakaze","year":"2023","journal-title":"Commun. Biol."},{"key":"10.1016\/j.bbamcr.2024.119798_bb0275","doi-asserted-by":"crossref","first-page":"3269","DOI":"10.1111\/jcmm.17333","article-title":"FOXO4 peptide targets myofibroblast ameliorates bleomycin-induced pulmonary fibrosis in mice through ECM-receptor interaction pathway","volume":"26","author":"Han","year":"2022","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.bbamcr.2024.119798_bb0280","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1016\/j.jcmgh.2022.01.015","article-title":"Peroxidasin deficiency re-programs macrophages toward pro-fibrolysis function and promotes collagen resolution in liver","volume":"13","author":"Sojoodi","year":"2022","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"10.1016\/j.bbamcr.2024.119798_bb0285","author":"Genevisible"},{"key":"10.1016\/j.bbamcr.2024.119798_bb0290","doi-asserted-by":"crossref","first-page":"4540","DOI":"10.1096\/fj.12-213496","article-title":"Defining the cellular repertoire of GPCRs identifies a profibrotic role for the most highly expressed receptor, protease-activated receptor 1, in cardiac fibroblasts","volume":"26","author":"Snead","year":"2012","journal-title":"FASEB J."},{"key":"10.1016\/j.bbamcr.2024.119798_bb0295","doi-asserted-by":"crossref","first-page":"2898","DOI":"10.1111\/bph.16101","article-title":"Single cell G-protein coupled receptor profiling of activated kidney fibroblasts expressing transcripition factor 21","volume":"180","author":"Kaur","year":"2023","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bbamcr.2024.119798_bb0300","article-title":"Orphan receptor GPR176 in hepatic stellate cells exerts a profibrotic role in chronic liver disease","volume":"6","author":"De Smet","year":"2024","journal-title":"JHEP Rep."},{"key":"10.1016\/j.bbamcr.2024.119798_bb0305","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.matbio.2017.07.005","article-title":"Identification of a myofibroblast-specific expression signature in skin wounds","volume":"65","author":"Bergmeier","year":"2018","journal-title":"Matrix Biol."},{"key":"10.1016\/j.bbamcr.2024.119798_bb0310","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1186\/s12931-019-1146-3","article-title":"Defining a role for lung function associated gene GSTCD in cell homeostasis","volume":"20","author":"Henry","year":"2019","journal-title":"Respir. Res."},{"key":"10.1016\/j.bbamcr.2024.119798_bb0315","doi-asserted-by":"crossref","first-page":"3077","DOI":"10.7150\/ijbs.83392","article-title":"Inhibition of KMO ameliorates myocardial ischemia injury via maintaining mitochondrial fusion and fission balance","volume":"19","author":"Lai","year":"2023","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.bbamcr.2024.119798_bb0320","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s11926-020-00903-w","article-title":"Dissecting fibroblast heterogeneity in health and fibrotic disease","volume":"22","author":"Shaw","year":"2020","journal-title":"Curr. Rheumatol. Rep."},{"key":"10.1016\/j.bbamcr.2024.119798_bb0325","doi-asserted-by":"crossref","first-page":"3852","DOI":"10.1016\/j.cell.2021.06.024","article-title":"Fibroblasts: origins, definitions, and functions in health and disease","volume":"184","author":"Plikus","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.bbamcr.2024.119798_bb0330","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/j.cell.2006.05.015","article-title":"A phosphatase controls the fate of receptor-regulated Smads","volume":"125","author":"Schilling","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.bbamcr.2024.119798_bb0335","doi-asserted-by":"crossref","DOI":"10.1172\/JCI165654","article-title":"Molecular pathways that drive diabetic kidney disease","volume":"133","author":"Mohandes","year":"2023","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbamcr.2024.119798_bb0340","doi-asserted-by":"crossref","first-page":"4018","DOI":"10.1038\/s41467-022-31772-9","article-title":"Single-cell analysis highlights differences in druggable pathways underlying adaptive or fibrotic kidney regeneration","volume":"13","author":"Balzer","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbamcr.2024.119798_bb0345","doi-asserted-by":"crossref","first-page":"3167","DOI":"10.1002\/j.2040-4603.2022.tb00210.x","article-title":"Oxidative stress and redox signaling in the pathophysiology of liver diseases","volume":"12","author":"Nooli","year":"2022","journal-title":"Compr. Physiol."},{"key":"10.1016\/j.bbamcr.2024.119798_bb0350","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbamcr.2022.119391","article-title":"Growth hormone induces transforming growth factor-\u03b21 in podocytes: implications in podocytopathy and proteinuria","volume":"1870","author":"Mukhi","year":"2023","journal-title":"Biochim. Biophys. Acta, Mol. Cell Res."},{"key":"10.1016\/j.bbamcr.2024.119798_bb0355","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1038\/s41419-021-03643-6","article-title":"Growth hormone induces mitotic catastrophe of glomerular podocytes and contributes to proteinuria","volume":"12","author":"Nishad","year":"2021","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bbamcr.2024.119798_bb0360","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1038\/s41467-017-01236-6","article-title":"Activation of STAT3 integrates common profibrotic pathways to promote fibroblast activation and tissue fibrosis","volume":"8","author":"Chakraborty","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbamcr.2024.119798_bb0365","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/j.neuropharm.2003.11.024","article-title":"Deletion of guanine nucleotide binding protein \u03b1z subunit in mice induces a gene dose dependent tolerance to morphine","volume":"46","author":"Leck","year":"2004","journal-title":"Neuropharmacol"},{"key":"10.1016\/j.bbamcr.2024.119798_bb0370","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.RA120.015585","article-title":"Agonist-independent G\u03b1z activity negatively regulates beta-cell compensation in a diet-induced obesity model of type 2 diabetes","volume":"296","author":"Schaid","year":"2021","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamcr.2024.119798_bb0375","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0138463","article-title":"Constitutive activity among orphan class-a G protein coupled receptors","volume":"10","author":"Martin","year":"2015","journal-title":"PloS One"},{"key":"10.1016\/j.bbamcr.2024.119798_bb0380","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.ympev.2014.01.022","article-title":"Sequence-structure based phylogeny of GPCR class a rhodopsin receptors","volume":"74","author":"Kakarala","year":"2014","journal-title":"Mol. Phylogenet. Evol."},{"key":"10.1016\/j.bbamcr.2024.119798_bb0385","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.cell.2010.07.041","article-title":"GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects","volume":"142","author":"Oh","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.bbamcr.2024.119798_bb0390","article-title":"Structure of GPR101-Gs enables identification of ligands with rejuvenating potential","author":"Yang","year":"2023","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.bbamcr.2024.119798_bb0395","article-title":"GPR101: modeling a constitutively active receptor linked to X-linked acrogigantism","volume":"127","author":"Costanzi","year":"2023","journal-title":"J. Mol. Graph. Model."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167488924001411?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167488924001411?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T01:29:15Z","timestamp":1759368555000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167488924001411"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":79,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["S0167488924001411"],"URL":"https:\/\/doi.org\/10.1016\/j.bbamcr.2024.119798","relation":{},"ISSN":["0167-4889"],"issn-type":[{"value":"0167-4889","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"GPR176 promotes fibroblast-to-myofibroblast transition in organ fibrosis progression","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Cell Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbamcr.2024.119798","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"119798"}}