{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T19:48:39Z","timestamp":1791748119778,"version":"4.3.4"},"reference-count":54,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003130","name":"Research Foundation Flanders","doi-asserted-by":"publisher","award":["G0D0417N"],"award-info":[{"award-number":["G0D0417N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Research Foundation Flanders","doi-asserted-by":"publisher","award":["G0B2219N"],"award-info":[{"award-number":["G0B2219N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004497","name":"KU Leuven Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004497","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004040","name":"KU Leuven","doi-asserted-by":"publisher","award":["C14\/18\/086"],"award-info":[{"award-number":["C14\/18\/086"]}],"id":[{"id":"10.13039\/501100004040","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Cell Research"],"published-print":{"date-parts":[[2027,1]]},"DOI":"10.1016\/j.bbamcr.2026.120232","type":"journal-article","created":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:04:12Z","timestamp":1791216252000},"page":"120232","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Activation by statins unveils two putative agonist binding sites in the pore domain of TRPA1"],"prefix":"10.1016","volume":"1874","author":[{"given":"Karel","family":"Talavera","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alina","family":"Milici","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Held","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariel","family":"Talavera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justyna B.","family":"Startek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.bbamcr.2026.120232_bb0005","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/nrd2757","article-title":"Transient receptor potential channels: targeting pain at the source","volume":"8","author":"Patapoutian","year":"2009","journal-title":"Nat. Rev. Drug Discov."},{"issue":"2","key":"10.1016\/j.bbamcr.2026.120232_bb0010","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1152\/physrev.00005.2019","article-title":"Mammalian transient receptor potential TRPA1 channels: from structure to disease","volume":"100","author":"Talavera","year":"2019","journal-title":"Physiol. Rev."},{"issue":"15","key":"10.1016\/j.bbamcr.2026.120232_bb0015","doi-asserted-by":"crossref","first-page":"4151","DOI":"10.1113\/JP270935","article-title":"TRPA1 channels: molecular sentinels of cellular stress and tissue damage","volume":"594","author":"Viana","year":"2016","journal-title":"J. Physiol."},{"key":"10.1016\/j.bbamcr.2026.120232_bb0020","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.46084","article-title":"Mouse TRPA1 function and membrane localization is modulated by direct interactions with cholesterol","volume":"8","author":"Startek","year":"2019","journal-title":"eLife"},{"issue":"11","key":"10.1016\/j.bbamcr.2026.120232_bb0025","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21113826","article-title":"Lipid raft destabilization impairs mouse TRPA1 responses to cold and bacterial lipopolysaccharides","volume":"21","author":"Startek","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbamcr.2026.120232_bb0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.ceca.2020.102255","article-title":"Human TRPA1 is an inherently mechanosensitive bilayer-gated ion channel","volume":"91","author":"Moparthi","year":"2020","journal-title":"Cell Calcium"},{"key":"10.1016\/j.bbamcr.2026.120232_bb0035","doi-asserted-by":"crossref","DOI":"10.1038\/srep28763","article-title":"Human TRPA1 is a heat sensor displaying intrinsic U-shaped thermosensitivity","volume":"6","author":"Moparthi","year":"2016","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.bbamcr.2026.120232_bb0040","doi-asserted-by":"crossref","first-page":"6113","DOI":"10.1038\/s41467-022-33876-8","article-title":"The human TRPA1 intrinsic cold and heat sensitivity involves separate channel structures beyond the N-ARD domain","volume":"13","author":"Moparthi","year":"2022","journal-title":"Nat. Commun."},{"issue":"47","key":"10.1016\/j.bbamcr.2026.120232_bb0045","doi-asserted-by":"crossref","first-page":"16901","DOI":"10.1073\/pnas.1412689111","article-title":"Human TRPA1 is intrinsically cold- and chemosensitive with and without its N-terminal ankyrin repeat domain","volume":"111","author":"Moparthi","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbamcr.2026.120232_bb0050","doi-asserted-by":"crossref","first-page":"43","DOI":"10.4137\/NMI.S38362","article-title":"Statin use in prostate Cancer: an update","volume":"9","author":"Babcook","year":"2016","journal-title":"Nutrition and metabolic insights"},{"issue":"2","key":"10.1016\/j.bbamcr.2026.120232_bb0055","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.cgh.2012.08.037","article-title":"Statins and colorectal cancer","volume":"11","author":"Lochhead","year":"2013","journal-title":"Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association"},{"issue":"1","key":"10.1016\/j.bbamcr.2026.120232_bb0060","doi-asserted-by":"crossref","first-page":"5804","DOI":"10.1038\/s41598-018-24248-8","article-title":"Use of statins and the risk of dementia and mild cognitive impairment: a systematic review and meta-analysis","volume":"8","author":"Chu","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbamcr.2026.120232_bb0065","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s40035-018-0110-3","article-title":"The role of statins in both cognitive impairment and protection against dementia: a tale of two mechanisms","volume":"7","author":"Schultz","year":"2018","journal-title":"Transl. Neurodegener."},{"key":"10.1016\/j.bbamcr.2026.120232_bb0070","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.phrs.2014.03.002","article-title":"The pharmacology of statins","volume":"88","author":"Sirtori","year":"2014","journal-title":"Pharmacol. Res."},{"issue":"3","key":"10.1016\/j.bbamcr.2026.120232_bb0075","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/apha.12378","article-title":"The essential role of transient receptor potential vanilloid 1 in simvastatin-induced activation of endothelial nitric oxide synthase and angiogenesis","volume":"212","author":"Su","year":"2014","journal-title":"Acta Physiol (Oxford)"},{"key":"10.1016\/j.bbamcr.2026.120232_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2025.178206","article-title":"Statins activate temperature-gated transient receptor potential ion channels","volume":"1006","author":"Oprita","year":"2025","journal-title":"Eur. J. Pharmacol."},{"issue":"7","key":"10.1016\/j.bbamcr.2026.120232_bb0085","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22073368","article-title":"The agonist action of Alkylphenols on TRPA1 relates to their effects on membrane lipid order: implications for TRPA1-mediated Chemosensation","volume":"22","author":"Startek","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.bbamcr.2026.120232_bb0090","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20020371","article-title":"TRP channels as sensors of chemically-induced changes in cell membrane mechanical properties","volume":"20","author":"Startek","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.bbamcr.2026.120232_bb0095","doi-asserted-by":"crossref","first-page":"12010","DOI":"10.1038\/s41598-018-30534-2","article-title":"Differential interactions of bacterial lipopolysaccharides with lipid membranes: implications for TRPA1-mediated chemosensation","volume":"8","author":"Startek","year":"2018","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.bbamcr.2026.120232_bb0100","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0006-3495(91)82041-0","article-title":"Quantitation of lipid phases in phospholipid vesicles by the generalized polarization of Laurdan fluorescence","volume":"60","author":"Parasassi","year":"1991","journal-title":"Biophys. J."},{"issue":"1","key":"10.1016\/j.bbamcr.2026.120232_bb0105","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0005-2736(02)00514-X","article-title":"Use of laurdan fluorescence intensity and polarization to distinguish between changes in membrane fluidity and phospholipid order","volume":"1565","author":"Harris","year":"2002","journal-title":"Biochim. Biophys. Acta"},{"issue":"10","key":"10.1016\/j.bbamcr.2026.120232_bb0110","doi-asserted-by":"crossref","first-page":"4519","DOI":"10.1016\/S0021-9258(19)85523-0","article-title":"The increase in bilayer fluidity of rat liver plasma membranes achieved by the local anesthetic benzyl alcohol affects the activity of intrinsic membrane enzymes","volume":"255","author":"Gordon","year":"1980","journal-title":"J. Biol. Chem."},{"issue":"7127","key":"10.1016\/j.bbamcr.2026.120232_bb0115","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/nature05544","article-title":"Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines","volume":"445","author":"Macpherson","year":"2007","journal-title":"Nature"},{"issue":"51","key":"10.1016\/j.bbamcr.2026.120232_bb0120","doi-asserted-by":"crossref","first-page":"19564","DOI":"10.1073\/pnas.0609598103","article-title":"TRP channel activation by reversible covalent modification","volume":"103","author":"Hinman","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbamcr.2026.120232_bb0125","article-title":"Elucidation of the binding mode of organic polysulfides on the human TRPA1 receptor","volume":"14\u20132023","author":"Nemes","year":"2023","journal-title":"Front. Physiol."},{"issue":"6","key":"10.1016\/j.bbamcr.2026.120232_bb0130","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1007\/s00424-011-1021-7","article-title":"Ligustilide: a novel TRPA1 modulator","volume":"462","author":"Zhong","year":"2011","journal-title":"Pflugers Arch."},{"issue":"39","key":"10.1016\/j.bbamcr.2026.120232_bb0135","doi-asserted-by":"crossref","first-page":"9640","DOI":"10.1523\/JNEUROSCI.2772-08.2008","article-title":"Identification of transmembrane domain 5 as a critical molecular determinant of menthol sensitivity in mammalian TRPA1 channels","volume":"28","author":"Xiao","year":"2008","journal-title":"J. Neurosci."},{"issue":"20","key":"10.1016\/j.bbamcr.2026.120232_bb0140","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222010997","article-title":"Activation of Drosophila melanogaster TRPA1 isoforms by citronellal and menthol","volume":"22","author":"Boonen","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"7570","key":"10.1016\/j.bbamcr.2026.120232_bb0145","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1038\/nature14871","article-title":"Structure of the TRPA1 ion channel suggests regulatory mechanisms","volume":"525","author":"Paulsen","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.bbamcr.2026.120232_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2024.107444","article-title":"Identification of the TRPA1 cannabinoid-binding site","volume":"209","author":"Amawi","year":"2024","journal-title":"Pharmacol. Res."},{"issue":"46","key":"10.1016\/j.bbamcr.2026.120232_bb0155","doi-asserted-by":"crossref","first-page":"31927","DOI":"10.1074\/jbc.M114.586891","article-title":"Molecular basis determining inhibition\/activation of nociceptive receptor TRPA1 protein","volume":"289","author":"Banzawa","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamcr.2026.120232_bb0160","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.phrs.2015.07.028","article-title":"Evidence for the role of lipid rafts and sphingomyelin in Ca2+\u2212gating of transient receptor potential channels in trigeminal sensory neurons and peripheral nerve terminals","volume":"100","author":"S\u00e1ghy","year":"2015","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.bbamcr.2026.120232_bb0165","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2024.1334130","article-title":"Cyclodextrin derivatives decrease transient receptor potential vanilloid 1 and ankyrin 1 ion channel activation via altering the surrounding membrane microenvironment by cholesterol depletion","volume":"12","author":"Nehr-Majoros","year":"2024","journal-title":"Front. Cell Dev. Biol."},{"issue":"7","key":"10.1016\/j.bbamcr.2026.120232_bb0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.jlr.2025.100844","article-title":"Cyclodextrins inhibit TRPV1 and TRPA1 activation-induced nociception via cholesterol depletion","volume":"66","author":"Nehr-Majoros","year":"2025","journal-title":"J. Lipid Res."},{"issue":"1","key":"10.1016\/j.bbamcr.2026.120232_bb0175","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25010466","article-title":"Statins-from fungi to pharmacy","volume":"25","author":"Sadowska","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.bbamcr.2026.120232_bb0180","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/s00424-018-2205-1","article-title":"To flourish or perish: evolutionary TRiPs into the sensory biology of plant-herbivore interactions","volume":"471","author":"Startek","year":"2019","journal-title":"Pflugers Arch."},{"issue":"1","key":"10.1016\/j.bbamcr.2026.120232_bb0185","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1111\/j.1365-2125.2011.03907.x","article-title":"What is a relevant statin concentration in cell experiments claiming pleiotropic effects?","volume":"72","author":"Bj\u00f6rkhem-Bergman","year":"2011","journal-title":"Br. J. Clin. Pharmacol."},{"issue":"3","key":"10.1016\/j.bbamcr.2026.120232_bb0190","first-page":"483","article-title":"Phase I study of lovastatin, an inhibitor of the mevalonate pathway, in patients with cancer","volume":"2","author":"Thibault","year":"1996","journal-title":"Clin. Cancer Res."},{"issue":"6","key":"10.1016\/j.bbamcr.2026.120232_bb0195","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1007\/s00280-013-2326-3","article-title":"Pharmacokinetics of high-dose simvastatin in refractory and relapsed chronic lymphocytic leukemia patients","volume":"72","author":"Ahmed","year":"2013","journal-title":"Cancer Chemother. Pharmacol."},{"issue":"10","key":"10.1016\/j.bbamcr.2026.120232_bb0200","doi-asserted-by":"crossref","first-page":"7145","DOI":"10.1074\/jbc.M609600200","article-title":"TRPA1 is differentially modulated by the amphipathic molecules trinitrophenol and chlorpromazine","volume":"282","author":"Hill","year":"2007","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.bbamcr.2026.120232_bb0205","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s00424-011-1069-4","article-title":"Primary alcohols activate human TRPA1 channel in a carbon chain length-dependent manner","volume":"463","author":"Komatsu","year":"2012","journal-title":"Pflugers Arch. - Eur. J. Physiol."},{"issue":"7823","key":"10.1016\/j.bbamcr.2026.120232_bb0210","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/s41586-020-2480-9","article-title":"Irritant-evoked activation and calcium modulation of the TRPA1 receptor","volume":"585","author":"Zhao","year":"2020","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.bbamcr.2026.120232_bb0215","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20201637","article-title":"A TRPA1 inhibitor suppresses neurogenic inflammation and airway contraction for asthma treatment","volume":"218","author":"Balestrini","year":"2021","journal-title":"J. Exp. Med."},{"issue":"2","key":"10.1016\/j.bbamcr.2026.120232_bb0220","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.neuron.2020.10.014","article-title":"A non-covalent ligand reveals biased Agonism of the TRPA1 Ion Channel","volume":"109","author":"Liu","year":"2021","journal-title":"Neuron"},{"issue":"5","key":"10.1016\/j.bbamcr.2026.120232_bb0225","doi-asserted-by":"crossref","first-page":"3161","DOI":"10.1074\/jbc.M114.600932","article-title":"Identification of significant amino acids in multiple transmembrane domains of human transient receptor potential Ankyrin 1 (TRPA1) for activation by Eudesmol, an oxygenized Sesquiterpene in hop essential oil","volume":"290","author":"Ohara","year":"2015","journal-title":"J. Biol. Chem."},{"issue":"37","key":"10.1016\/j.bbamcr.2026.120232_bb0230","doi-asserted-by":"crossref","first-page":"9874","DOI":"10.1523\/JNEUROSCI.2221-07.2007","article-title":"Bimodal action of menthol on the transient receptor potential channel TRPA1","volume":"27","author":"Karashima","year":"2007","journal-title":"J. Neurosci."},{"issue":"22","key":"10.1016\/j.bbamcr.2026.120232_bb0235","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21228745","article-title":"The role of structure and biophysical properties in the pleiotropic effects of statins","volume":"21","author":"Murphy","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"2\u20133","key":"10.1016\/j.bbamcr.2026.120232_bb0240","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0014-5793(00)02212-2","article-title":"Trp12, a novel Trp related protein from kidney","volume":"485","author":"Wissenbach","year":"2000","journal-title":"FEBS Lett."},{"issue":"6","key":"10.1016\/j.bbamcr.2026.120232_bb0245","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/S0092-8674(03)00158-2","article-title":"ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures","volume":"112","author":"Story","year":"2003","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.bbamcr.2026.120232_bb0250","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1002\/emmm.201100134","article-title":"Oxaliplatin-induced cold hypersensitivity is due to remodelling of ion channel expression in nociceptors","volume":"3","author":"Descoeur","year":"2011","journal-title":"EMBO Mol. Med."},{"issue":"6","key":"10.1016\/j.bbamcr.2026.120232_bb0255","doi-asserted-by":"crossref","first-page":"3440","DOI":"10.1016\/S0021-9258(19)83641-4","article-title":"A new generation of Ca2+ indicators with greatly improved fluorescence properties","volume":"260","author":"Grynkiewicz","year":"1985","journal-title":"J. Biol. Chem."},{"issue":"1\u20132","key":"10.1016\/j.bbamcr.2026.120232_bb0260","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s11010-010-0441-6","article-title":"Alterations in membrane fluidity and dynamics in experimental colon cancer and its chemoprevention by diclofenac","volume":"341","author":"Kaur","year":"2010","journal-title":"Mol. Cell. Biochem."},{"issue":"2","key":"10.1016\/j.bbamcr.2026.120232_bb0265","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jcc.21334","article-title":"AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading","volume":"31","author":"Trott","year":"2010","journal-title":"J. Comput. Chem."},{"issue":"4","key":"10.1016\/j.bbamcr.2026.120232_bb0270","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1211\/146080899128734820","article-title":"Differentiation of 3-Hydroxy-3-methylglutaryl-coenzyme a reductase inhibitors by their relative lipophilicity","volume":"5","author":"Joshi","year":"1999","journal-title":"Pharm. Pharmacol. Commun."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016748892600131X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016748892600131X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T19:23:29Z","timestamp":1791746609000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S016748892600131X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,1]]},"references-count":54,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2027,1]]}},"alternative-id":["S016748892600131X"],"URL":"https:\/\/doi.org\/10.1016\/j.bbamcr.2026.120232","relation":{},"ISSN":["0167-4889"],"issn-type":[{"value":"0167-4889","type":"print"}],"subject":[],"published":{"date-parts":[[2027,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Activation by statins unveils two putative agonist binding sites in the pore domain of TRPA1","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Cell Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbamcr.2026.120232","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"120232"}}