{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T15:36:43Z","timestamp":1776440203187,"version":"3.51.2"},"reference-count":56,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100019978","name":"Shanghai Pudong New Area Health Commission","doi-asserted-by":"publisher","award":["PW2023D-12"],"award-info":[{"award-number":["PW2023D-12"]}],"id":[{"id":"10.13039\/501100019978","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Cell Research"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.bbamcr.2025.119933","type":"journal-article","created":{"date-parts":[[2025,3,15]],"date-time":"2025-03-15T03:32:51Z","timestamp":1742009571000},"page":"119933","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Transcription factor EP300 targets SIRT5 to promote autophagy of nucleus pulposus cells and attenuate intervertebral disc degeneration"],"prefix":"10.1016","volume":"1872","author":[{"given":"Xiao-wei","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shan-shan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao-wei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dian-kai","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shan-jin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"18","key":"10.1016\/j.bbamcr.2025.119933_bb0005","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1056\/NEJMcp1512658","article-title":"Clinical practice. Herniated lumbar intervertebral disk","volume":"374","author":"Deyo","year":"2016","journal-title":"N. Engl. J. Med."},{"issue":"10137","key":"10.1016\/j.bbamcr.2025.119933_bb0010","doi-asserted-by":"crossref","first-page":"2356","DOI":"10.1016\/S0140-6736(18)30480-X","article-title":"What low back pain is and why we need to pay attention","volume":"391","author":"Hartvigsen","year":"2018","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.bbamcr.2025.119933_bb0015","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1038\/s41572-018-0052-1","article-title":"Low back pain","volume":"4","author":"Vlaeyen","year":"2018","journal-title":"Nat. Rev. Dis. Primers."},{"issue":"9178","key":"10.1016\/j.bbamcr.2025.119933_bb0020","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/S0140-6736(99)01312-4","article-title":"Epidemiological features of chronic low-back pain","volume":"354","author":"Andersson","year":"1999","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.bbamcr.2025.119933_bb0025","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.spinee.2007.10.005","article-title":"A systematic review of low back pain cost of illness studies in the United States and internationally","volume":"8","author":"Dagenais","year":"2008","journal-title":"Spine J."},{"key":"10.1016\/j.bbamcr.2025.119933_bb0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.114711","article-title":"Cellular senescence - molecular mechanisms of intervertebral disc degeneration from an immune perspective","volume":"162","author":"Song","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.bbamcr.2025.119933_bb0035","article-title":"Aging, cell senescence, the pathogenesis and targeted therapies of intervertebral disc degeneration","volume":"14","author":"Xu","year":"2023","journal-title":"Front. Pharmacol."},{"issue":"1","key":"10.1016\/j.bbamcr.2025.119933_bb0040","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s10020-024-00811-0","article-title":"Sirtuins in intervertebral disc degeneration: current understanding","volume":"30","author":"Shen","year":"2024","journal-title":"Mol. Med."},{"key":"10.1016\/j.bbamcr.2025.119933_bb0045","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2022.1052878","article-title":"The role of ageing and oxidative stress in intervertebral disc degeneration","volume":"9","author":"Wen","year":"2022","journal-title":"Front. Mol. Biosci."},{"issue":"1","key":"10.1016\/j.bbamcr.2025.119933_bb0050","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.neuron.2024.09.015","article-title":"Autophagy, aging, and age-related neurodegeneration","volume":"113","author":"Palmer","year":"2025","journal-title":"Neuron"},{"issue":"1","key":"10.1016\/j.bbamcr.2025.119933_bb0055","doi-asserted-by":"crossref","DOI":"10.1002\/jimd.12798","article-title":"An update on autophagy disorders","volume":"48","author":"Dafsari","year":"2025","journal-title":"J. Inherit. Metab. Dis."},{"issue":"1","key":"10.1016\/j.bbamcr.2025.119933_bb0060","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1186\/s12974-022-02602-y","article-title":"Emerging role of STING signalling in CNS injury: inflammation, autophagy, necroptosis, ferroptosis and pyroptosis","volume":"19","author":"Hu","year":"2022","journal-title":"J. Neuroinflammation"},{"issue":"9","key":"10.1016\/j.bbamcr.2025.119933_bb0065","doi-asserted-by":"crossref","first-page":"2082","DOI":"10.1080\/15548627.2020.1822097","article-title":"Mitophagy in degenerative joint diseases","volume":"17","author":"Sun","year":"2021","journal-title":"Autophagy"},{"issue":"9","key":"10.1016\/j.bbamcr.2025.119933_bb0070","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1038\/nrd.2018.109","article-title":"Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing","volume":"17","author":"Boland","year":"2018","journal-title":"Nat. Rev. Drug Discov."},{"issue":"2","key":"10.1016\/j.bbamcr.2025.119933_bb0075","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.molcel.2010.09.023","article-title":"Autophagy and the integrated stress response","volume":"40","author":"Kroemer","year":"2010","journal-title":"Mol. Cell"},{"issue":"11","key":"10.1016\/j.bbamcr.2025.119933_bb0080","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1097\/BRS.0000000000000865","article-title":"Autophagy in the degenerating human intervertebral disc: in vivo molecular and morphological evidence, and induction of autophagy in cultured annulus cells exposed to Proinflammatory cytokines-implications for disc degeneration","volume":"40","author":"Gruber","year":"2015","journal-title":"Spine (Phila Pa 1976)."},{"issue":"6","key":"10.1016\/j.bbamcr.2025.119933_bb0085","doi-asserted-by":"crossref","first-page":"472","DOI":"10.3109\/03008207.2011.564336","article-title":"Age-related increases of macroautophagy and chaperone-mediated autophagy in rat nucleus pulposus","volume":"52","author":"Ye","year":"2011","journal-title":"Connect. Tissue Res."},{"issue":"5","key":"10.1016\/j.bbamcr.2025.119933_bb0090","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/j.cell.2011.07.030","article-title":"Autophagy and aging","volume":"146","author":"Rubinsztein","year":"2011","journal-title":"Cell"},{"issue":"12","key":"10.1016\/j.bbamcr.2025.119933_bb0095","doi-asserted-by":"crossref","first-page":"2134","DOI":"10.1016\/j.joca.2017.08.019","article-title":"Selective interference of mTORC1\/RAPTOR protects against human disc cellular apoptosis, senescence, and extracellular matrix catabolism with Akt and autophagy induction","volume":"25","author":"Ito","year":"2017","journal-title":"Osteoarthr. Cartil."},{"issue":"6","key":"10.1016\/j.bbamcr.2025.119933_bb0100","doi-asserted-by":"crossref","first-page":"1936","DOI":"10.1007\/s11999-014-3497-x","article-title":"Spontaneous age-related cervical disc degeneration in the sand rat","volume":"472","author":"Gruber","year":"2014","journal-title":"Clin. Orthop. Relat. Res."},{"key":"10.1016\/j.bbamcr.2025.119933_bb0105","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.matbio.2020.12.002","article-title":"Role of autophagy in intervertebral disc and cartilage function: implications in health and disease","volume":"100-101","author":"Madhu","year":"2021","journal-title":"Matrix Biol."},{"issue":"5","key":"10.1016\/j.bbamcr.2025.119933_bb0110","doi-asserted-by":"crossref","first-page":"543","DOI":"10.4184\/asj.2014.8.5.543","article-title":"High glucose accelerates autophagy in adult rat intervertebral disc cells","volume":"8","author":"Kong","year":"2014","journal-title":"Asian Spine J."},{"issue":"1","key":"10.1016\/j.bbamcr.2025.119933_bb0115","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1002\/jor.23634","article-title":"Age-related spontaneous lumbar intervertebral disc degeneration in a mouse model","volume":"36","author":"Ohnishi","year":"2018","journal-title":"J. Orthop. Res."},{"issue":"9","key":"10.1016\/j.bbamcr.2025.119933_bb0120","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1080\/15548627.2016.1192753","article-title":"Hypoxia promotes noncanonical autophagy in nucleus pulposus cells independent of MTOR and HIF1A signaling","volume":"12","author":"Choi","year":"2016","journal-title":"Autophagy"},{"issue":"2","key":"10.1016\/j.bbamcr.2025.119933_bb0125","doi-asserted-by":"crossref","first-page":"R47","DOI":"10.1186\/ar2660","article-title":"Asporin, a susceptibility gene in osteoarthritis, is expressed at higher levels in the more degenerate human intervertebral disc","volume":"11","author":"Gruber","year":"2009","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.bbamcr.2025.119933_bb0130","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s13072-016-0082-4","article-title":"GAGA factor, a positive regulator of global gene expression, modulates transcriptional pausing and organization of upstream nucleosomes","volume":"9","author":"Tsai","year":"2016","journal-title":"Epigenetics Chromatin"},{"issue":"3","key":"10.1016\/j.bbamcr.2025.119933_bb0135","article-title":"clusterProfiler 4.0: a universal enrichment tool for interpreting omics data","volume":"2","author":"Wu","year":"2021","journal-title":"Innovation (Camb)."},{"key":"10.1016\/j.bbamcr.2025.119933_bb0140","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1186\/1471-2105-9-559","article-title":"WGCNA: an R package for weighted correlation network analysis","volume":"9","author":"Langfelder","year":"2008","journal-title":"BMC Bioinformatics."},{"issue":"3","key":"10.1016\/j.bbamcr.2025.119933_bb0145","volume":"1","author":"Shen","year":"2022","journal-title":"Sangerbox: A comprehensive, interaction-friendly clinical bioinformatics analysis platform. iMeta."},{"issue":"3","key":"10.1016\/j.bbamcr.2025.119933_bb0150","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1590\/1414-431X20122429","article-title":"Experimental model of intervertebral disc degeneration by needle puncture in Wistar rats","volume":"46","author":"Issy","year":"2013","journal-title":"Braz. J. Med. Biol. Res."},{"issue":"1","key":"10.1016\/j.bbamcr.2025.119933_bb0155","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1002\/jor.23637","article-title":"Histological and reference system for the analysis of mouse intervertebral disc","volume":"36","author":"Tam","year":"2018","journal-title":"J. Orthop. Res."},{"issue":"8","key":"10.1016\/j.bbamcr.2025.119933_bb0160","doi-asserted-by":"crossref","first-page":"2252","DOI":"10.7150\/thno.30658","article-title":"Progerin accumulation in nucleus pulposus cells impairs mitochondrial function and induces intervertebral disc degeneration and therapeutic effects of sulforaphane","volume":"9","author":"Xu","year":"2019","journal-title":"Theranostics"},{"issue":"5","key":"10.1016\/j.bbamcr.2025.119933_bb0165","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1053\/j.gastro.2021.06.045","article-title":"Metabolic rewiring by loss of Sirt5 promotes Kras-induced pancreatic Cancer progression","volume":"161","author":"Hu","year":"2021","journal-title":"Gastroenterology"},{"issue":"17","key":"10.1016\/j.bbamcr.2025.119933_bb0170","doi-asserted-by":"crossref","first-page":"4527","DOI":"10.1021\/jp067655s","article-title":"Activation of p300 histone acetyltransferase by small molecules altering enzyme structure: probed by surface-enhanced Raman spectroscopy","volume":"111","author":"Mantelingu","year":"2007","journal-title":"J. Phys. Chem. B"},{"issue":"1","key":"10.1016\/j.bbamcr.2025.119933_bb0175","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/15548627.2020.1797280","article-title":"Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)(1)","volume":"17","author":"Klionsky","year":"2021","journal-title":"Autophagy"},{"issue":"2","key":"10.1016\/j.bbamcr.2025.119933_bb0180","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1038\/s41419-022-04635-w","article-title":"PCLAF promotes neuroblastoma G1\/S cell cycle progression via the E2F1\/PTTG1 axis","volume":"13","author":"Liu","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bbamcr.2025.119933_bb0185","article-title":"JASPAR, the open access database of transcription factor-binding profiles: new content and tools in the 2008 update","volume":"36(Database issue):D102-6","author":"Bryne","year":"2008","journal-title":"Nucleic Acids Res."},{"issue":"12","key":"10.1016\/j.bbamcr.2025.119933_bb0190","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.261028","article-title":"Emerging roles of p300\/CBP in autophagy and autophagy-related human disorders","volume":"136","author":"Xu","year":"2023","journal-title":"J. Cell Sci."},{"issue":"5","key":"10.1016\/j.bbamcr.2025.119933_bb0195","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/j.molcel.2014.01.016","article-title":"Regulation of autophagy by cytosolic acetyl-coenzyme a","volume":"53","author":"Marino","year":"2014","journal-title":"Mol. Cell"},{"issue":"3","key":"10.1016\/j.bbamcr.2025.119933_bb0200","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s12276-019-0225-3","article-title":"Spermidine restores dysregulated autophagy and polyamine synthesis in aged and osteoarthritic chondrocytes via EP300: response to correspondence by Borzi et al","volume":"51","author":"Sacitharan","year":"2019","journal-title":"Exp. Mol. Med."},{"issue":"3","key":"10.1016\/j.bbamcr.2025.119933_bb0205","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1038\/cdd.2014.215","article-title":"Spermidine induces autophagy by inhibiting the acetyltransferase EP300","volume":"22","author":"Pietrocola","year":"2015","journal-title":"Cell Death Differ."},{"issue":"5","key":"10.1016\/j.bbamcr.2025.119933_bb0210","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1002\/ptr.8057","article-title":"Fucoxanthin ameliorates endoplasmic reticulum stress and inhibits apoptosis and alleviates intervertebral disc degeneration in rats by upregulating Sirt1","volume":"38","author":"Teng","year":"2024","journal-title":"Phytother. Res."},{"key":"10.1016\/j.bbamcr.2025.119933_bb0215","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.jot.2024.11.008","article-title":"Sirt1 blocks nucleus pulposus and macrophages crosstalk by inhibiting RelA\/Lipocalin 2 axis","volume":"50","author":"Wei","year":"2025","journal-title":"J Orthop Translat."},{"issue":"1","key":"10.1016\/j.bbamcr.2025.119933_bb0220","doi-asserted-by":"crossref","first-page":"27","DOI":"10.7150\/thno.48987","article-title":"Small molecule-based treatment approaches for intervertebral disc degeneration: current options and future directions","volume":"11","author":"Kamali","year":"2021","journal-title":"Theranostics"},{"issue":"4","key":"10.1016\/j.bbamcr.2025.119933_bb0225","doi-asserted-by":"crossref","DOI":"10.3390\/biom13040686","article-title":"Cellular senescence in intervertebral disc aging and degeneration: molecular mechanisms and potential therapeutic opportunities","volume":"13","author":"Silwal","year":"2023","journal-title":"Biomolecules"},{"issue":"9","key":"10.1016\/j.bbamcr.2025.119933_bb0230","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1007\/s00011-023-01784-2","article-title":"Intervertebral disc degeneration and inflammatory microenvironment: expression, pathology, and therapeutic strategies","volume":"72","author":"Chen","year":"2023","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.bbamcr.2025.119933_bb0235","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2021.101394","article-title":"The potential role of melatonin in retarding intervertebral disc ageing and degeneration: a systematic review","volume":"70","author":"Cheng","year":"2021","journal-title":"Ageing Res. Rev."},{"issue":"9","key":"10.1016\/j.bbamcr.2025.119933_bb0240","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.13448","article-title":"Oxidative stress in intervertebral disc degeneration: molecular mechanisms, pathogenesis and treatment","volume":"56","author":"Wang","year":"2023","journal-title":"Cell Prolif."},{"issue":"2","key":"10.1016\/j.bbamcr.2025.119933_bb0245","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1002\/jcp.30631","article-title":"Role of autophagy in intervertebral disc degeneration","volume":"237","author":"Kritschil","year":"2022","journal-title":"J. Cell. Physiol."},{"issue":"8","key":"10.1016\/j.bbamcr.2025.119933_bb0250","article-title":"Targeting autophagy for developing new therapeutic strategy in intervertebral disc degeneration","volume":"11","author":"Bahar","year":"2022","journal-title":"Antioxidants (Basel)."},{"issue":"9","key":"10.1016\/j.bbamcr.2025.119933_bb0255","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s12276-018-0149-3","article-title":"Spermidine restores dysregulated autophagy and polyamine synthesis in aged and osteoarthritic chondrocytes via EP300","volume":"50","author":"Sacitharan","year":"2018","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.bbamcr.2025.119933_bb0260","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.cca.2020.04.016","article-title":"Sirtuins and intervertebral disc degeneration: roles in inflammation, oxidative stress, and mitochondrial function","volume":"508","author":"Zhang","year":"2020","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.bbamcr.2025.119933_bb0265","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.atherosclerosis.2017.08.027","article-title":"The sirtuin family members SIRT1, SIRT3 and SIRT6: their role in vascular biology and atherogenesis","volume":"265","author":"Sosnowska","year":"2017","journal-title":"Atherosclerosis"},{"issue":"5","key":"10.1016\/j.bbamcr.2025.119933_bb0270","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20190112","article-title":"The resistant effect of SIRT1 in oxidative stress-induced senescence of rat nucleus pulposus cell is regulated by Akt-FoxO1 pathway","volume":"39","author":"He","year":"2019","journal-title":"Biosci. Rep."},{"issue":"9","key":"10.1016\/j.bbamcr.2025.119933_bb0275","doi-asserted-by":"crossref","first-page":"E515","DOI":"10.1097\/BRS.0000000000000817","article-title":"SIRT1 plays a protective role in intervertebral disc degeneration in a puncture-induced rodent model","volume":"40","author":"Xia","year":"2015","journal-title":"Spine (Phila Pa 1976)"},{"issue":"1","key":"10.1016\/j.bbamcr.2025.119933_bb0280","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1038\/s12276-023-00928-y","article-title":"SIRT5-related desuccinylation modification of AIFM1 protects against compression-induced intervertebral disc degeneration by regulating mitochondrial homeostasis","volume":"55","author":"Mao","year":"2023","journal-title":"Exp. Mol. Med."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167488925000382?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167488925000382?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T10:53:32Z","timestamp":1762253612000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167488925000382"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":56,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["S0167488925000382"],"URL":"https:\/\/doi.org\/10.1016\/j.bbamcr.2025.119933","relation":{},"ISSN":["0167-4889"],"issn-type":[{"value":"0167-4889","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Transcription factor EP300 targets SIRT5 to promote autophagy of nucleus pulposus cells and attenuate intervertebral disc degeneration","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Cell Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbamcr.2025.119933","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"119933"}}