{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T22:22:36Z","timestamp":1773008556651,"version":"3.50.1"},"reference-count":104,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T00:00:00Z","timestamp":1736467200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014131","name":"McGill University Health Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014131","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Cell Research"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.bbamcr.2025.119899","type":"journal-article","created":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T12:26:48Z","timestamp":1736425608000},"page":"119899","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Hippocampal reelin and GAD67 gene expression and methylation in the GFAP.HMOX1 mouse model of schizophrenia"],"prefix":"10.1016","volume":"1872","author":[{"given":"Ayda","family":"Tavitian","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elad","family":"Lax","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moshe","family":"Szyf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyman M.","family":"Schipper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbamcr.2025.119899_bb0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.schres.2008.04.011","article-title":"Schizophrenia, \u201cJust the facts\u201d what we know in 2008. 2. Epidemiology and etiology","volume":"102","author":"Tandon","year":"2008","journal-title":"Schizophr. Res."},{"key":"10.1016\/j.bbamcr.2025.119899_bb0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.schres.2009.03.005","article-title":"Schizophrenia, \u201cjust the facts\u201d 4. Clinical features and conceptualization","volume":"110","author":"Tandon","year":"2009","journal-title":"Schizophr. Res."},{"key":"10.1016\/j.bbamcr.2025.119899_bb0015","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1177\/0706743717719899","article-title":"Canadian guidelines for the assessment and diagnosis of patients with schizophrenia spectrum and other psychotic disorders","volume":"62","author":"Addington","year":"2017","journal-title":"Can. J. Psychiatr."},{"key":"10.1016\/j.bbamcr.2025.119899_bb0020","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.pneurobio.2018.06.008","article-title":"The sinister face of heme oxygenase-1 in brain aging and disease","volume":"172","author":"Schipper","year":"2019","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.bbamcr.2025.119899_bb0025","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1016\/j.freeradbiomed.2005.11.020","article-title":"Carbon monoxide, oxidative stress, and mitochondrial permeability pore transition","volume":"40","author":"Piantadosi","year":"2006","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbamcr.2025.119899_bb0030","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1172\/JCI115980","article-title":"Mitochondrial oxidative stress after carbon monoxide hypoxia in the rat brain","volume":"90","author":"Zhang","year":"1992","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbamcr.2025.119899_bb0035","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/S0891-5849(99)00223-3","article-title":"The heme synthesis and degradation pathways: role in oxidant sensitivity. Heme oxygenase has both pro- and antioxidant properties","volume":"28","author":"Ryter","year":"2000","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbamcr.2025.119899_bb0040","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1002\/1097-4652(200010)185:1<80::AID-JCP7>3.0.CO;2-W","article-title":"Role of heme oxygenase-1 in the regulation of manganese superoxide dismutase gene expression in oxidatively-challenged astroglia","volume":"185","author":"Frankel","year":"2000","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.bbamcr.2025.119899_bb0045","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.1089\/ars.2007.1803","article-title":"Mitochondrial and cellular heme-dependent proteins as targets for the bioactive function of the heme oxygenase\/carbon monoxide system","volume":"9","author":"Desmard","year":"2007","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.bbamcr.2025.119899_bb0050","doi-asserted-by":"crossref","first-page":"25350","DOI":"10.1074\/jbc.M503512200","article-title":"Mitochondrial respiratory chain and NAD(P)H oxidase are targets for the antiproliferative effect of carbon monoxide in human airway SmoothMuscle*","volume":"280","author":"Taill\u00e9","year":"2005","journal-title":"J. Biol. Chem."},{"issue":"643","key":"10.1016\/j.bbamcr.2025.119899_bb0055","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1038\/sj.mp.4001511","article-title":"Mitochondrial dysfunction in schizophrenia: evidence for compromised brain metabolism and oxidative stress","volume":"9","author":"Prabakaran","year":"2004","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.bbamcr.2025.119899_bb0060","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1038\/s41398-018-0216-5","article-title":"Mgs, transcriptomic signatures of schizophrenia revealed by dopamine perturbation in an ex vivo model","volume":"8","author":"Duan","year":"2018","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.bbamcr.2025.119899_bb0065","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.euroneuro.2019.03.011","article-title":"Impaired heme metabolism in schizophrenia-derived cell lines and in a rat model of the disorder: possible involvement of mitochondrial complex I","volume":"29","author":"Ifhar","year":"2019","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.bbamcr.2025.119899_bb0070","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1242\/dmm.005447","article-title":"Disease-specific, neurosphere-derived cells as models for brain disorders","volume":"3","author":"Matigian","year":"2010","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.bbamcr.2025.119899_bb0075","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1038\/npp.2013.38","article-title":"Deficiency of Schnurri-2, an MHC enhancer binding protein, induces mild chronic inflammation in the brain and confers molecular, neuronal, and behavioral phenotypes related to schizophrenia","volume":"38","author":"Takao","year":"2013","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bbamcr.2025.119899_bb0080","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.neuroscience.2018.07.046","article-title":"Abnormalities in prefrontal cortical gene expression profiles relevant to schizophrenia in MK-801-exposed C57BL\/6 mice","volume":"390","author":"Zhao","year":"2018","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbamcr.2025.119899_bb0085","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1038\/npp.2017.167","article-title":"Decreased brain pH as a shared endophenotype of psychiatric disorders","volume":"43","author":"Hagihara","year":"2018","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bbamcr.2025.119899_bb0090","doi-asserted-by":"crossref","first-page":"24964","DOI":"10.1073\/pnas.2006905117","article-title":"Influenza a virus causes maternal and fetal pathology via innate and adaptive vascular inflammation in mice","volume":"117","author":"Liong","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbamcr.2025.119899_bb0095","doi-asserted-by":"crossref","first-page":"10841","DOI":"10.1523\/JNEUROSCI.6469-11.2012","article-title":"Schizophrenia-like features in transgenic mice overexpressing human HO-1 in the astrocytic compartment","volume":"32","author":"Song","year":"2012","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbamcr.2025.119899_bb0100","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.freeradbiomed.2017.05.025","article-title":"Cysteine-rich whey protein isolate (Immunocal(R)) ameliorates deficits in the GFAP.HMOX1 mouse model of schizophrenia","volume":"110","author":"Song","year":"2017","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbamcr.2025.119899_bb0105","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1089\/ars.2019.7937","article-title":"Strategic timing of glial HMOX1 expression results in either schizophrenia-like or parkinsonian behavior in mice","volume":"32","author":"Tavitian","year":"2020","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.bbamcr.2025.119899_bb0110","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1177\/1073858418824072","article-title":"Dentate gyrus immaturity in schizophrenia","volume":"25","author":"Tavitian","year":"2019","journal-title":"Neuroscientist"},{"key":"10.1016\/j.bbamcr.2025.119899_bb0115","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1111\/j.1471-4159.2012.07914.x","article-title":"Unregulated brain iron deposition in transgenic mice over-expressing HMOX1 in the astrocytic compartment","volume":"123","author":"Song","year":"2012","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbamcr.2025.119899_bb0120","doi-asserted-by":"crossref","first-page":"3529","DOI":"10.1002\/ar.25449","article-title":"Craniofacial anomalies in schizophrenia-relevant GFAP.HMOX10-12m mice","volume":"307","author":"Tavitian","year":"2024","journal-title":"Anat. Rec."},{"key":"10.1016\/j.bbamcr.2025.119899_bb0125","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.pneurobio.2010.04.002","article-title":"Reelin-mediated signaling in neuropsychiatric and neurodegenerative diseases","volume":"91","author":"Knuesel","year":"2010","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.bbamcr.2025.119899_bb0130","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1073\/pnas.2637013100","article-title":"DNA-methyltransferase 1 mRNA is selectively overexpressed in telencephalic GABAergic interneurons of schizophrenia brains","volume":"101","author":"Veldic","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbamcr.2025.119899_bb0135","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1001\/archpsyc.57.11.1061","article-title":"Decrease in reelin and glutamic acid decarboxylase67 (gad67) expression in schizophrenia and bipolar disorder: a postmortem brain study","volume":"57","author":"Guidotti","year":"2000","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.bbamcr.2025.119899_bb0140","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/sj.mp.4000783","article-title":"Reduction in Reelin immunoreactivity in hippocampus of subjects with schizophrenia, bipolar disorder and major depression","volume":"5","author":"Fatemi","year":"2000","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.bbamcr.2025.119899_bb0145","doi-asserted-by":"crossref","first-page":"15718","DOI":"10.1073\/pnas.95.26.15718","article-title":"A decrease of reelin expression as a putative vulnerability factor in schizophrenia","volume":"95","author":"Impagnatiello","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbamcr.2025.119899_bb0150","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1159\/000337129","article-title":"Decreased reelin expression in the left prefrontal cortex (BA9) in chronic schizophrenia patients","volume":"66","author":"Habl","year":"2012","journal-title":"Neuropsychobiology"},{"key":"10.1016\/j.bbamcr.2025.119899_bb0155","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1038\/sj.mp.4001371","article-title":"Interstitial white matter neurons express less reelin and are abnormally distributed in schizophrenia: towards an integration of molecular and morphologic aspects of the neurodevelopmental hypothesis","volume":"8","author":"Eastwood","year":"2003","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.bbamcr.2025.119899_bb0160","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1176\/appi.ajp.163.3.540","article-title":"Cellular basis of reduced cortical reelin expression in schizophrenia","volume":"163","author":"Eastwood","year":"2006","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.bbamcr.2025.119899_bb0165","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.biopsych.2004.10.019","article-title":"Neurochemical markers for schizophrenia, bipolar disorder, and major depression in postmortem brains","volume":"57","author":"Torrey","year":"2005","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.bbamcr.2025.119899_bb0170","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/sj.mp.4001613","article-title":"Reelin glycoprotein: structure, biology and roles in health and disease","volume":"10","author":"Fatemi","year":"2005","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.bbamcr.2025.119899_bb0175","series-title":"The Mouse in Biomedical Research (Second Edition)","first-page":"637","article-title":"Chapter 20 - mouse models in aging research","author":"Flurkey","year":"2007"},{"key":"10.1016\/j.bbamcr.2025.119899_bb0180","series-title":"Paxinos and Franklin\u2019s the Mouse Brain in Stereotaxic Coordinates","author":"Franklin","year":"2013"},{"key":"10.1016\/j.bbamcr.2025.119899_bb0185","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212\u0394\u0394CT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.bbamcr.2025.119899_bb0190","article-title":"PrimerSuite: a high-throughput web-based primer design program for multiplex bisulfite PCR","volume":"7","author":"Lu","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbamcr.2025.119899_bb0195","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/s41398-023-02561-9","article-title":"Methyl-CpG binding domain 2 (Mbd2) is an epigenetic regulator of autism-risk genes and cognition","volume":"13","author":"Lax","year":"2023","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.bbamcr.2025.119899_bb0200","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1038\/nature14252","article-title":"Conserved epigenomic signals in mice and humans reveal immune basis of Alzheimer's disease","volume":"518","author":"Gjoneska","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.bbamcr.2025.119899_bb0205","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/s41398-018-0348-7","article-title":"Fetal glucocorticoid receptor (Nr3c1) deficiency alters the landscape of DNA methylation of murine placenta in a sex-dependent manner and is associated to anxiety-like behavior in adulthood","volume":"9","author":"Schmidt","year":"2019","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.bbamcr.2025.119899_bb0210","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1186\/1471-2105-10-232","article-title":"BSMAP: whole genome bisulfite sequence MAPping program","volume":"10","author":"Xi","year":"2009","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.bbamcr.2025.119899_bb0215","doi-asserted-by":"crossref","first-page":"R87","DOI":"10.1186\/gb-2012-13-10-r87","article-title":"methylKit: a comprehensive R package for the analysis of genome-wide DNA methylation profiles","volume":"13","author":"Akalin","year":"2012","journal-title":"Genome Biol."},{"key":"10.1016\/j.bbamcr.2025.119899_bb0220","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0005505","article-title":"Reelin secreted by GABAergic neurons regulates glutamate receptor homeostasis","volume":"4","author":"Campo","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.bbamcr.2025.119899_bb0225","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1111\/j.1460-9568.2005.04567.x","article-title":"Extracellular matrix molecules and synaptic plasticity: immunomapping of intracellular and secreted Reelin in the adult rat brain","volume":"23","author":"Ramos-Moreno","year":"2006","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.bbamcr.2025.119899_bb0230","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1515\/revneuro-2019-0020","article-title":"Perineuronal oligodendrocytes in health and disease: the journey so far","volume":"31","author":"Bernstein","year":"2020","journal-title":"Rev. Neurosci."},{"key":"10.1016\/j.bbamcr.2025.119899_bb0235","doi-asserted-by":"crossref","first-page":"90","DOI":"10.3389\/fnana.2018.00090","article-title":"The absolute number of oligodendrocytes in the adult mouse brain","volume":"12","author":"Val\u00e9rio-Gomes","year":"2018","journal-title":"Front. Neuroanat."},{"key":"10.1016\/j.bbamcr.2025.119899_bb0240","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/sj.mp.4001954","article-title":"Selective epigenetic alteration of layer I GABAergic neurons isolated from prefrontal cortex of schizophrenia patients using laser-assisted microdissection","volume":"12","author":"Ruzicka","year":"2007","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.bbamcr.2025.119899_bb0245","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.schres.2014.10.030","article-title":"DNA-methyltransferase1 (DNMT1) binding to CpG rich GABAergic and BDNF promoters is increased in the brain of schizophrenia and bipolar disorder patients","volume":"167","author":"Dong","year":"2015","journal-title":"Schizophr. Res."},{"key":"10.1016\/j.bbamcr.2025.119899_bb0250","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.brainresrev.2006.04.001","article-title":"Molecular and cellular mechanisms of altered GAD1\/GAD67 expression in schizophrenia and related disorders","volume":"52","author":"Akbarian","year":"2006","journal-title":"Brain Res. Rev."},{"issue":"544","key":"10.1016\/j.bbamcr.2025.119899_bb0255","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1038\/sj.mp.4001471","article-title":"Molecular abnormalities of the hippocampus in severe psychiatric illness: postmortem findings from the Stanley Neuropathology Consortium","volume":"9","author":"Knable","year":"2004","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.bbamcr.2025.119899_bb0260","doi-asserted-by":"crossref","first-page":"10164","DOI":"10.1073\/pnas.0703806104","article-title":"Regulation of the GABA cell phenotype in hippocampus of schizophrenics and bipolars","volume":"104","author":"Benes","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbamcr.2025.119899_bb0265","doi-asserted-by":"crossref","first-page":"2985","DOI":"10.1093\/cercor\/bhq047","article-title":"Roles of 17\u00df-estradiol involve regulation of reelin expression and synaptogenesis in the dentate gyrus","volume":"20","author":"Bender","year":"2010","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.bbamcr.2025.119899_bb0270","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.nbd.2009.07.001","article-title":"Interactions between neuroactive steroids and reelin haploinsufficiency in Purkinje cell survival","volume":"36","author":"Biamonte","year":"2009","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.bbamcr.2025.119899_bb0275","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/s00441-003-0701-9","article-title":"Effects of testosterone on Reelin expression in the brain of male European starlings","volume":"312","author":"Absil","year":"2003","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.bbamcr.2025.119899_bb0280","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.neuropharm.2012.08.015","article-title":"The involvement of Reelin in neurodevelopmental disorders","volume":"68","author":"Folsom","year":"2013","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bbamcr.2025.119899_bb0285","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1111\/nan.12608","article-title":"Invited review: epigenetics in neurodevelopment","volume":"46","author":"Salinas","year":"2020","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"10.1016\/j.bbamcr.2025.119899_bb0290","doi-asserted-by":"crossref","first-page":"5739","DOI":"10.1093\/cercor\/bhx250","article-title":"Dysregulation of cortical neuron DNA methylation profile in autism Spectrum disorder","volume":"27","author":"Nardone","year":"2017","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.bbamcr.2025.119899_bb0295","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/nrn.2016.41","article-title":"The landscape of DNA methylation amid a perfect storm of autism aetiologies","volume":"17","author":"Vogel Ciernia","year":"2016","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.bbamcr.2025.119899_bb0300","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.biopsych.2016.08.010","article-title":"Genome-wide DNA methylation changes in a mouse model of infection-mediated neurodevelopmental disorders","volume":"81","author":"Richetto","year":"2017","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.bbamcr.2025.119899_bb0305","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pbiomolbio.2015.04.008","article-title":"Epigenetic mechanisms in schizophrenia","volume":"118","author":"Shorter","year":"2015","journal-title":"Prog. Biophys. Mol. Biol."},{"key":"10.1016\/j.bbamcr.2025.119899_bb0310","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1002\/ajmg.b.30140","article-title":"Hypermethylation of the reelin (RELN) promoter in the brain of schizophrenic patients: a preliminary report","volume":"134b","author":"Abdolmaleky","year":"2005","journal-title":"Am. J. Med. Genet. B Neuropsychiatr. Genet."},{"key":"10.1016\/j.bbamcr.2025.119899_bb0315","doi-asserted-by":"crossref","first-page":"9341","DOI":"10.1073\/pnas.0503736102","article-title":"Reelin promoter hypermethylation in schizophrenia","volume":"102","author":"Grayson","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbamcr.2025.119899_bb0320","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.biopsych.2007.07.003","article-title":"Methylation status of the reelin promoter region in the brain of schizophrenic patients","volume":"63","author":"Tochigi","year":"2008","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.bbamcr.2025.119899_bb0325","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1016\/j.neuropharm.2010.09.017","article-title":"Analysis of the GAD1 promoter: trans-acting factors and DNA methylation converge on the 5\u2032 untranslated region","volume":"60","author":"Chen","year":"2011","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bbamcr.2025.119899_bb0330","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1038\/npp.2012.125","article-title":"The dynamics of DNA methylation in schizophrenia and related psychiatric disorders","volume":"38","author":"Grayson","year":"2013","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bbamcr.2025.119899_bb0335","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0000809","article-title":"GAD1 mRNA expression and DNA methylation in prefrontal cortex of subjects with schizophrenia","volume":"2","author":"Huang","year":"2007","journal-title":"PLoS One"},{"key":"10.1016\/j.bbamcr.2025.119899_bb0340","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1038\/mp.2017.105","article-title":"GAD1 alternative transcripts and DNA methylation in human prefrontal cortex and hippocampus in brain development, schizophrenia","volume":"23","author":"Tao","year":"2018","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.bbamcr.2025.119899_bb0345","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1001\/jamapsychiatry.2015.49","article-title":"Circuit- and diagnosis-specific DNA methylation changes at \u03b3-aminobutyric acid-related genes in postmortem human Hippocampus in schizophrenia and bipolar disorder","volume":"72","author":"Ruzicka","year":"2015","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.bbamcr.2025.119899_bb0350","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1001\/jamapsychiatry.2013.3730","article-title":"Methylome-wide association study of schizophrenia: identifying blood biomarker signatures of environmental insults","volume":"71","author":"Aberg","year":"2014","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.bbamcr.2025.119899_bb0355","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.jpsychires.2016.12.020","article-title":"Reelin (RELN) DNA methylation in the peripheral blood of schizophrenia","volume":"88","author":"Nabil Fikri","year":"2017","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.bbamcr.2025.119899_bb0360","doi-asserted-by":"crossref","first-page":"12578","DOI":"10.1073\/pnas.0505394102","article-title":"Reelin and glutamic acid decarboxylase67 promoter remodeling in an epigenetic methionine-induced mouse model of schizophrenia","volume":"102","author":"Dong","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbamcr.2025.119899_bb0365","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.biopsych.2004.11.046","article-title":"Valproate corrects the schizophrenia-like epigenetic behavioral modifications induced by methionine in mice","volume":"57","author":"Tremolizzo","year":"2005","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.bbamcr.2025.119899_bb0370","first-page":"72","article-title":"DNA methylation patterns associated with oxidative stress in an ageing population","volume":"9","author":"Hedman","year":"2016","journal-title":"BMC Med. Genet."},{"key":"10.1016\/j.bbamcr.2025.119899_bb0375","doi-asserted-by":"crossref","first-page":"13","DOI":"10.2174\/1389450116666150113121054","article-title":"ROS-mediated DNA methylation pattern alterations in carcinogenesis","volume":"16","author":"Wu","year":"2015","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.bbamcr.2025.119899_bb0380","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1073\/pnas.91.4.1261","article-title":"Free radical adducts induce alterations in DNA cytosine methylation","volume":"91","author":"Weitzman","year":"1994","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbamcr.2025.119899_bb0385","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1593\/neo.07712","article-title":"Oxidative stress modulates DNA methylation during melanocyte anchorage blockade associated with malignant transformation","volume":"9","author":"Campos","year":"2007","journal-title":"Neoplasia"},{"key":"10.1016\/j.bbamcr.2025.119899_bb0390","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1089\/ars.2010.3603","article-title":"Antioxidants, redox signaling, and pathophysiology in schizophrenia: an integrative view","volume":"15","author":"Yao","year":"2011","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.bbamcr.2025.119899_bb0395","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1155\/2006\/248387","article-title":"Altered glutathione redox state in schizophrenia","volume":"22","author":"Yao","year":"2006","journal-title":"Dis. Markers"},{"key":"10.1016\/j.bbamcr.2025.119899_bb0400","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1016\/j.neubiorev.2010.10.008","article-title":"Oxidative stress in schizophrenia: an integrated approach","volume":"35","author":"Bitanihirwe","year":"2011","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.bbamcr.2025.119899_bb0405","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1017\/S1461145710000805","article-title":"Decreased levels of glutathione, the major brain antioxidant, in post-mortem prefrontal cortex from patients with psychiatric disorders","volume":"14","author":"Gawryluk","year":"2011","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.bbamcr.2025.119899_bb0410","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.ccr.2011.09.012","article-title":"Oxidative damage targets complexes containing DNA methyltransferases, SIRT1, and polycomb members to promoter CpG Islands","volume":"20","author":"O'Hagan","year":"2011","journal-title":"Cancer Cell"},{"key":"10.1016\/j.bbamcr.2025.119899_bb0415","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.molcel.2016.12.013","article-title":"Acetylation enhances TET2 function in protecting against abnormal DNA methylation during oxidative stress","volume":"65","author":"Zhang","year":"2017","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bbamcr.2025.119899_bb0420","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1002\/ar.21370","article-title":"Oligodendroglial cells express and secrete reelin","volume":"294","author":"Siebert","year":"2011","journal-title":"Anat. Rec. (Hoboken)"},{"key":"10.1016\/j.bbamcr.2025.119899_bb0425","doi-asserted-by":"crossref","first-page":"3221","DOI":"10.1073\/pnas.95.6.3221","article-title":"Reelin is preferentially expressed in neurons synthesizing gamma-aminobutyric acid in cortex and hippocampus of adult rats","volume":"95","author":"Pesold","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbamcr.2025.119899_bb0430","doi-asserted-by":"crossref","first-page":"3217","DOI":"10.1073\/pnas.96.6.3217","article-title":"Cortical bitufted, horizontal, and Martinotti cells preferentially express and secrete reelin into perineuronal nets, nonsynaptically modulating gene expression","volume":"96","author":"Pesold","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbamcr.2025.119899_bb0435","doi-asserted-by":"crossref","first-page":"7779","DOI":"10.1523\/JNEUROSCI.18-19-07779.1998","article-title":"Regional and cellular patterns of reelin mRNA expression in the forebrain of the developing and adult mouse","volume":"18","author":"Alc\u00e1ntara","year":"1998","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbamcr.2025.119899_bb0440","doi-asserted-by":"crossref","first-page":"3550","DOI":"10.1073\/pnas.97.7.3550","article-title":"Colocalization of integrin receptors and reelin in dendritic spine postsynaptic densities of adult nonhuman primate cortex","volume":"97","author":"Rodriguez","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbamcr.2025.119899_bb0445","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/S0361-9230(01)00718-3","article-title":"Reelin immunoreactivity in the adult neocortex: a comparative study in rodents, carnivores, and non-human primates","volume":"57","author":"Mart\u00ednez-Cerde\u00f1o","year":"2002","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.bbamcr.2025.119899_bb0450","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1093\/cercor\/12.12.1298","article-title":"Reelin immunoreactivity in the adult primate brain: intracellular localization in projecting and local circuit neurons of the cerebral cortex, hippocampus and subcortical regions","volume":"12","author":"Martinez-Cerdeno","year":"2002","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.bbamcr.2025.119899_bb0455","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1111\/j.1460-9568.2005.04567.x","article-title":"Extracellular matrix molecules and synaptic plasticity: immunomapping of intracellular and secreted Reelin in the adult rat brain","volume":"23","author":"Ramos-Moreno","year":"2006","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.bbamcr.2025.119899_bb0460","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.schres.2007.04.014","article-title":"Deficit of perineuronal oligodendrocytes in the prefrontal cortex in schizophrenia and mood disorders","volume":"94","author":"Vostrikov","year":"2007","journal-title":"Schizophr. Res."},{"key":"10.1016\/j.bbamcr.2025.119899_bb0465","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1016\/S0006-3223(03)00237-3","article-title":"Loss and altered spatial distribution of oligodendrocytes in the superior frontal gyrus in schizophrenia","volume":"53","author":"Hof","year":"2003","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.bbamcr.2025.119899_bb0470","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1007\/s00401-008-0430-y","article-title":"Stereologic investigation of the posterior part of the hippocampus in schizophrenia","volume":"117","author":"Schmitt","year":"2009","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.bbamcr.2025.119899_bb0475","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1093\/schbul\/sbv157","article-title":"Decreased oligodendrocyte and neuron number in anterior hippocampal areas and the entire Hippocampus in schizophrenia: a stereological postmortem study","volume":"42","author":"Falkai","year":"2016","journal-title":"Schizophr. Bull."},{"key":"10.1016\/j.bbamcr.2025.119899_bb0480","doi-asserted-by":"crossref","unstructured":"S. Kelly, N. Jahanshad, A. Zalesky, P. Kochunov, I. Agartz, C. Alloza, O.A. Andreassen, C. Arango, N. Banaj, S. Bouix, C.A. Bousman, R.M. Brouwer, J. Bruggemann, J. Bustillo, W. Cahn, V. Calhoun, D. Cannon, V. Carr, S. Catts, J. Chen, J.X. Chen, X. Chen, C. Chiapponi, K.K. Cho, V. Ciullo, A.S. Corvin, B. Crespo-Facorro, V. Cropley, P. De Rossi, C.M. Diaz-Caneja, E.W. Dickie, S. Ehrlich, F.M. Fan, J. Faskowitz, H. Fatouros-Bergman, L. Flyckt, J.M. Ford, J.P. Fouche, M. Fukunaga, M. Gill, D.C. Glahn, R. Gollub, E.D. Goudzwaard, H. Guo, R.E. Gur, R.C. Gur, T.P. Gurholt, R. Hashimoto, S.N. Hatton, F.A. Henskens, D.P. Hibar, I.B. Hickie, L.E. Hong, J. Horacek, F.M. Howells, H.E. Hulshoff Pol, C.L. Hyde, D. Isaev, A. Jablensky, P.R. Jansen, J. Janssen, E.G. J\u00f6nsson, L.A. Jung, R.S. Kahn, Z. Kikinis, K. Liu, P. Klauser, C. Kn\u00f6chel, M. Kubicki, J. Lagopoulos, C. Langen, S. Lawrie, R.K. Lenroot, K.O. Lim, C. Lopez-Jaramillo, A. Lyall, V. Magnotta, R.C.W. Mandl, D.H. Mathalon, R.W. McCarley, S. McCarthy-Jones, C. McDonald, S. McEwen, A. McIntosh, T. Melicher, R.I. Mesholam-Gately, P.T. Michie, B. Mowry, B.A. Mueller, D.T. Newell, P. O'Donnell, V. Oertel-Kn\u00f6chel, L. Oestreich, S.A. Paciga, C. Pantelis, O. Pasternak, G. Pearlson, G.R. Pellicano, A. Pereira, J. Pineda Zapata, F. Piras, S.G. Potkin, A. Preda, P.E. Rasser, D.R. Roalf, R. Roiz, A. Roos, D. Rotenberg, T.D. Satterthwaite, P. Savadjiev, U. Schall, R.J. Scott, M.L. Seal, L.J. Seidman, C. Shannon Weickert, C.D. Whelan, M.E. Shenton, J.S. Kwon, G. Spalletta, F. Spaniel, E. Sprooten, M. St\u00e4blein, D.J. Stein, S. Sundram, Y. Tan, S. Tan, S. Tang, H.S. Temmingh, L.T. Westlye, S. T\u00f8nnesen, D. Tordesillas-Gutierrez, N.T. Doan, J. Vaidya, N.E.M. van Haren, C.D. Vargas, D. Vecchio, D. Velakoulis, A. Voineskos, J.Q. Voyvodic, Z. Wang, P. Wan, D. Wei, T.W. Weickert, H. Whalley, T. White, T.J. Whitford, J.D. Wojcik, H. Xiang, Z. Xie, H. Yamamori, F. Yang, N. Yao, G. Zhang, J. Zhao, T.G.M. van Erp, J. Turner, P.M. Thompson, G. Donohoe, Widespread white matter microstructural differences in schizophrenia across 4322 individuals: results from the ENIGMA Schizophrenia DTI Working Group, Mol. Psychiatry, 23 (2018) 1261\u20131269.","DOI":"10.1038\/mp.2017.170"},{"key":"10.1016\/j.bbamcr.2025.119899_bb0485","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1038\/333562a0","article-title":"Platelet-derived growth factor from astrocytes drives the clock that times oligodendrocyte development in culture","volume":"333","author":"Raff","year":"1988","journal-title":"Nature"},{"key":"10.1016\/j.bbamcr.2025.119899_bb0490","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1002\/glia.22605","article-title":"Astrocyte-specific activation of TNFR2 promotes oligodendrocyte maturation by secretion of leukemia inhibitory factor","volume":"62","author":"Fischer","year":"2014","journal-title":"Glia"},{"key":"10.1016\/j.bbamcr.2025.119899_bb0495","doi-asserted-by":"crossref","first-page":"14002","DOI":"10.1523\/JNEUROSCI.1592-15.2015","article-title":"Astrocytes promote oligodendrogenesis after white matter damage via brain-derived neurotrophic factor","volume":"35","author":"Miyamoto","year":"2015","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbamcr.2025.119899_bb0500","first-page":"305","article-title":"Determination of cleavage site of Reelin between its sixth and seventh repeat and contribution of meprin metalloproteases to the cleavage","volume":"159","author":"Sato","year":"2015","journal-title":"J. Biochem."},{"key":"10.1016\/j.bbamcr.2025.119899_bb0505","doi-asserted-by":"crossref","first-page":"12922","DOI":"10.1074\/jbc.M113.536326","article-title":"Cleavage within Reelin repeat 3 regulates the duration and range of the signaling activity of Reelin protein *","volume":"289","author":"Koie","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamcr.2025.119899_bb0510","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.112669","article-title":"Reelin through the years: from brain development to inflammation","volume":"42","author":"Alexander","year":"2023","journal-title":"Cell Rep."},{"key":"10.1016\/j.bbamcr.2025.119899_bb0515","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2016.00122","article-title":"New insights into Reelin-mediated signaling pathways","volume":"10","author":"Lee","year":"2016","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.bbamcr.2025.119899_bb0520","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1017\/S1461145714000121","article-title":"Corticosterone treatment during adolescence induces down-regulation of reelin and NMDA receptor subunit GLUN2C expression only in male mice: implications for schizophrenia","volume":"17","author":"Buret","year":"2014","journal-title":"Int. J. Neuropsychopharmacol."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167488925000047?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167488925000047?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T09:26:08Z","timestamp":1772357168000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167488925000047"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":104,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["S0167488925000047"],"URL":"https:\/\/doi.org\/10.1016\/j.bbamcr.2025.119899","relation":{},"ISSN":["0167-4889"],"issn-type":[{"value":"0167-4889","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hippocampal reelin and GAD67 gene expression and methylation in the GFAP.HMOX1 mouse model of schizophrenia","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Cell Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbamcr.2025.119899","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"119899"}}