{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T20:29:57Z","timestamp":1793996997912,"version":"4.8.0"},"reference-count":86,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:00:00Z","timestamp":1761609600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["PE00000007"],"award-info":[{"award-number":["PE00000007"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021856","name":"Ministero dell'Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","award":["C53D23003110006"],"award-info":[{"award-number":["C53D23003110006"]}],"id":[{"id":"10.13039\/501100021856","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100024370","name":"Ministero dell'Istruzione dell'Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","award":["2022F2YJNK"],"award-info":[{"award-number":["2022F2YJNK"]}],"id":[{"id":"10.13039\/501100024370","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Cell Research"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.bbamcr.2025.120074","type":"journal-article","created":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T07:50:08Z","timestamp":1761724208000},"page":"120074","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Importin \u03b1\/\u03b21 dependent nuclear import of black sea bass polyomavirus large tumor antigen is mediated by a classical NLS located downstream of the SF3 helicase domain"],"prefix":"10.1016","volume":"1873","author":[{"given":"Mikayla","family":"Hoad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Pavan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sepehr","family":"Nematollahzadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ole","family":"Tietz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jospeh","family":"Reeman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jade K.","family":"Forwood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gualtiero","family":"Alvisi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.bbamcr.2025.120074_bb0005","doi-asserted-by":"crossref","first-page":"414","DOI":"10.3181\/00379727-83-20376","article-title":"A filterable agent, recovered from Ak leukemic extracts, causing salivary gland carcinomas in C3H mice","volume":"83","author":"Gross","year":"1953","journal-title":"Proc. Soc. Exp. Biol. Med."},{"issue":"4","key":"10.1016\/j.bbamcr.2025.120074_bb0010","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1038\/nrmicro2992","article-title":"A cornucopia of human polyomaviruses","volume":"11","author":"DeCaprio","year":"2013","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.bbamcr.2025.120074_bb0015","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.virol.2021.08.008","article-title":"A novel lineage of polyomaviruses identified in bark scorpions","volume":"563","author":"Schmidlin","year":"2021","journal-title":"Virology"},{"issue":"1","key":"10.1016\/j.bbamcr.2025.120074_bb0020","doi-asserted-by":"crossref","DOI":"10.1128\/genomeA.01476-14","article-title":"Genome sequence of a fish-associated polyomavirus, Black Sea bass (Centropristis striata) polyomavirus 1","volume":"3","author":"Peretti","year":"2015","journal-title":"Genome Announc."},{"issue":"3","key":"10.1016\/j.bbamcr.2025.120074_bb0025","doi-asserted-by":"crossref","DOI":"10.1128\/genomeA.00391-16","article-title":"Complete sequence of the smallest polyomavirus genome, giant guitarfish (Rhynchobatus djiddensis) polyomavirus 1","volume":"4","author":"Dill","year":"2016","journal-title":"Genome Announc."},{"issue":"19","key":"10.1016\/j.bbamcr.2025.120074_bb0030","doi-asserted-by":"crossref","first-page":"8768","DOI":"10.1128\/JVI.01369-16","article-title":"Concurrence of Iridovirus, polyomavirus, and a unique member of a new Group of Fish Papillomaviruses in Lymphocystis disease-affected Gilthead Sea bream","volume":"90","author":"Lopez-Bueno","year":"2016","journal-title":"J. Virol."},{"issue":"4","key":"10.1016\/j.bbamcr.2025.120074_bb0035","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1099\/jgv.0.001041","article-title":"Fish polyomaviruses belong to two distinct evolutionary lineages","volume":"99","author":"Van Doorslaer","year":"2018","journal-title":"J. Gen. Virol."},{"issue":"1","key":"10.1016\/j.bbamcr.2025.120074_bb0040","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1186\/s12985-023-02149-1","article-title":"Identification and characterization of a polyomavirus in the thornback skate (Raja clavata)","volume":"20","author":"Abrantes","year":"2023","journal-title":"Virol. J."},{"key":"10.1016\/j.bbamcr.2025.120074_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.meegid.2019.104150","article-title":"Evolution and molecular epidemiology of polyomaviruses","volume":"79","author":"Torres","year":"2020","journal-title":"Infect. Genet. Evol."},{"key":"10.1016\/j.bbamcr.2025.120074_bb0050","doi-asserted-by":"crossref","first-page":"420","DOI":"10.3181\/00379727-105-26128","article-title":"The vacuolating virus, S.V. 40","volume":"105","author":"Sweet","year":"1960","journal-title":"Proc. Soc. Exp. Biol. Med."},{"issue":"10","key":"10.1016\/j.bbamcr.2025.120074_bb0055","doi-asserted-by":"crossref","DOI":"10.3390\/v11100930","article-title":"Novel polyomaviruses in mammals from multiple orders and reassessment of polyomavirus evolution and taxonomy","volume":"11","author":"Ehlers","year":"2019","journal-title":"Viruses"},{"issue":"4","key":"10.1016\/j.bbamcr.2025.120074_bb0060","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1005574","article-title":"The ancient evolutionary history of polyomaviruses","volume":"12","author":"Buck","year":"2016","journal-title":"PLoS Pathog."},{"issue":"6","key":"10.1016\/j.bbamcr.2025.120074_bb0065","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1099\/jgv.0.000839","article-title":"ICTV virus taxonomy profile: polyomaviridae","volume":"98","author":"Moens","year":"2017","journal-title":"J. Gen. Virol."},{"issue":"11","key":"10.1016\/j.bbamcr.2025.120074_bb0070","doi-asserted-by":"crossref","first-page":"2206","DOI":"10.1101\/gad.7.11.2206","article-title":"SV40 early-to-late switch involves titration of cellular transcriptional repressors","volume":"7","author":"Wiley","year":"1993","journal-title":"Genes Dev."},{"issue":"12","key":"10.1016\/j.bbamcr.2025.120074_bb0075","doi-asserted-by":"crossref","DOI":"10.3390\/v12121406","article-title":"Genetic diversity of the noncoding control region of the novel human polyomaviruses","volume":"12","author":"Moens","year":"2020","journal-title":"Viruses"},{"key":"10.1016\/j.bbamcr.2025.120074_bb0080","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1146\/annurev-micro-092611-150154","article-title":"Large T antigens of polyomaviruses: amazing molecular machines","volume":"66","author":"An","year":"2012","journal-title":"Ann. Rev. Microbiol."},{"issue":"2","key":"10.1016\/j.bbamcr.2025.120074_bb0085","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1128\/MMBR.66.2.179-202.2002","article-title":"T antigens of simian virus 40: molecular chaperones for viral replication and tumorigenesis","volume":"66","author":"Sullivan","year":"2002","journal-title":"Microbiol. Mol. Biol. Rev."},{"issue":"7","key":"10.1016\/j.bbamcr.2025.120074_bb0090","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/0968-0004(94)90003-5","article-title":"Chaperone power in a virus?","volume":"19","author":"Kelley","year":"1994","journal-title":"Trends Biochem. Sci."},{"issue":"2","key":"10.1016\/j.bbamcr.2025.120074_bb0095","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/0092-8674(88)90559-4","article-title":"SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene","volume":"54","author":"DeCaprio","year":"1988","journal-title":"Cell"},{"issue":"24","key":"10.1016\/j.bbamcr.2025.120074_bb0100","doi-asserted-by":"crossref","first-page":"5961","DOI":"10.1038\/sj.emboj.7601452","article-title":"Structure of the origin-binding domain of simian virus 40 large T antigen bound to DNA","volume":"25","author":"Bochkareva","year":"2006","journal-title":"EMBO J."},{"issue":"9","key":"10.1016\/j.bbamcr.2025.120074_bb0105","doi-asserted-by":"crossref","first-page":"4304","DOI":"10.1128\/JVI.80.9.4304-4312.2006","article-title":"Crystal structure of the simian virus 40 large T-antigen origin-binding domain","volume":"80","author":"Meinke","year":"2006","journal-title":"J. Virol."},{"issue":"7","key":"10.1016\/j.bbamcr.2025.120074_bb0110","doi-asserted-by":"crossref","first-page":"2086","DOI":"10.1073\/pnas.85.7.2086","article-title":"Geometry of the simian virus 40 large tumor antigen-DNA complex as probed by protease digestion","volume":"85","author":"Simmons","year":"1988","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"6","key":"10.1016\/j.bbamcr.2025.120074_bb0115","doi-asserted-by":"crossref","first-page":"3167","DOI":"10.1128\/jvi.65.6.3167-3174.1991","article-title":"The zinc finger region of simian virus 40 large T antigen is needed for hexamer assembly and origin melting","volume":"65","author":"Loeber","year":"1991","journal-title":"J. Virol."},{"issue":"6939","key":"10.1016\/j.bbamcr.2025.120074_bb0120","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1038\/nature01691","article-title":"Structure of the replicative helicase of the oncoprotein SV40 large tumour antigen","volume":"423","author":"Li","year":"2003","journal-title":"Nature"},{"issue":"8","key":"10.1016\/j.bbamcr.2025.120074_bb0125","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1002\/j.1460-2075.1986.tb04447.x","article-title":"DNA helicase activity of SV40 large tumor antigen","volume":"5","author":"Stahl","year":"1986","journal-title":"EMBO J."},{"issue":"23","key":"10.1016\/j.bbamcr.2025.120074_bb0130","doi-asserted-by":"crossref","first-page":"6205","DOI":"10.1093\/emboj\/cdg612","article-title":"Large T antigen on the simian virus 40 origin of replication: a 3D snapshot prior to DNA replication","volume":"22","author":"Gomez-Lorenzo","year":"2003","journal-title":"EMBO J."},{"issue":"4829","key":"10.1016\/j.bbamcr.2025.120074_bb0135","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1126\/science.2823389","article-title":"Unwinding of duplex DNA from the SV40 origin of replication by T antigen","volume":"238","author":"Dodson","year":"1987","journal-title":"Science"},{"key":"10.1016\/j.bbamcr.2025.120074_bb0140","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/0042-6822(62)90082-X","article-title":"Identification of the oncogenic substance in rhesus monkey kidney cell culture as simian virus 40","volume":"17","author":"Eddy","year":"1962","journal-title":"Virology"},{"issue":"5981","key":"10.1016\/j.bbamcr.2025.120074_bb0145","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/311033a0","article-title":"Sequence requirements for nuclear location of simian virus 40 large-T antigen","volume":"311","author":"Kalderon","year":"1984","journal-title":"Nature"},{"issue":"3 Pt 2","key":"10.1016\/j.bbamcr.2025.120074_bb0150","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/0092-8674(84)90457-4","article-title":"A short amino acid sequence able to specify nuclear location","volume":"39","author":"Kalderon","year":"1984","journal-title":"Cell"},{"issue":"12","key":"10.1016\/j.bbamcr.2025.120074_bb0155","doi-asserted-by":"crossref","first-page":"3235","DOI":"10.1002\/j.1460-2075.1985.tb04071.x","article-title":"The abnormal location of cytoplasmic SV40 large T is not caused by failure to bind to DNA or to p53","volume":"4","author":"Paucha","year":"1985","journal-title":"EMBO J."},{"issue":"5","key":"10.1016\/j.bbamcr.2025.120074_bb0160","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/s41580-021-00446-7","article-title":"Karyopherin-mediated nucleocytoplasmic transport","volume":"23","author":"Wing","year":"2022","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"2","key":"10.1016\/j.bbamcr.2025.120074_bb0165","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0092-8674(00)81419-1","article-title":"Crystallographic analysis of the recognition of a nuclear localization signal by the nuclear import factor karyopherin alpha","volume":"94","author":"Conti","year":"1998","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.bbamcr.2025.120074_bb0170","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/S0969-2126(00)00107-6","article-title":"Crystallographic analysis of the specific yet versatile recognition of distinct nuclear localization signals by karyopherin alpha","volume":"8","author":"Conti","year":"2000","journal-title":"Structure"},{"issue":"2","key":"10.1016\/j.bbamcr.2025.120074_bb0175","doi-asserted-by":"crossref","DOI":"10.1002\/pro.4876","article-title":"A functional and structural comparative analysis of large tumor antigens reveals evolution of different importin alpha-dependent nuclear localization signals","volume":"33","author":"Cross","year":"2024","journal-title":"Protein Sci."},{"issue":"12","key":"10.1016\/j.bbamcr.2025.120074_bb0180","doi-asserted-by":"crossref","first-page":"962","DOI":"10.15252\/msb.20177608","article-title":"Landscape of nuclear transport receptor cargo specificity","volume":"13","author":"Mackmull","year":"2017","journal-title":"Mol. Syst. Biol."},{"issue":"9","key":"10.1016\/j.bbamcr.2025.120074_bb0185","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/j.chembiol.2008.07.019","article-title":"Design of peptide inhibitors for the importin alpha\/beta nuclear import pathway by activity-based profiling","volume":"15","author":"Kosugi","year":"2008","journal-title":"Chem. Biol."},{"issue":"49","key":"10.1016\/j.bbamcr.2025.120074_bb0190","doi-asserted-by":"crossref","first-page":"29375","DOI":"10.1074\/jbc.M115.681908","article-title":"Retinoblastoma-binding protein 4-regulated classical nuclear transport is involved in cellular senescence","volume":"290","author":"Tsujii","year":"2015","journal-title":"J. Biol. Chem."},{"issue":"Pt 2","key":"10.1016\/j.bbamcr.2025.120074_bb0195","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1107\/S0907444998012943","article-title":"Crystallization of importin alpha, the nuclear-import receptor","volume":"55","author":"Teh","year":"1999","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.bbamcr.2025.120074_bb0200","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/978-1-59745-196-3_7","article-title":"A family of LIC vectors for high-throughput cloning and purification of proteins","volume":"498","author":"Eschenfeldt","year":"2009","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.bbamcr.2025.120074_bb0205","first-page":"253","article-title":"Transformation of plasmid DNA into E. coli using the heat shock method","volume":"6","author":"Froger","year":"2007","journal-title":"J. Vis. Exp."},{"issue":"1","key":"10.1016\/j.bbamcr.2025.120074_bb0210","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.pep.2005.01.016","article-title":"Protein production by auto-induction in high density shaking cultures","volume":"41","author":"Studier","year":"2005","journal-title":"Protein Expr. Purif."},{"issue":"4","key":"10.1016\/j.bbamcr.2025.120074_bb0215","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1007\/s10895-005-2819-5","article-title":"Quantitative analysis of protein-protein interactions by native page\/fluorimaging","volume":"15","author":"Wagstaff","year":"2005","journal-title":"J. Fluoresc."},{"issue":"1","key":"10.1016\/j.bbamcr.2025.120074_bb0220","doi-asserted-by":"crossref","DOI":"10.1093\/ve\/veaf069","article-title":"Nuclear trafficking of Anelloviridae capsid protein ORF1 reflects modular evolution of subcellular targeting signals","volume":"11","author":"Petersen","year":"2025","journal-title":"Virus Evol."},{"key":"10.1016\/j.bbamcr.2025.120074_bb0225","doi-asserted-by":"crossref","DOI":"10.1016\/j.antiviral.2023.105588","article-title":"Importin alpha\/beta-dependent nuclear transport of human parvovirus B19 nonstructural protein 1 is essential for viral replication","volume":"213","author":"Alvisi","year":"2023","journal-title":"Antivir. Res."},{"issue":"1","key":"10.1016\/j.bbamcr.2025.120074_bb0230","doi-asserted-by":"crossref","DOI":"10.1128\/jvi.01345-24","article-title":"Structural basis for nuclear import of adeno-associated virus serotype 6 capsid protein","volume":"99","author":"Hoad","year":"2025","journal-title":"J. Virol."},{"issue":"1","key":"10.1016\/j.bbamcr.2025.120074_bb0235","doi-asserted-by":"crossref","DOI":"10.1099\/jgv.0.001928","article-title":"Structural and functional characterization of siadenovirus core protein VII nuclear localization demonstrates the existence of multiple nuclear transport pathways","volume":"105","author":"Athukorala","year":"2024","journal-title":"J. Gen. Virol."},{"issue":"9","key":"10.1016\/j.bbamcr.2025.120074_bb0240","doi-asserted-by":"crossref","DOI":"10.1111\/tra.12953","article-title":"Mechanistic insights into an ancient adenovirus precursor protein VII show multiple nuclear import receptor pathways","volume":"25","author":"Nematollahzadeh","year":"2024","journal-title":"Traffic"},{"key":"10.1016\/j.bbamcr.2025.120074_bb0245","article-title":"Protein crystallization for X-ray crystallography","volume":"47","author":"Dessau","year":"2011","journal-title":"Journal of Visualized Experiments"},{"issue":"Pt 3","key":"10.1016\/j.bbamcr.2025.120074_bb0250","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1107\/S1600577518003120","article-title":"MX2: a high-flux undulator microfocus beamline serving both the chemical and macromolecular crystallography communities at the Australian Synchrotron","volume":"25","author":"Aragao","year":"2018","journal-title":"J. Synchrotron Radiat."},{"issue":"1","key":"10.1016\/j.bbamcr.2025.120074_bb0255","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1002\/pro.4224","article-title":"DIALS as a toolkit","volume":"31","author":"Winter","year":"2022","journal-title":"Protein Sci."},{"key":"10.1016\/j.bbamcr.2025.120074_bb0260","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1107\/S090744491003982X","article-title":"An introduction to data reduction: space-group determination, scaling and intensity statistics","volume":"67","author":"Evans","year":"2011","journal-title":"Acta Crystallogr D."},{"issue":"1","key":"10.1016\/j.bbamcr.2025.120074_bb0265","doi-asserted-by":"crossref","first-page":"3703","DOI":"10.1038\/s41467-018-05928-5","article-title":"Structural basis for importin alpha 3 specificity of W proteins in Hendra and Nipah viruses","volume":"9","author":"Smith","year":"2018","journal-title":"Nat. Commun."},{"issue":"Pt 4","key":"10.1016\/j.bbamcr.2025.120074_bb0270","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1107\/S0021889807021206","article-title":"Phaser crystallographic software","volume":"40","author":"McCoy","year":"2007","journal-title":"J. Appl. Cryst."},{"issue":"Pt 2","key":"10.1016\/j.bbamcr.2025.120074_bb0275","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1107\/S0907444909052925","article-title":"PHENIX: a comprehensive Python-based system for macromolecular structure solution","volume":"66","author":"Adams","year":"2010","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"issue":"Pt 4","key":"10.1016\/j.bbamcr.2025.120074_bb0280","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1107\/S0907444910007493","article-title":"Features and development of coot","volume":"66","author":"Emsley","year":"2010","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"issue":"1","key":"10.1016\/j.bbamcr.2025.120074_bb0285","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1002\/pro.4238","article-title":"PDBsum extras: SARS-CoV-2 and AlphaFold models","volume":"31","author":"Laskowski","year":"2022","journal-title":"Protein Sci."},{"issue":"5","key":"10.1016\/j.bbamcr.2025.120074_bb0290","doi-asserted-by":"crossref","DOI":"10.3390\/microorganisms9050928","article-title":"Live-cell analysis of human cytomegalovirus DNA polymerase holoenzyme assembly by resonance energy transfer methods","volume":"9","author":"Di Antonio","year":"2021","journal-title":"Microorganisms"},{"issue":"9","key":"10.1016\/j.bbamcr.2025.120074_bb0295","doi-asserted-by":"crossref","DOI":"10.3390\/v12091044","article-title":"Generation of combinatorial lentiviral vectors expressing multiple anti-hepatitis C virus shRNAs and their validation on a novel HCV replicon double reporter cell line","volume":"12","author":"Elbadawy","year":"2020","journal-title":"Viruses"},{"issue":"16","key":"10.1016\/j.bbamcr.2025.120074_bb0300","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13164083","article-title":"The dimeric form of HPV16 E6 is crucial to drive YAP\/TAZ upregulation through the targeting of hScrib","volume":"13","author":"Messa","year":"2021","journal-title":"Cancers (Basel)"},{"issue":"18","key":"10.1016\/j.bbamcr.2025.120074_bb0305","doi-asserted-by":"crossref","first-page":"9567","DOI":"10.1128\/JVI.00669-09","article-title":"The flexible loop of the human cytomegalovirus DNA polymerase processivity factor ppUL44 is required for efficient DNA binding and replication in cells","volume":"83","author":"Alvisi","year":"2009","journal-title":"J. Virol."},{"issue":"24","key":"10.1016\/j.bbamcr.2025.120074_bb0310","doi-asserted-by":"crossref","first-page":"12574","DOI":"10.1128\/JVI.01193-08","article-title":"Role of homodimerization of human cytomegalovirus DNA polymerase accessory protein UL44 in origin-dependent DNA replication in cells","volume":"82","author":"Sinigalia","year":"2008","journal-title":"J. Virol."},{"issue":"3","key":"10.1016\/j.bbamcr.2025.120074_bb0315","doi-asserted-by":"crossref","DOI":"10.3390\/v10030109","article-title":"Molecular requirements for self-interaction of the respiratory syncytial virus matrix protein in living mammalian cells","volume":"10","author":"Trevisan","year":"2018","journal-title":"Viruses"},{"issue":"8","key":"10.1016\/j.bbamcr.2025.120074_bb0320","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1016\/j.bbamcr.2018.05.006","article-title":"Contribution of the residue at position 4 within classical nuclear localization signals to modulating interaction with importins and nuclear targeting","volume":"1865","author":"Smith","year":"2018","journal-title":"Biochim. Biophys. Acta"},{"issue":"8","key":"10.1016\/j.bbamcr.2025.120074_bb0325","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1042\/BCJ20170897","article-title":"Intersectin goes nuclear: secret life of an endocytic protein","volume":"475","author":"Alvisi","year":"2018","journal-title":"Biochem. J."},{"issue":"2","key":"10.1016\/j.bbamcr.2025.120074_bb0330","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/1873-3468.14797","article-title":"Structural determinants of phosphorylation-dependent nuclear transport of HCMV DNA polymerase processivity factor UL44","volume":"598","author":"Cross","year":"2024","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bbamcr.2025.120074_bb0335","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/msb.2011.75","article-title":"Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal omega","volume":"7","author":"Sievers","year":"2011","journal-title":"Mol. Syst. Biol."},{"issue":"6","key":"10.1016\/j.bbamcr.2025.120074_bb0340","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1093\/molbev\/msy096","article-title":"MEGA X: molecular evolutionary genetics analysis across computing platforms","volume":"35","author":"Kumar","year":"2018","journal-title":"Mol. Biol. Evol."},{"issue":"25","key":"10.1016\/j.bbamcr.2025.120074_bb0345","doi-asserted-by":"crossref","first-page":"10171","DOI":"10.1073\/pnas.0900604106","article-title":"Systematic identification of cell cycle-dependent yeast nucleocytoplasmic shuttling proteins by prediction of composite motifs","volume":"106","author":"Kosugi","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbamcr.2025.120074_bb0350","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/978-1-4939-6783-4_2","article-title":"UniProt protein knowledgebase","volume":"1558","author":"Pundir","year":"2017","journal-title":"Methods Mol. Biol."},{"issue":"Database issue","key":"10.1016\/j.bbamcr.2025.120074_bb0355","first-page":"D344","article-title":"New and continuing developments at PROSITE","volume":"41","author":"Sigrist","year":"2013","journal-title":"Nucleic Acids Res."},{"issue":"Web Server issue","key":"10.1016\/j.bbamcr.2025.120074_bb0360","doi-asserted-by":"crossref","first-page":"W244","DOI":"10.1093\/nar\/gki408","article-title":"The HHpred interactive server for protein homology detection and structure prediction","volume":"33","author":"Soding","year":"2005","journal-title":"Nucleic Acids Res."},{"issue":"8016","key":"10.1016\/j.bbamcr.2025.120074_bb0365","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/s41586-024-07487-w","article-title":"Accurate structure prediction of biomolecular interactions with AlphaFold 3","volume":"630","author":"Abramson","year":"2024","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.bbamcr.2025.120074_bb0370","doi-asserted-by":"crossref","first-page":"858","DOI":"10.2144\/99265bm12","article-title":"Mapping of nuclear localization signals by simultaneous fusion to green fluorescent protein and to beta-galactosidase","volume":"26","author":"Sorg","year":"1999","journal-title":"Biotechniques"},{"issue":"52","key":"10.1016\/j.bbamcr.2025.120074_bb0375","doi-asserted-by":"crossref","first-page":"36638","DOI":"10.1074\/jbc.M109.036699","article-title":"Probing nuclear localization signal-importin alpha binding equilibria in living cells","volume":"284","author":"Cardarelli","year":"2009","journal-title":"J. Biol. Chem."},{"issue":"30","key":"10.1016\/j.bbamcr.2025.120074_bb0380","doi-asserted-by":"crossref","first-page":"27981","DOI":"10.1074\/jbc.M303275200","article-title":"Structural basis for the specificity of bipartite nuclear localization sequence binding by importin-alpha","volume":"278","author":"Fontes","year":"2003","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.bbamcr.2025.120074_bb0385","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1006\/jmbi.2000.3642","article-title":"Structural basis of recognition of monopartite and bipartite nuclear localization sequences by mammalian importin-alpha","volume":"297","author":"Fontes","year":"2000","journal-title":"J. Mol. Biol."},{"issue":"8","key":"10.1016\/j.bbamcr.2025.120074_bb0390","doi-asserted-by":"crossref","DOI":"10.4161\/psb.25106","article-title":"The function of importin beta1 is conserved in eukaryotes but the substrates may vary in organisms","volume":"8","author":"Luo","year":"2013","journal-title":"Plant Signal. Behav."},{"key":"10.1016\/j.bbamcr.2025.120074_bb0395","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1038\/msb4100160","article-title":"The adapter importin-alpha provides flexible control of nuclear import at the expense of efficiency","volume":"3","author":"Riddick","year":"2007","journal-title":"Mol. Syst. Biol."},{"issue":"46","key":"10.1016\/j.bbamcr.2025.120074_bb0400","doi-asserted-by":"crossref","first-page":"32699","DOI":"10.1074\/jbc.274.46.32699","article-title":"A bipartite nuclear localization signal is required for p53 nuclear import regulated by a carboxyl-terminal domain","volume":"274","author":"Liang","year":"1999","journal-title":"J. Biol. Chem."},{"issue":"44","key":"10.1016\/j.bbamcr.2025.120074_bb0405","doi-asserted-by":"crossref","first-page":"8000","DOI":"10.3748\/wjg.v19.i44.8000","article-title":"Identification and characterization of a novel bipartite nuclear localization signal in the hepatitis B virus polymerase","volume":"19","author":"Lupberger","year":"2013","journal-title":"World J. Gastroenterol."},{"issue":"4","key":"10.1016\/j.bbamcr.2025.120074_bb0410","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1111\/j.1600-0854.2012.01329.x","article-title":"Structural basis of high-affinity nuclear localization signal interactions with importin-alpha","volume":"13","author":"Marfori","year":"2012","journal-title":"Traffic"},{"issue":"2","key":"10.1016\/j.bbamcr.2025.120074_bb0415","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.jmb.2011.07.038","article-title":"Structural basis of importin-alpha-mediated nuclear transport for Ku70 and Ku80","volume":"412","author":"Takeda","year":"2011","journal-title":"J. Mol. Biol."},{"issue":"2","key":"10.1016\/j.bbamcr.2025.120074_bb0420","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1074\/jbc.M008522200","article-title":"Dissection of a nuclear localization signal","volume":"276","author":"Hodel","year":"2001","journal-title":"J. Biol. Chem."},{"issue":"43","key":"10.1016\/j.bbamcr.2025.120074_bb0425","doi-asserted-by":"crossref","first-page":"41947","DOI":"10.1074\/jbc.M307162200","article-title":"Dissection of the karyopherin alpha nuclear localization signal (NLS)-binding groove: functional requirements for NLS binding","volume":"278","author":"Leung","year":"2003","journal-title":"J. Biol. Chem."},{"issue":"6","key":"10.1016\/j.bbamcr.2025.120074_bb0430","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1007\/s00705-016-2794-y","article-title":"A taxonomy update for the family Polyomaviridae","volume":"161","author":"Calvignac-Spencer","year":"2016","journal-title":"Arch. Virol."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016748892500179X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016748892500179X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T16:35:34Z","timestamp":1766075734000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S016748892500179X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":86,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["S016748892500179X"],"URL":"https:\/\/doi.org\/10.1016\/j.bbamcr.2025.120074","relation":{},"ISSN":["0167-4889"],"issn-type":[{"value":"0167-4889","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Importin \u03b1\/\u03b21 dependent nuclear import of black sea bass polyomavirus large tumor antigen is mediated by a classical NLS located downstream of the SF3 helicase domain","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Cell Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbamcr.2025.120074","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"120074"}}