{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T09:19:55Z","timestamp":1787649595547,"version":"build-2736575974"},"reference-count":44,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,8,8]],"date-time":"2027-08-08T00:00:00Z","timestamp":1817683200000},"content-version":"am","delay-in-days":311,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100012952","name":"Universit\u00e9 Grenoble Alpes","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012952","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R35HL150778"],"award-info":[{"award-number":["R35HL150778"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Cell Research"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.bbamcr.2026.120202","type":"journal-article","created":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T06:19:35Z","timestamp":1785737975000},"page":"120202","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["The ubiquitin-activating enzyme inhibitor TAK-243 activates store-operated Ca2+ channels independently of endoplasmic reticulum Ca2+ stores and enhances mitochondrial Ca2+ buffering capacity in DU-145 human prostate cancer cells"],"prefix":"10.1016","volume":"1873","author":[{"given":"Marie","family":"Perrier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Cory","family":"Benson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Odile","family":"Fauvarque","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Trebak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Bouron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbamcr.2026.120202_bb0005","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1146\/annurev-pharmtox-010919-023603","article-title":"Proteasome inhibitor drugs","volume":"60","author":"Fricker","year":"2020","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.bbamcr.2026.120202_bb0010","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1038\/nrm2673","article-title":"Ubiquitin-like protein activation by E1 enzymes: the apex for downstream signalling pathways","volume":"10","author":"Schulman","year":"2009","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bbamcr.2026.120202_bb0015","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/j.molmed.2015.08.003","article-title":"UBA1: at the crossroads of ubiquitin homeostasis and neurodegeneration","volume":"21","author":"Groen","year":"2015","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.bbamcr.2026.120202_bb0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1124\/pharmrev.120.000053","article-title":"E1 enzymes as therapeutic targets in cancer","volume":"73","author":"Barghout","year":"2021","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.bbamcr.2026.120202_bb0025","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1038\/nm.4474","article-title":"A small-molecule inhibitor of the ubiquitin activating enzyme for cancer treatment","volume":"24","author":"Hyer","year":"2018","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbamcr.2026.120202_bb0030","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/s41375-018-0167-0","article-title":"Preclinical evaluation of the selective small-molecule UBA1 inhibitor, TAK-243, in acute myeloid leukemia","volume":"33","author":"Barghout","year":"2019","journal-title":"Leukemia"},{"key":"10.1016\/j.bbamcr.2026.120202_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2022.102026","article-title":"Binding of the erlin1\/2 complex to the third intralumenal loop of IP(3)R1 triggers its ubiquitin-proteasomal degradation","volume":"298","author":"Gao","year":"2022","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamcr.2026.120202_bb0040","doi-asserted-by":"crossref","DOI":"10.1093\/pnasnexus\/pgac232","article-title":"Genomic screening reveals ubiquitin-like modifier activating enzyme 1 as a potent and druggable target in c-MYC-high triple negative breast cancer models","volume":"1","author":"Jacob","year":"2022","journal-title":"PNAS Nexus"},{"key":"10.1016\/j.bbamcr.2026.120202_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbamcr.2023.119618","article-title":"The ubiquitin-proteasome pathway inhibitor TAK-243 has major effects on calcium handling in mammalian cells","volume":"1871","author":"Gao","year":"2024","journal-title":"Biochim. Biophys. Acta, Mol. Cell Res."},{"key":"10.1016\/j.bbamcr.2026.120202_bb0050","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1038\/nrc3105","article-title":"Calcium in tumour metastasis: new roles for known actors","volume":"11","author":"Prevarskaya","year":"2011","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.bbamcr.2026.120202_bb0055","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/nrc.2017.18","article-title":"The calcium-cancer signalling nexus","volume":"17","author":"Monteith","year":"2017","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.bbamcr.2026.120202_bb0060","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a035204","article-title":"The calcium-signaling toolkit in cancer: remodeling and targeting","volume":"11","author":"Roberts-Thomson","year":"2019","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.bbamcr.2026.120202_bb0065","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1016\/j.molcel.2020.04.017","article-title":"Ca(2+) fluxes and cancer","volume":"78","author":"Marchi","year":"2020","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bbamcr.2026.120202_bb0070","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1038\/s41419-019-1613-2","article-title":"Central role of IP(3)R2-mediated Ca(2+) oscillation in self-renewal of liver cancer stem cells elucidated by high-signal ER sensor","volume":"10","author":"Sun","year":"2019","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bbamcr.2026.120202_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2022.121823","article-title":"Human cancer cells generate spontaneous calcium transients and intercellular waves that modulate tumor growth","volume":"290","author":"Liang","year":"2022","journal-title":"Biomaterials"},{"key":"10.1016\/j.bbamcr.2026.120202_bb0080","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/s41467-019-13842-7","article-title":"BCL9 provides multi-cellular communication properties in colorectal cancer by interacting with paraspeckle proteins","volume":"11","author":"Jiang","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbamcr.2026.120202_bb0085","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2022112198","article-title":"NALCN-mediated sodium influx confers metastatic prostate cancer cell invasiveness","volume":"42","author":"Folcher","year":"2023","journal-title":"EMBO J."},{"key":"10.1016\/j.bbamcr.2026.120202_bb0090","doi-asserted-by":"crossref","first-page":"5700","DOI":"10.1038\/s41388-019-0823-5","article-title":"Androgen receptor-modulatory microRNAs provide insight into therapy resistance and therapeutic targets in advanced prostate cancer","volume":"38","author":"Fletcher","year":"2019","journal-title":"Oncogene"},{"key":"10.1016\/j.bbamcr.2026.120202_bb0095","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2016.00486","article-title":"Pharmacological characterization of the native store-operated calcium channels of cortical neurons from embryonic mouse brain","volume":"7","author":"Chauvet","year":"2016","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bbamcr.2026.120202_bb0100","doi-asserted-by":"crossref","first-page":"2649","DOI":"10.1038\/s41598-020-59565-4","article-title":"Inhibition of store-operated calcium channels by N-arachidonoyl glycine (NAGly): no evidence for the involvement of lipid-sensing G protein coupled receptors","volume":"10","author":"Deveci","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbamcr.2026.120202_bb0105","doi-asserted-by":"crossref","first-page":"98","DOI":"10.2144\/000113610","article-title":"Mitochondrial membrane potential probes and the proton gradient: a practical usage guide","volume":"50","author":"Perry","year":"2011","journal-title":"Biotechniques"},{"key":"10.1016\/j.bbamcr.2026.120202_bb0110","doi-asserted-by":"crossref","first-page":"4441","DOI":"10.4049\/jimmunol.170.9.4441","article-title":"A Pyrazole derivative, YM-58483, potently inhibits store-operated sustained Ca2+ influx and IL-2 production in T lymphocytes","volume":"170","author":"Ishikawa","year":"2003","journal-title":"J. Immunol."},{"issue":"2","key":"10.1016\/j.bbamcr.2026.120202_bb0115","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1111\/j.1469-7793.2000.t01-1-00461.x","article-title":"Dihydropyridine-induced Ca2+ release from ryanodine-sensitive Ca2+ pools in human skeletal muscle cells","volume":"525","author":"Weigl","year":"2000","journal-title":"J. Physiol."},{"key":"10.1016\/j.bbamcr.2026.120202_bb0120","doi-asserted-by":"crossref","first-page":"C1193","DOI":"10.1152\/ajpcell.2001.280.5.C1193","article-title":"Nifedipine-activated Ca(2+) permeability in newborn rat cortical collecting duct cells in primary culture","volume":"280","author":"Valencia","year":"2001","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.bbamcr.2026.120202_bb0125","doi-asserted-by":"crossref","first-page":"17369","DOI":"10.1073\/pnas.2007598117","article-title":"L-type Ca(2+) channel blockers promote vascular remodeling through activation of STIM proteins","volume":"117","author":"Johnson","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbamcr.2026.120202_bb0130","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/s42003-023-04858-3","article-title":"Orai, RyR, and IP3R channels cooperatively regulate calcium signaling in brain mid-capillary pericytes","volume":"6","author":"Phillips","year":"2023","journal-title":"Commun. Biol."},{"key":"10.1016\/j.bbamcr.2026.120202_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2023.105310","article-title":"A multiple-oscillator mechanism underlies antigen-induced Ca2+ oscillations in Jurkat T-cells","volume":"299","author":"Benson","year":"2023","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamcr.2026.120202_bb0140","doi-asserted-by":"crossref","first-page":"4153","DOI":"10.1038\/ncomms5153","article-title":"Imaging intraorganellar Ca2+ at subcellular resolution using CEPIA","volume":"5","author":"Suzuki","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbamcr.2026.120202_bb0145","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1161\/01.RES.30.1.44","article-title":"Excitation-contraction coupling in rabbit aorta studied by lanthanum method for measuring cellular calcium influx","volume":"30","author":"Vanbreemen","year":"1972","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbamcr.2026.120202_bb0150","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/S0092-8674(00)80301-3","article-title":"Mitochondria are excitable organelles capable of generating and conveying electrical and calcium signals","volume":"89","author":"Ichas","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.bbamcr.2026.120202_bb0155","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1111\/j.1471-4159.2009.06446.x","article-title":"The TRPC6 channel activator hyperforin induces the release of zinc and calcium from mitochondria","volume":"112","author":"Tu","year":"2010","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbamcr.2026.120202_bb0160","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0143-4160(03)00024-1","article-title":"Mechanisms of ATP-induced calcium signaling and growth arrest in human prostate cancer cells","volume":"34","author":"Vanoverberghe","year":"2003","journal-title":"Cell Calcium"},{"key":"10.1016\/j.bbamcr.2026.120202_bb0165","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1677\/erc.1.01079","article-title":"Epidermal growth factor-induced neuroendocrine differentiation and apoptotic resistance of androgen-independent human prostate cancer cells","volume":"13","author":"Humez","year":"2006","journal-title":"Endocr. Relat. Cancer"},{"key":"10.1016\/j.bbamcr.2026.120202_bb0170","article-title":"STIM1 accelerates cell senescence in a remodeled microenvironment but enhances the epithelial-to-mesenchymal transition in prostate cancer","volume":"5","author":"Xu","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbamcr.2026.120202_bb0175","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1002\/mc.22324","article-title":"Resveratrol activates autophagic cell death in prostate cancer cells via downregulation of STIM1 and the mTOR pathway","volume":"55","author":"Selvaraj","year":"2016","journal-title":"Mol. Carcinog."},{"key":"10.1016\/j.bbamcr.2026.120202_bb0180","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a004226","article-title":"Calcium oscillations","volume":"3","author":"Dupont","year":"2011","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.bbamcr.2026.120202_bb0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbamcr.2022.119293","article-title":"Spatial and temporal crosstalk between the cAMP and Ca2+ signaling systems","volume":"1869","author":"Arige","year":"2022","journal-title":"Biochim. Biophys. Acta, Mol. Cell Res."},{"key":"10.1016\/j.bbamcr.2026.120202_bb0190","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1038\/31960","article-title":"Calcium oscillations increase the efficiency and specificity of gene expression","volume":"392","author":"Dolmetsch","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.bbamcr.2026.120202_bb0195","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/s41586-022-05520-4","article-title":"Autonomous rhythmic activity in glioma networks drives brain tumour growth","volume":"613","author":"Hausmann","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.bbamcr.2026.120202_bb0200","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2023.1071037","article-title":"Sustained IP3-linked Ca2+ signaling promotes progression of triple negative breast cancer cells by regulating fatty acid metabolism","volume":"11","author":"Filadi","year":"2023","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.bbamcr.2026.120202_bb0205","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1083\/jcb.137.3.633","article-title":"Mitochondrial regulation of store-operated calcium signaling in T lymphocytes","volume":"137","author":"Hoth","year":"1997","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.bbamcr.2026.120202_bb0210","doi-asserted-by":"crossref","first-page":"10607","DOI":"10.1073\/pnas.180143997","article-title":"Mitochondrial control of calcium-channel gating: a mechanism for sustained signaling and transcriptional activation in T lymphocytes","volume":"97","author":"Hoth","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbamcr.2026.120202_bb0215","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.141518","article-title":"A genome-wide CRISPR\/Cas9 screen in acute myeloid leukemia cells identifies regulators of TAK-243 sensitivity","volume":"6","author":"Barghout","year":"2021","journal-title":"JCI Insight"},{"key":"10.1016\/j.bbamcr.2026.120202_bb0220","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1021\/acschembio.4c00450","article-title":"Functional characterization of pathway inhibitors for the ubiquitin-proteasome system (UPS) as tool compounds for CRBN and VHL-mediated targeted protein degradation","volume":"20","author":"Schwalm","year":"2025","journal-title":"ACS Chem. Biol."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167488926001011?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167488926001011?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T08:31:05Z","timestamp":1787646665000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167488926001011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":44,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["S0167488926001011"],"URL":"https:\/\/doi.org\/10.1016\/j.bbamcr.2026.120202","relation":{},"ISSN":["0167-4889"],"issn-type":[{"value":"0167-4889","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The ubiquitin-activating enzyme inhibitor TAK-243 activates store-operated Ca2+ channels independently of endoplasmic reticulum Ca2+ stores and enhances mitochondrial Ca2+ buffering capacity in DU-145 human prostate cancer cells","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Cell Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbamcr.2026.120202","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"120202"}}