{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T11:35:52Z","timestamp":1787225752916,"version":"build-2736575974"},"reference-count":56,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2022M712268"],"award-info":[{"award-number":["2022M712268"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","award":["CSCF2020B04"],"award-info":[{"award-number":["CSCF2020B04"]}],"id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013365","name":"West China Hospital of Sichuan University","doi-asserted-by":"publisher","award":["ZYGD23021"],"award-info":[{"award-number":["ZYGD23021"]}],"id":[{"id":"10.13039\/501100013365","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013365","name":"West China Hospital of Sichuan University","doi-asserted-by":"publisher","award":["23HXFH009"],"award-info":[{"award-number":["23HXFH009"]}],"id":[{"id":"10.13039\/501100013365","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013365","name":"West China Hospital of Sichuan University","doi-asserted-by":"publisher","award":["2023HXBH130"],"award-info":[{"award-number":["2023HXBH130"]}],"id":[{"id":"10.13039\/501100013365","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U23A20395"],"award-info":[{"award-number":["U23A20395"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170375"],"award-info":[{"award-number":["82170375"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012542","name":"Sichuan Province Science and Technology Support Program","doi-asserted-by":"publisher","award":["2023YFS0296"],"award-info":[{"award-number":["2023YFS0296"]}],"id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012542","name":"Sichuan Province Science and Technology Support Program","doi-asserted-by":"publisher","award":["2023NSFSC1650"],"award-info":[{"award-number":["2023NSFSC1650"]}],"id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012542","name":"Sichuan Province Science and Technology Support Program","doi-asserted-by":"publisher","award":["2023NSFC1645"],"award-info":[{"award-number":["2023NSFC1645"]}],"id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004912","name":"Sichuan University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004912","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016086","name":"Key Laboratory in Science and Technology Development Project of Suzhou","doi-asserted-by":"publisher","award":["2022ZDZX0020"],"award-info":[{"award-number":["2022ZDZX0020"]}],"id":[{"id":"10.13039\/100016086","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Cell Research"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.bbamcr.2025.119911","type":"journal-article","created":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T19:04:25Z","timestamp":1738004665000},"page":"119911","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["MARCH5 ameliorates aortic valve calcification via RACGAP1-DRP1 associated mitochondrial quality control"],"prefix":"10.1016","volume":"1872","author":[{"given":"Jialiang","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaoyu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhua","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanjiani","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhou","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanbiao","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangyang","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbamcr.2025.119911_bb0005","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/s41569-021-00528-1","article-title":"Calcific aortic valve disease: turning therapeutic discovery up a notch","volume":"18","author":"Wang","year":"2021","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.bbamcr.2025.119911_bb0010","doi-asserted-by":"crossref","first-page":"2618","DOI":"10.1093\/eurheartj\/ehx653","article-title":"Calcific aortic valve stenosis: hard disease in the heart: a biomolecular approach towards diagnosis and treatment","volume":"39","author":"Peeters","year":"2018","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.bbamcr.2025.119911_bb0015","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1161\/CIRCRESAHA.120.317979","article-title":"Multi-omics approaches to define calcific aortic valve disease pathogenesis","volume":"128","author":"Blaser","year":"2021","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbamcr.2025.119911_bb0020","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1038\/s41569-023-00845-7","article-title":"Calcific aortic valve disease: mechanisms, prevention and treatment","volume":"20","author":"Moncla","year":"2023","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.bbamcr.2025.119911_bb0025","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1146\/annurev-pathmechdis-012419-032711","article-title":"Mitochondrial dynamics and its involvement in disease","volume":"15","author":"Chan","year":"2020","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.bbamcr.2025.119911_bb0030","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1038\/s42255-023-00783-1","article-title":"Multifaceted mitochondria: moving mitochondrial science beyond function and dysfunction","volume":"5","author":"Monzel","year":"2023","journal-title":"Nat. Metab."},{"key":"10.1016\/j.bbamcr.2025.119911_bb0035","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.611922","article-title":"Mitochondrial dysfunction: cause or consequence of vascular calcification?","volume":"9","author":"Phadwal","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.bbamcr.2025.119911_bb0040","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21144899","article-title":"Aortic valve stenosis and mitochondrial dysfunctions: clinical and molecular perspectives","volume":"21","author":"Pedriali","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbamcr.2025.119911_bb0045","doi-asserted-by":"crossref","first-page":"2548","DOI":"10.1093\/cvr\/cvab267","article-title":"Impairment of mitophagy and autophagy accompanies calcific aortic valve stenosis favouring cell death and the severity of disease","volume":"118","author":"Morciano","year":"2022","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.bbamcr.2025.119911_bb0050","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1161\/CIRCRESAHA.116.310293","article-title":"Dynamin-related protein 1 inhibition attenuates cardiovascular calcification in the presence of oxidative stress","volume":"121","author":"Rogers","year":"2017","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbamcr.2025.119911_bb0055","doi-asserted-by":"crossref","first-page":"3404","DOI":"10.1016\/j.molcel.2023.08.021","article-title":"Mitochondrial degradation: mitophagy and beyond","volume":"83","author":"Uoselis","year":"2023","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bbamcr.2025.119911_bb0060","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1091\/mbc.e15-09-0678","article-title":"Mitochondrial E3 ubiquitin ligase MARCH5 controls mitochondrial fission and cell sensitivity to stress-induced apoptosis through regulation of MiD49 protein","volume":"27","author":"Xu","year":"2016","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.bbamcr.2025.119911_bb0065","doi-asserted-by":"crossref","first-page":"495","DOI":"10.15252\/embr.201643309","article-title":"Mitochondrial E3 ligase MARCH5 regulates FUNDC1 to fine-tune hypoxic mitophagy","volume":"18","author":"Chen","year":"2017","journal-title":"EMBO Rep."},{"key":"10.1016\/j.bbamcr.2025.119911_bb0070","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1093\/jb\/mvu016","article-title":"Roles of mitochondrial ubiquitin ligase MITOL\/MARCH5 in mitochondrial dynamics and diseases","volume":"155","author":"Nagashima","year":"2014","journal-title":"J. Biochem."},{"key":"10.1016\/j.bbamcr.2025.119911_bb0075","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1111\/febs.13568","article-title":"Self-clearance mechanism of mitochondrial E3 ligase MARCH5 contributes to mitochondria quality control","volume":"283","author":"Kim","year":"2016","journal-title":"FEBS J."},{"key":"10.1016\/j.bbamcr.2025.119911_bb0080","doi-asserted-by":"crossref","first-page":"7112","DOI":"10.1038\/ncomms8112","article-title":"Mitochondrial E3 ligase March5 maintains stemness of mouse ES cells via suppression of ERK signalling","volume":"6","author":"Gu","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbamcr.2025.119911_bb0085","doi-asserted-by":"crossref","first-page":"7910","DOI":"10.1038\/ncomms8910","article-title":"The mitochondrial ubiquitin ligase MARCH5 resolves MAVS aggregates during antiviral signalling","volume":"6","author":"Yoo","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbamcr.2025.119911_bb0090","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1242\/jcs.061481","article-title":"Loss of MARCH5 mitochondrial E3 ubiquitin ligase induces cellular senescence through dynamin-related protein 1 and mitofusin 1","volume":"123","author":"Park","year":"2010","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.bbamcr.2025.119911_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2022.104582","article-title":"Protective roles of MITOL against myocardial senescence and ischemic injury partly via Drp1 regulation","volume":"25","author":"Tokuyama","year":"2022","journal-title":"Iscience"},{"key":"10.1016\/j.bbamcr.2025.119911_bb0100","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1080\/15548627.2017.1310789","article-title":"MARCH5-FUNDC1 axis fine-tunes hypoxia-induced mitophagy","volume":"13","author":"Chen","year":"2017","journal-title":"Autophagy"},{"key":"10.1016\/j.bbamcr.2025.119911_bb0105","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21113781","article-title":"Overview of mitochondrial E3 ubiquitin ligase MITOL\/MARCH5 from molecular mechanisms to diseases","volume":"21","author":"Shiiba","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbamcr.2025.119911_bb0110","doi-asserted-by":"crossref","first-page":"3618","DOI":"10.1038\/sj.emboj.7601249","article-title":"A novel mitochondrial ubiquitin ligase plays a critical role in mitochondrial dynamics","volume":"25","author":"Yonashiro","year":"2006","journal-title":"EMBO J."},{"key":"10.1016\/j.bbamcr.2025.119911_bb0115","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1038\/sj.embor.7400790","article-title":"MARCH-V is a novel mitofusin 2- and Drp1-binding protein able to change mitochondrial morphology","volume":"7","author":"Nakamura","year":"2006","journal-title":"EMBO Rep."},{"key":"10.1016\/j.bbamcr.2025.119911_bb0120","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1083\/jcb.200611064","article-title":"The mitochondrial E3 ubiquitin ligase MARCH5 is required for Drp1 dependent mitochondrial division","volume":"178","author":"Karbowski","year":"2007","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.bbamcr.2025.119911_bb0125","doi-asserted-by":"crossref","first-page":"2935","DOI":"10.1093\/eurheartj\/ehab316","article-title":"DUSP26 induces aortic valve calcification by antagonizing MDM2-mediated ubiquitination of DPP4 in human valvular interstitial cells","volume":"42","author":"Wang","year":"2021","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.bbamcr.2025.119911_bb0130","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1161\/CIRCULATIONAHA.122.063481","article-title":"Toll-like receptor 3 mediates aortic stenosis through a conserved mechanism of calcification","volume":"147","author":"Gollmann-Tepekoylu","year":"2023","journal-title":"Circulation"},{"key":"10.1016\/j.bbamcr.2025.119911_bb0135","doi-asserted-by":"crossref","first-page":"e0277981","DOI":"10.1371\/journal.pone.0277981","article-title":"Comparison of measured LDL cholesterol with calculated LDL-cholesterol using the Friedewald and Martin-Hopkins formulae in diabetic adults at Charlotte Maxeke Johannesburg Academic Hospital\/NHLS Laboratory","volume":"17","author":"Dintshi","year":"2022","journal-title":"PLoS One"},{"key":"10.1016\/j.bbamcr.2025.119911_bb0140","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1038\/s41594-024-01350-2","article-title":"AlphaFold3 takes a step toward decoding molecular behavior and biological computation","volume":"31","author":"Roy","year":"2024","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.bbamcr.2025.119911_bb0145","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.jacbts.2019.10.004","article-title":"Celastrol alleviates aortic valve calcification via inhibition of NADPH oxidase 2 in valvular interstitial cells","volume":"5","author":"Liu","year":"2020","journal-title":"JACC Basic Transl. Sci."},{"key":"10.1016\/j.bbamcr.2025.119911_bb0150","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1093\/cvr\/cvab142","article-title":"Role of oxidative stress in calcific aortic valve disease and its therapeutic implications","volume":"118","author":"Greenberg","year":"2022","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.bbamcr.2025.119911_bb0155","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1186\/s12964-024-01703-w","article-title":"Reciprocal regulation between RACGAP1 and AR contributes to endocrine therapy resistance in prostate cancer","volume":"22","author":"Wang","year":"2024","journal-title":"Cell Commun. Signal"},{"key":"10.1016\/j.bbamcr.2025.119911_bb0160","doi-asserted-by":"crossref","first-page":"107250","DOI":"10.1016\/j.phrs.2024.107250","article-title":"Role of dynamin-related protein 1-dependent mitochondrial fission in drug-induced toxicity","volume":"206","author":"Li","year":"2024","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.bbamcr.2025.119911_bb0165","doi-asserted-by":"crossref","first-page":"112493","DOI":"10.1016\/j.yexcr.2021.112493","article-title":"RACGAP1 modulates ECT2-dependent mitochondrial quality control to drive breast cancer metastasis","volume":"400","author":"Ren","year":"2021","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.bbamcr.2025.119911_bb0170","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241311105","article-title":"The complex relationship between hypoxia signaling, mitochondrial dysfunction and inflammation in calcific aortic valve disease: insights from the molecular mechanisms to therapeutic approaches","volume":"24","author":"Bouhamida","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbamcr.2025.119911_bb0175","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1161\/CIRCRESAHA.116.310293","article-title":"Dynamin-related protein 1 inhibition attenuates cardiovascular calcification in the presence of oxidative stress","volume":"121","author":"Rogers","year":"2017","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbamcr.2025.119911_bb0180","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.257808","article-title":"MITOL-mediated DRP1 ubiquitylation and degradation promotes mitochondrial hyperfusion in a CMT2A-linked MFN2 mutant","volume":"135","author":"Das","year":"2022","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.bbamcr.2025.119911_bb0185","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1242\/jcs.061481","article-title":"Loss of MARCH5 mitochondrial E3 ubiquitin ligase induces cellular senescence through dynamin-related protein 1 and mitofusin 1","volume":"123","author":"Park","year":"2010","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.bbamcr.2025.119911_bb0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.117084","article-title":"New insights into the role of mitochondrial dynamics in oxidative stress-induced diseases","volume":"178","author":"Chen","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.bbamcr.2025.119911_bb0195","doi-asserted-by":"crossref","first-page":"103269","DOI":"10.1016\/j.redox.2024.103269","article-title":"Oxidative stress and the multifaceted roles of ATM in maintaining cellular redox homeostasis","volume":"75","author":"Lee","year":"2024","journal-title":"Redox Biol."},{"key":"10.1016\/j.bbamcr.2025.119911_bb0200","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1186\/s12916-023-02888-6","article-title":"Targeted inhibition of PTPN22 is a novel approach to alleviate osteogenic responses in aortic valve interstitial cells and aortic valve lesions in mice","volume":"21","author":"Li","year":"2023","journal-title":"BMC Med."},{"key":"10.1016\/j.bbamcr.2025.119911_bb0205","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1186\/s12916-024-03342-x","article-title":"Autotaxin inhibition attenuates the aortic valve calcification by suppressing inflammation-driven fibro-calcific remodeling of valvular interstitial cells","volume":"22","author":"Yoon","year":"2024","journal-title":"BMC Med."},{"key":"10.1016\/j.bbamcr.2025.119911_bb0210","article-title":"HDL-C role in acquired aortic valve stenosis patients and its relationship with oxidative stress","volume":"55","author":"Hofmanis","year":"2019","journal-title":"Medicina (Kaunas)"},{"key":"10.1016\/j.bbamcr.2025.119911_bb0215","doi-asserted-by":"crossref","first-page":"104582","DOI":"10.1016\/j.isci.2022.104582","article-title":"Protective roles of MITOL against myocardial senescence and ischemic injury partly via Drp1 regulation","volume":"25","author":"Tokuyama","year":"2022","journal-title":"iScience"},{"key":"10.1016\/j.bbamcr.2025.119911_bb0220","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1001\/jamacardio.2019.3903","article-title":"Association of low-density lipoprotein cholesterol with risk of aortic valve stenosis in familial hypercholesterolemia","volume":"4","author":"Mundal","year":"2019","journal-title":"JAMA Cardiol."},{"key":"10.1016\/j.bbamcr.2025.119911_bb0225","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1161\/CIRCULATIONAHA.124.070982","article-title":"Rare genetic variants in LDLR, APOB, and PCSK9 are associated with aortic stenosis","volume":"150","author":"Ramo","year":"2024","journal-title":"Circulation"},{"key":"10.1016\/j.bbamcr.2025.119911_bb0230","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.jacbts.2022.03.002","article-title":"PTP1B inhibition improves mitochondrial dynamics to alleviate calcific aortic valve disease via regulating OPA1 homeostasis","volume":"7","author":"Liu","year":"2022","journal-title":"JACC Basic Transl. Sci."},{"key":"10.1016\/j.bbamcr.2025.119911_bb0235","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/s10495-020-01592-7","article-title":"Lactate accelerates vascular calcification through NR4A1-regulated mitochondrial fission and BNIP3-related mitophagy","volume":"25","author":"Zhu","year":"2020","journal-title":"Apoptosis"},{"key":"10.1016\/j.bbamcr.2025.119911_bb0240","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1038\/s41401-020-00518-y","article-title":"Drp1-dependent mitochondrial fission in cardiovascular disease","volume":"42","author":"Jin","year":"2021","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.bbamcr.2025.119911_bb0245","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1038\/s41569-022-00703-y","article-title":"The role of mitochondrial fission in cardiovascular health and disease","volume":"19","author":"Quiles","year":"2022","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.bbamcr.2025.119911_bb0250","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1038\/s41419-024-07015-8","article-title":"Drp1 depletion protects against ferroptotic cell death by preserving mitochondrial integrity and redox homeostasis","volume":"15","author":"Tang","year":"2024","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bbamcr.2025.119911_bb0255","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.yjmcc.2020.04.015","article-title":"The role of Drp1 in mitophagy and cell death in the heart","volume":"142","author":"Tong","year":"2020","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.bbamcr.2025.119911_bb0260","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.7150\/ijbs.58857","article-title":"Rac GTPase activating protein 1 promotes gallbladder cancer via binding DNA ligase 3 to reduce apoptosis","volume":"17","author":"Bian","year":"2021","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.bbamcr.2025.119911_bb0265","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.180582","article-title":"Targeting DRP1 with Mdivi-1 to correct mitochondrial abnormalities in ADOA+ syndrome","volume":"9","author":"Lin","year":"2024","journal-title":"JCI Insight"},{"key":"10.1016\/j.bbamcr.2025.119911_bb0270","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1161\/CIRCULATIONAHA.123.065213","article-title":"AVCAPIR: a novel procalcific PIWI-interacting RNA in calcific aortic valve disease","volume":"149","author":"Han","year":"2024","journal-title":"Circulation"},{"key":"10.1016\/j.bbamcr.2025.119911_bb0275","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/s41467-024-44726-0","article-title":"Enhancing aortic valve drug delivery with PAR2-targeting magnetic nano-cargoes for calcification alleviation","volume":"15","author":"Chen","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbamcr.2025.119911_bb0280","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1093\/eurheartj\/ehac818","article-title":"Sortilin enhances fibrosis and calcification in aortic valve disease by inducing interstitial cell heterogeneity","volume":"44","author":"Iqbal","year":"2023","journal-title":"Eur. Heart J."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167488925000163?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167488925000163?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T09:27:08Z","timestamp":1772357228000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167488925000163"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":56,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["S0167488925000163"],"URL":"https:\/\/doi.org\/10.1016\/j.bbamcr.2025.119911","relation":{},"ISSN":["0167-4889"],"issn-type":[{"value":"0167-4889","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"MARCH5 ameliorates aortic valve calcification via RACGAP1-DRP1 associated mitochondrial quality control","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Cell Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbamcr.2025.119911","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"119911"}}