{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T17:19:57Z","timestamp":1773335997888,"version":"3.50.1"},"reference-count":72,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T00:00:00Z","timestamp":1760745600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["2019477"],"award-info":[{"award-number":["2019477"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000971","name":"Diabetes Australia","doi-asserted-by":"publisher","award":["IPAP2022 0041"],"award-info":[{"award-number":["IPAP2022 0041"]}],"id":[{"id":"10.13039\/501100000971","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000971","name":"Diabetes Australia","doi-asserted-by":"publisher","award":["Y23G-NORR"],"award-info":[{"award-number":["Y23G-NORR"]}],"id":[{"id":"10.13039\/501100000971","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001774","name":"University of Sydney","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001774","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021779","name":"Perpetual","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021779","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001779","name":"Monash University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001779","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Cell Research"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.bbamcr.2025.120071","type":"journal-article","created":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T14:19:10Z","timestamp":1760797150000},"page":"120071","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cell-penetrant peptides as novel inhibitors of the interaction of coatomer protein COPB2\/RACK2 with protein kinase C\u03b5 and cargo proteins"],"prefix":"10.1016","volume":"1873","author":[{"given":"Abisola A.","family":"Olushola-Siedoks","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lewin","family":"Small","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathryn J.","family":"Fincham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorothy C.C.","family":"Wai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dhruv","family":"Monteiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James R.W.","family":"Conway","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonia","family":"Cadell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin J.","family":"Parker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David R.","family":"Croucher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carsten","family":"Schmitz-Peiffer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymond S.","family":"Norton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbamcr.2025.120071_bb0005","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1042\/CS20160036","article-title":"Protein kinase C mechanisms that contribute to cardiac remodelling","volume":"130","author":"Newton","year":"2016","journal-title":"Clin. Sci. (Lond.)"},{"key":"10.1016\/j.bbamcr.2025.120071_bb0010","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1242\/jcs.00982","article-title":"PKC at a glance","volume":"117","author":"Parker","year":"2004","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.bbamcr.2025.120071_bb0015","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.cmet.2007.08.012","article-title":"Inhibition of PKC\u03b5 improves glucose-stimulated insulin secretion and reduces insulin clearance","volume":"6","author":"Schmitz-Peiffer","year":"2007","journal-title":"Cell Metab."},{"key":"10.1016\/j.bbamcr.2025.120071_bb0020","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.2337\/db09-0132","article-title":"Deletion of PKC\u03b5 selectively enhances the amplifying pathways of glucose-stimulated insulin secretion via increased lipolysis in mouse \u03b2-cells","volume":"58","author":"Cantley","year":"2009","journal-title":"Diabetes"},{"key":"10.1016\/j.bbamcr.2025.120071_bb0025","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1172\/JCI30400","article-title":"Inhibition of protein kinase C\u03b5 prevents hepatic insulin resistance in nonalcoholic fatty liver disease","volume":"117","author":"Samuel","year":"2007","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbamcr.2025.120071_bb0030","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1007\/s00125-011-2073-0","article-title":"Time-dependent effects of Prkce deletion on glucose homeostasis and hepatic lipid metabolism on dietary lipid oversupply in mice","volume":"54","author":"Raddatz","year":"2011","journal-title":"Diabetologia"},{"key":"10.1016\/j.bbamcr.2025.120071_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.cmet.2018.09.013","article-title":"Protein kinase C\u03b5 deletion in adipose tissue, but not in liver, improves glucose tolerance","volume":"29","author":"Brandon","year":"2019","journal-title":"Cell Metab."},{"key":"10.1016\/j.bbamcr.2025.120071_bb0040","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/j.cmet.2012.03.005","article-title":"Diacylglycerol activation of protein kinase Cepsilon and hepatic insulin resistance","volume":"15","author":"Jornayvaz","year":"2012","journal-title":"Cell Metab."},{"key":"10.1016\/j.bbamcr.2025.120071_bb0045","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1152\/physrev.00063.2017","article-title":"Mechanisms of insulin action and insulin resistance","volume":"98","author":"Petersen","year":"2018","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.bbamcr.2025.120071_bb0050","doi-asserted-by":"crossref","first-page":"16381","DOI":"10.1073\/pnas.1113359108","article-title":"Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease","volume":"108","author":"Kumashiro","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbamcr.2025.120071_bb0055","doi-asserted-by":"crossref","first-page":"2938","DOI":"10.1172\/JCI118001","article-title":"Protein kinase C is increased in the liver of humans and rats with non-insulin-dependent diabetes mellitus: an alteration not due to hyperglycemia","volume":"95","author":"Considine","year":"1995","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbamcr.2025.120071_bb0060","doi-asserted-by":"crossref","first-page":"32345","DOI":"10.1074\/jbc.M313478200","article-title":"Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease","volume":"279","author":"Samuel","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamcr.2025.120071_bb0065","doi-asserted-by":"crossref","first-page":"2593","DOI":"10.1038\/onc.2011.428","article-title":"Proteins kinase C\u03b5 is required for non-small cell lung carcinoma growth and regulates the expression of apoptotic genes","volume":"31","author":"Caino","year":"2012","journal-title":"Oncogene"},{"key":"10.1016\/j.bbamcr.2025.120071_bb0070","doi-asserted-by":"crossref","first-page":"5225","DOI":"10.1038\/onc.2013.524","article-title":"Protein kinase C and cancer: what we know and what we do not","volume":"33","author":"Garg","year":"2014","journal-title":"Oncogene"},{"key":"10.1016\/j.bbamcr.2025.120071_bb0075","first-page":"2517","article-title":"PKC epsilon functions as an oncogene by enhancing activation of the Raf kinase","volume":"13","author":"Cacace","year":"1996","journal-title":"Oncogene"},{"key":"10.1016\/j.bbamcr.2025.120071_bb0080","doi-asserted-by":"crossref","first-page":"29079","DOI":"10.1074\/jbc.M102001200","article-title":"Constitutive association of c-N-Ras with c-Raf-1 and protein kinase C epsilon in latent signaling modules","volume":"276","author":"Hamilton","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamcr.2025.120071_bb0085","doi-asserted-by":"crossref","first-page":"3345","DOI":"10.1038\/sj.onc.1201871","article-title":"Protein kinase Cepsilon is oncogenic in colon epithelial cells by interaction with the ras signal transduction pathway","volume":"16","author":"Perletti","year":"1998","journal-title":"Oncogene"},{"key":"10.1016\/j.bbamcr.2025.120071_bb0090","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.yjmcc.2010.10.020","article-title":"\u03b2IIPKC and \u03b5PKC isozymes as potential pharmacological targets in cardiac hypertrophy and heart failure","volume":"51","author":"Ferreira","year":"2010","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.bbamcr.2025.120071_bb0095","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.tins.2009.07.007","article-title":"Critical role of nociceptor plasticity in chronic pain","volume":"32","author":"Reichling","year":"2009","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.bbamcr.2025.120071_bb0100","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.alcohol.2009.01.002","article-title":"Neurobiological mechanisms contributing to alcohol-stress-anxiety interactions","volume":"43","author":"Silberman","year":"2009","journal-title":"Alcohol"},{"key":"10.1016\/j.bbamcr.2025.120071_bb0105","doi-asserted-by":"crossref","first-page":"17600","DOI":"10.3390\/ijms242417600","article-title":"An update on protein kinases as therapeutic targets-part I: protein kinase C activation and its role in cancer and cardiovascular diseases","volume":"24","author":"Silnitsky","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbamcr.2025.120071_bb0110","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1007\/s10741-017-9634-3","article-title":"Protein kinase C and cardiac dysfunction: a review","volume":"22","author":"Singh","year":"2017","journal-title":"Heart Fail. Rev."},{"key":"10.1016\/j.bbamcr.2025.120071_bb0115","doi-asserted-by":"crossref","first-page":"29200","DOI":"10.1074\/jbc.272.46.29200","article-title":"The Coatomer protein \u03b2\u2019-COP, a selective binding protein (RACK) for protein kinase C\u03b5","volume":"272","author":"Csukai","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamcr.2025.120071_bb0120","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/349248a0","article-title":"\u2018Coatomer\u2019: a cytosolic protein complex containing subunits of non-clathrin-coated Golgi transport vesicles","volume":"349","author":"Waters","year":"1991","journal-title":"Nature"},{"key":"10.1016\/j.bbamcr.2025.120071_bb0125","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/0092-8674(91)90176-Y","article-title":"ADP-ribosylation factor is a subunit of the coat of Golgi-derived COP-coated vesicles: a novel role for a GTP-binding protein","volume":"67","author":"Serafini","year":"1991","journal-title":"Cell"},{"key":"10.1016\/j.bbamcr.2025.120071_bb0130","doi-asserted-by":"crossref","first-page":"24962","DOI":"10.1074\/jbc.271.40.24962","article-title":"A protein kinase C translocation inhibitor as an isozyme-selective antagonist of cardiac function","volume":"271","author":"Johnson","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamcr.2025.120071_bb0135","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1074\/jbc.272.3.1417","article-title":"Translocation inhibitors define specificity of protein kinase C isoenzymes in pancreatic \u03b2-cells","volume":"272","author":"Yedovitzky","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamcr.2025.120071_bb0140","doi-asserted-by":"crossref","first-page":"30945","DOI":"10.1074\/jbc.272.49.30945","article-title":"A selective epsilon-protein kinase c antagonist inhibits protection of cardiac myocytes from hypoxia-induced cell death","volume":"272","author":"Gray","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamcr.2025.120071_bb0145","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1002\/1873-3468.12953","article-title":"Characterisation of peptide interactions that regulate PKCepsilon activation","volume":"592","author":"Chandrashekaran","year":"2018","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bbamcr.2025.120071_bb0150","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.cell.2010.05.030","article-title":"Structure of coatomer cage proteins and the relationship among COPI, COPII, and clathrin vesicle coats","volume":"142","author":"Lee","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.bbamcr.2025.120071_bb0155","doi-asserted-by":"crossref","first-page":"12798","DOI":"10.1073\/pnas.96.22.12798","article-title":"Sustained in vivo cardiac protection by a rationally designed peptide that causes epsilon protein kinase C translocation","volume":"96","author":"Dorn","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbamcr.2025.120071_bb0160","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1111\/j.1365-2958.2010.07159.x","article-title":"Essential lysine residues within transmembrane helix 1 of diphtheria toxin facilitate COPI binding and catalytic domain entry","volume":"76","author":"Trujillo","year":"2010","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.bbamcr.2025.120071_bb0165","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1038\/emboj.2013.41","article-title":"Rules for the recognition of dilysine retrieval motifs by coatomer","volume":"32","author":"Ma","year":"2013","journal-title":"EMBO J."},{"key":"10.1016\/j.bbamcr.2025.120071_bb0170","doi-asserted-by":"crossref","first-page":"4043","DOI":"10.1093\/hmg\/ddt254","article-title":"Dilysine motifs in exon 2b of SMN protein mediate binding to the COPI vesicle protein alpha-COP and neurite outgrowth in a cell culture model of spinal muscular atrophy","volume":"22","author":"Custer","year":"2013","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbamcr.2025.120071_bb0175","doi-asserted-by":"crossref","first-page":"2601","DOI":"10.1021\/acs.biochem.6b00226","article-title":"Discovery and mechanism of highly efficient cyclic cell-penetrating peptides","volume":"55","author":"Qian","year":"2016","journal-title":"Biochem"},{"key":"10.1016\/j.bbamcr.2025.120071_bb0180","doi-asserted-by":"crossref","first-page":"4370","DOI":"10.1021\/acs.analchem.5b00140","article-title":"Bayesian deconvolution of mass and ion mobility spectra: from binary interactions to polydisperse ensembles","volume":"87","author":"Marty","year":"2015","journal-title":"Anal. Chem."},{"key":"10.1016\/j.bbamcr.2025.120071_bb0185","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s10858-016-0060-y","article-title":"CcpNmr AnalysisAssign: a flexible platform for integrated NMR analysis","volume":"66","author":"Skinner","year":"2016","journal-title":"J. Biomol. NMR"},{"key":"10.1016\/j.bbamcr.2025.120071_bb0190","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1007\/BF00227466","article-title":"\u2018Random coil\u2019 1H chemical shifts obtained as a function of temperature and trifluoroethanol concentration for the peptide series GGXGG","volume":"5","author":"Merutka","year":"1995","journal-title":"J. Biomol. NMR"},{"key":"10.1016\/j.bbamcr.2025.120071_bb0195","doi-asserted-by":"crossref","first-page":"24296","DOI":"10.1016\/S0021-9258(20)80525-0","article-title":"Molecular cloning and characterization of PKC iota, an atypical isoform of protein kinase C derived from insulin-secreting cells","volume":"268","author":"Selbie","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamcr.2025.120071_bb0200","doi-asserted-by":"crossref","first-page":"3721","DOI":"10.1038\/s41467-021-23997-x","article-title":"Unravelling cytosolic delivery of cell penetrating peptides with a quantitative endosomal escape assay","volume":"12","author":"Teo","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbamcr.2025.120071_bb0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2025.177465","article-title":"Effects of a protein kinase C epsilon inhibitor on insulin signalling in lipid-treated HepG2 hepatocytes and glucose tolerance in fat-fed mice","volume":"997","author":"Agoncillo","year":"2025","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bbamcr.2025.120071_bb0210","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/s41592-019-0638-x","article-title":"DIA-NN: neural networks and interference correction enable deep proteome coverage in high throughput","volume":"17","author":"Demichev","year":"2020","journal-title":"Nat. Methods"},{"key":"10.1016\/j.bbamcr.2025.120071_bb0215","article-title":"Gene set knowledge discovery with Enrichr","volume":"1","author":"Xie","year":"2021","journal-title":"Curr. Protoc."},{"key":"10.1016\/j.bbamcr.2025.120071_bb0220","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.aaf0793","article-title":"Bimolecular complementation affinity purification (BiCAP) reveals dimer-specific protein interactions for ERBB2 dimers","volume":"9","author":"Croucher","year":"2016","journal-title":"Sci. Signal."},{"key":"10.1016\/j.bbamcr.2025.120071_bb0225","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1038\/nbt.1511","article-title":"MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification","volume":"26","author":"Cox","year":"2008","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.bbamcr.2025.120071_bb0230","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1038\/nmeth.3901","article-title":"The Perseus computational platform for comprehensive analysis of (prote)omics data","volume":"13","author":"Tyanova","year":"2016","journal-title":"Nat. Methods"},{"key":"10.1016\/j.bbamcr.2025.120071_bb0235","doi-asserted-by":"crossref","DOI":"10.1152\/ajpendo.00487.2001","article-title":"Inhibition of glycogen synthesis by fatty acid in C2C12 muscle cells is independent of PKC-\u03b1, -\u03b5, and -\u03b8","volume":"282","author":"Cazzolli","year":"2002","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.bbamcr.2025.120071_bb0240","doi-asserted-by":"crossref","first-page":"2","DOI":"10.2174\/1875397300801010002","article-title":"The use of AlphaScreen technology in HTS: current status","volume":"1","author":"Eglen","year":"2008","journal-title":"Curr. Chem. Genom."},{"key":"10.1016\/j.bbamcr.2025.120071_bb0245","doi-asserted-by":"crossref","first-page":"19784","DOI":"10.1074\/jbc.M411285200","article-title":"Diacylglycerol-induced membrane targeting and activation of protein kinase C\u03f5: mechanistic differences between protein kinases C\u03b4 and C\u03f5","volume":"280","author":"Stahelin","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamcr.2025.120071_bb0250","doi-asserted-by":"crossref","first-page":"4113","DOI":"10.1074\/jbc.M608521200","article-title":"Peptides derived from the C2 domain of protein kinase C epsilon (epsilon PKC) modulate epsilon PKC activity and identify potential protein-protein interaction surfaces","volume":"282","author":"Brandman","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamcr.2025.120071_bb0255","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1016\/j.devcel.2012.10.017","article-title":"Molecular basis for recognition of dilysine trafficking motifs by COPI","volume":"23","author":"Jackson","year":"2012","journal-title":"Dev. Cell"},{"key":"10.1016\/j.bbamcr.2025.120071_bb0260","series-title":"CPP, Cell-Penetrating Peptides","first-page":"359","article-title":"Cell-translocation mechanisms of CPPs","author":"Langel","year":"2023"},{"key":"10.1016\/j.bbamcr.2025.120071_bb0265","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.tem.2020.01.016","article-title":"Deconstructing the role of PKC epsilon in glucose homeostasis","volume":"31","author":"Schmitz-Peiffer","year":"2020","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.bbamcr.2025.120071_bb0270","article-title":"Formation of COPI-coated vesicles at a glance","volume":"131","author":"Arakel","year":"2018","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.bbamcr.2025.120071_bb0275","first-page":"293","article-title":"Hats off to 20S proteasome substrate discovery","volume":"20","author":"Church","year":"2024","journal-title":"Mol. Syst. Biol."},{"key":"10.1016\/j.bbamcr.2025.120071_bb0280","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.80911","article-title":"Ubiquitination drives COPI priming and Golgi SNARE localization","volume":"11","author":"Date","year":"2022","journal-title":"eLife"},{"key":"10.1016\/j.bbamcr.2025.120071_bb0285","first-page":"487","article-title":"ARF1-regulated coatomer directs the steady-state localization of protein kinase C epsilon at the Golgi apparatus","volume":"2013","author":"Peterson","year":"1833","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbamcr.2025.120071_bb0290","doi-asserted-by":"crossref","first-page":"11549","DOI":"10.1074\/jbc.M609424200","article-title":"Activation of acid sphingomyelinase by protein kinase C\u03b4-mediated phosphorylation","volume":"282","author":"Zeidan","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamcr.2025.120071_bb0295","doi-asserted-by":"crossref","first-page":"1284586","DOI":"10.3389\/fphar.2023.1284586","article-title":"Features and mechanisms of propofol-induced protein kinase C (PKC) translocation and activation in living cells","volume":"14","author":"Noguchi","year":"2023","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bbamcr.2025.120071_bb0300","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1091\/mbc.e12-12-0886","article-title":"Golgi-situated endoplasmic reticulum \u03b1-1, 2-mannosidase contributes to the retrieval of ERAD substrates through a direct interaction with \u03b3-COP","volume":"24","author":"Pan","year":"2013","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.bbamcr.2025.120071_bb0305","doi-asserted-by":"crossref","first-page":"811","DOI":"10.2337\/db11-1652","article-title":"Proteasome dysfunction mediates obesity-induced endoplasmic reticulum stress and insulin resistance in the liver","volume":"62","author":"Otoda","year":"2013","journal-title":"Diabetes"},{"key":"10.1016\/j.bbamcr.2025.120071_bb0310","doi-asserted-by":"crossref","first-page":"271","DOI":"10.4049\/jimmunol.1700243","article-title":"Golgi-associated protein kinase C\u03b5 is delivered to phagocytic cups: role of phosphatidylinositol 4-phosphate","volume":"199","author":"Hanes","year":"2017","journal-title":"J. Immunol."},{"key":"10.1016\/j.bbamcr.2025.120071_bb0315","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.01607","article-title":"Arf1\/COPI machinery acts directly on lipid droplets and enables their connection to the ER for protein targeting","volume":"3","author":"Wilfling","year":"2014","journal-title":"Elife"},{"key":"10.1016\/j.bbamcr.2025.120071_bb0320","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1073\/pnas.1219456110","article-title":"CGI-58 knockdown sequesters diacylglycerols in lipid droplets\/ER-preventing diacylglycerol-mediated hepatic insulin resistance","volume":"110","author":"Cantley","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbamcr.2025.120071_bb0325","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.molcel.2012.01.021","article-title":"ATM-dependent downregulation of USP7\/HAUSP by PPM1G activates p53 response to DNA damage","volume":"45","author":"Khoronenkova","year":"2012","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bbamcr.2025.120071_bb0330","doi-asserted-by":"crossref","first-page":"22774","DOI":"10.1074\/jbc.M801869200","article-title":"Scyl1, mutated in a recessive form of spinocerebellar neurodegeneration, regulates COPI-mediated retrograde traffic","volume":"283","author":"Burman","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamcr.2025.120071_bb0335","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2016.12.029","article-title":"Ligand and target discovery by fragment-based screening in human cells","volume":"168","author":"Parker","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.bbamcr.2025.120071_bb0340","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1042\/BJ20050291","article-title":"Mammalian Lass6 and its related family members regulate synthesis of specific ceramides","volume":"390","author":"Mizutani","year":"2005","journal-title":"Biochem. J."},{"key":"10.1016\/j.bbamcr.2025.120071_bb0345","doi-asserted-by":"crossref","first-page":"15080","DOI":"10.1074\/jbc.274.21.15080","article-title":"Protein targeting to endoplasmic reticulum by dilysine signals involves direct retention in addition to retrieval","volume":"274","author":"Andersson","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamcr.2025.120071_bb0350","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1091\/mbc.e03-10-0724","article-title":"The alpha- and beta\u2019-COP WD40 domains mediate cargo-selective interactions with distinct di-lysine motifs","volume":"15","author":"Eugster","year":"2004","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.bbamcr.2025.120071_bb0355","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.202008061","article-title":"An interaction between beta\u2019-COP and the ArfGAP, Glo3, maintains post-Golgi cargo recycling","volume":"222","author":"Xie","year":"2023","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.bbamcr.2025.120071_bb0360","doi-asserted-by":"crossref","first-page":"2217","DOI":"10.1002\/hep.30829","article-title":"Considering the links between nonalcoholic fatty liver disease and insulin resistance: revisiting the role of protein kinase C\u03b5","volume":"70","author":"Samuel","year":"2019","journal-title":"Hepatology"}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167488925001764?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167488925001764?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T05:58:14Z","timestamp":1773295094000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167488925001764"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":72,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["S0167488925001764"],"URL":"https:\/\/doi.org\/10.1016\/j.bbamcr.2025.120071","relation":{},"ISSN":["0167-4889"],"issn-type":[{"value":"0167-4889","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cell-penetrant peptides as novel inhibitors of the interaction of coatomer protein COPB2\/RACK2 with protein kinase C\u03b5 and cargo proteins","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Cell Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbamcr.2025.120071","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"120071"}}