{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T15:55:58Z","timestamp":1787586958122,"version":"build-2736575974"},"reference-count":42,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Cell Research"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.bbamcr.2025.120078","type":"journal-article","created":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T00:07:15Z","timestamp":1761782835000},"page":"120078","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Basic leucine zipper ATF-like transcription factor (Batf) aggravates central sensitization in nitroglycerin-induced chronic migraine mouse model"],"prefix":"10.1016","volume":"1873","author":[{"given":"Yanhong","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"17","key":"10.1016\/j.bbamcr.2025.120078_bb0005","doi-asserted-by":"crossref","DOI":"10.3390\/cells11172767","article-title":"Pathophysiology and therapy of associated features of migraine","volume":"11","author":"Villar-Martinez","year":"2022","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.bbamcr.2025.120078_bb0010","doi-asserted-by":"crossref","DOI":"10.1186\/s10194-023-01619-9","article-title":"Global, regional, and national time trends in incidence for migraine, from 1990 to 2019: an age-period-cohort analysis for the GBD 2019","volume":"24","author":"Fan","year":"2023","journal-title":"J. Headache Pain"},{"issue":"5","key":"10.1016\/j.bbamcr.2025.120078_bb0015","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s11916-022-01034-w","article-title":"Sex differences in chronic migraine: focusing on clinical features, pathophysiology, and treatments","volume":"26","author":"Tsai","year":"2022","journal-title":"Curr. Pain Headache Rep."},{"key":"10.1016\/j.bbamcr.2025.120078_bb0020","unstructured":"Kumar A, Kadian R: Migraine prophylaxis."},{"issue":"4","key":"10.1016\/j.bbamcr.2025.120078_bb0025","article-title":"Non-pharmacological interventions for prophylaxis of vestibular migraine","volume":"4","author":"Webster","year":"2023","journal-title":"Cochrane Database Syst. Rev."},{"issue":"1","key":"10.1016\/j.bbamcr.2025.120078_bb0030","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.ncl.2022.05.005","article-title":"Chronic migraine: diagnosis and management","volume":"41","author":"Kung","year":"2023","journal-title":"Neurol. Clin."},{"issue":"63","key":"10.1016\/j.bbamcr.2025.120078_bb0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3310\/AYWA5297","article-title":"Preventive drug treatments for adults with chronic migraine: a systematic review with economic modelling","volume":"28","author":"Mistry","year":"2024","journal-title":"Health Technol. Assess."},{"issue":"27","key":"10.1016\/j.bbamcr.2025.120078_bb0040","doi-asserted-by":"crossref","first-page":"2919","DOI":"10.2174\/1381612825666190709204107","article-title":"Novelty in inflammation and immunomodulation in migraine","volume":"25","author":"Cavestro","year":"2019","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.bbamcr.2025.120078_bb0045","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2023.1219574","article-title":"A systematic literature review on the role of glial cells in the pathomechanisms of migraine","volume":"16","author":"Zhang","year":"2023","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.bbamcr.2025.120078_bb0050","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.jneuroim.2017.09.008","article-title":"Unbalanced plasma TNF-\u03b1 and IL-12\/IL-10 profile in women with migraine is associated with psychological and physiological outcomes","volume":"313","author":"Oliveira","year":"2017","journal-title":"J. Neuroimmunol."},{"issue":"103957","key":"10.1016\/j.bbamcr.2025.120078_bb0055","first-page":"5","article-title":"Study on the involvement of microglial S100A8 in neuroinflammation and microglia activation during migraine attacks","volume":"130","author":"An","year":"2024","journal-title":"Mol. Cell. Neurosci."},{"issue":"1","key":"10.1016\/j.bbamcr.2025.120078_bb0060","doi-asserted-by":"crossref","DOI":"10.1186\/s10194-024-01739-w","article-title":"AMPK activation attenuates central sensitization in a recurrent nitroglycerin-induced chronic migraine mouse model by promoting microglial M2-type polarization","volume":"25","author":"Lu","year":"2024","journal-title":"J. Headache Pain"},{"issue":"1","key":"10.1016\/j.bbamcr.2025.120078_bb0065","doi-asserted-by":"crossref","first-page":"019","DOI":"10.1186\/s12974-019-1603-4","article-title":"P2Y12 receptor mediates microglial activation via RhoA\/ROCK pathway in the trigeminal nucleus caudalis in a mouse model of chronic migraine","volume":"16","author":"Jing","year":"2019","journal-title":"J. Neuroinflammation"},{"issue":"1","key":"10.1016\/j.bbamcr.2025.120078_bb0070","doi-asserted-by":"crossref","DOI":"10.1186\/s10194-023-01707-w","article-title":"Microglia TREM1-mediated neuroinflammation contributes to central sensitization via the NF-\u03baB pathway in a chronic migraine model","volume":"25","author":"Sun","year":"2024","journal-title":"J. Headache Pain"},{"issue":"7","key":"10.1016\/j.bbamcr.2025.120078_bb0075","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1136\/gutjnl-2014-308227","article-title":"Batf-dependent Th17 cells critically regulate IL-23 driven colitis-associated colon cancer","volume":"65","author":"Punkenburg","year":"2016","journal-title":"Gut"},{"key":"10.1016\/j.bbamcr.2025.120078_bb0080","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.molimm.2025.03.001","article-title":"BATF participates in airway inflammation of neutrophilic asthma via regulating Th17 cells activation","volume":"181","author":"Liu","year":"2025","journal-title":"Mol. Immunol."},{"issue":"1","key":"10.1016\/j.bbamcr.2025.120078_bb0085","doi-asserted-by":"crossref","DOI":"10.1186\/s13075-018-1658-0","article-title":"BATF regulates collagen-induced arthritis by regulating T helper cell differentiation","volume":"20","author":"Park","year":"2018","journal-title":"Arthritis Res. Ther."},{"issue":"1","key":"10.1016\/j.bbamcr.2025.120078_bb0090","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/s41418-024-01329-y","article-title":"The m(6)a methyltransferase METTL3 drives neuroinflammation and neurotoxicity through stabilizing BATF mRNA in microglia","volume":"32","author":"Wu","year":"2025","journal-title":"Cell Death Differ."},{"issue":"2","key":"10.1016\/j.bbamcr.2025.120078_bb0095","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1007\/s13311-017-0592-1","article-title":"Migraine treatment: current acute medications and their potential mechanisms of action","volume":"15","author":"Ong","year":"2018","journal-title":"Neurotherapeutics"},{"issue":"1","key":"10.1016\/j.bbamcr.2025.120078_bb0100","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.jaci.2013.09.049","article-title":"The activating protein 1 transcription factor basic leucine zipper transcription factor, ATF-like (BATF), regulates lymphocyte- and mast cell-driven immune responses in the setting of allergic asthma","volume":"133","author":"\u00dcbel","year":"2014","journal-title":"J. Allergy Clin. Immunol."},{"issue":"7","key":"10.1016\/j.bbamcr.2025.120078_bb0105","article-title":"Nonsteroidal anti-inflammatory drugs for dysmenorrhoea","volume":"30","author":"Marjoribanks","year":"2015","journal-title":"Cochrane Database Syst. Rev."},{"issue":"4","key":"10.1016\/j.bbamcr.2025.120078_bb0110","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1002\/jcp.24815","article-title":"Cyclooxygenase-2 regulates NLRP3 inflammasome-derived IL-1\u03b2 production","volume":"230","author":"Hua","year":"2015","journal-title":"J. Cell. Physiol."},{"issue":"7","key":"10.1016\/j.bbamcr.2025.120078_bb0115","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25073706","article-title":"Differences in neuropathology between nitroglycerin-induced mouse models of episodic and chronic migraine","volume":"25","author":"Park","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbamcr.2025.120078_bb0120","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.pneurobio.2019.02.002","article-title":"Nitroglycerin as a comparative experimental model of migraine pain: from animal to human and back","volume":"177","author":"Demartini","year":"2019","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.bbamcr.2025.120078_bb0125","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.pbb.2014.06.023","article-title":"Chronic activation of sigma-1 receptor evokes nociceptive activation of trigeminal nucleus caudalis in rats","volume":"124","author":"Pyun","year":"2014","journal-title":"Pharmacol. Biochem. Behav."},{"issue":"2","key":"10.1016\/j.bbamcr.2025.120078_bb0130","doi-asserted-by":"crossref","first-page":"70007","DOI":"10.1111\/ejn.70007","article-title":"Neural plasticity in migraine Chronification","volume":"61","author":"Fila","year":"2025","journal-title":"Eur. J. Neurosci."},{"issue":"1","key":"10.1016\/j.bbamcr.2025.120078_bb0135","doi-asserted-by":"crossref","first-page":"021","DOI":"10.1186\/s12974-021-02342-5","article-title":"Microrna-155-5p promotes neuroinflammation and central sensitization via inhibiting SIRT1 in a nitroglycerin-induced chronic migraine mouse model","volume":"18","author":"Wen","year":"2021","journal-title":"J. Neuroinflammation"},{"issue":"10","key":"10.1016\/j.bbamcr.2025.120078_bb0140","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1016\/S1474-4422(23)00206-5","article-title":"Migraine in older adults","volume":"22","author":"Hugger","year":"2023","journal-title":"Lancet Neurol."},{"issue":"5","key":"10.1016\/j.bbamcr.2025.120078_bb0145","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1212\/01.WNL.0000137107.27585.F7","article-title":"Clinical recognition of allodynia in migraine","volume":"63","author":"Mathew","year":"2004","journal-title":"Neurology"},{"issue":"1","key":"10.1016\/j.bbamcr.2025.120078_bb0150","doi-asserted-by":"crossref","DOI":"10.1186\/s10194-021-01302-x","article-title":"Activation of microglial GLP-1R in the trigeminal nucleus caudalis suppresses central sensitization of chronic migraine after recurrent nitroglycerin stimulation","volume":"22","author":"Jing","year":"2021","journal-title":"J. Headache Pain."},{"issue":"5","key":"10.1016\/j.bbamcr.2025.120078_bb0155","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1111\/head.13529","article-title":"CGRP and the trigeminal system in migraine","volume":"59","author":"Iyengar","year":"2019","journal-title":"Headache"},{"key":"10.1016\/j.bbamcr.2025.120078_bb0160","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.biopha.2017.03.052","article-title":"Analgesia effect of baicalein against NTG-induced migraine in rats","volume":"90","author":"Zhang","year":"2017","journal-title":"Biomed. Pharmacother."},{"issue":"1","key":"10.1016\/j.bbamcr.2025.120078_bb0165","doi-asserted-by":"crossref","first-page":"021","DOI":"10.1186\/s10194-021-01299-3","article-title":"Repeated oxytocin prevents central sensitization by regulating synaptic plasticity via oxytocin receptor in a chronic migraine mouse model","volume":"22","author":"Wang","year":"2021","journal-title":"J. Headache Pain"},{"issue":"6","key":"10.1016\/j.bbamcr.2025.120078_bb0170","doi-asserted-by":"crossref","first-page":"3697","DOI":"10.1007\/s12035-023-03781-2","article-title":"TLR2 mediates microglial activation and contributes to central sensitization in a recurrent nitroglycerin-induced chronic migraine model","volume":"61","author":"Liu","year":"2024","journal-title":"Mol. Neurobiol."},{"issue":"1","key":"10.1016\/j.bbamcr.2025.120078_bb0175","doi-asserted-by":"crossref","first-page":"020","DOI":"10.1186\/s12974-020-02056-0","article-title":"P2X7R-mediated autophagic impairment contributes to central sensitization in a chronic migraine model with recurrent nitroglycerin stimulation in mice","volume":"18","author":"Jiang","year":"2021","journal-title":"J. Neuroinflammation"},{"issue":"1","key":"10.1016\/j.bbamcr.2025.120078_bb0180","doi-asserted-by":"crossref","first-page":"019","DOI":"10.1186\/s10194-019-1070-4","article-title":"Microglia P2X4R-BDNF signalling contributes to central sensitization in a recurrent nitroglycerin-induced chronic migraine model","volume":"21","author":"Long","year":"2020","journal-title":"J. Headache Pain"},{"issue":"7","key":"10.1016\/j.bbamcr.2025.120078_bb0185","doi-asserted-by":"crossref","first-page":"2989","DOI":"10.1093\/brain\/awad045","article-title":"Neuronal NLRP3 inflammasome mediates spreading depolarization-evoked trigeminovascular activation","volume":"146","author":"Chen","year":"2023","journal-title":"Brain"},{"issue":"1","key":"10.1016\/j.bbamcr.2025.120078_bb0190","doi-asserted-by":"crossref","first-page":"019","DOI":"10.1186\/s12974-019-1459-7","article-title":"Microglial NLRP3 inflammasome activation mediates IL-1\u03b2 release and contributes to central sensitization in a recurrent nitroglycerin-induced migraine model","volume":"16","author":"He","year":"2019","journal-title":"J. Neuroinflammation"},{"issue":"113851","key":"10.1016\/j.bbamcr.2025.120078_bb0195","first-page":"15","article-title":"BAY-117082-driven NLRP3 inflammasome inhibition resolves nitro-glycerine (NTG) neuronal damage in in vivo model of migraine","volume":"156","author":"Filippone","year":"2022","journal-title":"Biomed. Pharmacother."},{"issue":"156754","key":"10.1016\/j.bbamcr.2025.120078_bb0200","first-page":"11","article-title":"Xiongshao Zhitong granules alleviate nitroglycerin-induced migraine by regulating the TRPV1-mediated NLRP3 inflammatory pathway in rats","volume":"142","author":"Wang","year":"2025","journal-title":"Phytomedicine"},{"issue":"1","key":"10.1016\/j.bbamcr.2025.120078_bb0205","doi-asserted-by":"crossref","DOI":"10.1186\/s12974-024-03313-2","article-title":"Metformin attenuates central sensitization by regulating neuroinflammation through the TREM2-SYK signaling pathway in a mouse model of chronic migraine","volume":"21","author":"Fan","year":"2024","journal-title":"J. Neuroinflammation"},{"issue":"23","key":"10.1016\/j.bbamcr.2025.120078_bb0210","doi-asserted-by":"crossref","first-page":"24270","DOI":"10.18632\/aging.202143","article-title":"Metformin protects against myocardial ischemia-reperfusion injury and cell pyroptosis via AMPK\/NLRP3 inflammasome pathway","volume":"12","author":"Zhang","year":"2020","journal-title":"Aging"}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167488925001831?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167488925001831?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T05:08:13Z","timestamp":1764133693000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167488925001831"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["S0167488925001831"],"URL":"https:\/\/doi.org\/10.1016\/j.bbamcr.2025.120078","relation":{},"ISSN":["0167-4889"],"issn-type":[{"value":"0167-4889","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Basic leucine zipper ATF-like transcription factor (Batf) aggravates central sensitization in nitroglycerin-induced chronic migraine mouse model","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Cell Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbamcr.2025.120078","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"120078"}}