{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T15:21:18Z","timestamp":1783092078236,"version":"3.54.6"},"reference-count":31,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T00:00:00Z","timestamp":1779840000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100020581","name":"AIRC Associazione Italiana per la Ricerca sul Cancro","doi-asserted-by":"publisher","award":["IG2019-23040"],"award-info":[{"award-number":["IG2019-23040"]}],"id":[{"id":"10.13039\/100020581","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005010","name":"Associazione Italiana per la Ricerca sul Cancro","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100024370","name":"Ministero dell&apos;Istruzione dell&apos;Universita e della Ricerca","doi-asserted-by":"publisher","award":["B53D23021740006"],"award-info":[{"award-number":["B53D23021740006"]}],"id":[{"id":"10.13039\/501100024370","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Cell Research"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.bbamcr.2026.120164","type":"journal-article","created":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T23:35:22Z","timestamp":1779838522000},"page":"120164","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["The yin and yang interplay between HDAC6 and KDM1 regulates the lysosomal degradation of mutp53 in colon cancer cells undergoing TG-induced ER stress"],"prefix":"10.1016","volume":"1873","author":[{"given":"Rossella","family":"Benedetti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosanna Paola","family":"Amato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Di Crosta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Saveria","family":"Gilardini Montani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Santarelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Gonnella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella","family":"D'Orazi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mara","family":"Cirone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.bbamcr.2026.120164_bb0005","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/s41418-018-0246-9","article-title":"Mutant p53 as a guardian of the cancer cell","volume":"26","author":"Mantovani","year":"2019","journal-title":"Cell Death Differ."},{"issue":"12","key":"10.1016\/j.bbamcr.2026.120164_bb0010","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.1038\/cdd.2011.71","article-title":"SAHA shows preferential cytotoxicity in mutant p53 cancer cells by destabilizing mutant p53 through inhibition of the HDAC6-Hsp90 chaperone axis","volume":"18","author":"Li","year":"2011","journal-title":"Cell Death Differ."},{"issue":"7","key":"10.1016\/j.bbamcr.2026.120164_bb0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2023.107003","article-title":"Acetylation halts missense mutant p53 aggregation and rescues tumor suppression in non-small cell lung cancers","volume":"26","author":"Xu","year":"2023","journal-title":"iScience"},{"issue":"13","key":"10.1016\/j.bbamcr.2026.120164_bb0020","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25137020","article-title":"SAHA\/5-AZA enhances acetylation and degradation of mutp53, upregulates p21 and downregulates c-Myc and BRCA-1 in pancreatic cancer cells","volume":"25","author":"Di Crosta","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"9","key":"10.1016\/j.bbamcr.2026.120164_bb0025","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines13092279","article-title":"Valemetostat-SAHA-driven acetylation of p53 via SET\/TAF-Ibeta displacement and p300 activation modulates cell cycle regulators in pancreatic cancer cells","volume":"13","author":"Di Crosta","year":"2025","journal-title":"Biomedicines"},{"issue":"12","key":"10.1016\/j.bbamcr.2026.120164_bb0030","doi-asserted-by":"crossref","first-page":"3304","DOI":"10.1080\/15548627.2025.2576615","article-title":"Acetylation promotes mutant (MUT) TP53-HSPA8 and HSPA8-BAG3 interactions, facilitating MUT TP53 lysosomal degradation preferentially via CASA","volume":"21","author":"Di Crosta","year":"2025","journal-title":"Autophagy"},{"issue":"15","key":"10.1016\/j.bbamcr.2026.120164_bb0035","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1101\/gad.220897.113","article-title":"Chaperone-mediated autophagy degrades mutant p53","volume":"27","author":"Vakifahmetoglu-Norberg","year":"2013","journal-title":"Genes Dev."},{"issue":"6","key":"10.1016\/j.bbamcr.2026.120164_bb0040","doi-asserted-by":"crossref","DOI":"10.1172\/JCI164354","article-title":"The ubiquitin ligase TRIM21 regulates mutant p53 accumulation and gain of function in cancer","volume":"133","author":"Liu","year":"2023","journal-title":"J. Clin. Invest."},{"issue":"8","key":"10.1016\/j.bbamcr.2026.120164_bb0045","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.1080\/15548627.2024.2338577","article-title":"ATF6 supports lysosomal function in tumor cells to enable ER stress-activated macroautophagy and CMA: impact on mutant TP53 expression","volume":"20","author":"Benedetti","year":"2024","journal-title":"Autophagy"},{"issue":"6","key":"10.1016\/j.bbamcr.2026.120164_bb0050","doi-asserted-by":"crossref","DOI":"10.3390\/biom14060649","article-title":"Recent advances on mutant p53: Unveiling novel oncogenic roles, degradation pathways, and therapeutic interventions","volume":"14","author":"Cordani","year":"2024","journal-title":"Biomolecules"},{"key":"10.1016\/j.bbamcr.2026.120164_bb0055","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2024.1363543","article-title":"Proteasome inhibition paradoxically degrades gain-of-function mutant p53 R273H in NSCLC and could have therapeutic implications","volume":"14","author":"Oduah","year":"2024","journal-title":"Front. Oncol."},{"issue":"3","key":"10.1016\/j.bbamcr.2026.120164_bb0060","doi-asserted-by":"crossref","first-page":"361","DOI":"10.2217\/epi.11.21","article-title":"Regulation of p53 function by lysine methylation","volume":"3","author":"West","year":"2011","journal-title":"Epigenomics"},{"issue":"9","key":"10.1016\/j.bbamcr.2026.120164_bb0065","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines9091262","article-title":"Role of UPR sensor activation in cell death-survival decision of colon cancer cells stressed by DPE treatment","volume":"9","author":"Benedetti","year":"2021","journal-title":"Biomedicines"},{"issue":"1","key":"10.1016\/j.bbamcr.2026.120164_bb0070","doi-asserted-by":"crossref","first-page":"5637","DOI":"10.1038\/s41598-019-42220-y","article-title":"Metabolic stress controls mutant p53 R248Q stability in acute myeloid leukemia cells","volume":"9","author":"Allende-Vega","year":"2019","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.bbamcr.2026.120164_bb0075","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/s41420-022-01085-3","article-title":"ATF6 prevents DNA damage and cell death in colon cancer cells undergoing ER stress","volume":"8","author":"Benedetti","year":"2022","journal-title":"Cell Death Discov."},{"issue":"1","key":"10.1016\/j.bbamcr.2026.120164_bb0080","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/s41420-025-02433-9","article-title":"Mutant p53 upregulates HDAC6 to resist ER stress and facilitates Ku70 deacetylation, which prevents its degradation and mitigates DNA damage in colon cancer cells","volume":"11","author":"Benedetti","year":"2025","journal-title":"Cell Death Discov."},{"issue":"5","key":"10.1016\/j.bbamcr.2026.120164_bb0085","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2013.163","article-title":"Glucose restriction induces cell death in parental but not in homeodomain-interacting protein kinase 2-depleted RKO colon cancer cells: molecular mechanisms and implications for tumor therapy","volume":"4","author":"Garufi","year":"2013","journal-title":"Cell Death Dis."},{"issue":"7","key":"10.1016\/j.bbamcr.2026.120164_bb0090","article-title":"Post-translational modifications (PTMs) of mutp53 and epigenetic changes induced by mutp53","volume":"13","author":"Benedetti","year":"2024","journal-title":"Biol.-Basel"},{"key":"10.1016\/j.bbamcr.2026.120164_bb0095","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.canlet.2017.01.033","article-title":"HDAC6 deacetylates p53 at lysines 381\/382 and differentially coordinates p53-induced apoptosis","volume":"391","author":"Ryu","year":"2017","journal-title":"Cancer Lett."},{"issue":"6","key":"10.1016\/j.bbamcr.2026.120164_bb0100","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1093\/emboj\/20.6.1331","article-title":"p300\/CBP-mediated p53 acetylation is commonly induced by p53-activating agents and inhibited by MDM2","volume":"20","author":"Ito","year":"2001","journal-title":"EMBO J."},{"issue":"1","key":"10.1016\/j.bbamcr.2026.120164_bb0105","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1186\/s13148-024-01725-8","article-title":"HDAC6 inhibition disrupts HDAC6-P300 interaction reshaping the cancer chromatin landscape","volume":"16","author":"Zamperla","year":"2024","journal-title":"Clin. Epigenetics"},{"key":"10.1016\/j.bbamcr.2026.120164_bb0110","doi-asserted-by":"crossref","first-page":"8651","DOI":"10.1038\/ncomms9651","article-title":"Histone methyltransferase SETDB1 regulates liver cancer cell growth through methylation of p53","volume":"6","author":"Fei","year":"2015","journal-title":"Nat. Commun."},{"issue":"4","key":"10.1016\/j.bbamcr.2026.120164_bb0115","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1002\/bip.22643","article-title":"KDM1 class flavin-dependent protein lysine demethylases","volume":"104","author":"Burg","year":"2015","journal-title":"Biopolymers"},{"issue":"1","key":"10.1016\/j.bbamcr.2026.120164_bb0120","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/15548627.2020.1797280","article-title":"Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)(1)","volume":"17","author":"Klionsky","year":"2021","journal-title":"Autophagy"},{"issue":"1","key":"10.1016\/j.bbamcr.2026.120164_bb0125","doi-asserted-by":"crossref","first-page":"30","DOI":"10.3390\/cancers7010030","article-title":"p53 Acetylation: Regulation and Consequences","volume":"7","author":"Reed","year":"2014","journal-title":"Cancers (Basel)"},{"issue":"2","key":"10.1016\/j.bbamcr.2026.120164_bb0130","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1042\/BST20231025","article-title":"Post-translational modifications: emerging directors of cell-fate decisions during endoplasmic reticulum stress in Arabidopsis thaliana","volume":"52","author":"Thibault","year":"2024","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.bbamcr.2026.120164_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.mcpro.2021.100129","article-title":"Decoding Post-Translational Modification Crosstalk With Proteomics","volume":"20","author":"Leutert","year":"2021","journal-title":"Mol. Cell. Proteomics"},{"issue":"3","key":"10.1016\/j.bbamcr.2026.120164_bb0140","doi-asserted-by":"crossref","DOI":"10.3390\/biom10030392","article-title":"Interplay between Endoplasmic Reticulum (ER) Stress and autophagy induces mutant p53H273 degradation","volume":"10","author":"Garufi","year":"2020","journal-title":"Biomolecules"},{"issue":"32","key":"10.1016\/j.bbamcr.2026.120164_bb0145","doi-asserted-by":"crossref","first-page":"11099","DOI":"10.1074\/jbc.REV120.011833","article-title":"Post-translational modifications of Hsp90 and translating the chaperone code","volume":"295","author":"Backe","year":"2020","journal-title":"J. Biol. Chem."},{"issue":"7158","key":"10.1016\/j.bbamcr.2026.120164_bb0150","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/nature06092","article-title":"p53 is regulated by the lysine demethylase LSD1","volume":"449","author":"Huang","year":"2007","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.bbamcr.2026.120164_bb0155","doi-asserted-by":"crossref","DOI":"10.3892\/ijo.2022.5393","article-title":"Targeting histone demethylases as a potential cancer therapy (Review)","volume":"61","author":"Diao","year":"2022","journal-title":"Int. J. Oncol."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167488926000625?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167488926000625?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T14:57:06Z","timestamp":1783090626000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167488926000625"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":31,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["S0167488926000625"],"URL":"https:\/\/doi.org\/10.1016\/j.bbamcr.2026.120164","relation":{},"ISSN":["0167-4889"],"issn-type":[{"value":"0167-4889","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The yin and yang interplay between HDAC6 and KDM1 regulates the lysosomal degradation of mutp53 in colon cancer cells undergoing TG-induced ER stress","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Cell Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbamcr.2026.120164","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"120164"}}