{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T02:46:22Z","timestamp":1792723582116,"version":"4.5.0"},"reference-count":42,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2006,8,1]],"date-time":"2006-08-01T00:00:00Z","timestamp":1154390400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,18]],"date-time":"2013-07-18T00:00:00Z","timestamp":1374105600000},"content-version":"vor","delay-in-days":2543,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Biomembranes"],"published-print":{"date-parts":[[2006,8]]},"DOI":"10.1016\/j.bbamem.2005.11.006","type":"journal-article","created":{"date-parts":[[2005,12,6]],"date-time":"2005-12-06T12:20:52Z","timestamp":1133871652000},"page":"1071-1077","source":"Crossref","is-referenced-by-count":55,"title":["Transfer of the AQP1 cDNA for the correction of radiation-induced salivary hypofunction"],"prefix":"10.1016","volume":"1758","author":[{"given":"Bruce J.","family":"Baum","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changyu","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana P.","family":"Cotrim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corinne M.","family":"Goldsmith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane C.","family":"Atkinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime S.","family":"Brahim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A.","family":"Chiorini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonis","family":"Voutetakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rose Anne","family":"Leakan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carter","family":"Van Waes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James B.","family":"Mitchell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Delporte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songlin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen M.","family":"Kaminsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabor G.","family":"Illei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbamem.2005.11.006_bib1","unstructured":"Oral cancer facts - http:\/\/www.oralcancerfoundation.org\/."},{"key":"10.1016\/j.bbamem.2005.11.006_bib2","unstructured":"G.L. Day, Cancer Rates and Risks - NIH; NCI - online publication\u2014 From the Epidemiology and Extramural Programs Branch, Division of Cancer Etiology, National Cancer Institute, Bethesda, Maryland -http:\/\/seer.cancer.gov\/publications\/raterisk\/risks175.html."},{"key":"10.1016\/j.bbamem.2005.11.006_bib3","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1097\/00005537-200108000-00022","article-title":"A prospective study of quality of life in head and neck cancer patients. Part II: longitudinal data","volume":"111","author":"Bjordal","year":"2001","journal-title":"Laryngoscope"},{"key":"10.1016\/j.bbamem.2005.11.006_bib4","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1001\/archotol.130.4.401","article-title":"Clinical predictors of quality of life in patients with head and neck cancer","volume":"130","author":"Terrell","year":"2004","journal-title":"Arch. Otolaryngol. Head Neck Surg."},{"key":"10.1016\/j.bbamem.2005.11.006_bib5","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.ijrobp.2005.01.040","article-title":"Recent progress in defining mechanisms and potential targets for prevention of normal tissue injury after radiation therapy","volume":"62","author":"Anscher","year":"2005","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"10.1016\/j.bbamem.2005.11.006_bib6","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1001\/archotol.130.6.764","article-title":"University of Michigan Head and Neck Cancer Team, Disability in patients with head and neck cancer","volume":"130","author":"Taylor","year":"2004","journal-title":"Arch. Otolaryngol. Head Neck Surg."},{"key":"10.1016\/j.bbamem.2005.11.006_bib7","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1177\/154411130301400305","article-title":"Oral sequelae of head and neck radiotherapy","volume":"14","author":"Vissink","year":"2003","journal-title":"Crit. Rev. Oral Biol. Med."},{"key":"10.1016\/j.bbamem.2005.11.006_bib8","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1177\/154411130301400306","article-title":"Prevention and treatment of the consequences of head and neck radiotherapy","volume":"14","author":"Vissink","year":"2003","journal-title":"Crit. Rev. Oral Biol. Med."},{"key":"10.1016\/j.bbamem.2005.11.006_bib9","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1001\/archotol.129.2.247","article-title":"Prophylactic treatment reduces the severity of xerostomia following irradiation therapy for oral cavity cancer","volume":"129","author":"Nagler","year":"2003","journal-title":"Arch. Otolaryngol. Head Neck Surg."},{"key":"10.1016\/j.bbamem.2005.11.006_bib10","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1046\/j.1365-2354.2003.00417.x","article-title":"Experiences of oral care in patients with haematological malignancies or head and neck cancer","volume":"12","author":"Ohrn","year":"2003","journal-title":"Eur. J. Cancer Care (Engl.)"},{"key":"10.1016\/j.bbamem.2005.11.006_bib11","first-page":"15","article-title":"Head and neck cancer: managing xerostomia and other treatment induced side effects","volume":"20","author":"Gosselin","year":"2002","journal-title":"ORL Head Neck Nurs."},{"key":"10.1016\/j.bbamem.2005.11.006_bib12","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1034\/j.1601-0825.2002.02838.x","article-title":"The enigmatic mechanism of irradiation-induced damage to the major salivary glands","volume":"8","author":"Nagler","year":"2002","journal-title":"Oral Dis."},{"key":"10.1016\/j.bbamem.2005.11.006_bib13","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1034\/j.1601-0825.2002.1o816.x","article-title":"Saliva\u2014The defender of the oral cavity","volume":"8","author":"Amerongen","year":"2002","journal-title":"Oral. Dis."},{"key":"10.1016\/j.bbamem.2005.11.006_bib14","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1034\/j.1601-0825.2002.02865.x","article-title":"The use of gene transfer for the protection and repair of salivary glands","volume":"8","author":"Vitolo","year":"2002","journal-title":"Oral. Dis."},{"key":"10.1016\/j.bbamem.2005.11.006_bib15","first-page":"G1146","article-title":"Direct in vivo adenovirus-mediated gene transfer to salivary glands","volume":"266","author":"Mastrangeli","year":"1994","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.bbamem.2005.11.006_bib16","doi-asserted-by":"crossref","first-page":"179","DOI":"10.14219\/jada.archive.1995.0143","article-title":"The impact of gene therapy on dentistry","volume":"126","author":"Baum","year":"1995","journal-title":"J. Am. Dent. Assoc."},{"key":"10.1016\/j.bbamem.2005.11.006_bib17","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0074-7696(02)13013-0","article-title":"Gene transfer to salivary glands","volume":"213","author":"Baum","year":"2002","journal-title":"Int. Rev. Cytol."},{"key":"10.1016\/j.bbamem.2005.11.006_bib18","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1038\/sj.gt.3302321","article-title":"Salivary glands and gene therapy: the mouth waters","volume":"11","author":"Zufferey","year":"2004","journal-title":"Gene Ther."},{"key":"10.1016\/j.bbamem.2005.11.006_bib19","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.molmed.2004.10.003","article-title":"Salivary glands: novel target sites for gene therapeutics","volume":"10","author":"Baum","year":"2004","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.bbamem.2005.11.006_bib20","first-page":"167","article-title":"Relationship between the cellular distribution of the alpha(v), beta3\/5 integrins and adenoviral infection in salivary glands","volume":"77","author":"Delporte","year":"1997","journal-title":"Lab. Invest."},{"key":"10.1016\/j.bbamem.2005.11.006_bib21","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1007\/s004240050526","article-title":"A polarized salivary cell monolayer useful for studying transepithelial fluid movement in vitro","volume":"435","author":"He","year":"1998","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.bbamem.2005.11.006_bib22","doi-asserted-by":"crossref","first-page":"3268","DOI":"10.1073\/pnas.94.7.3268","article-title":"Increased fluid secretion after adenoviral-mediated transfer of the aquaporin-1 cDNA to irradiated rat salivary glands","volume":"94","author":"Delporte","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbamem.2005.11.006_bib23","doi-asserted-by":"crossref","first-page":"11110","DOI":"10.1073\/pnas.88.24.11110","article-title":"Isolation of the cDNA for erythrocyte integral membrane protein of 28 kilodaltons: member of an ancient channel family","volume":"88","author":"Preston","year":"1991","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbamem.2005.11.006_bib24","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1006\/bbrc.1998.8668","article-title":"Relationship between adenovirus-mediated aquaporin 1 expression and fluid movement across epithelial cells","volume":"246","author":"Delporte","year":"1998","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbamem.2005.11.006_bib25","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0091-679X(08)60603-2","article-title":"Use of recombinant adenovirus for metabolic engineering of mammalian cells","volume":"43A","author":"Becker","year":"1994","journal-title":"Methods Cell Biol."},{"key":"10.1016\/j.bbamem.2005.11.006_bib26","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/sj.cgt.7700078","article-title":"Safety and efficacy of adenovirus-mediated transfer of the human aquaporin-1 cDNA to irradiated parotid glands of non-human primates","volume":"6","author":"O'Connell","year":"1999","journal-title":"Cancer Gene Ther."},{"key":"10.1016\/j.bbamem.2005.11.006_bib27","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1089\/10430340152710559","article-title":"Evaluation of salivary gland acinar and ductal cell-specific promoters in vivo with recombinant adenoviral vectors","volume":"12","author":"Zheng","year":"2001","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.bbamem.2005.11.006_bib28","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1002\/jgm.476","article-title":"Developing a convenient large animal model for gene transfer to salivary glands in vivo","volume":"6","author":"Li","year":"2004","journal-title":"J. Gene Med."},{"key":"10.1016\/j.bbamem.2005.11.006_bib29","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.ijrobp.2005.04.029","article-title":"Structural and functional characteristics of irradiation damage to parotid glands in the miniature pig","volume":"62","author":"Li","year":"2005","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"10.1016\/j.bbamem.2005.11.006_bib30","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.ymthe.2004.11.007","article-title":"Increased fluid secretion after adenoviral-mediated transfer of the human aquaporin-1 cDNA to irradiated miniature pig parotid glands","volume":"11","author":"Shan","year":"2005","journal-title":"Mol. Ther."},{"key":"10.1016\/j.bbamem.2005.11.006_bib31","unstructured":"http:\/\/www.fda.gov\/ora\/compliance_ref\/bimo\/7348_808\/default.htm."},{"key":"10.1016\/j.bbamem.2005.11.006_bib32","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1111\/j.1600-0714.1998.tb02088.x","article-title":"Safety of salivary gland-administered replication-deficient recombinant adenovirus in rats","volume":"27","author":"Delporte","year":"1998","journal-title":"J. Oral Pathol. Med."},{"key":"10.1016\/j.bbamem.2005.11.006_bib33","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1034\/j.1600-0714.2003.t01-1-00004.x","article-title":"Distribution and toxicity resulting from adenoviral vector administration to a single salivary gland in adult rats","volume":"32","author":"O'Connell","year":"2003","journal-title":"J. Oral Pathol. Med."},{"key":"10.1016\/j.bbamem.2005.11.006_bib34","doi-asserted-by":"crossref","unstructured":"C. Zheng, A. Voutetakis, M.R. Kok, C.M. Goldsmith, G.B.J. Smith, M. Vallant, R.D. Irwin, B.J. Baum, Toxicity and biodistribution of a first-generation recombinant adenoviral vector, in the presence of hydroxychloroquine, following retroductal delivery to a single rat submandibular gland, Oral Dis. (in press).","DOI":"10.1111\/j.1601-0825.2005.01170.x"},{"key":"10.1016\/j.bbamem.2005.11.006_bib35","unstructured":"http:\/\/www.accessdata.fda.gov\/scripts\/cdrh\/cfdocs\/cfcfr\/CFRSearch.cfm?CFRPart=211."},{"key":"10.1016\/j.bbamem.2005.11.006_bib36","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1089\/hum.1996.7.9-1085","article-title":"Immediate inflammatory responses to adenovirus-mediated gene transfer in rat salivary glands","volume":"10","author":"Adesanya","year":"1996","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.bbamem.2005.11.006_bib37","doi-asserted-by":"crossref","first-page":"2777","DOI":"10.1089\/hum.1998.9.18-2777","article-title":"Adenoassociated virus-mediated transfer of a functional water channel into salivary epithelial cells in vitro and in vivo","volume":"9","author":"Braddon","year":"1998","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.bbamem.2005.11.006_bib38","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1089\/10430340152712638","article-title":"Safety of local delivery of low- and intermediate-dose adenovirus gene transfer vectors to individuals with a spectrum of morbid conditions","volume":"13","author":"Harvey","year":"2002","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.bbamem.2005.11.006_bib39","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1089\/10430340152712647","article-title":"Analysis of risk factors for local delivery of low- and intermediate-dose adenovirus gene transfer vectors to individuals with a spectrum of comorbid conditions","volume":"13","author":"Crystal","year":"2002","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.bbamem.2005.11.006_bib40","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1200\/JCO.2001.19.3.800","article-title":"Concurrent paclitaxel and radiation in the treatment of locally advanced head and neck cancer","volume":"19","author":"Sunwoo","year":"2001","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.bbamem.2005.11.006_bib41","first-page":"F463","article-title":"Aquaporin CHIP: the archetypal molecular water channel","volume":"265","author":"Agre","year":"1993","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.bbamem.2005.11.006_bib42","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.ymgme.2003.08.016","article-title":"Fatal systemic inflammatory response syndrome in a ornithine transcarbamylase deficient patient following adenoviral gene transfer","volume":"80","author":"Raper","year":"2003","journal-title":"Mol. Genet. Metab."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Biomembranes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0005273605003603?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0005273605003603?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,20]],"date-time":"2019-01-20T12:26:42Z","timestamp":1547987202000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0005273605003603"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,8]]},"references-count":42,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2006,8]]}},"alternative-id":["S0005273605003603"],"URL":"https:\/\/doi.org\/10.1016\/j.bbamem.2005.11.006","relation":{},"ISSN":["0005-2736"],"issn-type":[{"value":"0005-2736","type":"print"}],"subject":[],"published":{"date-parts":[[2006,8]]}}}