{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T04:29:17Z","timestamp":1788323357273,"version":"build-2803163510"},"reference-count":42,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82203670"],"award-info":[{"award-number":["82203670"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Cell Research"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.bbamcr.2025.119989","type":"journal-article","created":{"date-parts":[[2025,5,11]],"date-time":"2025-05-11T18:32:28Z","timestamp":1746988348000},"page":"119989","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Salinomycin inhibits SREBP1 to sensitize ferroptosis and ameliorate sorafenib resistance in clear cell renal cell carcinoma"],"prefix":"10.1016","volume":"1872","author":[{"given":"Yu","family":"Su","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dekun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Mi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shijing","family":"Yue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhujun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyu","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyue","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.bbamcr.2025.119989_bb0005","first-page":"209","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. Clin."},{"issue":"3","key":"10.1016\/j.bbamcr.2025.119989_bb0010","article-title":"Renal cell carcinoma: an overview of the epidemiology, diagnosis, and treatment","volume":"39","author":"Bahadoram","year":"2022","journal-title":"G. Ital. Nefrol."},{"issue":"2","key":"10.1016\/j.bbamcr.2025.119989_bb0015","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1080\/14737140.2019.1559058","article-title":"Sorafenib: key lessons from over 10 years of experience","volume":"19","author":"Escudier","year":"2019","journal-title":"Expert. Rev. Anticancer. Ther."},{"issue":"5","key":"10.1016\/j.bbamcr.2025.119989_bb0020","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/s41571-020-00462-0","article-title":"Broadening horizons: the role of ferroptosis in cancer","volume":"18","author":"Chen","year":"2021","journal-title":"Nat. Rev. Clin. Oncol."},{"issue":"2","key":"10.1016\/j.bbamcr.2025.119989_bb0025","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1002\/hep.28574","article-title":"Metallothionein-1G facilitates sorafenib resistance through inhibition of ferroptosis","volume":"64","author":"Sun","year":"2016","journal-title":"Hepatology"},{"issue":"23","key":"10.1016\/j.bbamcr.2025.119989_bb0030","doi-asserted-by":"crossref","first-page":"3940","DOI":"10.1158\/0008-5472.CAN-22-4001","article-title":"DPP9 stabilizes NRF2 to suppress ferroptosis and induce sorafenib resistance in clear cell renal cell carcinoma","volume":"83","author":"Chang","year":"2023","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbamcr.2025.119989_bb0035","doi-asserted-by":"crossref","DOI":"10.1038\/srep28932","article-title":"Lipidomic signatures and associated transcriptomic profiles of clear cell renal cell carcinoma","volume":"6","author":"Saito","year":"2016","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.bbamcr.2025.119989_bb0040","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/s41585-022-00654-6","article-title":"Fatty acid metabolism reprogramming in ccRCC: mechanisms and potential targets","volume":"20","author":"Tan","year":"2023","journal-title":"Nat. Rev. Urol."},{"issue":"1","key":"10.1016\/j.bbamcr.2025.119989_bb0045","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1038\/s41420-024-01944-1","article-title":"MED15 is upregulated by HIF-2alpha and promotes proliferation and metastasis in clear cell renal cell carcinoma via activation of SREBP-dependent fatty acid synthesis","volume":"10","author":"Hua","year":"2024","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.bbamcr.2025.119989_bb0050","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1038\/s41467-017-01965-8","article-title":"HIF drives lipid deposition and cancer in ccRCC via repression of fatty acid metabolism","volume":"8","author":"Du","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbamcr.2025.119989_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2023.110838","article-title":"CPT2-mediated fatty acid oxidation inhibits tumorigenesis and enhances sorafenib sensitivity via the ROS\/PPARgamma\/NF-kappaB pathway in clear cell renal cell carcinoma","volume":"110","author":"Zeng","year":"2023","journal-title":"Cell. Signal."},{"key":"10.1016\/j.bbamcr.2025.119989_bb0060","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.ejmech.2018.12.057","article-title":"A medicinal chemistry perspective on salinomycin as a potent anticancer and anti-CSCs agent","volume":"164","author":"Antoszczak","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bbamcr.2025.119989_bb0065","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.ejmech.2019.01.034","article-title":"A comprehensive review of salinomycin derivatives as potent anticancer and anti-CSCs agents","volume":"166","author":"Antoszczak","year":"2019","journal-title":"Eur. J. Med. Chem."},{"issue":"3","key":"10.1016\/j.bbamcr.2025.119989_bb0070","doi-asserted-by":"crossref","DOI":"10.1177\/1010428317695035","article-title":"Salinomycin: a new paradigm in cancer therapy","volume":"39","author":"Dewangan","year":"2017","journal-title":"Tumour Biol."},{"key":"10.1016\/j.bbamcr.2025.119989_bb0075","article-title":"Anticancer mechanisms of salinomycin in breast cancer and its clinical applications","volume":"11","author":"Wang","year":"2021","journal-title":"Front. Oncol."},{"issue":"3","key":"10.1016\/j.bbamcr.2025.119989_bb0080","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/s41419-023-05719-x","article-title":"PDIA4 confers resistance to ferroptosis via induction of ATF4\/SLC7A11 in renal cell carcinoma","volume":"14","author":"Kang","year":"2023","journal-title":"Cell Death Dis."},{"issue":"48","key":"10.1016\/j.bbamcr.2025.119989_bb0085","doi-asserted-by":"crossref","first-page":"79141","DOI":"10.18632\/oncotarget.13003","article-title":"Ubenimex attenuates acquired sorafenib resistance in renal cell carcinoma by inhibiting Akt signaling in a lipophagy associated mechanism","volume":"7","author":"Liu","year":"2016","journal-title":"Oncotarget"},{"issue":"5","key":"10.1016\/j.bbamcr.2025.119989_bb0090","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.tibs.2018.01.005","article-title":"SREBPs in lipid metabolism, insulin signaling, and beyond","volume":"43","author":"DeBose-Boyd","year":"2018","journal-title":"Trends Biochem. Sci."},{"issue":"7","key":"10.1016\/j.bbamcr.2025.119989_bb0095","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1002\/ijc.28159","article-title":"Iron-dependent cell death of hepatocellular carcinoma cells exposed to sorafenib","volume":"133","author":"Louandre","year":"2013","journal-title":"Int. J. Cancer"},{"issue":"5","key":"10.1016\/j.bbamcr.2025.119989_bb0100","first-page":"1303","article-title":"Molecular targeted therapies for cancer: sorafenib mono-therapy and its combination with other therapies (review)","volume":"27","author":"Ibrahim","year":"2012","journal-title":"Oncol. Rep."},{"issue":"4","key":"10.1016\/j.bbamcr.2025.119989_bb0105","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1007\/s00204-024-03681-x","article-title":"ATF4 in cellular stress, ferroptosis, and cancer","volume":"98","author":"Tang","year":"2024","journal-title":"Arch. Toxicol."},{"issue":"8","key":"10.1016\/j.bbamcr.2025.119989_bb0110","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1158\/2159-8290.CD-18-1354","article-title":"The metabolic basis of kidney cancer","volume":"9","author":"Linehan","year":"2019","journal-title":"Cancer Discov."},{"issue":"1","key":"10.1016\/j.bbamcr.2025.119989_bb0115","article-title":"GP73 regulates hepatic steatosis by enhancing SCAP-SREBPs interaction","volume":"7","author":"Yang","year":"2017","journal-title":"Sci. Rep."},{"issue":"5","key":"10.1016\/j.bbamcr.2025.119989_bb0120","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1158\/0008-5472.CAN-15-1766","article-title":"Arginine methylation of SREBP1a via PRMT5 promotes de novo lipogenesis and tumor growth","volume":"76","author":"Liu","year":"2016","journal-title":"Cancer Res."},{"issue":"11","key":"10.1016\/j.bbamcr.2025.119989_bb0125","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1136\/gutjnl-2014-308430","article-title":"MicroRNA-21 is a potential link between non-alcoholic fatty liver disease and hepatocellular carcinoma via modulation of the HBP1-p53-Srebp1c pathway","volume":"65","author":"Wu","year":"2016","journal-title":"Gut"},{"key":"10.1016\/j.bbamcr.2025.119989_bb0130","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.canlet.2021.05.012","article-title":"E2F1 promotes proliferation and metastasis of clear cell renal cell carcinoma via activation of SREBP1-dependent fatty acid biosynthesis","volume":"514","author":"Shen","year":"2021","journal-title":"Cancer Lett."},{"issue":"2","key":"10.1016\/j.bbamcr.2025.119989_bb0135","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/s41419-020-2298-2","article-title":"Ferroptosis: past, present and future","volume":"11","author":"Li","year":"2020","journal-title":"Cell Death Dis."},{"issue":"2","key":"10.1016\/j.bbamcr.2025.119989_bb0140","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.cell.2017.09.021","article-title":"Ferroptosis: a regulated cell death Nexus linking metabolism, redox biology, and disease","volume":"171","author":"Stockwell","year":"2017","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.bbamcr.2025.119989_bb0145","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1002\/cac2.12250","article-title":"Ferroptosis in cancer and cancer immunotherapy","volume":"42","author":"Zhao","year":"2022","journal-title":"Cancer Commun (Lond)."},{"issue":"6","key":"10.1016\/j.bbamcr.2025.119989_bb0150","article-title":"Ferroptosis and cancer: mitochondria meet the \u201ciron maiden\u201d","volume":"9","author":"Battaglia","year":"2020","journal-title":"Cell Death. Cells."},{"issue":"49","key":"10.1016\/j.bbamcr.2025.119989_bb0155","doi-asserted-by":"crossref","first-page":"31189","DOI":"10.1073\/pnas.2017152117","article-title":"Oncogenic activation of PI3K-AKT-mTOR signaling suppresses ferroptosis via SREBP-mediated lipogenesis","volume":"117","author":"Yi","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"11","key":"10.1016\/j.bbamcr.2025.119989_bb0160","first-page":"6417","article-title":"Sorafenib induces ferroptosis in human cancer cell lines originating from different solid tumors","volume":"34","author":"Lachaier","year":"2014","journal-title":"Anticancer Res."},{"key":"10.1016\/j.bbamcr.2025.119989_bb0165","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.02523","article-title":"Pharmacological inhibition of cystine-glutamate exchange induces endoplasmic reticulum stress and ferroptosis","volume":"3","author":"Dixon","year":"2014","journal-title":"Elife"},{"issue":"1","key":"10.1016\/j.bbamcr.2025.119989_bb0170","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1186\/s13046-019-1057-7","article-title":"Glycerol kinase 5 confers gefitinib resistance through SREBP1\/SCD1 signaling pathway","volume":"38","author":"Zhou","year":"2019","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"7","key":"10.1016\/j.bbamcr.2025.119989_bb0175","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0069086","article-title":"Dose-dependent adverse effects of salinomycin on male reproductive organs and fertility in mice","volume":"8","author":"Ojo","year":"2013","journal-title":"PLoS One"},{"issue":"8","key":"10.1016\/j.bbamcr.2025.119989_bb0180","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1007\/s00109-014-1155-0","article-title":"Specific targeting of neurotoxic side effects and pharmacological profile of the novel cancer stem cell drug salinomycin in mice","volume":"92","author":"Boehmerle","year":"2014","journal-title":"J. Mol. Med. (Berl)"},{"key":"10.1016\/j.bbamcr.2025.119989_bb0185","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/950658","article-title":"Salinomycin as a drug for targeting human cancer stem cells","volume":"2012","author":"Naujokat","year":"2012","journal-title":"J. Biomed. Biotechnol."},{"issue":"8","key":"10.1016\/j.bbamcr.2025.119989_bb0190","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics13081120","article-title":"Salinomycin-based drug delivery systems: overcoming the hurdles in cancer therapy","volume":"13","author":"Tefas","year":"2021","journal-title":"Pharmaceutics"},{"issue":"8","key":"10.1016\/j.bbamcr.2025.119989_bb0195","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1080\/15548627.2017.1327104","article-title":"An iron hand over cancer stem cells","volume":"13","author":"Hamai","year":"2017","journal-title":"Autophagy"},{"issue":"10","key":"10.1016\/j.bbamcr.2025.119989_bb0200","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1038\/nchem.2778","article-title":"Salinomycin kills cancer stem cells by sequestering iron in lysosomes","volume":"9","author":"Mai","year":"2017","journal-title":"Nat. Chem."},{"issue":"1","key":"10.1016\/j.bbamcr.2025.119989_bb0205","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/s13046-018-0733-3","article-title":"Iron-dependent cell death as executioner of cancer stem cells","volume":"37","author":"Zhao","year":"2018","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.bbamcr.2025.119989_bb0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2023.175913","article-title":"Understanding sorafenib-induced ferroptosis and resistance mechanisms: implications for cancer therapy","volume":"955","author":"Li","year":"2023","journal-title":"Eur. J. Pharmacol."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167488925000941?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167488925000941?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T12:31:31Z","timestamp":1779539491000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167488925000941"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":42,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["S0167488925000941"],"URL":"https:\/\/doi.org\/10.1016\/j.bbamcr.2025.119989","relation":{},"ISSN":["0167-4889"],"issn-type":[{"value":"0167-4889","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Salinomycin inhibits SREBP1 to sensitize ferroptosis and ameliorate sorafenib resistance in clear cell renal cell carcinoma","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Cell Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbamcr.2025.119989","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"119989"}}