{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T03:30:29Z","timestamp":1790998229268,"version":"4.1.0"},"reference-count":47,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100014717","name":"Youth Science Fund Project","doi-asserted-by":"publisher","award":["82200061"],"award-info":[{"award-number":["82200061"]}],"id":[{"id":"10.13039\/100014717","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014717","name":"Youth Science Fund Project","doi-asserted-by":"publisher","award":["82500138"],"award-info":[{"award-number":["82500138"]}],"id":[{"id":"10.13039\/100014717","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Cell Research"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.bbamcr.2026.120151","type":"journal-article","created":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T06:42:07Z","timestamp":1776408127000},"page":"120151","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Methionine drives lung adenocarcinoma progression via regulation of BACH1-SERPINE1"],"prefix":"10.1016","volume":"1873","author":[{"given":"Xupeng","family":"Wen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengyu","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.bbamcr.2026.120151_bb0005","first-page":"394","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA Cancer J. Clin."},{"issue":"9","key":"10.1016\/j.bbamcr.2026.120151_bb0010","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1097\/JTO.0000000000000630","article-title":"The 2015 World Health Organization classification of lung tumors: impact of genetic, clinical and radiologic advances since the 2004 classification","volume":"10","author":"Travis","year":"2015","journal-title":"J. Thorac. Oncol."},{"issue":"3","key":"10.1016\/j.bbamcr.2026.120151_bb0015","doi-asserted-by":"crossref","first-page":"223","DOI":"10.5301\/tj.5000479","article-title":"Is the chemotherapy era in advanced non-small cell lung cancer really over? Maybe not yet","volume":"2016","author":"Lo Russo","year":"2016","journal-title":"Tumori"},{"issue":"4","key":"10.1016\/j.bbamcr.2026.120151_bb0020","first-page":"271","article-title":"Cancer treatment and survivorship statistics, 2016","volume":"66","author":"Miller","year":"2016","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.bbamcr.2026.120151_bb0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.jnutbio.2023.109416","article-title":"EGCG alleviates obesity-exacerbated lung cancer progression by STAT1\/SLC7A11 pathway and gut microbiota","volume":"120","author":"Li","year":"2023","journal-title":"J. Nutr. Biochem."},{"issue":"1","key":"10.1016\/j.bbamcr.2026.120151_bb0030","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s11658-022-00345-5","article-title":"Effect of chronic intermittent hypoxia-induced HIF-1alpha\/ATAD2 expression on lung cancer stemness","volume":"27","author":"Hao","year":"2022","journal-title":"Cell. Mol. Biol. Lett."},{"issue":"1","key":"10.1016\/j.bbamcr.2026.120151_bb0035","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1186\/s12931-021-01918-2","article-title":"BTB and CNC homology 1 (Bach1) induces lung cancer stem cell phenotypes by stimulating CD44 expression","volume":"22","author":"Jiang","year":"2021","journal-title":"Respir. Res."},{"issue":"11","key":"10.1016\/j.bbamcr.2026.120151_bb0040","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/nrc.2016.85","article-title":"Altered metabolite levels in cancer: implications for tumour biology and cancer therapy","volume":"16","author":"Sullivan","year":"2016","journal-title":"Nat. Rev. Cancer"},{"issue":"11","key":"10.1016\/j.bbamcr.2026.120151_bb0045","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1038\/s41568-019-0187-8","article-title":"Methionine metabolism in health and cancer: a nexus of diet and precision medicine","volume":"19","author":"Sanderson","year":"2019","journal-title":"Nat. Rev. Cancer"},{"issue":"1","key":"10.1016\/j.bbamcr.2026.120151_bb0050","doi-asserted-by":"crossref","first-page":"8076","DOI":"10.1038\/s41598-018-26254-2","article-title":"Effects of single amino acid deficiency on mRNA translation are markedly different for methionine versus leucine","volume":"8","author":"Mazor","year":"2018","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.bbamcr.2026.120151_bb0055","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1002\/ijc.32128","article-title":"Genetic variants in RUNX3, AMD1 and MSRA in the methionine metabolic pathway and survival in nonsmall cell lung cancer patients","volume":"145","author":"Chen","year":"2019","journal-title":"Int. J. Cancer"},{"issue":"6","key":"10.1016\/j.bbamcr.2026.120151_bb0060","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.ctrv.2012.01.004","article-title":"A review of methionine dependency and the role of methionine restriction in cancer growth control and life-span extension","volume":"38","author":"Cavuoto","year":"2012","journal-title":"Cancer Treat. Rev."},{"issue":"5","key":"10.1016\/j.bbamcr.2026.120151_bb0065","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/BF02796468","article-title":"Methionine dependence in cancer cells - a review","volume":"18","author":"Hoffman","year":"1982","journal-title":"In Vitro"},{"key":"10.1016\/j.bbamcr.2026.120151_bb0070","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.mam.2016.09.001","article-title":"Metabolic interactions with cancer epigenetics","volume":"54","author":"Gao","year":"2017","journal-title":"Mol. Aspects Med."},{"issue":"16","key":"10.1016\/j.bbamcr.2026.120151_bb0075","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1177\/15353702211005390","article-title":"Cancer and stem cells","volume":"246","author":"Yin","year":"2021","journal-title":"Exp. Biol. Med. (Maywood)"},{"issue":"1","key":"10.1016\/j.bbamcr.2026.120151_bb0080","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/s41392-020-0110-5","article-title":"Targeting cancer stem cell pathways for cancer therapy","volume":"5","author":"Yang","year":"2020","journal-title":"Signal Transduct. Target. Ther."},{"issue":"1","key":"10.1016\/j.bbamcr.2026.120151_bb0085","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s10549-019-05146-7","article-title":"S-adenosylmethionine biosynthesis is a targetable metabolic vulnerability of cancer stem cells","volume":"175","author":"Strekalova","year":"2019","journal-title":"Breast Cancer Res. Treat."},{"issue":"1","key":"10.1016\/j.bbamcr.2026.120151_bb0090","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.cmet.2007.10.002","article-title":"The biology of cancer: metabolic reprogramming fuels cell growth and proliferation","volume":"7","author":"DeBerardinis","year":"2008","journal-title":"Cell Metab."},{"issue":"4","key":"10.1016\/j.bbamcr.2026.120151_bb0095","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1055\/s-0033-1334487","article-title":"Three decades of research on plasminogen activator inhibitor-1: a multifaceted serpin","volume":"39","author":"Declerck","year":"2013","journal-title":"Semin. Thromb. Hemost."},{"issue":"24","key":"10.1016\/j.bbamcr.2026.120151_bb0100","doi-asserted-by":"crossref","first-page":"4873","DOI":"10.1182\/blood-2012-06-436188","article-title":"Genome-wide association study for circulating levels of PAI-1 provides novel insights into its regulation","volume":"120","author":"Huang","year":"2012","journal-title":"Blood"},{"issue":"5","key":"10.1016\/j.bbamcr.2026.120151_bb0105","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22052721","article-title":"A narrative review on plasminogen activator Inhibitor-1 and its (patho)physiological role: to target or not to target?","volume":"22","author":"Sillen","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"5","key":"10.1016\/j.bbamcr.2026.120151_bb0110","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1038\/s41591-019-0423-5","article-title":"Methionine is a metabolic dependency of tumor-initiating cells","volume":"25","author":"Wang","year":"2019","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbamcr.2026.120151_bb0115","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.semcancer.2022.11.006","article-title":"The role of stem cells in small-cell lung cancer: evidence from chemoresistance to immunotherapy","volume":"87","author":"Guo","year":"2022","journal-title":"Semin. Cancer Biol."},{"issue":"1","key":"10.1016\/j.bbamcr.2026.120151_bb0120","doi-asserted-by":"crossref","first-page":"111","DOI":"10.3892\/ijo.2020.5153","article-title":"Crosstalk between YAP and TGFbeta regulates SERPINE1 expression in mesenchymal lung cancer cells","volume":"58","author":"Kong","year":"2021","journal-title":"Int. J. Oncol."},{"issue":"5","key":"10.1016\/j.bbamcr.2026.120151_bb0125","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1158\/0008-5472.CAN-13-1541","article-title":"CD133+ cancer stem-like cells in small cell lung cancer are highly tumorigenic and chemoresistant but sensitive to a novel neuropeptide antagonist","volume":"74","author":"Sarvi","year":"2014","journal-title":"Cancer Res."},{"issue":"9","key":"10.1016\/j.bbamcr.2026.120151_bb0130","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1016\/j.ccell.2023.07.012","article-title":"CD44(+) lung cancer stem cell-derived pericyte-like cells cause brain metastases through GPR124-enhanced trans-endothelial migration","volume":"41","author":"Huang","year":"2023","journal-title":"Cancer Cell"},{"issue":"5","key":"10.1016\/j.bbamcr.2026.120151_bb0135","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.cmet.2015.08.024","article-title":"Histone methylation dynamics and gene regulation occur through the sensing of one-carbon metabolism","volume":"22","author":"Mentch","year":"2015","journal-title":"Cell Metab."},{"key":"10.1016\/j.bbamcr.2026.120151_bb0140","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.44235","article-title":"Quantification of microenvironmental metabolites in murine cancers reveals determinants of tumor nutrient availability","volume":"8","author":"Sullivan","year":"2019","journal-title":"Elife"},{"issue":"7824","key":"10.1016\/j.bbamcr.2026.120151_bb0145","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/s41586-020-2682-1","article-title":"Cancer SLC43A2 alters T cell methionine metabolism and histone methylation","volume":"585","author":"Bian","year":"2020","journal-title":"Nature"},{"issue":"7769","key":"10.1016\/j.bbamcr.2026.120151_bb0150","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/s41586-019-1437-3","article-title":"Dietary methionine influences therapy in mouse cancer models and alters human metabolism","volume":"572","author":"Gao","year":"2019","journal-title":"Nature"},{"issue":"22","key":"10.1016\/j.bbamcr.2026.120151_bb0155","doi-asserted-by":"crossref","DOI":"10.3390\/cells11223607","article-title":"Stemness of normal and cancer cells: the influence of methionine needs and SIRT1\/PGC-1alpha\/PPAR-alpha players","volume":"11","author":"Siblini","year":"2022","journal-title":"Cells"},{"issue":"5","key":"10.1016\/j.bbamcr.2026.120151_bb0160","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1097\/CCO.0000000000000870","article-title":"Targeting the methionine-methionine adenosyl transferase 2A- S -adenosyl methionine axis for cancer therapy","volume":"34","author":"Guo","year":"2022","journal-title":"Curr. Opin. Oncol."},{"issue":"5","key":"10.1016\/j.bbamcr.2026.120151_bb0165","first-page":"2249","article-title":"Targeting the methionine addiction of cancer","volume":"12","author":"Sedillo","year":"2022","journal-title":"Am. J. Cancer Res."},{"issue":"8","key":"10.1016\/j.bbamcr.2026.120151_bb0170","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1038\/s41419-019-1836-2","article-title":"Folate can promote the methionine-dependent reprogramming of glioblastoma cells towards pluripotency","volume":"10","author":"Zgheib","year":"2019","journal-title":"Cell Death Dis."},{"issue":"9","key":"10.1016\/j.bbamcr.2026.120151_bb0175","doi-asserted-by":"crossref","DOI":"10.3390\/nu14091887","article-title":"ALDH1L2 knockout in U251 glioblastoma cells reduces tumor sphere formation by increasing oxidative stress and suppressing methionine dependency","volume":"14","author":"Quere","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.bbamcr.2026.120151_bb0180","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.biopha.2018.05.119","article-title":"Plasminogen activator inhibitor-1 in cancer research","volume":"105","author":"Li","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.bbamcr.2026.120151_bb0185","article-title":"Pan-cancer analysis of SERPINE family genes as biomarkers of cancer prognosis and response to therapy","volume":"10","author":"Liu","year":"2023","journal-title":"Front. Mol. Biosci."},{"issue":"1","key":"10.1016\/j.bbamcr.2026.120151_bb0190","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/S0361-090X(02)00002-8","article-title":"The active fraction of plasmatic plasminogen activator inhibitor type 1 as a possible indicator of increased risk for metastatic melanoma","volume":"26","author":"Hanekom","year":"2002","journal-title":"Cancer Detect. Prev."},{"issue":"3","key":"10.1016\/j.bbamcr.2026.120151_bb0195","first-page":"1153","article-title":"Plasma plasminogen activator inhibitor-1 (PAI-1) levels in breast cancer - relationship with clinical outcome","volume":"34","author":"Ferroni","year":"2014","journal-title":"Anticancer Res."},{"issue":"4","key":"10.1016\/j.bbamcr.2026.120151_bb0200","doi-asserted-by":"crossref","first-page":"2984","DOI":"10.1111\/jcmm.14205","article-title":"Inhibition of PAI-1 limits chemotherapy resistance in lung cancer through suppressing myofibroblast characteristics of cancer-associated fibroblasts","volume":"23","author":"Masuda","year":"2019","journal-title":"J. Cell. Mol. Med."},{"issue":"2","key":"10.1016\/j.bbamcr.2026.120151_bb0205","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1002\/hed.25437","article-title":"Effect of serpinE1 overexpression on the primary tumor and lymph node, and lung metastases in head and neck squamous cell carcinoma","volume":"41","author":"Arroyo-Solera","year":"2019","journal-title":"Head Neck"},{"key":"10.1016\/j.bbamcr.2026.120151_bb0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.114635","article-title":"Total alkaloids in Stephania tetrandra induce apoptosis by regulating BBC3 in human non-small cell lung cancer cells","volume":"162","author":"Li","year":"2023","journal-title":"Biomed. Pharmacother."},{"issue":"2","key":"10.1016\/j.bbamcr.2026.120151_bb0215","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.cell.2019.06.005","article-title":"BACH1 stabilization by antioxidants stimulates lung cancer metastasis","volume":"178","author":"Wiel","year":"2019","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.bbamcr.2026.120151_bb0220","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1002\/jcp.30599","article-title":"LINC00662: a new oncogenic lncRNA with great potential","volume":"237","author":"Zhong","year":"2022","journal-title":"J. Cell. Physiol."},{"issue":"10","key":"10.1016\/j.bbamcr.2026.120151_bb0225","doi-asserted-by":"crossref","DOI":"10.3390\/cells13100796","article-title":"SERPINE1: role in cholangiocarcinoma progression and a therapeutic target in the desmoplastic microenvironment","volume":"13","author":"Czekay","year":"2024","journal-title":"Cells"},{"key":"10.1016\/j.bbamcr.2026.120151_bb0230","article-title":"Identification and validation of SERPINE1 as a prognostic and immunological biomarker in pan-cancer and in ccRCC","volume":"14","author":"Li","year":"2023","journal-title":"Front. Pharmacol."},{"issue":"20","key":"10.1016\/j.bbamcr.2026.120151_bb0235","doi-asserted-by":"crossref","first-page":"3734","DOI":"10.1158\/0008-5472.CAN-22-1695","article-title":"CD248 regulates Wnt signaling in pericytes to promote angiogenesis and tumor growth in lung cancer","volume":"82","author":"Hong","year":"2022","journal-title":"Cancer Res."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167488926000492?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167488926000492?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T12:31:10Z","timestamp":1780489870000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167488926000492"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":47,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["S0167488926000492"],"URL":"https:\/\/doi.org\/10.1016\/j.bbamcr.2026.120151","relation":{},"ISSN":["0167-4889"],"issn-type":[{"value":"0167-4889","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Methionine drives lung adenocarcinoma progression via regulation of BACH1-SERPINE1","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Cell Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbamcr.2026.120151","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"120151"}}