{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T01:33:58Z","timestamp":1790472838728,"version":"4.1.0"},"reference-count":48,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82360301"],"award-info":[{"award-number":["82360301"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004479","name":"Jiangxi Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["20224BAB216027"],"award-info":[{"award-number":["20224BAB216027"]}],"id":[{"id":"10.13039\/501100004479","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Cell Research"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.bbamcr.2025.120045","type":"journal-article","created":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T06:12:21Z","timestamp":1755497541000},"page":"120045","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["E3 ligase SMURF2 alleviated intrauterine adhesion by stabilizing SMAD6"],"prefix":"10.1016","volume":"1872","author":[{"given":"Ke","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lishi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenfu","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lirong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingzhu","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huihua","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbamcr.2025.120045_bb0005","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1186\/s13287-020-01990-3","article-title":"si-SNHG5-FOXF2 inhibits TGF-\u03b21-induced fibrosis in human primary endometrial stromal cells by the Wnt\/\u03b2-catenin signalling pathway","volume":"11","author":"Liu","year":"2020","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.bbamcr.2025.120045_bb0010","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1093\/humupd\/dmt045","article-title":"Systematic review and meta-analysis of intrauterine adhesions after miscarriage: prevalence, risk factors and long-term reproductive outcome","volume":"20","author":"Hooker","year":"2013","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.bbamcr.2025.120045_bb0015","doi-asserted-by":"crossref","first-page":"1264006","DOI":"10.3389\/fbioe.2023.1264006","article-title":"Treatment strategies for intrauterine adhesion: focus on the exosomes and hydrogels","volume":"11","author":"Wu","year":"2023","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.bbamcr.2025.120045_bb0020","doi-asserted-by":"crossref","first-page":"e13262","DOI":"10.1111\/aji.13262","article-title":"Transforming growth factor-\u03b21 in intrauterine adhesion","volume":"84","author":"Abudukeyoumu","year":"2020","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.bbamcr.2025.120045_bb0025","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1038\/s41580-021-00448-5","article-title":"Ubiquitin ligases: guardians of mammalian development","volume":"23","author":"Cruz Walma","year":"2022","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bbamcr.2025.120045_bb0030","doi-asserted-by":"crossref","first-page":"7957","DOI":"10.1021\/acs.jmedchem.9b01451","article-title":"Medicinal chemistry of inhibiting RING-type E3 ubiquitin ligases","volume":"63","author":"Blaquiere","year":"2020","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bbamcr.2025.120045_bb0035","doi-asserted-by":"crossref","first-page":"jcs228072","DOI":"10.1242\/jcs.228072","article-title":"HECT E3 ubiquitin ligases\u2014emerging insights into their biological roles and disease relevance","volume":"133","author":"Wang","year":"2020","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.bbamcr.2025.120045_bb0040","series-title":"Seminars in Cancer Biology","first-page":"92","article-title":"NEDD4 E3 ligase: functions and mechanism in human cancer","author":"Wang","year":"2020"},{"issue":"1","key":"10.1016\/j.bbamcr.2025.120045_bb0045","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s43556-021-00043-2","article-title":"E3 ubiquitin ligases: styles, structures and functions","volume":"2","author":"Yang","year":"2021","journal-title":"Mol. Biomed."},{"issue":"37","key":"10.1016\/j.bbamcr.2025.120045_bb0050","doi-asserted-by":"crossref","first-page":"25721","DOI":"10.1074\/jbc.M113.545475","article-title":"The ubiquitin-associated domain of cellular inhibitor of apoptosis proteins facilitates ubiquitylation","volume":"289","author":"Budhidarmo","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamcr.2025.120045_bb0055","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/978-981-15-1025-0_2","article-title":"Structural biology of CRL ubiquitin ligases","volume":"1217","author":"Rusnac","year":"2020","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.bbamcr.2025.120045_bb0060","doi-asserted-by":"crossref","first-page":"3467","DOI":"10.1042\/BCJ20200864","article-title":"The BRCA1\/BARD1 ubiquitin ligase and its substrates","volume":"478","author":"Witus","year":"2021","journal-title":"Biochem. J."},{"issue":"4","key":"10.1016\/j.bbamcr.2025.120045_bb0065","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1042\/BST20200237","article-title":"Chain reactions: molecular mechanisms of RBR ubiquitin ligases","volume":"48","author":"Cotton","year":"2020","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.bbamcr.2025.120045_bb0070","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23073882","article-title":"The roles of NEDD4 subfamily of HECT E3 ubiquitin ligases in neurodevelopment and neurodegeneration","volume":"23","author":"Haouari","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbamcr.2025.120045_bb0075","doi-asserted-by":"crossref","first-page":"foaa058","DOI":"10.1093\/femsyr\/foaa058","article-title":"The C2 domain of the ubiquitin ligase Rsp5 is required for ubiquitination of the endocytic protein Rvs167 upon change of nitrogen source","volume":"20","author":"Tanahashi","year":"2020","journal-title":"FEMS Yeast Res."},{"key":"10.1016\/j.bbamcr.2025.120045_bb0080","doi-asserted-by":"crossref","first-page":"e23110","DOI":"10.1096\/fj.202300598R","article-title":"The role of SMURFs in non-cancerous diseases","volume":"37","author":"Wang","year":"2023","journal-title":"FASEB J."},{"key":"10.1016\/j.bbamcr.2025.120045_bb0085","article-title":"MicroRNA-322-5p targeting Smurf2 regulates the TGF-\u03b2\/Smad pathway to protect cardiac function and inhibit myocardial infarction","author":"Guo","year":"2024","journal-title":"Hum. Cell"},{"key":"10.1016\/j.bbamcr.2025.120045_bb0090","doi-asserted-by":"crossref","first-page":"100537","DOI":"10.1016\/j.jbc.2021.100537","article-title":"Smurf2 exerts neuroprotective effects on cerebral ischemic injury","volume":"297","author":"Liu","year":"2021","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamcr.2025.120045_bb0095","doi-asserted-by":"crossref","first-page":"4758","DOI":"10.4049\/jimmunol.1302632","article-title":"Smurf2 negatively modulates RIG-I-dependent antiviral response by targeting VISA\/MAVS for ubiquitination and degradation","volume":"192","author":"Pan","year":"2014","journal-title":"J. Immunol."},{"key":"10.1016\/j.bbamcr.2025.120045_bb0100","doi-asserted-by":"crossref","first-page":"415","DOI":"10.3892\/ijmm.2015.2448","article-title":"The downregulation of SnoN expression in human renal proximal tubule epithelial cells under high-glucose conditions is mediated by an increase in Smurf2 expression through TGF-\u03b21 signaling","volume":"37","author":"Li","year":"2016","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.bbamcr.2025.120045_bb0105","doi-asserted-by":"crossref","first-page":"295","DOI":"10.3389\/fonc.2018.00295","article-title":"Smurfs in protein homeostasis, signaling, and cancer","volume":"8","author":"Koganti","year":"2018","journal-title":"Front. Oncol."},{"key":"10.1016\/j.bbamcr.2025.120045_bb0110","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.semcancer.2019.12.023","article-title":"The functions and regulation of Smurfs in cancers","volume":"67","author":"Fu","year":"2020","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.bbamcr.2025.120045_bb0115","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/S0092-8674(03)00432-X","article-title":"Mechanisms of TGF-\u03b2 signaling from cell membrane to the nucleus","volume":"113","author":"Shi","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.bbamcr.2025.120045_bb0120","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1083\/jcb.200311015","article-title":"Smad6\/Smurf1 overexpression in cartilage delays chondrocyte hypertrophy and causes dwarfism with osteopenia","volume":"165","author":"Horiki","year":"2004","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.bbamcr.2025.120045_bb0125","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1006\/bbrc.1998.9170","article-title":"Induction of inhibitory Smad6 and Smad7 mRNA by TGF-beta family members","volume":"249","author":"Afrakhte","year":"1998","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbamcr.2025.120045_bb0130","doi-asserted-by":"crossref","first-page":"2802","DOI":"10.1111\/jcmm.14708","article-title":"Foxf2 and Smad6 co-regulation of collagen 5A2 transcription is involved in the pathogenesis of intrauterine adhesion","volume":"24","author":"Chen","year":"2020","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.bbamcr.2025.120045_bb0135","doi-asserted-by":"crossref","first-page":"82","DOI":"10.3389\/fphys.2015.00082","article-title":"TGF-\u03b2\/Smad signaling in renal fibrosis","volume":"6","author":"Meng","year":"2015","journal-title":"Front. Physiol."},{"key":"10.1016\/j.bbamcr.2025.120045_bb0140","doi-asserted-by":"crossref","first-page":"F1076","DOI":"10.1152\/ajprenal.00323.2007","article-title":"Smad ubiquitination regulatory factor-2 in the fibrotic kidney: regulation, target specificity, and functional implication","volume":"294","author":"Tan","year":"2008","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.bbamcr.2025.120045_bb0145","doi-asserted-by":"crossref","first-page":"8687","DOI":"10.1073\/pnas.0400035101","article-title":"Down-regulation of Smad7 expression by ubiquitin-dependent degradation contributes to renal fibrosis in obstructive nephropathy in mice","volume":"101","author":"Fukasawa","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbamcr.2025.120045_bb0150","doi-asserted-by":"crossref","first-page":"1162754","DOI":"10.3389\/fendo.2023.1162754","article-title":"Central role of cardiac fibroblasts in myocardial fibrosis of diabetic cardiomyopathy","volume":"14","author":"Cheng","year":"2023","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.bbamcr.2025.120045_bb0155","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/s41422-023-00918-9","article-title":"The roles and regulatory mechanisms of TGF-\u03b2 and BMP signaling in bone and cartilage development, homeostasis and disease","volume":"34","author":"Wu","year":"2024","journal-title":"Cell Res."},{"key":"10.1016\/j.bbamcr.2025.120045_bb0160","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1016\/j.burns.2020.12.017","article-title":"Smad7 down-regulation via ubiquitin degradation mediated by Smurf2 in fibroblasts of hypertrophic scars in burned patients","volume":"47","author":"Zhang","year":"2021","journal-title":"Burns"},{"key":"10.1016\/j.bbamcr.2025.120045_bb0165","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.tjog.2024.02.004","article-title":"Intrauterine adhesion","volume":"63","author":"Wang","year":"2024","journal-title":"Taiwan. J. Obstet. Gynecol."},{"key":"10.1016\/j.bbamcr.2025.120045_bb0170","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1016\/S1097-2765(00)00134-9","article-title":"Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation","volume":"6","author":"Kavsak","year":"2000","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bbamcr.2025.120045_bb0175","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1139\/Y09-076","article-title":"c-Ski, Smurf2, and Arkadia as regulators of TGF-\u03b2 signaling: new targets for managing myofibroblast function and cardiac fibrosis","volume":"87","author":"Cunnington","year":"2009","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.bbamcr.2025.120045_bb0180","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/nrneph.2016.48","article-title":"TGF-\u03b2: the master regulator of fibrosis","volume":"12","author":"Meng","year":"2016","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.bbamcr.2025.120045_bb0185","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.3892\/mmr.2020.11277","article-title":"Activation of calcium-sensing receptor-mediated autophagy in high glucose-induced cardiac fibrosis in vitro","volume":"22","author":"Yuan","year":"2020","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.bbamcr.2025.120045_bb0190","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.cell.2007.06.050","article-title":"Autoinhibition of the HECT-type ubiquitin ligase Smurf2 through its C2 domain","volume":"130","author":"Wiesner","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.bbamcr.2025.120045_bb0195","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.3892\/ijo.2015.3076","article-title":"Mir-15b promotes epithelial-mesenchymal transition by inhibiting SMURF2 in pancreatic cancer","volume":"47","author":"Zhang","year":"2015","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.bbamcr.2025.120045_bb0200","doi-asserted-by":"crossref","first-page":"6107","DOI":"10.1158\/0008-5472.CAN-14-0389","article-title":"Metastatic heterogeneity of breast cancer cells is associated with expression of a heterogeneous TGF\u03b2-activating miR424\u2013503 gene cluster","volume":"74","author":"Li","year":"2014","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbamcr.2025.120045_bb0205","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/1471-2407-14-57","article-title":"Downregulation of Smurf2, a tumor-suppressive ubiquitin ligase, in triple-negative breast cancers: involvement of the RB-microRNA axis","volume":"14","author":"Liu","year":"2014","journal-title":"BMC Cancer"},{"key":"10.1016\/j.bbamcr.2025.120045_bb0210","doi-asserted-by":"crossref","first-page":"948628","DOI":"10.3389\/fgene.2022.948628","article-title":"Role of noncoding RNA in the pathophysiology and treatment of intrauterine adhesion","volume":"13","author":"Liu","year":"2022","journal-title":"Front. Genet."},{"key":"10.1016\/j.bbamcr.2025.120045_bb0215","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1038\/cdd.2015.152","article-title":"The ubiquitin ligase Smurf2 suppresses TGF\u03b2-induced epithelial\u2013mesenchymal transition in a sumoylation-regulated manner","volume":"23","author":"Chandhoke","year":"2016","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.bbamcr.2025.120045_bb0220","doi-asserted-by":"crossref","first-page":"1972","DOI":"10.1038\/sj.onc.1207436","article-title":"The Nedd4 family of E3 ubiquitin ligases: functional diversity within a common modular architecture","volume":"23","author":"Ingham","year":"2004","journal-title":"Oncogene"},{"key":"10.1016\/j.bbamcr.2025.120045_bb0225","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1016\/j.str.2014.09.006","article-title":"Structural and functional framework for the autoinhibition of Nedd4-family ubiquitin ligases","volume":"22","author":"Mari","year":"2014","journal-title":"Structure"},{"key":"10.1016\/j.bbamcr.2025.120045_bb0230","first-page":"456","article-title":"The roles of ubiquitin modifying enzymes in neoplastic disease","volume":"1868","author":"Kumari","year":"2017","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbamcr.2025.120045_bb0235","doi-asserted-by":"crossref","first-page":"36818","DOI":"10.1074\/jbc.C000580200","article-title":"Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in transforming growth factor-\u03b2 signaling","volume":"275","author":"Lin","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamcr.2025.120045_bb0240","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1038\/ncomms1469","article-title":"Smad6-specific recruitment of Smurf E3 ligases mediates TGF-\u03b21-induced degradation of MyD88 in TLR4 signalling","volume":"2","author":"Lee","year":"2011","journal-title":"Nat. Commun."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167488925001508?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167488925001508?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T21:24:46Z","timestamp":1778534686000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167488925001508"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":48,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["S0167488925001508"],"URL":"https:\/\/doi.org\/10.1016\/j.bbamcr.2025.120045","relation":{},"ISSN":["0167-4889"],"issn-type":[{"value":"0167-4889","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"E3 ligase SMURF2 alleviated intrauterine adhesion by stabilizing SMAD6","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Cell Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbamcr.2025.120045","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"120045"}}